Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway by Jiangtao Wang, Lina Guan, Jian Yu, Bohua Ma, Huihua Shen, Guozhu Xing, Yawei Xu, Qiufang Li, Juan Liu, Qin Xu, Wenhui Shi, Jia He, Yixuan Huang, Dongfeng Yin, Wu Li, Rui Wang

“…We further detected the expression levels of inflammatory factors interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and proliferative/antiproliferative indicators proliferating cell nuclear antigen (PCNA), cyclin-dependent kinase 6 (CDK6), Cyclin D1, p21 in lung tissue, and found that HF could attenuate the lung tissue inflammatory response and proliferative response in HAPH rats. In addition, we also examined the expression levels of transforming growth factor-β1 (TGF-β1), Smad2/3 and p-Smad2/3 in lung tissue, and found that HF exerted therapeutic effects by inhibiting the TGF-β1/Smad signaling pathway.…”
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Hydrogen Sulfide Increases Nitric Oxide Production and Subsequent S-Nitrosylation in Endothelial Cells by Ping-Ho Chen, Yaw-Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang

“…The level of H2S was also monitored by a new designed fluorescent probe, 4-nitro-7-thiocyanatobenz-2-oxa-1,3-diazole (NBD-SCN) with high specificity. Therefore, NO did not reciprocally increase the expression of H2S-generating enzymes and the H2S level. …”
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A Graphene/MXene-Modified Flexible Fabric for Infrared Camouflage, Electrothermal, and Electromagnetic Interference Shielding by Xianguang Hou, Ziyi Zang, Yaxin Meng, Tian Wang, Shuai Gao, Qingman Liu, Lijun Qu, Xiansheng Zhang

“…The modified fabric also demonstrates excellent Joule heating capabilities; at 4 V of power, a temperature of 91.7 °C may be reached in 30 s. In addition, customized materials exhibit strong electromagnetic shielding performance. …”
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The first two mitochondrial genomes for the genus Ramaria reveal mitochondrial genome evolution of Ramaria and phylogeny of Basidiomycota by Qiang Li, Lijiao Li, Ting Zhang, Peng Xiang, Qian Wu, Wenying Tu, Zhijie Bao, Liang Zou, Cheng Chen

“…The genetic contents, gene length, tRNAs, and codon usages of the two Ramaria mitogenomes varied greatly. In addition, the evolutionary rates of different core protein coding genes (PCGs) in Phallomycetidae mitogenomes varied. …”
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Nystose attenuates bone loss and promotes BMSCs differentiation to osteoblasts through BMP and Wnt/β-catenin pathway in ovariectomized mice by Qi Zhang, Sijing Hu, Jianjun Wu, Peng Sun, Quanlong Zhang, Yang Wang, Qiming Zhao, Ting Han, Luping Qin, Qiaoyan Zhang

“…Furthermore, we found that NST increased osteogenic differentiation, inhibited adipogenic differentiation of BMSCs in vitro, and upregulated the expression of the key proteins of BMP and Wnt/β-catenin pathways. In addition, Noggin and Dickkopf-related protein-1 (DKK-1) reversed the effect of NST on osteogenic differentiation and expression of the key proteins in BMP and Wnt/β-catenin pathway. …”
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Heterologous Expression and Functional Analysis of <i>Exiguobacterium</i> Algin Lyase Gene by <i>Pichia pastoris</i> by Hanwen Wu, Kai Hou, Yutong Jiang, Mingjian Luan, Yuxia Sun, Xi He, Xiangzhong Zhao

“…The results of the enzymatic analysis revealed that the optimal temperature and the pH range of recombinant EbAlg664 were narrower compared to the original strain. Additionally, the presence of Cu²⁺ and Co²⁺ enhanced the enzymatic activity, whereas Mg²⁺ and Fe³⁺ exhibited inhibitory effects on the recombinant alginate lyase. …”
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Differentiated effects and mechanisms of N-, P-, S-, and Fe-modified biochar materials for remediating Cd- and Pb-contaminated calcareous soil by Amir Bostani, Xingying Meng, Le Jiao, Srđan D. Rončević, Peng Zhang, Hongwen Sun

