The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer by Si Chen, Caihong Yao, Na Tian, Chunying Zhang, Yuemei Chen, Xuting Wang, Yue Jiang, Tonghao Zhang, Tingting Zeng, Yali Song

“…Abstract Background Chronic infections by pathogenic microorganisms play a significant role in cancer development, disrupting the body's immune system and microenvironment. This interference impairs the body's ability to eliminate these microorganisms promptly, allowing them to persist by evading immune defenses. …”
Get full text

DEPEND study protocol: early detection of patients with pancreatic cancer – a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as scr... by Christopher D Byrne, Sam Wilding, Paul Remi Afolabi, Declan McDonnell, Victoria Goss, Jocelyn Walters, Zaed Z Hamady

“…Continuous flow isotope ratio mass spectrometry in the 13C-MTG breath test will be used to analyse enriched 13CO2 in exhaled breath samples. The additional predictive benefit of other potential biomarkers of PC will also be considered. …”
Get full text

Similarities and differences in physiological adaptation to cadmium interactions with nitrogen levels between two aquatic iris life forms in urban wetlands by Zhenzuo Lei, Yuan Jiang, Yanqiong Meng, Yiyong Li, Yucong Li, Tao Hu, Yanjun Ma

“…Specifically, for deciduous irises, the shoot mass (SM) and root-to-shoot ratio (S/R) increased with higher N concentrations, whereas in evergreen irises, these parameters initially increased and then decreased as N levels increased, suggesting that the two life forms have different efficiencies in utilizing N. Additionally, under the combined stress of N and Cd, evergreen irises exhibited higher malondialdehyde (MDA) content and antioxidant enzyme activity than deciduous irises, whereas deciduous irises had higher chlorophyll content and aboveground biomass. …”
Get full text

Protective effects of resveratrol and naringenin against nonylphenol-induced oxidative stress in rats by Haitham S. Elewa, Dawlat A. Salama, Mohamed S. Hikal, Mohamed F. Abd El hamid, Mohamed H. Eid, Fatma M. A. Khalil, Muayad S. Albadrani, Khaled Abdelaal, Ahmed I. El-Tokhy

“…All the recorded effects induced by NP treatment were effectively countered by co-treatment with RES or NG. In addition, molecular docking studies were carried out to reveal the interactions between NP, RES, NG and estrogen receptor beta which provide a possible mechanism for their potential estrogenic activity. …”
Get full text

Effects of Coach’s Verbal Encouragement During Small-Sided Volleyball Games on Specific Physical Fitness and Technical-Tactical Behavior of Youth Athletes by Taufiq Hidayat, Irma Febriyanti, Advendi Kristiyandaru, Suroto, Hari Wisnu, Ahmet Kurtoğlu, Amayra Tannoubi, Joseph Lobo, Baglan Yermakhanov, Jarosław Muracki, Edi Setiawan

“…Results: The results of the 2-Way ANOVA showed that there were differences in physical performance based on effect factors (all, p < 0.05), interaction factors (p < 0.05), except MBTT (p > 0.05), group factors (p < 0.05), except MBTT (p > 0.05). In addition, there were differences in technical-tactical behavioral factors based on time effects (all, p < 0.05), interaction factors (p < 0.05), except service (p > 0.05), and group factors (all, p < 0.05). …”
Get full text

The Impact of Reich’s Vegetotherapy on Emotional Regulation and Postural Balance in Military Personnel: A Non-Pharmacological Approach to Combat Stress by Sana Khadhrani, Imed Touhemi, Amri Hammami, Chiraz Goumni, Jihen Khalfoun, Mohanad Omar, Rebai Haithem, Abderraouf Ben Abderrahman

“…The EG improved more (−36%) compared to the CG (24%). In addition, anger levels significantly improved post-intervention ( p  = .001), with a significant time × group interaction ( p  = .001). …”
Get full text

Beetroot (Beta vulgaris L.) Extract Ameliorates Gentamicin-Induced Nephrotoxicity Associated Oxidative Stress, Inflammation, and Apoptosis in Rodent Model by Ali A. El Gamal, Mansour S. AlSaid, Mohammad Raish, Mohammed Al-Sohaibani, Shaza M. Al-Massarani, Ajaz Ahmad, Mohamed Hefnawy, Mohammed Al-Yahya, Omer A. Basoudan, Syed Rafatullah

