Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer by Shaopeng Zhang, Ximo Xu, Kundong Zhang, Changzheng Lei, Yitian Xu, Pengshan Zhang, Yuan Zhang, Haitao Gu, Chen Huang, Zhengjun Qiu

“…M2d is characterized by elevated secretion of IL-10 and VEGF-A, which diminish CD8+T cells cytotoxicity and promote tumor neoangiogenesis simultaneously. Additionally, we identify 2,5’-oligoadenylate synthase 3 (OAS3) as an essential regulator of M2d polarization, upregulated by PCs via lactate/METTL3/OAS3 axis. …”
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Development of a prognostic gene signature and exploration of P4HA1 in the modulation of cuproptosis in colorectal cancer by RenJie Jiang, LinLin Ruan, Taohui Ding, Hongtao Wan, Yanglin Chen, XiaoJian Zhu, Zhijiang Huang, Dengke Yao, Ming Li, Bo Yi, Dan Liu

“…P4HA1 was identified as a key gene of interest, where downregulation was found to inhibit tumor progression in single-cell sequencing analyses and in vitro experiments. Additionally, suppression of P4HA1 enhanced the sensitivity of CRC cells to the cuproptosis inducer elesclomol (ES), potentially through oxidative stress mechanisms. …”
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Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-... by Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen

“…In vivo therapeutic investigation suggested that MCDs reduced synovial inflammation and hyperplasia, ultimately prevented cartilage destruction, bone erosion, and synovial fibrosis in CIA rats. In addition, MCDs eliminated the cellular ROS in M1 phenotype macrophages in RA microenvironment through the enzyme-like catalytic activity as well as inhibiting NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome signaling pathway, effectively polarizing them into the M2 phenotype to realize the anti-inflammatory effect. …”
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Distinct neural computations scale the violation of expected reward and emotion in social transgressions by Ting Xu, Lei Zhang, Feng Zhou, Kun Fu, Xianyang Gan, Zhiyi Chen, Ran Zhang, Chunmei Lan, Lan Wang, Keith M. Kendrick, Dezhong Yao, Benjamin Becker

“…We further identified a fronto-insular network encompassing the left anterior cingulate cortex, bilateral insula, left dmPFC and inferior frontal gyrus that encoded punishment decisions. In addition, a stronger fronto-insular pattern expression under reward PE predicted more punishment decisions. …”
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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Our findings show that AgNPs effectively do not affect cell viability in Calu-3 cells, inhibit viral infection in Vero-E6 cells and progression of infection in vitro. Additionally, AgNPs impair caspase-1 activation, lactate dehydrogenase release and IL-1β production by human monocytes. …”
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Cricket protein-based film containing Caralluma fimbriata extract-based nanoparticles for preservation of cheddar cheese by Aunzar Bashir Lone, Hina F. Bhat, Sunil Kumar, Abderrahmane Aït-Kaddour, Rana Muhammad Aadil, Abdo Hassoun, Zuhaib F. Bhat

“…The Car-Fim-NPs were developed using an ultrasonication-mediated (20 kHz, 500 W, 10 min, pulse duration of 5/5 s on/off) green method. The addition of Car-Fim-NPs modified the film characteristics [density (%), WVTR (mg/mt2), transmittance (%), elongation at break (%), and colour (L*, a*, b*)] and enhanced its antioxidant [DPPH, ABTS and FRAP activities, total phenolic and flavonoid contents, and antioxidant release (%)] and antimicrobial (inhibitory halos against E. coli and S. aureus) potential. …”
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Disaster Control of Roof Falling in Deep Coal Mine Roadway Subjected to High Abutment Pressure by Shizhong Zhang, Gangwei Fan, Ling Chai, Qizhen Li, Mingwei Chen, Tao Luo, Shang Ren

“…The support length of the belt roadway should be at least 57.7 m, with 0-30 m away from the coalface supported by hydraulic supports and 32-57.7 m supported by single props. In addition, the maximum setting load and movable column length of hydraulic supports were 21.67 MPa and 280.3 mm and 12.44 MPa and 177.1 mm for single props, respectively. …”
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Reduced graphene oxide anchored MnCo2S4 for solid state asymmetric capacitor device by Yuttana Mona, Uma Shankar Veerasamy, Vigneshwaran Baskaran, Nakorn Tippayawong, Phrut Sakulchangsatjatai, Niti Kammuang-lue, Pana Suttakul, Ramnarong Wanison

“…Moreover, the constructed rGO@MnCo2S4//rGO ASC device shows a higher capacity of 140.83 mAh g-1 at 1 A g-1. In addition, the rGO@MnCo2S4//rGO ASC device also delivers a higher energy density of 37.55 Wh kg-1 and power density of 800 W kg-1. …”
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An Integrating Approach for Genome-Wide Screening of MicroRNA Polymorphisms Mediated Drug Response Alterations by Xianyue Wang, Hong Jiang, Wei Wu, Rongxin Zhang, Lingxiang Wu, Huan Chen, Pengping Li, Yumin Nie, Jiaofang Shao, Yan Li, Xue Lin, Sali Lv, Qh Wang, Jie Hu

“…We integrated large scale of genetic variations, drug targets, gene interaction networks, biological pathways, and seeds region of miRNA to identify miRNA polymorphisms affecting drug response. In addition, harnessing the abundant high quality biological network/pathways, we evaluated the cascade distribution of tarSNP impacts. …”
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Association between five novel anthropometric indices and erectile dysfunction in US adults from NHANES database by Ningning Xu, Haoxi Zou, Huanying Xu, Yanfen Chen, Qidan Wen, Xiaoyan Xing, Suzhen Wu

“…The analysis of logistic regressions, smooth curve fitting, subgroup analyses and generalized addition model were performed to examine the relationship between five novel anthropometric indicators and the prevalence of ED. …”
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Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages by Suzanne Pickering, Harry Wilson, Enrico Bravo, Marianne R. Perera, Jeffrey Seow, Carl Graham, Nathalia Almeida, Lazaros Fotopoulos, Thomas Williams, Atlanta Moitra, Helena Winstone, Tinne A. D. Nissen, Rui Pedro Galão, Luke B. Snell, Katie J. Doores, Michael H. Malim, Stuart J. D. Neil

“…Infection was not seen in the absence of antibody with the same quantity of virus. Addition of ruxolitinib significantly increased infection, indicating restraint of infection through innate immune mechanisms rather than entry. …”
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Sexual and reproductive health and rights, HIV and migration in southern Africa: A rapid review by G Musuka, I Chingombe, E Moyo, T Chikava, B Moyo, M Mapingure, H Musuka, T Dzinamarira

“…The lessons learnt emphasised the importance of community involvement, healthcare worker (HCW) training and inclusive policies to address migrants’ diverse needs effectively. Additionally, projects facilitated cross-border collaborations and policy integration, enhancing access to SRH-HIV services and migrant health rights. …”
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Reinforcement of PMMA Denture Base Material with a Mixture of ZrO2 Nanoparticles and Glass Fibers by Mohammed M. Gad, Ahmad M. Al-Thobity, Ahmed Rahoma, Reem Abualsaud, Fahad A. Al-Harbi, Sultan Akhtar

“…For the control group, the specimens did not receive any additions; for the test group, different concentrations of nano-ZrO2/GFs at 5% of the PMMA polymer were added. …”
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Sex-Specific Differences in the Pathophysiology of Hypertension by Hannah Zhang, Pawan K. Singal, Amir Ravandi, Inna Rabinovich-Nikitin

“…As a result, its pathophysiological mechanisms have been studied extensively and are focused around pressure natriuresis, the renin–angiotensin system (RAS), the sympathetic nervous system, oxidative stress, and endothelial dysfunction. Additionally, hypertension secondary to other underlying etiologies also exists. …”
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Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury by Di Wu, Wenjie Ma, Liucheng Wang, Chengcheng Long, Silin Chen, Jingyu Liu, Yiguan Qian, Jun Zhao, Changcheng Zhou, Ruipeng Jia

“…Moreover, N-EVs effectively promoted the proliferation, migration, and tube-formation abilities of injured endothelial cells (ECs) and contributed to overall renal function improvement in IRI kidneys through targeted delivery of miR-21-5p. Additionally, N-EVs could restore damaged endothelial integrity, reduce cytokine release, and inhibit leukocyte infiltration, hence alleviating renal inflammation. …”
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MUSEQuBES: Unveiling Cosmic Web Filaments at z ≈ 3.6 through Dual Absorption and Emission Line Analysis by Eshita Banerjee, Sowgat Muzahid, Joop Schaye, Sebastiano Cantalupo, Sean D. Johnson

“…Here, we report the discovery of an extremely metal-poor ([ X / H ] ≈ −3.7), low-density ( ${\mathrm{log}}_{10}{n}_{{\rm{H}}}/{{\rm{cm}}}^{-3}\,\approx $ −4, corresponding to an overdensity of ≈5) partial Lyman limit system (pLLS) at z  ≈ 3.577 along the quasar sightline Q1317–0507, probing cosmic filaments. Additionally, two other low-metallicity ([ X / H ] ≲ −2) absorption systems are detected at similar redshifts, one of which is also a pLLS. …”
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Deep Learning Applications in Ionospheric Modeling: Progress, Challenges, and Opportunities by Renzhong Zhang, Haorui Li, Yunxiao Shen, Jiayi Yang, Wang Li, Dongsheng Zhao, Andong Hu

“…This paper systematically reviews the development of deep learning applications in ionospheric modeling, summarizing findings that demonstrate how integrating multi-source data and employing multi-model ensemble strategies has substantially improved the stability of spatiotemporal predictions, especially in handling complex space weather events. Additionally, this study explores the potential of deep learning in ionospheric modeling for the early warning of geological hazards such as earthquakes, volcanic eruptions, and tsunamis, offering new insights for constructing ionospheric-geological activity warning models. …”
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Fourier Transform Infrared Spectroscopy Analysis as a Tool to Address Aβ Impact on Extracellular Vesicles by Margarida Vaz, Tânia Soares Martins, Kevin Leandro, Luís Pereira de Almeida, Odete A. B. da Cruz e Silva, Alexandra Nunes, Ana Gabriela Henriques

“…The peak intensity analysis revealed additional peaks with significant differences in EVs’ spectra relative to N2a, following Aβ treatment. …”
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Impact of UV-C irradiation on storage pests with different ecological functions and the viability of the treated grains by Sándor Keszthelyi, Szilvia Gibicsar, Antal Binder, Katalin Somfalvi-Tóth, Ferenc Pál-Fám

“….: Silvanidae) as secondary pests. Additionally, the viability of treated maize and wheat grains influenced by UV-C radiation (10 mins of UV-C at a distance of 22 cm) was analyzed by using a tetrazolium test. …”
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Tailoring the Anomalous Hall Effect in van der Waals Ferromagnet Fe3GeTe2 by WU Kaile, WANG Junshan, JIANG Jiaolin, CHAI Qian, WANG Qin, SANG Shengbo, GE Yang

“…[Methods] Herein, the ferromagnetism and magnetic anisotropy of bulk Fe3GeTe2 (FGT) were investigated. In addition, the anomalous Hall effect of FGT nanoflakes was studied at various temperatures and thicknesses by standard Hall bar device in detail. …”
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