Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them by Philip Smith, Stuart Bloom, Christian Selinger, Ailsa Hart, Christopher Lamb, Anjan Dhar, Helen Steed, Matthew Brookes, Jonathan Macdonald, Ian Arnott, Shellie Radford, Gordon W Moran, Susan Ritchie, Victoria Fletcher, Jonathan Segal, N Sharma, Shahida Din, Daniel Gaya, J Butterworth, S Andrews, P Adams, Deborah Morris, Pearl Avery, Philip Oppong, Mario Guslandi, Maro Kyriacou, Rachel Linger, Madhoor Ramdeen, John Appleton, John Anneh, B Kussel

“…Following this, there were three rounds of Delphi surveys in which the participants were asked to rank the importance of the statements and provide any additional comments or clarifications. Calculation of mean scores, analysis of comments and revisions were performed to produce a final list of statements.Results In total, 14 statements were suggested by the focus group at the initial brainstorming stage. …”
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2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity by Rodrigo Santos Aquino de Araújo, Vitória Gaspar Bernardo, Robert da Silva Tibúrcio, Danilo Cesar Galindo Bedor, Michel Leandro de Campos, Roberto Pontarolo, Julyanne Maria Saraiva de Sousa, Klinger Antonio da Franca Rodrigues, Marcus Tullius Scotti, Anuraj Nayarisseri, Pascal Marchand, Francisco Jaime Bezerra Mendonça-Junior

“…Thus, new compounds were synthesized containing chemical modifications at the C-3, C-4, and C-5 positions of the 2-aminothiophene ring, in addition to the S-Se bioisosterism. <b>Methods</b>: Dozens of 2-AT and 2-aminoselenophen (2-AS) derivatives were sequentially synthesized through applications of the Gewald reaction and were then evaluated in vitro for their activities against <i>L. amazonensis</i> and for cytotoxicity against macrophages. …”
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GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…Further mechanistic study revealed that GEN-27 remarkably inhibited the nuclear translocation of NF-κB and phosphorylation of IκB and IKKα/β in both HCT116 and THP-1 cells. In addition, GEN-27 markedly suppressed the HCT116 cell proliferation stimulated by IL-1β treatment, which was dependent on the inhibition of NF-κB/p65 nuclear localization, as verified by p65 overexpression and BAY 11-7082, an NF-κB inhibitor. …”
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Gaia-4b and 5b: Radial Velocity Confirmation of Gaia Astrometric Orbital Solutions Reveal a Massive Planet and a Brown Dwarf Orbiting Low-mass Stars by Gudmundur Stefánsson, Suvrath Mahadevan, Joshua N. Winn, Marcus L. Marcussen, Shubham Kanodia, Simon Albrecht, Evan Fitzmaurice, Onė Mikulskytė, Caleb I. Cañas, Juan I. Espinoza-Retamal, Yiri Zwart, Daniel M. Krolikowski, Andrew Hotnisky, Paul Robertson, Jaime A. Alvarado-Montes, Chad F. Bender, Cullen H. Blake, J. R. Callingham, William D. Cochran, Megan Delamer, Scott A. Diddams, Jiayin Dong, Rachel B. Fernandes, Mark R. Giovinazzi, Samuel Halverson, Jessica Libby-Roberts, Sarah E. Logsdon, Michael W. McElwain, Joe P. Ninan, Jayadev Rajagopal, Varghese Reji, Arpita Roy, Christian Schwab, Jason T. Wright

“…Here we present RV follow-up observations of 28 M and K stars with candidate astrometric substellar companions, which led to the confirmation of two systems, Gaia-4b and Gaia-5b, identification of five systems that are single lined but require additional data to confirm as substellar companions, and the refutation of 21 systems as stellar binaries. …”
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Development and Application of <i>Lactobacillus plantarum</i> PSCPL13 Probiotics in Olive Flounder (<i>Paralichthys olivaceus</i>) Farming by Muhammad Aleem Abbas, Hae-Jung Kim, Ga-Yeong Lee, Hae-Yeon Cho, Syed Al Jawad Sayem, Eon-Bee Lee, Seung-Jin Lee, Seung-Chun Park

“…In vivo assays in olive flounder revealed that the body weight and length of the fish were significantly higher, while the prevalence of pathogens was lower in their gut microbiota. …”
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Single-mode microwave heating for food science research: Understanding specific microwave effects and reliability concerns by Xidong Jiao, Haifeng Diao, Tianyi Liu, Bowen Yan, Xiangwei Tang, Daming Fan

