Anti-Inflammatory Effects of Artemisia Leaf Extract in Mice with Contact Dermatitis In Vitro and In Vivo by Chanyong Yun, Youngchul Jung, Wonjoo Chun, Beodeul Yang, Junghyun Ryu, Chiyeon Lim, Jung-Hoon Kim, Hyungwoo Kim, Su-In Cho

“…ALE prevented epidermal hyperplasia and infiltration of immune cells and lowered the production of interferon- (IFN-) gamma (γ), tumour necrosis factor- (TNF-) alpha (α), and interleukin- (IL-) 6 in inflamed tissues. In addition, ALE inhibited expression of COX-2 and iNOS and production of NO and PGE2 in Raw 264.7 cells. …”
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Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway by Peng Yu, Xi Xu, Jing Zhang, Xuan Xia, Fen Xu, Jianping Weng, Xiaoyang Lai, Yunfeng Shen

“…Moreover, SHP1 silencing could further increase the expression of p-AMPK to ameliorate lipid metabolism and relative lipogenic gene induced by LR. In addition, abrogation of AMPK by Compound C eliminated the protective effects of LR on lipid metabolism without changing the expression of SHP1. …”
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Cross-modal feature interaction network for heterogeneous change detection by Zhiwei Yang, Xiaoqin Wang, Haihan Lin, Mengmeng Li, Mengjing Lin

“…This approach promotes consistent representation of heterogeneous features while preserving image characteristics. Additionally, we design a differential feature extraction module (DFEM) to enhance the extraction of true change features from spatial and channel dimensions, facilitating efficient comparison after feature interaction. …”
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Identification of a postoperative survival scoring index for adult liver transplantation by Shuai Wang, Xiaohong Lin, Yefu Li, Zhonghao Xie, Ming Zhang, Yicheng Liang, Chuchen Zhu, Yuqi Dong, Ping Zeng, Xiaoshun He, Weiqiang Ju, Maogen Chen

“…Background In addition to surgical technology, successful liver transplantation (LT) depends on perioperative management, which needs an effective prognostic index. …”
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De Novo Assembly of the Polyhydroxybutyrate (PHB) Producer <i>Azohydromonas lata</i> Strain H1 Genome and Genomic Analysis of PHB Production Machinery by Daniele Traversa, Carlo Pazzani, Pietro D’Addabbo, Lucia Trisolini, Matteo Chiara, Marta Oliva, Angelo Marzella, Camilla Mandorino, Carla Calia, Guglielmina Chimienti, Caterina Manzari, Graziano Pesole, Maria Scrascia

“…The genome assembly is over 7.7 Mb in size, including a circular megaplasmid of approximately 456 Kbp. In addition to the <i>phaCAB</i> operon, single genes ascribable to PhaC and PhaA functions and auxiliary genes were also detected. …”
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Association between physical activity, cardiometabolic risk factors and vitamin D in children and adolescents: a systematic review by Patricia Ribeiro Paes Corazza, Maiara Cristina Tadiotto, Derick Andrade Michel, Jorge Mota, Neiva Leite

“…All studies (n = 8) that tested association between physical activity and 25-hydroxyvitamin D (25 (OH) D) concentrations showed a significant and direct relationship between them. In addition, nine out of eleven studies that tested the association between 25 (OH) D and body mass index reported an inverse and significant relationship between 25 (OH) D and obesity. …”
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RiskTree: Decision trees for asset and process risk assessment quantification in big data platforms by Zhan Haomou, Yang Jiawei, Guo Zhenyang, Cao Jin, Zhang Dong, Zhao Xingwen, You Wei, Li Hui

“…These platforms are characterized by large scale, diverse forms, high update frequency, and rapid data flow, making it challenging to directly apply existing risk quantification methods to them. Additionally, the composition of big data platforms varies among enterprises due to factors such as industry, economic capability, and technical proficiency. …”
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Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue by Jieun Shin, Kavita B. Hosur, Kalyani Pyaram, Ravi Jotwani, Shuang Liang, Triantafyllos Chavakis, George Hajishengallis

“…Here we investigated additional novel mechanisms whereby Del-1 could interfere with neutrophil recruitment and inflammation. …”
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Microbiological Quality and Risk Assessment for Aflatoxins in Groundnuts and Roasted Cashew Nuts Meant for Human Consumption by Modupeade Christianah Adetunji, Ogechi Precious Alika, Ngozi Precious Awa, Olusegun Oladimeji Atanda, Mulunda Mwanza

“…Eleven fungal species belonging to 5 genera were isolated from the nuts, with Aspergillus flavus, Rhizopus oryzae, and Fusarium oxysporum having the highest percentage occurrence of 50%. In addition, the aflatoxin concentration ranged 0.1–6.8 and 29–33.78 ng kg−1 for cashew nuts and groundnuts, respectively. …”
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Dimethomorph induces heart and vascular developmental defects by disrupting thyroid hormone in zebrafish embryos by You Wei, Yunlong Meng, Kun Jia, Weijian Lu, Yushan Huang, Huiqiang Lu

