Effects and Potential Mechanisms of Pioglitazone on Lipid Metabolism in Obese Diabetic KKAy Mice by Jun Peng, Yi Huan, Qian Jiang, Su-juan Sun, Chun-ming Jia, Zhu-fang Shen

“…Plasma alanine aminotransferase activities were also significantly increased. Additionally, pioglitazone increased plasma concentrations of total cholesterol, HDL-cholesterol, and LDL-cholesterol but decreased hepatic cholesterol. …”
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Detection of Bovine IgG Isotypes in a PPA-ELISA for Johne's Disease Diagnosis in Infected Herds by Bárbara Fernández, Liliana Rosa Gilardoni, Ana Jolly, Silvia Beatriz Colavecchia, Fernando Alberto Paolicchi, Silvia Leonor Mundo

“…Meanwhile, IgG2/PPA-ELISA improved the number of subclinically infected cattle detected as compared with conventional IgG/PPA-ELISA (53.8 versus 23.1%). In addition, it had the maximum sensitivity (65.0%, taking into account all Map-infected cattle). …”
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Tailor-Made, Linear, and “Comb-Like” Polyester-Based Copolymers: Synthesis, Characterization, and Thermal Behavior of Potential 3D-Printing/Electrospinning Candidates by Franco L. Redondo, Mario D. Ninago, Augusto G. O. de Freitas, Cristiano Giacomelli, Andrés E. Ciolino, Marcelo A. Villar

“…Poly(dimethylsiloxane-block-ε-caprolactone) copolymers (SCL#) were synthesized by a combination of anionic and ring-opening polymerization (ROP), whereas “comb-like” poly(hydroxyethylmethacrylate-co-(hydroxyethylmethacrylate-graft-ε-caprolactone)-block-ε-caprolactone) (HEMACL#) were synthesized through simultaneous ROP and reversible addition fragmentation chain transfer (RAFT) polymerization. …”
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2D SnSe2 micro-flower decorated with 0D In2O3 nanoparticles for low-temperature low-concentration TEA detection by Li Wang, Jianpeng Li, Cheng Xu, Ziqin Yang, Xiangyun Tan, Zhihu Dong, Li Xu, Dongwei Zhang, Chunqing He

“…The SnSe2/In2O3 sensor has a response value of 4.86 for 10 ​ppm TEA gas at 120 ​°C, with response and recovery times of 18 ​s and 79 ​s respectively, and detection limits as low as 100 ​ppb. In addition, the SnSe2/In2O3 sensor is essentially unaffected by humidity in the 30% RH to 60% RH range, and the SnSe2/In2O3 sensor response value decreases slightly in the 70% RH to 97% RH range, demonstrating excellent humidity tolerance. …”
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Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients by Jae-Ghi Lee, Ilkyu Park, Hannah Lee, Seungyoon Nam, Jisup Kim, Won-Suk Lee, Myunghee Kang, Jung Ho Kim

“…It then assessed their 5-year event-free survival (EFS) and disease-specific survival (DSS) hazard ratios (HRs). Additionally, the prognosis of patients was analyzed by combining E-cadherin expression levels with TNM staging, particularly focusing on patients in stages III and IV. …”
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Mechanical Properties of SiO2-Coated Carbon Fiber-Reinforced Mortar Composites with Different Fiber Lengths and Fiber Volume Fractions by Gwang-Hee Heo, Jong-Gun Park, Ki-Chang Song, Jong-Ho Park, Hyung-Min Jun

“…However, the air content increased more or less. In addition, regardless of whether the fibers were coated, the compressive strength of carbon fiber-reinforced mortar (CFRM) composite specimens tended to gradually decrease as the fiber volume fractions increased. …”
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Impacts of an Early Morning Low Earth Orbit Observing Platform in a Future Global Observing Network Scenario by Nikki C. Privé, Bryan M. Karpowicz, Erica L. McGrath-Spangler, Satya Kalluri