“…This study explores microwave heating characteristics by conducting Multiphysics numerical simulations within a single-mode microwave system, emphasizing the impact of solvent type and volume on the heating rate, temperature profile, and distribution of the electric field and power dissipation density. In addition, the study examined the microwave-induced aggregation behavior of myofibrillar proteins (MPs) in diverse monovalent salt solvents by employing an established heating protocol. …”
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A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism by Xiao He, Fang Xie, Ying Nie, Xuefeng Wang, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun

“…Further in vitro and in vivo experiments indicated that circANKRD17 can regulate lipid metabolism through various mechanisms involving the PPAR pathway, including promoting adipocyte differentiation, fatty acid transport and metabolism, triglyceride synthesis, and lipid droplet formation and maturation. In addition, we discovered that circANKRD17 has an open reading frame and can be translated into a novel 571-amino-acid protein that promotes lipid metabolism. …”
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Mid-trimester resolution of marked dextroposition of the fetal heart preceding regression of extensive left fetal lung lesion consisting of hybrid congenital pulmonary airway malfo... by David M. Sherer, MD, Ida Dhanuka, MD, Kayla Schacher, MD, Hubert Rodriguez-Tejada, MD, Aleksandra Zigalo, RDMS, Mila Kheyman, RDMS, Harry Zinn, MD, Fancisca T. Velcek, MD, Mudar Dalloul, MD

“…Neonatal CT angiography demonstrated CPAM of the left lower lobe. In addition, a feeding vessel was seen emanating directly from the thoracic aorta, indicating an intralobar brochopulmonary sequestration (BPS) component of the left lung lesion, consistent with a hybrid lung lesion (CPAM and intralobar BPS). …”
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Modeling of wave-induced drift based on stepwise parameter calibration by Kui Zhu, Xueyao Chen, Lin Mu, Lin Mu, Lin Mu, Dingfeng Yu, Dingfeng Yu, Runze Yu, Zhaolong Sun, Tong Zhou, Tong Zhou

“…Compared with the force analysis method, the accuracy of the ML methods in the verification test was higher. In addition, the results show that for OFVs, considering wave-induced drift’s influence in the ensemble-trajectory prediction could improve the simulation accuracy. …”
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General and simple salts-mediating approach enables superior magnesium plating/stripping properties by Ning Yuan, Jing Liu, Wenhao Sun, Min Wang, Changming Mao, Kun Chao, Zhenfang Zhou, Xiaosong Guo, Zhonghua Zhang, Guicun Li

“…This greatly improves active ion accessibility for Mg-metal anode and is beneficial for uniform Mg electrodeposition. In addition, unique MgCl-rich and carbonyl organic compounds-containing interphases are unveiled, which is conducive to active Mg electrodeposition. …”
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Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System by Shuaishuai Zhang, Junqin Li, Huijie Jiang, Yi Gao, Pengzhen Cheng, Tianqing Cao, Donglin Li, Jimeng Wang, Yue Song, Bin Liu, Hao Wu, Chunmei Wang, Liu Yang, Guoxian Pei

“…Moreover, the autophagy level of BMSCs, regulating their stemness, was promoted in the coculture group, mediated by the AMPK/mTOR pathway. In addition, AMPK inhibitor compound C could significantly downregulate the protein expression of LC3 and the mRNA level of stemness genes in the coculture group. …”
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Effect of Curry Leaf (Murraya koenigii) as Edwardsiellosis Treatment on Gourami Fish (Osphronemus goramy) by Muyassar H. Abualreesh, Agus Pariawan, Annisa Isti Fauziyyah, Farid Mukhtar Riyadi, Mohammad Fadjar, Arief Prajitno, Arif Syaifurrisal, Muhammad Browijoyo Santanumurti, Suciyono Suciyono

“…The most effective dose in treating Edwardsiellosis in gourami fish was found to be 600 mg/L, as it significantly improved various hematological parameters, including hematocrit, hemoglobin, erythrocyte count, leukocyte count, lymphocytes, monocytes, and neutrophils. Additionally, histopathological analysis showed improvements in tissue conditions, with lower scores for degeneration, congestion, and necrosis. …”
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Multi-Band Scattering Characteristics of Miniature Masson Pine Canopy Based on Microwave Anechoic Chamber Measurement by Kai Du, Yuan Li, Huaguo Huang, Xufeng Mao, Xiulai Xiao, Zhiqu Liu

