Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage by Hongya Zhang, Xiaohui Li, Jing Bai, Cong Zhang

“…Therefore, in this study, we investigate the role of NSUN5 in mice.Methods In the present research, we built a mouse model (Nsun5-/-) using the CRISPR/Cas9 system to investigated the specific role of NSUN5.Results We observed that Nsun5-/- mice had a reduced body weight compared to wild-type mice. Additionally, their survival rate gradually decreased to 20% after postnatal day (PD) 21. …”
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Leiomyosarcomas of the inferior vena cava: diagnostic features on contrast-enhanced CT, ultrasonography and MRI by Xiaolin Xu, Shilei Zhao, Lifang Xue

“…All participants underwent CECT, and additionally, 12 participants had US examinations and 3 had MRI. …”
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Network analyses of brain tumor multiomic data reveal pharmacological opportunities to alter cell state transitions by Brandon Bumbaca, Jonah R. Huggins, Marc R. Birtwistle, James M. Gallo

“…Abstract Glioblastoma Multiforme (GBM) remains a particularly difficult cancer to treat, and survival outcomes remain poor. In addition to the lack of dedicated drug discovery programs for GBM, extensive intratumor heterogeneity and epigenetic plasticity related to cell-state transitions are major roadblocks to successful drug therapy in GBM. …”
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Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinica... by Enji Ahmed, Olfat G. Shaker, Nermin Yussif, Dalia M. Ghalwash

“…Melatonin-treated sites showed a more statistically significant percent reduction in PD and more statistically significant percent gain in CAL than the control site. Additionally, a significant increase in TAC and a significant decrease in MMP-9 levels in GCF were found in melatonin-treated sites in comparison to control sites. …”
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Predictors of Response to Oral Medications and Low-Histamine Diet in Patients with Chronic Urticaria by Hui-Ling Chiang, Chen-Hung Chen, Malcolm Koo, Tzung-Yi Tsai, Cheng-Han Wu

“…A low-histamine diet response was significantly associated with LTRA response (aOR=67.29). In addition, a DAO level<5.4 U/mL (aOR=71.95) was significantly associated with H2 blocker response. …”
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Male infertility along with the era of coronavirus infection SARS-CoV-2 by N. G. Kulchenko, N. K. Druzhinina, G. I. Myandina

“…To begin with, when infected, the virus has a direct damaging effect on the testicle itself with the provocation of orchitis. In addition to the previous statement, high body temperature during inflammation contributes to an increase in testicular temperature, which can lead to a deterioration in the quality of sperm. …”
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Studying the impact of chitosan salicylaldehyde/schiff base/CuFe2O4 in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling by Ghada H. Elsayed, Asmaa M. Fahim

“…Furthermore, the docking stimulation of the chitosan derivatives with different proteins showed the presence of CuFe2O4 particles effect on the interaction inside their pockets and increased the activities, and it’s related to biological evaluation. Additionally, the theoretical investigation of these chitosan derivatives and the determination of their physical descriptors showed the activity of bimetallic oxide and the presence of electrostatic hydrogen bond interaction. …”
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Certain Aspects of the Analysis of Cryptocurrency Transactions during the Prevention and Investigation of Crimes by V. V. Nosov, I. A. Manzhai

“…Different types of bitcoin addresses’ holders and risk levels have been described. The main and additional investigation tools used on the “Crystal Expert” platform have been revealed. …”
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Clinical significance of retrograde inferior parathyroid protection technique based on thymus preservation in thyroid surgery by Shouyi Yan, Yuhan Chen, Wenxin Zhao, Liyong Zhang, Shaojun Cai

“…The anatomical relationship between IPG and thymus was observed in 77.97% of patients (184/236). Additionally, PTH levels were higher in patients with IPG orthotopic retention compared to those with IPG auto-transplantation both on postoperative day 1 (POD1) and at 6 months. …”
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Electrophysiological properties of vestibular hair cells isolated from human crista by Nesrien Mohamed, Mohammad Al-Amin, Frances L. Meredith, Olivia Kalmanson, Anna Dondzillo, Stephen Cass, Samuel Gubbels, Katherine J. Rennie

“…Perfusion with the K+ channel blocker 4-aminopyridine (1 mM) substantially reduced outward current in both hair cell types. Additionally, extracellular application of 8-bromo-cGMP inhibited IKLV in human crista type I hair cells suggesting modulation via a nitric oxide/cGMP mechanism. …”
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Pathogenicity role of human herpesvirus-8 in patients with acute myeloid leukemia by Zahraa Ali Abdullah, Luma Amer Yasir, Ruqaya Munther J. Ewadh, Shakir H. Mohammed Al. Alwany

“…There was a nonsignificant difference between patients with AML and the control group. In addition, the male in this study group constituted 56% (42/75), whereas 44% (33/75) were female. …”
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Legal provision of financing the health care sphere in Ukraine by S. V. Knysh

“…The author has offered to provide additional guarantees for disadvantaged population by developing and financing social programs for the availability of medical care. …”
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Prediction of mortality risk in patients with severe community-acquired pneumonia in the intensive care unit using machine learning by Jingjing Pan, Tao Guo, Haobo Kong, Wei Bu, Min Shao, Zhi Geng

“…The model was interpreted using Shapley Additive Explanations. We selected the optimal model to generate the web calculator. …”
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Do Salivary <i>Cullin7</i> Gene Expression and Protein Levels Provide Advantages over Plasma Levels in Diagnosing Breast Cancer? by Ceren Tilgen Yasasever, Derya Duranyıldız, Süleyman Bademler, Hilal Oğuz Soydinç

“…In addition to the tumor suppressor role of Cullin 7 (Cul7), one of the proteins belonging to the Cullin (Cul) family, studies have also suggested that Cul7 may act as an oncogene under certain conditions. …”
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Characteristics of traditional Chinese acidic rice soup (rice-acid) prepared with different fermentation methods by Na Liu, Likang Qin, Jihong Pan, Song Miao

“…The physicochemical characteristics including titratable acidity, pH, reducing sugars, amino acid nitrogen, gamma-aminobutyric acid showed significant differences between low-temperature fermentation samples and high-temperature fermentation samples. In addition, relationships linking all data through Pearson coefficient correlation were also reported. …”
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Research on Cold-Energy Loss of Long-Distance Sleeve-Type Insulated Pipe for High-Temperature Deep Mines by Lijuan Zhang, Wenlong Wang, Fengtian Yue, Jingsheng Wei, Tao Gao, Yangjie Wang, Yang Zhou

“…Implementing modifications such as increasing the inlet temperature, enhancing the water flow rate, or utilizing materials with lower thermal conductivity can effectively mitigate temperature rises. Additionally, the novel sleeve-type design enhanced the pipe’s pressure-bearing capacity, reduced the required pipe length by 4752 m and minimized energy loss compared to traditional systems. …”
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The In Vitro Antioxidant and Antiadipogenic Properties of Pigmented Flower Extracts of Geraniaceae and Lamiaceae Plant Families by Anton Venter, Hennie Fisher, Gary I. Stafford, June C. Serem, Megan J. Bester, Kwaku G. Duodu

“…Overall, the pigmented flower extracts of Geraniaceae and Lamiaceae show a range of health-promoting properties that represent an additional benefit to their potential use as natural food colourants.…”
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Complexity of near-surface deformation and subsurface structure of the Chihshang creeping fault-line scarp, eastern Taiwan: insights from integration of geological and geophysical... by W. J. Huang, M. T. Fitrianto, C. C. Chen, P. Y. Chang, I. C. Yen, M. Le Béon, S. T. Lu

“…Frontal collapse and flattening of reverse faulting, in addition to fluviation and landslide have complicated the process for defining the Chihshang fault configuration. …”
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Dynamics of special endurance of athletes aged 13-15 years under the influence of the program of the Cossack duel by Andrij Plokhikh, Gennadij Ogar

“…One of such sports is the Cossack duel - a national martial art in Ukraine. In addition to the purely sports component, this sport has national traditions of educating healthy youth. …”
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TCBGY net for enhanced wear particle detection in ferrography using self attention and multi scale fusion by Lei He, Haijun Wei, Cunxun Sun

“…Experimental results demonstrate that TCBGY-Net achieves outstanding precision in detecting wear particles against complex backgrounds, with a mAP@0.5 value of 98.3%, which is a 10.2% improvement over YOLOv5s. In addition, we conducted comprehensive ablation experiments, to validate the contribution of each module and the robustness of our model. …”
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