Transcription factor DREF regulates expression of the microRNA gene <i>bantam in Drosophila melanogaster</i> by M. B.  Schwartz, M. M. Prudnikova, O. V. Andreenkov, E. I. Volkova, I. F. Zhimulev, O. V. Antonenko, S.  A. Demakov

“…The effect of DREF binding to the promoter region of the bantam gene on its expression level suggests an additional level of complexity in the regulation of expression of this microRNA. …”
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Transforming education with AI: A systematic review of ChatGPT's role in learning, academic practices, and institutional adoption by Sayeed Salih, Omayma Husain, Mosab Hamdan, Samah Abdelsalam, Hashim Elshafie, Abdelwahed Motwakel

“…It focuses on ChatGPT's application in areas such as academic writing, lesson planning, student assessment, and the professional development of educators. Additionally, the study explores institutional strategies for balancing the benefits of AI with the need to maintain academic integrity and educational quality. …”
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The Effects of Disinfection Byproduct 2,6-Dichloro-1,4-benzoquinone on the Cyanobacterium <i>Microcystis aeruginosa</i>: From the Perspectives of Biochemistry and Non-Targeted Meta... by Tianqi Zhang, Zhaoyang Wang, Liang Wu, Chaonan Liu, Liang Meng, Fuxiang Tian, Meifang Hou, Haizhuan Lin, Jing Ye

“…2,6-Dichloro-1,4-benzoquinone (2,6-DCBQ) is an emerging chlorinated disinfection byproduct (DBP) in bodies of water. However, this compound poses an unknown toxic effect on cyanobacteria. …”
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Triiodothyronine treatment in mice improves stroke outcome and reduces blood–brain barrier damage by Daniel Ullrich, Dagmar Führer, Heike Heuer, Steffen Mayerl, Steffen Haupeltshofer, Linda-Isabell Schmitt, Markus Leo, Rebecca D Szepanowski, Tim Hagenacker, Markus Schwaninger, Christoph Kleinschnitz, Friederike Langhauser

“…Results: We demonstrated a dose-dependent protective effect of T3 reducing infarct volumes with an optimal T3 dosage of 25 μg/kg. In addition, we observed a time-dependent effectiveness that was most profound when T3 was administered 1 h after tMCAO (P < 0.001), with a gradual reduction in efficacy at 4.5 h (P = 0.066), and no reduction in infarct volumes when T3 was injected with an 8-h delay (P > 0.999). …”
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Enhanced Proliferation of Porcine Bone Marrow Mesenchymal Stem Cells Induced by Extracellular Calcium is Associated with the Activation of the Calcium-Sensing Receptor and ERK Sign... by Jingjing Ye, Wei Ai, Fenglin Zhang, Xiaotong Zhu, Gang Shu, Lina Wang, Ping Gao, Qianyun Xi, YongLiang Zhang, Qingyan Jiang, Songbo Wang

“…Accordingly, Ca2+o stimulated the expression levels of proliferative genes such as cyclin A2, cyclin D1/3, cyclin E2, and PCNA and inhibited the expression of p21. In addition, Ca2+o resulted in a significant elevation of intracellular calcium and an increased ratio of p-ERK/ERK. …”
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Alpha-Linolenic Acid Attenuates Inflammatory Response in LPS-stimulated Macrophages by Regulating TLR4/MyD88/NF-κB Signaling Pathway by Ruixin CAI, Xiaodie CHEN, Haibin ZHU, Yushun QIAN, Jianhua XIE, Mingyue SHEN

“…At the same time, α-linolenic acid also reduced ROS production and alleviated ROS-mediated inflammatory damage. In addition, α-linolenic acid could reduce the accumulation of MDA by increasing the expression of antioxidant enzymes SOD, thereby reducing the concomitant harm of oxidative stress in inflammatory responses. …”
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Exploring <i>RNF213</i> in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights by Benjamin Y. Q. Tan, Charlene H. P. Kok, Megan B. J. Ng, Shaun Loong, Eric Jou, Leonard L. L. Yeo, Weiping Han, Christopher D. Anderson, Chiea Chuen Khor, Poh San Lai

“…Key mechanisms by which <i>RNF213</i> variants contribute to disease pathogenesis are explored, alongside discussions on their clinical utility as biomarkers and therapeutic targets. Additionally, we address the gene’s implications for disease prediction, risk assessment, and cascade screening. …”
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Elucidating the metabolic mechanisms and active constituents of ZuoGui Wan in combatting postmenopausal osteoporosis: A metabolomics and network pharmacology approach by Yanchen Feng, KaiKai Shi, Dingming Li, Shunzhi Yang, Xue Dang, Jinyao Li, Yan Chen, Jianping Yao, Yunke Zhang, Lu Sun, Feixiang Liu

“…Metabolomics analysis revealed 33 differential metabolites involved in pathways such as arginine biosynthesis, and the metabolism of arginine, proline, histidine, aspartate, and glutamate. Additionally, network pharmacology and molecular docking analyses further dissected the active ingredients of ZGW, constructing a ''Compound-Targets-Metabolic pathway-Metabolites'' network against PMOP. …”
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3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects by Kai Chen, Fang Wang, Xiumei Sun, Wenwei Ge, Mingjun Zhang, Lin Wang, Haoyu Zheng, Shikang Zheng, Haoyu Tang, Zhengjie Zhou, Guomin Wu

“…The results indicated that the addition of ZnO-NPs significantly improved the piezoelectric properties of BT, facilitating a higher HA content within the ceramic scaffold system, which is essential for bone regeneration. …”
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Expression of genes of cytokines, transcription factors and differentiation antigens in human dendritic cells activated by double-stranded DNA by A. S. Proskurina, K. E. Orishchenko, E. A. Potter, E. V. Dolgova, A. V. Spaselnikova, G. S. Ritter, N. A. Varaksin, T. G. Ryabicheva, O. Y. Leplina, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…In this work, the expression of cytokines, differentiation antigens and transcription factor genes has been investigated in DCs activated by double-stranded human DNA (i) without any additional factors, (ii) using a lipophilic agent, and (iii) by blocking TLR9 with chloroquine. …”
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Impact of frailty and prevalent fractures on the long-term prognosis of patients with cirrhosis: a retrospective study by Takashi Niwa, Chisato Saeki, Mitsuru Saito, Tsunekazu Oikawa, Hiroshi Kamioka, Tomoya Kanai, Kaoru Ueda, Masanori Nakano, Yuichi Torisu, Masayuki Saruta, Akihito Tsubota

“…Frailty and prevalent fractures were independently associated with mortality in patients with cirrhosis. Additionally, the coexistence of both comorbidities worsened the prognosis.…”
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Genome-wide identification of HbVQ proteins and their interaction with HbWRKY14 to regulate the expression of HbSRPP in Hevea brasiliensis by Jiahong Zhu, Long Qu, Liwang Zeng, Ying Wang, Huiliang Li, Shiqing Peng, Dong Guo

“…Gene expression analysis revealed that HbVQ4, 5, and 21 were expressed at relatively high levels in latex. In addition, HbVQ4, 5, and 21 interact with the WRKY transcription factor HbWRKY14. …”
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Synthesis of N-Methylmorpholinium Derivatives Possessing a 1,3,4-Oxadiazole Core as Feasible Antibacterial Agents against Plant Bacterial Diseases by Xinxin Tuo, Jie Yang, Yedong Zhang, Peiyi Wang

“…Preliminary antibacterial mechanism studies suggested that target compounds had strong interactions with the cell membrane of bacteria via scanning electron microscopy imaging. Additionally, this kind of framework also displayed certain antifungal activity toward Fusarium oxysporum and Phytophthora cinnamomi. …”
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The first multiple center prospective study of rhFSH CTP in patients undergoing assisted reproductive technology in China by Longmei Wu, Huayan Yin, Lingfang Guan, Guanjian Li, Junqiang Zhang, Qunshan Shen, Xiaoqing Ni, Chao Wang, Tianjuan Wang, Hao Geng, Chuan Xu, Yunxia Cao, Xiaojin He, Bing Song

“…At a confidence interval of 95%, the difference in the number of oocytes (1.13–4.22, 2.67) suggested that rhFSH-CTP was not inferior to rhFSH. Additionally, the top-quality embryos, implantation rates, and pregnancy outcomes were similar between the two groups (P > 0.05). …”
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Associations of serum and tissue TIMP1 with host response and survival in colorectal cancer by Akseli Kehusmaa, Anne Tuomisto, Päivi Sirniö, Henna Karjalainen, Meeri Kastinen, Vilja V. Tapiainen, Ville K. Äijälä, Taina Tervahartiala, Timo Sorsa, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Markus J. Mäkinen, Juha P. Väyrynen

“…Abstract Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is a multifaceted, cytokine-like bioactive molecule whose levels are elevated in a wide range of inflammatory diseases and are associated with prognosis. Additionally, TIMP1 may play a role in driving systemic inflammation. …”
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Safety and Biodistribution of an Autologous Bone Marrow-Derived Mononuclear Cell Infusion into Renal Arteries in Patients with Focal Segmental Glomerulosclerosis: A Phase 1 Study by Bruno Freire Botelho, André Luis Barreira, Marcio Gomes Filippo, Karina Dutra Asensi, Lanuza A P Faccioli, Anna Beatriz dos Santos Salgado, Elizabeth Figueiredo de Salles, Carlos Eduardo Cruz Marques, Pedro Leme Silva, Regina Coeli dos Santos Goldenberg, Angelo Maiolino, Bianca Gutfilen, Sergio Augusto Lopes de Souza, Maurilo Leite Junior, Marcelo Marcos Morales

“…Five patients with refractory FSGS and an estimated glomerular filtration rate (eGFR) between 20 and 40 ml/min/1.73 m2 underwent bone marrow aspiration and received an arterial infusion of autologous BMDMCs (5 × 107) for each kidney. In addition, BMDMCs labeled with technetium-99m (99mTc-BMDMCs) were used to assess the biodistribution by scintigraphy. …”
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Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Se... by Fatma Alzahraa Mokhtar, Mariam Ahmed, Aishah Saeed Al Dhanhani, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Ali A. Shati, Amal M. Fakhry

“…Notably, the galactomannan derivatives from <i>S. sesban</i> exhibit significant immune-modulating properties. Additionally, nanoparticles synthesized from <i>Sesbania</i> species, including Cadmium oxide and PEGylated silver nanoparticles, have demonstrated promising cytotoxic activity by disrupting mitosis and enhancing immune responses. …”
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Lutein-stevioside nanoparticle attenuates H2O2-induced oxidative damage in ARPE cells by Zhuqing Dai, Meimei Nie, Ye Chen, Jiangfeng Song, Yayuan Xu, Zhongyuan Zhang, Guodong Zhang, Shumo Yan, Xing Zhang, Dajing Li

“…After pretreatment with LUT-STE in ARPE cells, the levels of superoxide dismutase (SOD), catalase (CAT) and glutathion peroxidase (GSH-Px) in ARPE cells were significantly increased (P &lt; 0.05), the contents of reactive oxygen species (ROS) and malondialdehyde (MDA) were decreased. In addition, the vascular endothelial growth factor (VEGF) levels were inhibited by 13.61% and 17.39%, respectively, pretreatment with LUT and LUT-STE. …”
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Deep Learning in the Fast Lane: A Survey on Advanced Intrusion Detection Systems for Intelligent Vehicle Networks by Mohammed Almehdhar, Abdullatif Albaseer, Muhammad Asif Khan, Mohamed Abdallah, Hamid Menouar, Saif Al-Kuwari, Ala Al-Fuqaha

“…Our systematic review covers a range of AI algorithms, including traditional ML, and advanced neural network models, such as Transformers, illustrating their effectiveness in IDS applications within IVNs. Additionally, we explore emerging technologies, such as Federated Learning (FL) and Transfer Learning, to enhance the robustness and adaptability of IDS solutions. …”
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5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity by Thomas Stübig, Anita Badbaran, Tim Luetkens, York Hildebrandt, Djordje Atanackovic, Thomas M. C. Binder, Boris Fehse, Nicolaus Kröger

“…Furthermore, numbers of IFN-γ+ T-helper 1 cells (Th1) were reduced, while Treg-cells showed substantial increase. Additionally, CD8+ T-cells exhibited limited killing capacity against leukemic target cells. …”
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