Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi by Marcos Vinicius da Silva, Vera Lúcia de Almeida, Wendyson Duarte de Oliveira, Natália Carasek Matos Cascudo, Pollyana Guimarães de Oliveira, Crislaine Aparecida da Silva, Aline Cristina Souza da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Rosana Rosa Miranda Correa, Milton Adriano Pelli Oliveira, Ruy de Sousa Lino-Júnior, Mara Rúbia Nunes Celes, Juliana Reis Machado

“…In addition, IL-4 absence did not influence IL-17 expression. …”
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UNet-Att: a self-supervised denoising and recovery model for two-photon microscopic image by Yuer Lu, Yongfa Ying, Chen Lin, Yan Wang, Jun Jin, Xiaoming Jiang, Jianwei Shuai, Xiang Li, Jinjin Zhong

“…The architecture is completed by an ingenious upsampling pathway that reconstructs the image with high fidelity, ensuring the retention of textural integrity. Additionally, the model supports end-to-end training, optimizing its denoising efficacy. …”
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The morphological, clinical, and prognostic factors in the management of giant anterior communicating artery aneurysms: A systematic review of cases by Roua Nasir, Midhat e Zahra Naqvi, Salaar Ahmed, Maarij ul Hassan, Rabeet Tariq, Saad Akhter Khan, Pia Koeskemeier, Rajiv K. Khajuria, Mohammad Hamza Bajwa, Sajjad Muhammad

“…The study type, sample size, patient age, aneurysm site, aneurysm size, presenting complaints, and treatment modality were tabulated, and methodological quality was assessed. Additionally, two cases from our institution were included. …”
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Does hydrogen-rich water mitigate MP toxicity in rainbow trout (Oncorhyncus mykiss)? Monitoring with hematology, DNA damage, and apoptosis via ROS/GSH/MDA pathway by Atamanalp Muhammed, Kırıcı Muammer, Köktürk Mine, Kırıcı Mahinur, Alwazeer Duried, Kocaman Esat Mahmut, Ucar Arzu, Parlak Veysel, Özcan Sinan, Alak Gonca

“…In this direction, the following were determined: PP+PE chronic toxicity in aquatic organisms, the toxicity mechanism and the effect of HRW as a possible treatment method in blood tissue; with hematological indices ([RBC count [RBC], leukocyte count [WBC], hemoglobin value [Hb], hematocrit ratio [Hct], platelet count [PLT], hemoglobin count per erythrocyte [MCHC], mean hemoglobin amount per erythrocyte [MCH] and mean erythrocyte volume [MCV]) in other tissues (liver, gill and brain tissue) oxidative stress response (catalase [CAT]), glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), glutathione (GSH), reactive oxygen products (ROS), malondialdehyde ([MDA] levels), DNA damage (8-OHdG: 8-Hydroxy-2-Deoxyguanosine), and the apoptosis (caspase 3) levels were investigated. In addition, acetylcholinesterase enzyme (AChE) activity, which is important in neurotoxicity pathways in the brain, was determined. …”
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Image-based anomaly detection in low-light industrial environments with feature enhancement by Dinh-Cuong Hoang, Phan Xuan Tan, Anh-Nhat Nguyen, Son-Anh Bui, Ta Huu Anh Duong, Tuan-Minh Huynh, Duc-Manh Nguyen, Viet-Anh Trinh, Quang-Huy Ha, Nguyen Dinh Bao Long, Duc-Thanh Tran, Xuan-Tung Dinh, Van-Hiep Duong, Tran Thi Thuy Trang

“…Specifically, it achieves a mean image-level anomaly detection accuracy (I-AUROC) of 0.899 and a localization performance (AUPRO) of 0.862, surpassing the next-best method by 16.2% and 16.5%, respectively. Additionally, the framework maintains a real-time inference speed of 60 frames per second (FPS), making it well-suited for deployment in industrial settings. …”
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p54-Fc-Labeled Gold Nanoparticle-Based Lateral Flow Strip-Assisted Portable Devices for Rapid and Quantitative Point-of-Care Detection of ASFV Antibodies by Yang Yang, Yuhao Li, Ziyang Wang, Minglong Tong, Pengcheng Zhu, Juanxian Deng, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Zhongren Zhou, Yafeng Qiu, Zhiyong Ma, Jianchao Wei

“…In summary, our method is rapid, cost-effective, precise, and highly selective. Additionally, it introduces a new approach for constructing IC test strips using SPA protein without antibody preparation, making it a reliable on-site antibody test for ASFV.…”
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Enhancing physicochemical, bioactive, and nutritional properties of sweet potatoes: Ultrasonic contact drying with slot jet nozzles compared to hot-air drying and freeze drying by Gulcin Yildiz, Yuan Gao, Junzhou Ding, Si Zhu, Guibing Chen, Hao Feng

Subjects: “…Ultrasonic-contact drying…”
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Machine learning-based prediction of in-hospital mortality for critically ill patients with sepsis-associated acute kidney injury by Tianyun Gao, Zhiqiang Nong, Yuzhen Luo, Manqiu Mo, Zhaoyan Chen, Zhenhua Yang, Ling Pan

“…The best-performing model was interpreted by Shapley additive explanations (SHAP).Results A total of 12,196 patients were enrolled in this study. …”
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Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease by Kyung In Woo, Suk-Woo Yang, Jeong Kyu Lee, Sang In Khwarg, Jin Sook Yoon, Sehyun Baek, Jae Wook Yang, JaeSang Ko, Koung Hoon Kook, Sang Duck Kim, Jun Hyuk Son, Helen Lew, Sung Bok Lee, Jae Woo Jang, Hee Young Choi, Mi Jung Chi

“…In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels and course of disease activity and severity over time.Design This was a multicentre, prospective, observational study.Setting Fifteen tertiary care oculoplastic service centres in Korea.Participants Seventy-six patients with newly diagnosed TED were included and followed up for 12 months.Methods We evaluated clinical characteristics and serum TRAb levels at baseline, 6 and 12 months of TED diagnosis. Additionally, we analysed longitudinal associations between the serum TRAb levels and clinical activity score (CAS), no signs or symptoms, only signs, soft tissue involvement, proptosis, extraocular muscle involvement, corneal involvement, sight loss (NOSPECS) score and proptosis.Results Thyroid-stimulating immunoglobulin (TSI) and TSH-binding inhibitory immunoglobulin (TBII) levels decreased during the 1-year follow-up, whereas disease activity measured using CAS decreased mainly in the first 6 months. …”
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Unravelling spatiotemporal propagation processes among meteorological, soil, and evaporative flash droughts from a three-dimensional perspective by Chen Hu, