Anti-Inflammatory and Antioxidant Effects of Carpesium cernuum L. Methanolic Extract in LPS-Stimulated RAW 264.7 Macrophages by Yea-Jin Park, Se-Yun Cheon, Dong-Sung Lee, Divina C. Cominguez, Zhiyun Zhang, Sangwoo Lee, Hyo-Jin An

“…A hypernomic reaction or an abnormal inflammatory process could cause a series of diseases, such as cardiovascular disease, neurodegeneration, and cancer. Additionally, oxidative stress has been identified to induce severe tissue injury and inflammation. …”
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A family with normal sperm motility carrying a sY86 deletion in AZFa region and partial deletion in AZFc region by Yuhong Zhao, Weiwei Zhi, Weiwei Zhi, Dongsheng Xiong, Dongsheng Xiong, Ningjing Li, Xinrong Du, Jiuzhi Zeng, Jiuzhi Zeng, Guohui Zhang, Guohui Zhang, Weixin Liu, Weixin Liu

“…Notably, although the son’s sperm motility parameters showed no significant abnormalities, there was a history of failed pregnancies for twice, with sperm exhibiting a high rate of head defect.DiscussionGiven the complexities of the reproductive phenotype following AZF region deletions, additional extended genetic testing is necessary when partial deletions in the AZF region are detected, thus providing more accurate predictions of the spermatogenesis in patient. …”
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Sources and Transmission Routes of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i>: Study Design and Methodology of the SAMPAN Study by Anneloes van Veen, Selvi N. Shahab, Amber Rijfkogel, Anne F. Voor in ’t holt, Corné H. W. Klaassen, Margreet C. Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Merel Kemper, Anniek E. E. de Jong, Sima Mohammadi, Valentine Renaud, Irena Kukavica-Ibrulj, Marianne Potvin, Guillaume Q. Nguyen, Jeff Gauthier, Roger C. Levesque, Heike Schmitt, Juliëtte A. Severin

“…Clinical CRPA isolates will also be included. Additionally, samples will be taken twice from wet hospital environments and monthly from the hospitals’ (drinking) water system, hospital and municipal wastewater treatment plants, and receiving rivers. …”
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Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease by Kelly Rose Tavares Neves, Hélio Vitoriano Nobre, Luzia Kalyne A. M. Leal, Geanne Matos de Andrade, Gerly Anne de Castro Brito, Glauce Socorro de Barros Viana

“…Furthermore, PTX partially reversed the decrease in DA contents and improved neuronal viability. In addition, decreases in immunostaining for TH and dopamine transporter (DAT) were reversed. …”
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RED-Net: A Neural Network for 3D Thyroid Segmentation in Chest CT Using Residual and Dilated Convolutions for Measuring Thyroid Volume by Min-Ji Kim, Jin-A Kim, Naae Kim, Yul Hwangbo, Hyun Jeong Jeon, Dong-Hwa Lee, Ji Eun Oh

“…This combination allows the model to extract features at multiple scales and capture contextual information to effectively segment even tiny thyroid glands in the complex anatomical structures observed in chest CT scans. Additionally, we constructed training and validation sets comprising CT scans of 1,150 adults (aged <inline-formula> <tex-math notation="LaTeX">$\ge 19$ </tex-math></inline-formula> years) who underwent chest CT scans at the National Cancer Center and included data of those without a history of thyroid nodules, C73 diagnosis, or thyroid surgery before scanning procedure. …”
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Gap dynamics in the U.S. between urban areas in the current trend and in sustainable scenario by Haoyu Wang, Xiuyuan Zhang, Shihong Du, Yuyu Zhou, Donghai Wu, Qian Wang, Lubin Bai, Bo Liu, Shuping Xiong

“…Filling the gap without additional urban growth planning could lead to a reduction of crop production ranging from 0.3 % to 3 % and a 0.68 % loss of biomass. …”
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Profile of intestinal fungal microbiota in acute pancreatitis patients and healthy individuals by Meng-Qi Zhao, Miao-Yan Fan, Meng-Yan Cui, Su-Min Chen, Jing-Jing Wang, Ying-Ying Lu, Qiao-Li Jiang

