Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus by Jiaqi Bao, Dawei Cui, Xiaochen Wang, Qianda Zou, Dejian Zhao, Shufa Zheng, Fei Yu, Li Huang, Yuejiao Dong, Xianzhi Yang, Guoliang Xie, Weizhen Chen, Yu Chen

“…In vitro infection experiments revealed decreased Th17 and Tc17 cell frequency and IL-17A levels at various time points postinfection. In addition, Th17 cells were the predominant sources of IL-17A in PBMCs of patients infected with H7N9 virus. …”
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Presence of dengue virus RNA in urine and oral fluid of laboratory-confirmed dengue patients: Implications for wastewater surveillance by Christine Stauber, Leile Camila Jacob-Nascimento, Caroline Grosch, Moisés da Silva Sousa, Moyra M. Portilho, Rosângela O. Anjos, Margo A. Brinton, Uriel Kitron, Mitermayer G. Reis, Guilherme S. Ribeiro

“…Conclusion: The low presence of DENV RNA in urine suggests that additional research is needed to evaluate whether using wastewater-based epidemiology to monitor DENV transmission is possible.…”
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Microbiota Landscape of Gut System of Guppy Fish (Poecilia reticulata) Plays an Outstanding Role in Adaptation Mechanisms by Christian Aimé Kayath, Armel Ibala Zamba, Joseph Goma-Tchimbakala, Victor Mamonékéné, Gloire Moniceth Mombo Makanga, Aimé Augustin Lebonguy, Etienne Nguimbi

“…Mineral-conditioned medium contributes to identify bacteria with the ability to grow and/or to tolerate hydrocarbon and trace metals. Additionally, trace metals’ tolerance minimum inhibitory concentration (MIC) of microbiota was evaluated. …”
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3D Convective Urca Process in a Simmering White Dwarf by Brendan Boyd, Alan Calder, Dean Townsley, Michael Zingale

“…Because the neutron excess of the fluid both sets and is set by the extent of the convection zone, the realistic steady state can only be determined in simulations with real 3D mixing processes. Additionally, the convection is relatively slow (Mach number less than 0.005) and thus a low Mach number method is needed to model the flow over many convective turnovers. …”
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Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Structurally, bozitinib is optimally embedded in the ATP pocket of c-Met and firmly binds via an extensive interaction network. In addition, bozitinib efficiently inhibits c-Met resistance-conferring mutations G1163R and Y1230H, although its potency is significantly decreased against the D1228N and Y1230C mutations. …”
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Developing a multivariate drought index to assess drought characteristics based on the SWAT-Copula method in the Poyang Lake basin, China by Liping Guo, Fusheng Chen, Bin Wang, De Li Liu, Xiulong Chen, Hongsheng Huang, Hua Bai, Kaitao Liao, Zhiming Xia, Keyu Xiang, Linchao Li, Taihui Zheng, Qiang Yu

“…We found that (1) The SWAT can simulate monthly streamflow well with NS being 0.76–0.92 for validation data over the sub-basins in the PLB. (2) The MSDI index indicated that there were more drought events during 1960–1979 and 2000–2019, highlighting a cyclical pattern of drought events in the PLB. (3) The Xiushui River Basin encountered the most extreme drought conditions since 2000, indicating the basin faced a high risk of dry conditions. …”
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Bacterial Adhesion and Surface Roughness for Different Clinical Techniques for Acrylic Polymethyl Methacrylate by Lucas Costa de Medeiros Dantas, João Paulo da Silva-Neto, Talita Souza Dantas, Lucas Zago Naves, Flávio Domingues das Neves, Adérito Soares da Mota

“…For each group, five specimens were submitted to bacterial adhesion tests and analyzed by scanning electron microscopy (SEM). Two additional specimens were subjected to surface topography analysis by SEM and the remaining three specimens were subjected to surface roughness measurements. …”
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Nanocomposite magnetic hydrogel with dual anisotropic properties induces osteogenesis through the NOTCH-dependent pathways by Shijia Tang, Yue Yan, Xiaoli Lu, Peng Wang, Xueqin Xu, Ke Hu, Sen Yan, Zhaobin Guo, Xiao Han, Feimin Zhang, Ning Gu