“…Two instruments, a microwave radiometer modeled on the Advanced Technology Microwave Sounder (ATMS) and a hyperspectral infrared radiometer modeled on the Cross-track Infrared Sounder (CrIS), are tested both individually and in conjunction on a new early morning orbit in addition to the future baseline scenario. The microwave instrument is found to have beneficial impacts for up to 4–7 days in the medium range forecast period with beneficial impacts for the infrared instrument for up to 3–5 days. …”
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Genetic variation in zona pellucida-3 (ZP3) gene and its association with litter size variation in Kari sheep by Izaz Ali, Muhammad Ibrahim, Sohail Ahmad, Sher Hayat Khan, Ihtesham Ul Haq, Ibrahim A. Alhidary, Rifat Ullah Khan, Naseer Khan Momand, Marco Ragni

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Dynamic Demodulation Algorithm for Bio-radar Sensors Based on Range Tapper by Changyu LIU, Hao ZHANG, Fanglin GENG, Zhongrui BAI, Peng WANG, Zhenfeng LI, Lidong DU, Xianxiang CHEN, Zhen FANG

“…Simulation results indicate that processing signals crossing range bins with our algorithm improves the signal-to-noise ratio by 17±5 dB. In addition, experiments recorded Doppler Heartbeat Diagram (DHD) signals from eight subjects, comparing the consistency between the DHD signals and the ballistocardiogram. …”
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Genetic and peripheral biomarkers of comorbid posttraumatic stress disorder and traumatic brain injury: a systematic review by Kiriana Cowansage, Reshmi Nair, Jose M. Lara-Ruiz, Daniel E. Berman, Courtney C. Boyd, Tiffany L. Milligan, Daniel Kotzab, Dawn M. Bellanti, Lisa M. Shank, Maria A. Morgan, Derek J. Smolenski, Ida Babakhanyan, Nancy A. Skopp, Daniel P. Evatt, Marija S. Kelber

“…This PROSPERO-registered systematic review evaluates the current body of literature on genetic and peripheral biomarkers associated with comorbid TBI and PTSD.MethodsSearches were conducted in four databases (PubMed, PsycInfo, PTSDPubs, Scopus). …”
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Clinical characteristics of female Fabry disease patients with hypertrophic cardiomyopathy with mid-ventricular obstruction by Natsuko Inagaki, Yasuyoshi Takei, Tsuguhisa Hatano, Yasuyuki Takada, Yoshinao Yazaki, Hisanori Kosuge, Masatake Kobayashi, Shinji Suzuki, Tomohiro Umezu, Masahiko Kuroda, Kazuhiro Satomi, Takeharu Hayashi

“…Therefore, it is difficult to determine the efficacy of myocardial involvement in FD using a lymphocyte-based Lyso-Gb3 assay system. In addition, none of these female patients had renal dysfunction, indicating a different pattern of organ damage compared with that previously reported in male patients.…”
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Nephronectin Is Required for Vascularization in Zebrafish and Sufficient to Promote Mammalian Vessel‐Like Structures in Hydrogels for Tissue Engineering by Chinmoy Patra, Amey Rayrikar, Ganesh Wagh, Florian Kleefeldt, Kaveh Roshanbinfar, Florian Cop, Iva Nikolic, Mirko H. H. Schmidt, Amparo Acker‐Palmer, Süleyman Ergün, Felix B. Engel

“…Notably, the angiogenesis‐associated integrins itgav and itgb3.1 are coexpressed with nephronectin a in the region of the caudal vein plexus and posterior somites; nephronectin binds to integrin alpha‐V/integrin beta‐3.1 (ITGAV/ITGB3.1), and itgav morphants phenocopy nephronectin a mutants. In addition, nephronectin a mutants showed decreased vessel maturation compared with wild‐type siblings during caudal fin regeneration in adult zebrafish. …”
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Tongue-LiteSAM: A Lightweight Model for Tongue Image Segmentation With Zero-Shot by Daiqing Tan, Hao Zang, Xinyue Zhang, Han Gao, Ji Wang, Zaijian Wang, Xing Zhai, Huixia Li, Yan Tang, Aiqing Han

“…Based on the basic SAM model, the improvement involved modifying the image encoder by integrating two lightweight ViT-Tiny image encoders, effectively reducing the model’s parameter count. Additionally, data perturbation techniques were employed to enhance the zero-shot segmentation capability of the model and ensure robust performance across different data sources. …”
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Effect of hydrophobic corrosion inhibitor on the cement hydration and leaching resistance of shotcrete by Wei Wang, Junsong Chen, Shuang Zhao, Luping Zeng, Jingshun Cai, Song Mu, Jinxiang Hong, Min Qiao