“…Gentamicin-induced increased renal inflammatory cytokines (TNF-α and IL-6), nuclear protein expression of NF-κB (p65), NF-κB-DNA binding activity, myeloperoxidase (MPO) activity, and nitric oxide level were significantly down regulated upon BVEE treatment. In addition, BVEE treatment significantly reduced the amount of cleaved caspase 3 and Bax, protein expression and increased the Bcl-2 protein expression. …”
Get full text

Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction by Cun Li, Yifei Yu, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Shuxin Zhang, Xiaoxin Zhu, Qiaoshuai Lan, Yanlin Deng, Ying Zhou, Wei Xue, Ming Yue, Jian-Piao Cai, Cyril Chik-Yan Yip, Kenneth Kak-Yuen Wong, Xiaojuan Liu, Yang Yu, Lin Huang, Hin Chu, Jasper Fuk-Woo Chan, Hans Clevers, Kwok Yung Yuen, Jie Zhou

“…Treatment with α-CDHR3 and antivirals significantly reduces HRV-C viral growth in airway and nasal organoids. Additionally, an organoid-based immunofluorescence assay is established to titrate HRV-C infectious particles. …”
Get full text

The Efficient Integration of Dust and Numerical Weather Prediction for Renewable Energy Applications by Xi Chen, Mei Chong, Shian‐Jiann Lin, Zhi Liang, Paul Ginoux, Yuan Liang, Bihui Zhang, Qian Song, Shengkai Wang, Jiawei Li, Yimin Liu

“…Using about one‐eighth additional computing power, iDust extends global 12.5 km resolution NWP with dust prediction capabilities. iDust's forecasting abilities are evaluated against ECMWF CAMS forecast and NASA MERRA2 reanalysis, including verifications over China from March to May 2023 and three extreme dust events. …”
Get full text

Reading between the lines: exploring the discriminative ability of the Short-Story Task in identifying autistic individuals within autism outpatient services by Irina Jarvers, Monika Sommer, Monika Sommer, Manuela Ullmann, Verena Simmel, Lore Blaas, Stefanie Gorski, Saskia Krüger-Lassen, Matthias Vogel, Berthold Langguth

“…In 100 of them an autism spectrum disorder has been diagnosed and 111 individuals were diagnosed with other conditions or none at all.ResultsPerformance on the SST did not significantly differ between the two groups, and receiver operator curve analysis did not support the SST as a reliable discriminator. …”
Get full text

A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies by Yazhou Zhang, Steve A. McClain, Hsi-Ming Lee, Muna S. Elburki, Huiwen Yu, Ying Gu, Yu Zhang, Mark Wolff, Francis Johnson, Lorne M. Golub

“…MMP-8 was increased 10-fold in the diabetic wounds and topically applied 1% (but not 0.25%) CMC2.24 significantly reduced this excessive collagenase-2; MMP-13/collagenase-3 did not show significant changes. Additional studies indicated efficacy of 1% CMC2.24 over more prolonged periods of time up to 30 days.…”
Get full text

Molecular response to multiple trace element contamination of the European sardine by Beauvieux, Anaïs, Fromentin, Jean-Marc, Saraux, Claire, Romero, Diego, Couffin, Nathan, Brown, Adrien, Metral, Luisa, Bertile, Fabrice, Schull, Quentin

“…The associated energetic cost may add a substantial burden to sardines that already face multi-factorial constraints. …”
Get full text

Recent advancement and design in supercapacitor hybrid electrode materials: Bridging the gap between energy and power density by Soumen Mandal, Arpit B. Mendhe, Hitesh M. Rakhade, Neha S. Barse, Mayna Roy, P. Rosaiah, Taejoon Park, Han-Seung Lee, Avinash C. Mendhe, Daewon Kim

“…Advances in material modifications such as the integration of nanomaterials are analyzed, with a focus on their ability to improve energy density and cycling stability. Additionally, the review assesses various types of electrode materials such as carbon-based, metal oxide-based, conducting polymers, and metal chalcogenide-based electrodes, in combination with nanomaterials like carbon, metal oxides, among others. …”
Get full text

Fluorescence properties of long-range-transported smoke: insights from five-channel lidar observations over Moscow during the 2023 wildfire season by I. Veselovskii, M. Korenskiy, N. Kasianik, B. Barchunov, Q. Hu, P. Goloub, T. Podvin

“…Observations reveal that the fluorescence capacity generally increases with altitude, suggesting a higher concentration of organic compounds in the MUT compared to the lower troposphere. Additionally, the measurements consistently show differences in the fluorescence spectra of smoke and urban aerosol. …”
Get full text

Lack of Association of C677T Methylenetetrahydrofolate Reductase Polymorphism with Breast Cancer Risk in Mali by Brehima Diakite, Yaya Kassogue, Mamoudou Maiga, Guimogo Dolo, Oumar Kassogue, Jane L. Holl, Brian Joyce, Jun Wang, Kadidiatou Cisse, Fousseyni Diarra, Mamadou L. Keita, Cheick B. Traore, Bakarou Kamate, Sidi B. Sissoko, Bourama Coulibaly, Adama S. Sissoko, Drissa Traore, Fatoumata M. Sidibe, Sekou Bah, Ibrahim Teguete, Madani Ly, Sellama Nadifi, Hind Dehbi, Kyeezu Kim, Robert Murphy, Lifang Hou

“…The same trend was observed when the analysis was extended to other genetic models, including dominant (p = 0.50), recessive (p = 0.87), and additive (p = 0.50) models. The C677T polymorphism of MTHFR gene did not influence the risk of breast cancer in the Malian samples.…”
Get full text

Toxicological impact of rabeprazole and evaluation of toxic effects on the plant-based eukaryotic test models by Muhammad Torequl Islam, Marcello Iriti, Hicham Harhar, Youssef Elouafy, Imane Chamkhi, Eda Sönmez Gürer, Javad Sharifi-Rad

“…Methods: A comprehensive search of published literature was conducted in various databases up until April 2020, using specific keywords. Additionally, toxic effects of RPZ-Na (0.025-0.4 mM) were evaluated on Allium cepa, Allium sativum and Cicer arietinum at different exposure times using CuSO4 as a reference standard. …”
Get full text

The burden of group A Streptococcus (GAS) infections: The challenge continues in the twenty-first century by Aswin Thacharodi, Saqib Hassan, Avadh Vithlani, Tawfeeq Ahmed, Sanjana Kavish, Nicole-Mae Geli Blacknell, Ali Alqahtani, Arivalagan Pugazhendhi

“…GAS produces a variety of virulence factors and exotoxins that can lead to deadly infections such as necrotizing fasciitis, impetigo, cellulitis, pneumonia, empyema, streptococcal toxic shock syndrome, bacteremia, and puerperal sepsis. In addition, post-immune mediated disorders such as post-streptococcal glomerulonephritis, acute rheumatic fever, and rheumatic heart disease contribute to extremely high death rates in developing nations. …”
Get full text

Enhancing aviation control security through ADS-B injection detection using ensemble meta-learning models with Explainable AI by Vajratiya Vajrobol, Geetika Jain Saxena, Sanjeev Singh, Amit Pundir, Brij B. Gupta, Akshat Gaurav, Kwok Tai Chui

“…Ensemble methods, which combine several models can increase the detection accuracy and robustness of the model used to identify the threat. In addition, Explainable AI (XAI) methods are employed to enhance the process of explaining how the model reaches its decisions and building trust in aviation security systems. …”
Get full text

Proton motive force generated by microbial rhodopsin promotes extracellular electron transfer by Wenqi Ding, Tong Lin, Yun Yang, Wen-Wei Li, Shaoan Cheng, Hao Song

“…The results suggested that strain cR-1 effectively expels protons to generate additional PMF and provide extra ATP supply to the cells, which facilitated lactate uptake and utilization, thus enhancing electrons generation in cells. …”
Get full text

Montreal Cognitive Assessment and Modified Mini Mental State Examination in African Americans by Kaycee M. Sink, Suzanne Craft, S. Carrie Smith, Joseph A. Maldjian, Donald W. Bowden, Jianzhao Xu, Barry I. Freedman, Jasmin Divers

“…Sparse data limit the interpretation of Montreal Cognitive Assessment (MoCA) scores, particularly in minority populations. Additionally, there are no published data on how MoCA scores compare to the widely used Modified Mini Mental State Examination (3MSE). …”
Get full text