“…However, FBC had strong acidity and poor immobilization ability, which increased the available concentrations of Cd and Pb in the soil. Additionally, PBC promoted the growth, enzyme activity, and tolerance to Cd- and Pb-contaminated soil of Chinese cabbage. …”
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Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation by Pei Zhou, Feng Jin, Shenshen Yao, Ben Sun, Ni Sun, Hongbo Guan, Xiaomei Liu

“…Additionally, MMS19 deficiency resulted in mitochondrial fragmentation, ROS accumulation, and the induction of autosis and apoptosis. …”
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Chemoproteomic analysis of the promising candidate molecule of the indole derivative with lab code SV-1010 and other non-steroidal anti-inflammatory drugs by Pavel A. Galenko-Yaroshevsky, Ivan Yu. Torshin, Andrey N. Gromov, Ivan A. Reyer, Olga A. Gromova, Tereza R. Glechyan, Konstantin F. Suzdalev, Andrey V. Zadorozhniy, Anait V. Zelenskaya

“…Conclusion: The chemoreactomic and chemoproteomic profiling of SV-1010 indicated its potential central effect through dopaminergic and GABA-neurotransmission and additional anti-inflammatory mechanisms, which can help increase pain-relieving effects.…”
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Short-Term Restriction of Physical and Social Activities Effects on Brain Structure and Connectivity by Yajuan Zhang, Lianghu Guo, Zhuoyang Gu, Qing Yang, Siyan Han, Han Zhang

“…Results: Results showed significant GMV reductions in the right gyrus rectus and cuneus post-lockdown, with further reductions observed four months after lifting the restrictions, affecting additional brain regions. Longitudinal FC trajectories revealed decreased connectivity between the default mode network (DMN) and sensorimotor/attention networks post-lockdown, and recovery after four months post-lifting of the lockdown. …”
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Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People by Bing Han, Qin Li, Ningjian Wang, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Zhen Cang, Meng Lu, Ying Meng, Chi Chen, Yingli Lu

“…Many factors could influence this relationship. In addition, this relationship in different genders was still unclear. …”
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Polarization variable terahertz metasurface along the propagation path by Jitao Li, Jingyu Liu, Zhen Yue, Jie Li, Chenglong Zheng, Fan Yang, Hui Li, Yating Zhang, Yan Zhang, Jianquan Yao

“…Based on the variable property of longitudinal polarization, we propose an application concept of dielectric refractive index sensing, in which an additional medium is placed in the terahertz propagation path and the unknown refractive index is determined by detecting the rotation angle of the output polarization state. …”
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Multidisciplinary nursing care in chronic Chagas disease: a scoping review by Ângelo Antônio Oliveira Silva, Leonardo Maia Leony, Ramona Tavares Daltro, Emily Ferreira Santos, Natália Erdens Maron Freitas, Larissa de Carvalho Medrado Vasconcelos, Daniel Dias Sampaio, Faber Neves Santos, Lívia Dórea Dantas Fernandes, Roque Aras, Alejandro Marcel Hasslocher-Moreno, Fred Luciano Neves Santos

“…Results These studies underscored the crucial role of nurses in supporting patients with chronic Chagas disease, particularly those with cardiac and/or digestive manifestations. Additionally, interventions pertaining to neonates with the infection and users of pacemakers/implantable cardioverter defibrillators were examined. …”
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In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatment by Yitong Guo, Weice Wang, Weichen Li, Junyao Li, Mingxu Zhu, Ruteng Song, Wenjing Zhu, Lei Wang, Zhenyu Ji, Xuetao Shi

“…Significant differences were observed between livers and tumors at 1, 10 and 50 kHz (p < 0.05). Additionally, it was demonstrated that the electrical properties could be reversed when the temperature was below or equal to 45 °C.Conclusion: We believe that these results will contribute to the advancement of radiofrequency ablation systems and the development of techniques for temperature monitoring during liver thermal treatment.…”
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Gut Microbial Composition and Antibiotic Resistance Profiles in Dairy Calves with Diarrhea by Lu Zhang, Jun Bai, Qian Guo, Long Li, Yanqing Jia, Xinxin Qiu, Dong Zhou, Zhencang Zhang, Huafeng Niu