“…Based on indoor accelerated leaching test, hydrophobic corrosion inhibitor could enhance the long-term compressive strength development stability in corrosion solution and avoid the phenomenon of shrinkage in the later stage. In addition, hydrophobic corrosion inhibitor could effectively diminish the leaching amount of calcium ions, thereby suppressing the precipitation of corrosion products such as calcium sulfate crystals. …”
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The global, regional burden of pancreatic cancer and its attributable risk factors from 1990 to 2021 by Weidong Yu, Danyi Zhou, Fanhao Meng, Jinjing Wang, Bo Wang, Jianling Qiang, Lijun Shen, Maofeng Wang, Hezhi Fang

“…Besides, the pancreatic cancer-associated rates of incidence, mortality, DALYs, and prevalence were higher in males than in females. In addition, these indicators in the high SDI (Sociodemographic index) region were higher than the global mean. …”
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Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation by Inmaculada Gayoso, Sara Cantisán, Carolina Cerrato, Joaquín Sánchez-García, Carmen Martin, Rafael Solana, Antonio Torres-Gomez, Julian Torre-Cisneros

“…Our results showed that the patients receiving stem cells from donors ≥40 years old were 12 times more likely to have HCMV-specific CD8+ T cells with “differentiated phenotype” (CD45RA+CCR7+ ≤6.7% and CD28+ ≤30%) than patients grafted from donors <40 years old (OR=12; P=0.014). In addition, a detectable IFN-γ production in response to HCMV peptides (cutoff 0.2 IU/mL IFN-γ; “reactive” QuantiFERON-HCMV test) was statistically associated with HCMV replication after transplantation (OR=11; P=0.026), recipients ≥40 versus <40 years old (OR=11; P=0.026), and the use of peripheral blood versus bone marrow as stem cell source (OR=17.5; P=0.024). …”
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Longevity Recipe - Lifestyle Influences on the Quantity and Quality of Life by Katarzyna Piotrowicz, Hubert Piotrowicz, Jacek Kurzeja, Agnieszka Bajkacz, Wojciech Kraśnik, Olga Jankowska, Anna Rogala, Joanna Osmólska

“…It also emphasises the significance of dietary habits and the role of phytochemicals. Additionally, it addresses the following questions: Does consuming small amounts of alcohol prolong life? …”
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The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue by Angelica Johansson, Eirini Kalliara, Emma Belfrage, Teodor Alling, Paul Theodor Pyl, Anna Sandström Gerdtsson, Urban Gullberg, Anna Porwit, Kristina Drott, Sara Ek

“…<b>Methods:</b> We applied 10× genomics-based single-cell RNA sequencing to CD3+ peripheral T-cells, combined with T-cell receptor sequencing, to samples collected at multiple timepoints during the progression of the disease. In addition, GeoMx-based digital spatial profiling of T-helper (CD3+/CD8−), T-cytotoxic (CD3+/CD8+), and CD163+ cells was performed on skin biopsies. …”
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Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis by Louisane Desbiens, Catherine Lapointe, Marjan Gharagozloo, Shaimaa Mahmoud, Gunnar Pejler, Denis Gris, Pedro D’Orléans-Juste

“…Immunized WT mice presented an initial acute phase characterized by progressive increases in clinical score, which were significantly reduced in mMCP-4 KO mice. In addition, higher levels of spinal myelin were found in mMCP-4 KO as compared with WT mice. …”
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Styloid process phenotype and atheromatous plaque: Radiographic and bone density assessment in parathyroid disease by Adilia Mirela Pereira Lima Cid, Davi de Sá Cavalcante, Marcela Lima Gurgel, Ana Carolina Saraiva, Ana Alicia Sales Ricardo, Lúcio Mitsuo Kurita, Paulo Goberlânio de Barros Silva, Catarina Brasil d’Alva, Ana Rosa Pinto Quidute, Fabio Wildson Gurgel Costa

“…Purpose: This study aimed to assess the styloid process (TBSP) phenotype and to identify suggestive images of calcified atheromatous plaques (CAP) in panoramic radiographs of patients with primary hyperparathyroidism (PHPT) and post-surgical hypoparathyroidism (hypoPT). Additionally, it aimed to analyze the association between the bone mineral status of patients with parathyroid diseases and the radiographic findings. …”
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