“…The alkaline phosphatase activity and the expression of osteogenic-related genes and proteins induced by the MAH were greater than those induced by the pure PEGDA–GelMA hydrogel (PGH) and the magnetic isotropic hydrogel (MIH). In addition, the present study revealed that the dual anisotropic properties of the MAH activated the NOTCH1/2 pathway by upregulating SNHG5 and downstream SIRT6, which modulates the level of NOTCH1/2 by antagonizing DNMT1 protein stability, ultimately inducing the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). …”
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Selected Biomarkers Correlate with the Origin and Severity of Sepsis by Michal Holub, Olga Džupová, Michaela Růžková, Alžběta Stráníková, Eva Bartáková, Jan Máca, Jiří Beneš, Heiko Herwald, Ondřej Beran

“…Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. …”
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Influence of Alkali Metal Oxide Slag Aggregating Agent on the Performance of Magnesium Desulfurization Slags by Wufeng JIANG, Liang TIAN, Suju HAO, He BO, Tengfei MA, Yuzhu ZHANG

“…The initial melting temperature, hemispherical point temperature and fluidity temperature of the desulfurization slag were measured by a melting point melt rate meter, and the effect of the addition amount of slag aggregation agent on the melting performance of the desulfurization slag was studied. …”
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Improving quality and safety in nursing homes and home care: the study protocol of a mixed-methods research design to implement a leadership intervention by Eline Ree, Terese Johannessen, Siri Wiig, Torunn Strømme, Ingunn Aase, Roland Bal, Karina Aase, Marianne Storm, Berit Ullebust, Elisabeth Holen-Rabbersvik, Line Hurup Thomsen, Anne Torhild Sandvik Pedersen, Hester van de Bovenkamp

“…There is a lack of knowledge regarding implementation and impact of quality and safety interventions as most research evidence so far is generated in hospitals. Additionally, there is a lack of effective leadership tools for quality and safety improvement work in this context.Methods and analysis The aim of the ‘Improving Quality and Safety in Primary Care—Implementing a Leadership Intervention in Nursing Homes and Homecare’ (SAFE-LEAD) study is to develop and evaluate a research-based leadership guide for managers to increase quality and safety competence. …”
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Synthesis of Cu-BTC Metal-Organic Framework for CO2 Capture via Solvent-free Method: Effect of Metal Precursor and Molar Ratio by Pui San Ho, Kok Chung Chong, Soon Onn Lai, Sze Sin Lee, Woei Jye Lau, Shih-Yuan Lu, Boon Seng Ooi

“…However, its conventional synthesis duration is relatively long, and the process requires the addition of bulk amounts of organic solvents. Herein, an enhanced solvent-free synthesis strategy was demonstrated in this work for the Cu-BTC synthesis. …”
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New insights into the salt-responsive regulation in eelgrass at transcriptional and post-transcriptional levels by Huan Zhao, Huan Zhao, Xu Dong, Xu Dong, Dazuo Yang, Dazuo Yang, Qingchao Ge, Qingchao Ge, Peng Lu, Peng Lu, Chang Liu, Chang Liu

“…At the post-transcriptional regulation level, miRNA156 and miRNA166 might be involved in the response by regulating potential target genes, such as members of the WRKY and HD-ZIP families. Additionally, eelgrass exhibits unique responses to salt, such as the up-regulation of genes involved in the “fucose biosynthetic process”. …”
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The Evolving Roles of Macrophages in Organ Transplantation by Junhui Li, Cai Li, Quan Zhuang, Bo Peng, Yi Zhu, Qifa Ye, Yingzi Ming