“…Methods In this study, we sequenced ITS rRNA gene amplicons and examined the intestinal fungal microbiota in feces from 11 AP patients (the test group) and 15 healthy people (the control group). Additionally, we examined the relationship between fungus and clinical and biochemical markers. …”
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Metagenomic exploration and computational prediction of novel enzymes for polyethylene terephthalate degradation by Donya Afshar Jahanshahi, Mohammad Reza Rezaei Barzani, Mohammad Bahram, Shohreh Ariaeenejad, Kaveh Kavousi

“…These enzymes were further validated through active site analysis, amino acid composition analysis, and 3D structure comparison. Additionally, we isolated bacterial strains from contaminated soils and extracted plastizymes to demonstrate their potential for environmental remediation. …”
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Role of the epithelial layer in the generation of superoxide anion by the guinea-pig isolated trachea by G. Sadeghi-Hashjin, P. A. J. Henricks, G. Folkerts, T. Muis, J. Garssen, F. P. Nijkamp

“…However, the presence of the precursor or of inhibitors of nitric oxide synthase did not influence zymosan-induced chemiluminescence. …”
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RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis by Jing Ma, Yanru Yang, Kaijing Wang, Jin Liu, Junyi Feng, Gongcheng Wang, Shuangping Guo, Linni Fan

“…We also conducted tube formation assays and VEGF ELISAs to understand the role of RSK4 in angiogenesis. Additionally, we evaluated the regulatory effect of RUNX1 on EPHA2 transcription using a luciferase reporter gene assay and observed that the effect of RUNX1 on activating EPHA2 transcription was negated after the binding site was mutated. …”
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The abnormal flow behavior of Mg-9Gd-4Y-2Zn-0.5Zr alloy during hot tensile deformation at high temperature and low strain rate by Mu Meng, Xiaoying Wang, Jinbiao Zhang, Xingxing Chen, Genxing Lei, Zhaoming Yan, Zhimin Zhang

“…GBS induced by dynamic recrystallization (DRX) is considered to belong to the core-mantle mechanism. Additionally, microcracks near large block-shaped long-period stacking ordered (LPSO) phases have been observed. …”
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Effects of P1G10 against UVB-induced damage: Reduction of antioxidant stress, inflammation and cell proliferation by Kátia M. Freitas, Emerson S. Veloso, Ênio Ferreira, Marcelo V. Caliari, Carlos E. Salas, Miriam T.P. Lopes

“…The anti-inflammatory effect of the fraction was consolidated by reduction in TNF-α (∼70 %) and IL1β (∼90 %) and confirmed by histological analyses showing a reduction in cellularity and leukocyte infiltration into the hypodermis. Additionally, epidermal hyperplasia induced by UVB was reduced as shown by a decrease of PCNA immunolabeling in keratinocytes. …”
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Acute Febrile Illness Accompanied by 7th and 12th Cranial Nerve Palsy Due to Lyme Disease Following Travel to Rural Ecuador: A Case Report and Mini-Review by Teslin S. Sandstrom, Kumudhavalli Kavanoor Sridhar, Judith Joshi, Ali Aunas, Sheliza Halani, Andrea K. Boggild

“…Given the travel history to a South American country in which Lyme disease is exceedingly uncommon, consideration of infections acquired in Ecuador necessitated a broad differential diagnosis and more comprehensive microbiological testing than would have been required in the absence of tropical travel. Additionally, cranial nerve XII involvement is an uncommon feature of Lyme neuroborreliosis, and therefore warranted consideration of an alternative, non-infectious etiology such as stroke or a mass lesion, both of which were excluded in this patient through neuroimaging.…”
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The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review by Meiwen Huang, Xuena Xie, Rong Yuan, Qiqi Xin, Shudong Ma, Hongai Guo, Yu Miao, Chunyu Hu, Yizhun Zhu, Weihong Cong