“…The scene’s backscattering energy was influenced by the scattering and extinction of canopy branches and needles, as well as by ground scattering, resulting in a complex relationship with canopy density. In addition, applying orientation correction to the polarization scattering matrix can mitigate the impact of the incident angle and reduce the decomposition energy errors in the Freeman–Durden model. …”
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Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status by Luca Formichella, Laura Romberg, Hannelore Meyer, Christian Bolz, Michael Vieth, Michael Geppert, Gereon Göttner, Christina Nölting, Wolfgang Schepp, Arne Schneider, Kurt Ulm, Petra Wolf, Ingrid Lisanne Holster, Ernst J. Kuipers, Bernd Birkner, Erwin Soutschek, Markus Gerhard

“…An isolated CagA band often represents past eradication with a likelihood of 88.7%. In addition, a high recomLine score was significantly associated with high-grade gastritis, atrophy, intestinal metaplasia, and gastric cancer. …”
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Organic Light-Emitting Diode with Color Tunable between Bluish-White Daylight and Orange-White Dusk Hue by Shih-Yun Liao, Sudhir Kumar, Hui-Huan Yu, Chih-Chia An, Ya-Chi Wang, Jhong-Wei Lin, Yung-Lee Wang, Yung-Chun Liu, Chun-Long Wu, Jwo-Huei Jou

“…Unlike the prior arts, the color-temperature span can be made much wider without any additional carrier modulation layer, which should enable a more cost effective fabrication. …”
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Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

“…Reduction of increased Gli3 levels via heterozygous genetic deletion in Cpk mice did not affect cyst formation. Additionally, lowering GLI3 transcripts to wildtype levels did not influence PKHD1‐mutant spheroid size. …”
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Uterine Natural Killer Cell and Human Leukocyte Antigen-G1 and Human Leukocyte Antigen-G5 Expression in Vaginal Discharge of Threatened-Abortion Women: A Case-Control Study by Saeideh Sadat Shobeiri, Zahra Rahmani, Hadi Hossein Nataj, Hossein Ranjbaran, Masoud Mohammadi, Saeid Abediankenari

“…The results of this study showed that threatened-abortion women had increased uNK cells and decreased T cells percentage in vaginal discharge in comparison with normal pregnant women (p=0.01, p=0.003, resp.). In addition, HLA-G1 isoform had lower expression in threatened-abortion women in comparison with control group p=0.0001. …”
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Investigating the Allelopathic and Bioherbicidal Potential of <i>Solidago altissima</i> with a Focus on Chemical Signaling in <i>Trifolium repens</i> by Ho-Jun Gam, Arjun Adhikari, Yosep Kang, Md. Injamum-Ul-Hoque, Shifa Shaffique, Ji-In Woo, Jin Ryeol Jeon, Byeong-Kwan An, Min Young Back, Ki-Yong Kim, Sang-Mo Kang, In-Jung Lee

“…Additionally, antioxidant activities, such as superoxide dismutase, catalase, and peroxidase enzyme activities, were significantly elevated in <i>T. repens</i> treated with SRE. …”
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Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease by Colomba Falcone, Sara Bozzini, Luigina Guasti, Angela D’Angelo, Anna Clizia Capettini, Edoardo Maria Paganini, Rossana Falcone, Roberto Moia, Carmine Gazzaruso, Gabriele Pelissero

“…The objective of the present study was define in a relatively large patient population with coronary artery disease (CAD) whether the concomitant presence of peripheral artery disease (PAD), which is known to convey additional cardiovascular risk, was associated with different circulating levels of sRAGE with respect to CAD alone and control subjects. …”
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Edibility of cultivated green seaweed Ulva intestinalis from Monkhali Beach, Cox’s Bazar coast of Bangladesh: bio-toxicity and heavy metal contents by Md. Mohibbullah, Md. Afzal Hossain, Mahfuzul Alam Mithu, Md. Maynul Islam, Mohammed Shariful Azam, Mohammed Nurul Absar Khan, Jae-Suk Choi

“…Moreover, Fe, Cr, Ni, Cu and Zn (43.60, 0.10, 0.44, 0.07, 0.27 and 0.13 mg kg−1 of dry weight, respectively) in UI were found to be low levels compared to previous studies, in addition, Cd and As remained not detected. …”
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