“…In this process, macrophage-mediated mobilization of first-line defenses, particularly phagocytosis and the release of acute inflammatory mediators, is important, but macrophages also launch adaptive alloimmune reactions against grafts through antigen processing and presentation, as well as providing costimulation. Additionally, crosstalk with other immune cells and graft endothelial cells causes tissue damage or fibrosis in transplanted organs, contributing to graft loss or tolerance resistance. …”
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Active Disturbance Rejection Power Predictive Control of Rectifier Based on Bus Voltage Optimized ESO Observer by Xiong Xiao, Junyu Zhao, Xian Song, Yuntao Zhao, Yongjun Zhang, Fei Zhang

“…For the improvement of system response performance, bus voltage extended state observer and active disturbance rejection controller are designed for the outer loop. In addition, error differential term is added to the extended state observer to realize fast tracking of dynamic voltage without sensor. …”
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Poly-γ-Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis by Munkhtugs Davaatseren, Jin-Taek Hwang, Jae Ho Park, Myung-Sunny Kim, Shuaiyu Wang, Mi Jeong Sung

“…Disease activity index (DAI), histopathological scores, microvascular density, myeloperoxidase activity, and VEGF-A and VEGFR2 expression were compared among control mice, DSS-treated mice, and mice receiving 3% DSS along with γ-PGA at 50 mg/kg body weight per day or 3% DSS with γ-PGA at 200 mg/kg body weight per day. …”
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Biosynthesis of reduced graphene oxide using Turbinaria ornata and its cytotoxic effect on MCF‐7 cells by K. M. Smita, L. Stanley Abraham, V. Ganesh Kumar, Raguraman Vasantharaja, R. Thirugnanasambandam, Ajit Antony, K. Govindaraju, T. Senthil Velan

“…The IC50 of TrGO treatment against MCF‐7 was calculated to be 31.25 µg, which is onefold lower than the cytotoxic effect of methanolic extract of T. ornata (60.0 ± 1.14 µg/ml). In addition, there was a statistically significant difference in cell viability between MCF‐10A and MCF‐7 cells in the treatment of TrGO. …”
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TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility by Elijah Edmondson, Takahito Kimura, Eunmi Hwang, Minjun Kim, Andrew Warner, Yuelin Zhu, Li Zhao, Yanlin Yu, Xuguang Zhu, Maria Hernandez, Noemi Kedei, Sheue-yann Cheng

“…We created a mouse model expressing a dominant negative mutated TRα1 (Thra1PV/+ mice) that exhibits growth retardation, bone abnormalities, constipation, and anemia, as found in RTHα patients. In addition, female Thra1PV/+ mice exhibit decreased fertility. …”
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Piezo1 aggravates ischemia/reperfusion-induced acute kidney injury by Ca2+-dependent calpain/HIF-1α/Notch signaling by Xiaoting Chen, Jintao Jiang, Bin He, Shangfei Luo, Qiaorui Tan, Youfen Yao, Rentao Wan, Honglin Xu, Silin Liu, Xianmei Pan, Xin Chen, Jing Li

“…Genetically modified mice with targeted knockout of Piezo1 in myeloid cells were established, and acute kidney injury was induced by bilateral renal vascular clamping surgery. Additionally, hypoxia treatment was performed on bone marrow-derived macrophages in vitro. …”
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A faunal inventory of methane seeps on the Pacific margin of Costa Rica by Charlotte A. Seid, Avery S. Hiley, Marina F. McCowin, José I. Carvajal, Harim Cha, Shane T. Ahyong, Oliver S. Ashford, Odalisca Breedy, Douglas J. Eernisse, Shana K. Goffredi, Michel E. Hendrickx, Kevin M. Kocot, Christopher L. Mah, Allison K. Miller, Nicolás Mongiardino Koch, Rich Mooi, Timothy D. O'Hara, Fredrik Pleijel, Josefin Stiller, Ekin Tilic, Paul Valentich-Scott, Anders Warén, Mary K. Wicksten, Nerida G. Wilson, Erik E. Cordes, Lisa A. Levin, Jorge Cortés, Greg W. Rouse

“…Of these, 131 are described species, at least 58 are undescribed species, and the remainder include some degree of taxonomic uncertainty, likely representing additional undescribed species. Of the described species, 38 are known only from the Costa Rica seeps and their vicinity. …”
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