“…Researches on natural compounds derived from herbal medicines, such as flavonoids, hold significant promise in combating AS by regulating lipid metabolism, reducing oxidative stress and inflammation, inhibiting the proliferation of vascular smooth muscle cells, modulating autophagy and additional pathways. Various targets participate in these physiological processes, encompassing acyl-CoA: cholesterol acyltransferase (ACAT), ATP citrate lyase (ACLY), nuclear factor erythroid 2-related factor 2 (Nrf2), krüppel-like factor 2 (KLF2), NOD-like receptor protein 3 (NLRP3), transcription factor EB (TFEB) and so on. …”
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Characterizing the agroecological transition of Italian farming systems using FADN database by Sarah Stempfle, Simone Russo, Vincenzo Fiore, Ruggiero Sardaro, Piermichele La Sala, Luigi Roselli

“…The results indicate that agroecology has not yet been widely adopted by the Italian farms. Additionally, factors such as the type of farming, farm management, farm economic and physical size, farm location, and farmer's socio-demographics play a significant role in explaining the variation in the transition intensity towards an agroecological production system. …”
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Effect of Allium cepa L. on Lipopolysaccharide-Stimulated Osteoclast Precursor Cell Viability, Count, and Morphology Using 4′,6-Diamidino-2-phenylindole-Staining by Tatiane Oliveira, Camila A. Figueiredo, Carlos Brito, Alexander Stavroullakis, Anuradha Prakki, Eudes Da Silva Velozo, Getulio Nogueira-Filho

“…Resazurin reduction and total protein content assays were used to detect cell viability. AcE did not affect cell viability. Resazurin reduction assay showed that AcE, at up to 1000 μg/mL, did not significantly affect cell viability and cellular protein levels. …”
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Alcohol Inhibits Odontogenic Differentiation of Human Dental Pulp Cells by Activating mTOR Signaling by Wei Qin, Qi-Ting Huang, Michael D. Weir, Zhi Song, Ashraf F. Fouad, Zheng-Mei Lin, Liang Zhao, Hockin H. K. Xu

“…EtOH significantly activated the mTOR pathway in a dose-dependent manner. In addition, EtOH downregulated the alkaline phosphatase activity, attenuated the mineralized nodule formation, and suppressed the expression of odontoblastic markers including ALP, DSPP, DMP-1, Runx2, and OCN. …”
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pH‐Dependent Assembly and Stability of Toll‐Like Receptor 3/dsRNA Signaling Complex: Insights from Constant pH Molecular Dynamics and Metadynamics Simulations by Penghui Li, Mingsong Shi, Yibo Wang, Qiong Liu, Xiubo Du, Xiaohui Wang

“…Histidines in TLR3 act as pH‐dependent, positively charged binding sites that capture negatively charged dsRNA. Additionally, these histidines form a [H682⁺]—[E626⁻] dipole, facilitating the assembly of two TLR3 molecules into an antisymmetric dimer through dipole–dipole interactions. …”
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Tannins for food preservation and human health: A review of current knowledge by Yesim Ozogul, Yilmaz Ucar, Eskindir Endalew Tadesse, Nikheel Rathod, Piotr Kulawik, Monica Trif, Tuba Esatbeyoglu, Fatih Ozogul

“…Thus, they are widely used in the pharmaceutical, nutraceutical and food industries. In addition, the use of tannins as film and coating matrices, antimicrobial and antioxidant agents can enhance the quality of food. …”
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Simulation and explanatory analysis of dissolved oxygen dynamics in Lake Ulansuhai, China by Fan Zhang, Xiaohong Shi, Shengnan Zhao, Ruonan Hao, Biao Sun, Guohua Li, Shihuan Wang, Hao Zhang

“…The optimal hybrid model for each period was selected through extensive analysis, and the shapley additive explanations method was utilized to quantify the contribution of feature variables to the results. …”
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