“…However, LEfSe analysis identified six genera (<i>Eubacterium, Eubacteriaceae, Prevotella, Comamonadaceae, Comamonas</i>, and <i>Firmicutes</i>) significantly enriched in diarrheic calves compared to healthy ones (LDA scores > 2, <i>p</i> < 0.05). Additionally, antibiotic resistance genes for quinolones, β-lactams, chloramphenicol, tetracyclines, and aminoglycosides were detected, with significantly higher prevalence in diarrheic calves. …”
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Pathogen delivery route impacts disease severity in experimental Mycoplasma ovipneumoniae infection of domestic lambs by Bryan Tegner Jacobson, Jessica DeWit-Dibbert, LaShae Zanca, Sobha Sonar, Carol Hardy, Michael Throolin, Patricia C. Brewster, Kaitlyn Andujo, Kerri Jones, Jonathon Sago, Stephen Smith, Lizabeth Bowen, Diane Bimczok

“…At necropsy, lambs inoculated via the LRT showed consolidation of the cranial lung lobes. In addition, histological signs of  alveolar, bronchiolar, and interstitial inflammation were significantly more severe in the LRT compared to the URT group. …”
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Impact of Different Amounts of Biochar as Growth Media on Macronutrient Transport Systems of Carrizo Citrange Rootstocks and Related Expression Analysis by Paola Caruso, Maria Patrizia Russo, Maria Allegra, Biagio Torrisi, Giancarlo Fascella, Giuseppina Las Casas, Concetta Licciardello, Marco Caruso, Alessandra Caruso, Filippo Ferlito

“…A general comparison of the averages from the sampling and the various analyzed substrates revealed that in February, the evaluated genes involved in the absorption and transport of nutrients were differentially expressed in both leaves and roots, while in April, the expression was not consistent. Additionally, a general comparison between the analyzed tissues showed that, in most cases, expression was higher in the roots than in the leaves. …”
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Exploring sustainable construction: A case study on the potential of municipal solid waste incineration ashes as building materials in San Andres island by Julián David Carmona-Ramírez, Carlos Andrés Bedoya-Henao, Francisco Darío Cabrera-Poloche, Isabella Taborda-Llano, Gustavo Adolfo Viana-Casas, Óscar Jaime Restrepo-Baena, Jorge Iván Tobón

“…However, mortars and prefabricated concrete items incorporating bottom ash as aggregates showed compressive and flexural strength values greater than those set by the standards. Additionally, the ash met the performance specifications required for use in road construction materials, demonstrating its potential for use in different construction applications. …”
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BDMANGO: An image dataset for identifying the variety of mango based on the mango leavesMendeley Data by Mohammad Manzurul Islam, Md. Jubayer Ahmed, Mahmud Bin Shafi, Aritra Das, Md. Rakibul Hasan, Abdullah Al Rafi, Mohammad Rifat Ahmmad Rashid, Nishat Tasnim Niloy, Md. Sawkat Ali, Abdullahi Chowdhury, Ahmed Abdal Shafi Rasel

“…This will ensure the trained model's efficacy in identifying a specific mango leaf while implemented alongside any segmentation algorithm. Additionally, image augmentation techniques such as rotation, horizontal flip, vertical flip, width shift, height shift, shear range, and zooming were applied to expand the dataset from 837 original images to a total of 6696 images (837 original image and 5859 augmented images). …”
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Sonographic and Clinical Features of Upper Extremity Deep Venous Thrombosis in Critical Care Patients by Michael Blaivas, Konstantinos Stefanidis, Serafim Nanas, John Poularas, Mitchell Wachtel, Rubin Cohen, Dimitrios Karakitsos

“…When an UEDVT was detected, therapeutic anticoagulation was started. Additionally, a standardized ultrasound scan was performed to detect the extent of the thrombus. …”
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