A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

“…These results led to over 5000 additional studies including carrier, prenatal and preimplantational tests or pharmacological and gene therapy treatments. …”
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Effect of ecological restoration on physicochemical properties, bacterial and fungal communities of red sand soil in Longquan Mountain forest park by Yan Wang, Yu-Long Zhang, Rui Zhang, Cai-Xia Li, Xian-Jun Lai, Xin-Rong Ma

“…Another dominant bacterium in the restored soil, Gemmatimonadetes, may have contributed to the soil’s adaptation to the seasonally dry environment of the restoration area. In addition, fungi may participate in ecological restoration activities by assisting bacteria, particularly Sordariales, which were once decomposers of decaying matter. …”
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Self-Assembly Strategy for Synthesis of WO₃@TCN Heterojunction: Efficient for Photocatalytic Degradation and Hydrogen Production via Water Splitting by Li Zhou, Wenjie Zhang, Zezhao Huang, Feng Hu, Peng Li, Xiaoquan Yao

“…Overall, this study facilitates the structural design of green TCN-based heterojunction photocatalysts and expands the application of TCN in the diverse photocatalytic processes. Additionally, this study offers valuable insights into strategically employing acid regulation modulation to enhance the performance of carbon nitride-based photocatalysts by altering the topography of WO₃@TCN composite material dramatically.…”
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Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content by Haoxiang Zhu, Ling Xu, Yinhua Lv, Juan Yang, Jihan Huang, Qingshan Zheng, Guang Ji, Lujin Li

“…From the 121 biomarkers analyzed, alanine aminotransferase and aspartate aminotransferase demonstrated moderate correlations with LFC; specifically, changes of −5.9 U/L in alanine aminotransferase or −3.3 U/L in aspartate aminotransferase were associated with an additional 1% reduction in LFC. Conclusion: The results of this study provide valuable insights for the clinical development of future NAFLD therapeutics, highlighting the efficacy of specific drug mechanisms and the potential of certain biomarkers as surrogate endpoints.…”
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Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model by Hua Tao, Jianghao Zhao, Tingting Liu, Yujie Cai, Xu Zhou, Huaijie Xing, Yan Wang, Mingkang Yin, Wangtao Zhong, Zhou Liu, Keshen Li, Bin Zhao, Haihong Zhou, Lili Cui

“…After intranasal delivery of miR-146a mimics (30 min before pilocarpine injection), the percent of animals with no induced seizures increased by 6.7%, the latency to generalized convulsions was extended, and seizure severity was reduced. Additionally, hippocampal damage was alleviated. While the relative miR-146a levels significantly increased, the expression of its target mRNAs (IRAK-1 and TRAF-6) and typical inflammatory modulators (NF-κB, TNF-α, IL-1β, and IL-6) decreased, supporting an anti-inflammatory role of miR-146a via the TLR pathway. …”
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Atlantic mackerel population structure does not support genetically distinct spawning components [version 2; peer review: 1 approved, 2 approved with reservations] by Imanol Aguirre-Sarabia, Alice Manuzzi, Dorte Bekkevold, Natalia Díaz-Arce, Jessica Gomez-Garrido, Teunis Jansen, Marta Gut, Tyler S. Alioto, Sonia Sanchez-Maroño, Martin Castonguay, Naiara Rodriguez-Ezpeleta, Paula Álvarez

“…Conclusions Therefore, our findings resolved previous uncertainties by confirming the absence of genetically isolated spawning components in each side of the northern Atlantic, thus rejecting homing behaviour and the need to redefine management boundaries in this species. In addition, no further genetic signs of ongoing adaptation were detected in this species.…”
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Assessment of ante mortem welfare indicators and the pathophysiology of captive-bolt trauma in equids at slaughter by Katharine A Fletcher, Barbara Padalino, Martina Felici, Daniele Bigi, Georgina Limon-Vega, Andrew Grist, Troy J Gibson

“…All animals in the study showed stress-related behaviours at all stages of the slaughter process. Additionally, 53% (33/62) of horses slipped in the stunning box, with poor floor surface condition and use of force associated with this. …”
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Identification and Analysis of Circular RNAs in Mammary Gland from Yaks Between Lactation and Dry Period by Yilin Shi, Xiaoyun Wu, Guangyao Meng, Xiaoming Ma, Yongfu La, Pengjia Bao, Min Chu, Ping Yan

“…This study employed circular RNA sequencing (circRNA-seq) to examine the differential expression of circRNAs in yak mammary tissues during lactation and the dry period. Additionally, an enrichment analysis of the differentially expressed circRNAs (DECs) was performed. …”
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Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 by Meiyue Wang, Zejie Wu, Xiaoyu Zheng, Yishu Huang, Yizhou Jin, Jiaxin Song, Wanzhen Lei, Hua Liu, Riyue Yu, Haoqing Yang, Runtao Gao

“…WDR81 overexpression promoted chondrogenic differentiation of SCAPs, while WDR81 depletion inhibited chondrogenic differentiation. In addition, both betaine treatment and WDR81 overexpression reduced intracellular reactive oxygen species levels and increased mitochondrial membrane potential in SCAPs. …”
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Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival by Sandra Bien-Möller, Ellen Balz, Susann Herzog, Laura Plantera, Silke Vogelgesang, Kerstin Weitmann, Carolin Seifert, Matthias A. Fink, Sascha Marx, Angela Bialke, Chitra Venugopal, Sheila K. Singh, Wolfgang Hoffmann, Bernhard H. Rauch, Henry W. S. Schroeder

“…At protein level, CD44, ELF4, Nanog, Nestin, and Sparc were elevated in GBM, but only CD133 and Nestin were strongly associated with survival time. In addition, ABCG2 and GFAP expression was decreased in LN18 neurospheres whereas CD44, CD95, CD133, ELF4, Nanog, Nestin, and Sparc were upregulated. …”
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The Impact of Grape Maceration on Quality and Biogenic Amine Formation in Slovak Tokaj Wines: Examination of Microbial, Chemical and Sensory Properties by Boris Semjon, Martin Bartkovský, Peter Očenáš, Ivana Regecová, Zuzana Megyesy Eftimová, Jana Výrostková, Lýdia Mesarčová, Mariana Kováčová, Matúš Várady, Lucia Šuľáková, Slavomír Marcinčák

“…The formation of bioactive components in wine was affected by maceration and maceration with the addition of a yeast culture, which resulted in a significantly increased antioxidant activity, as well as total phenolic and flavonoid content (<i>p</i> < 0.001). …”
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Pt-Co and Pt-Ni Catalysts of Low Metal Content for H2 Production by Reforming of Oxygenated Hydrocarbons and Comparison with Reported Pt-Based Catalysts by Liza A. Dosso, Carlos R. Vera, Javier M. Grau

“…The UMC/IWI H2 yield ratio was 23.5/15.2 for Pt, 24.0/17.0 for PtCo, 26.6/21.0 for PtNi, and 8.0/3.9 for NiCo. Ni or Co addition to Pt increased the carbon conversion while keeping the H2 turnover high. …”
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Tunning valence state of cobalt centers in Cu/Co-CoO1-x for significantly boosting water-gas shift reaction by Xing-Chi Li, Jun-Hao Wang, Tao-Tao Huang, Yang Hu, Xin Li, De-Jiu Wang, Wei-Wei Wang, Kai Xu, Chun-Jiang Jia, Hao Dong, Guangshe Li, Chen Li, Ya-Wen Zhang

“…Systematic in situ characterization results reveal that the addition of Cu can regulate the redox properties of Co species and thus modulate the adsorption properties of catalysts. …”
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The impact of adherence counseling incorporating a point of care urine tenofovir assay on virologic suppression among individuals failing tenofovir-lamivudine-dolutegravir: A pre-p... by Leonard Bikinesi, Matthew A. Spinelli, Ntombizodwa Nyoni, Daniella Mouton, Assegid Mengistu, Jacques Kamangu, Iyaloo Konstantinus, Pearl Kalimugogo, Gram Mutandi, Fekir Negussie, Guohong Wang, Susie Welty, Willi McFarland, R. Suzanne Beard, Jessica Haberer, Suzanne McCluskey, Monica Gandhi, Steven Y. Hong

“…If VS was not achieved after 3 months of EAC+, up to 3 additional rounds of EAC+ were provided, with resistance testing at month (M)9. …”
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Cigarette Smoking Is Associated with Prolongation of the QTc Interval Duration in Patients with Type 2 Diabetes Mellitus by Petros Thomakos, Stavros Liatis, Stavroula Kalopita, Ioannis Vlahodimitris, Chryssoula Stathi, Nicholas Katsilambros, Nicholas Tentolouris, Konstantinos Makrilakis

“…Results. Smokers had lower body mass index (BMI) and exhibited higher 24-hour mean heart rate. …”
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Adsorptive removal of toxic heavy metal and dyes from wastewater by rice husk (lignocellulosic biomass) derived activated biochar: A fixed-bed column adsorption study by Md. Mahmudur Rahman, Mohd. Maniruzzaman, Nor ealam, Parvej Mahmud, Sumiya Khatun, Md. Kaowsar Hossain, Md. Ismail Hossain, Md. Hasanuzzaman, Md. Ashraful Alam, Md. Al-amin, Bijoy Chandra Ghos

“…As per the findings it has been stated that the synthesized FRHBC adsorbents have possessed a promizing 2D honeycomb-like well-oriented mesoporous surface microstructure with a larger surface area around 36.84 m2/g. Additionally holds substantial active binding sites, lower crystallinity nearly 23±0.03%, and higher thermal stability upto 700 °C. …”
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A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance by Muhammad Redzwan S. Rashid Ali, Uma Parameswaran, Timothy William, Elspeth Bird, Christopher S. Wilkes, Wai Khew Lee, Tsin Wen Yeo, Nicholas M. Anstey, Anna P. Ralph

“…Prospective study of adult outpatients with smear-positive pulmonary tuberculosis (PTB) in Sabah, Malaysia. Additionally, hospital clinicians accessed the reference laboratory for clinical purposes during the study. …”
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Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo by Xiangwei Liu, Naiwen Tan, Yuchao Zhou, Xueying Zhou, Hui Chen, Hongbo Wei, Ji Chen, Xiaoru Xu, Sijia Zhang, Guodong Yang, Yingliang Song

“…As expected, Sema3A modified ASCs encapsulation significantly promoted new bone formation with higher bone volume fraction and bone mineral density. Additionally, Sema3A was found to simultaneously increase multiple Wnt related genes and thus activating Wnt pathway. …”
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Laryngeal cancer diagnosis based on improved YOLOv8 algorithm by Xin Nie, Xueyan Zhang, Di Wang, Yuankun Liu, Lumin Xing, Wenjian Liu

“…A novel multiscale enhanced convolution module has been introduced to improve the model’s feature extraction capabilities for small-sized targets. Additionally, a tiny fully convolutional network architecture has been employed, reducing the number of model parameters and computational costs while maintaining or enhancing performance, which is crucial for real-time medical imaging analysis. …”
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Economic impact of cholera in households in rural southern Malawi: a prospective study by Florian Marks, Wilm Quentin, Vittal Mogasale, Amber Hsiao, Enusa Ramani, Hye-Jin Seo, GiDeok Pak, Dan Vuntade, Maurice M’bang’ombe, Bagrey Ngwira

“…While cholera treatment is provided for free in government-run health centres, additional investments in cholera control and prevention at the community level and financial support beyond direct medical costs may be necessary to alleviate the economic burden of cholera on households in southern Malawi.…”
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