“…The results showed a concentration-dependent decrease in survival rate and hatching rate, shortened body length, slowed heart rate, and pericardial edema, body curvature and reduced eye size as DMT exposure concentration increased. …”
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Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon by Ying Zheng, Benjamin Moorlach, Desiree Jakobs-Schönwandt, Anant Patel, Chiara Pastacaldi, Stefan Jacob, Ana R. Sede, Manfred Heinlein, Minna M. Poranen, Karl-Heinz Kogel, Maria Ladera Carmona

“…Overall, our study opens up additional possibilities for the development and use of dsRNA pesticides in agriculture.…”
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Research on multi-objective control of PPCI diesel engine combustion process based on data driven modelling by Ziqiang Chen, Peng Ju, Zhe Wang, Du Huang, Lei Shi, Kangyao Deng

“…Through comparisons under different operating conditions, it was found that the adjustment of algorithm parameters needs to adapt to the sensitivity changes of control parameters. In addition, the study validated the real-time performance and control effect of the algorithm, the experimental results indicate that the execution time of the control algorithm is approximately 5.59 milliseconds, which satisfies the real-time control requirements for the combustion process. …”
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TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch by Tunyu Jian, Niuniu Yang, Yan Yang, Chan Zhu, Xiaolin Yuan, Guang Yu, Changming Wang, Zhongli Wang, Hao Shi, Min Tang, Qian He, Lei Lan, Guanyi Wu, Zongxiang Tang

“…U73122 could inhibit immepip-induced Ca2+ responses. In addition, immepip-induced Ca2+i increase could be blocked by ruthenium red, capsazepine, and AMG9810; however it could not be blocked by TRPA1 antagonist HC-030031. …”
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Climatic impacts on mortality in pre-industrial Sweden by T. T. Chen, T. T. Chen, R. Edvinsson, K. Modig, H. W. Linderholm, F. C. Ljungqvist, F. C. Ljungqvist, F. C. Ljungqvist

“…These findings call for further research, especially with respect to investigating specific diseases and additional factors contributing to the observed increase in mortality following cold late winter and spring seasons in Sweden during the late pre-industrial period.…”
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Surface topography modulates initial platelet adhesion to titanium substrata by Cecilia Yan Guo, Raymond Mo, Hugh Kim

“…Platelets were isolated from human blood, washed, and seeded on to the 4 test surfaces; platelet adhesion was quantified by microscopy. In addition, the secretion of critical molecules stored in platelet granules (platelet factor 4, PF4; soluble P-selectin, sCD62P; transforming growth factor-beta1, TGF-β1; platelet-derived growth factor-AB, PDGF-AB) was measured by enzyme-linked immunosorbent assay (ELISA) analysis of the supernatants. …”
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Impact of COVID-19 on the qualitative and quantitative aspect of household solid waste by O. Ouhsine, A. Ouigmane, El. Layati, B. Aba, R. Isaifan, M. Berkani

“…Thus, the results showed that the quantity of organic fractions had decreased in the domestic waste with the appearance of other fractions such as residues of cleaning products. In addition, the survey conducted showed that 87% of respondents mix coronavirus protective equipment with household waste, which may contribute to the spread of the virus. …”
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Composite Materials Based on Henequen Fiber as a Thermal Barrier in the Automotive Sector by J. M. Olivares-Ramírez, A. Dector, A. Duarte-Moller, D. Ortega Díaz, Diana Dector, J. A. Cano-López, R. Rangel-Martínez, J. J. Pérez-Bueno, A. Castañeda-Miranda, Felipe Samuel Tovar-Pacheco

“…In this research, 35 different laminates of 5 layers were prepared, combining carbon fiber, henequen natural fiber, fiberglass, and additives such as resin + Al2O3 or resin + Al. Reference samples were taken from stainless steel and one reference sample was extracted from the roof of the car. …”
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Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair by Penghui Wang, Zaifeng Chen, Ping Li, Abdullah Al Mamun, Shaoxia Ning, Jinjing Zhang, Chonghui Tang, Tianmiao Sun, Jian Xiao, Xiaojie Wei, Fenzan Wu

“…This intervention additionally preserves the integrity of the blood-spinal cord barrier, optimizes the spinal cord microenvironment, reduces glial scarring, promotes axonal regeneration, and enhances motor function recovery in SCI mice. …”
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Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides by Heqian Zhang, Yihan Wang, Yanran Zhu, Pengtao Huang, Qiandi Gao, Xiaojie Li, Zhaoying Chen, Yu Liu, Jiakun Jiang, Yuan Gao, Jiaquan Huang, Zhiwei Qin

“…Results: The NMR solution structure showed that LBDB possesses a circular extended structure with a disulfide crosslink at the terminus and two 310-helices and exhibits a broad antimicrobial spectrum. In addition, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed that LBDB induced the formation of a cluster of bacteria wrapped in a flexible coating that ruptured and consequently killed the bacteria. …”
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Synergistic evolution of dual-precipitation and reverted austenite on mechanical properties in 2.4 GPa ultrahigh strength steel by Aijun Li, Yangxin Wang, Xinyu Jin, Jiaxin Liu, Chundong Hu, Han Dong

“…As the aging temperature gradually increases, precipitation growth reduces their strengthening effect, while the increased spacing between the precipitations enhances toughness. Additionally, the increasing amount of reverted austenite further contributes to improve toughness. …”
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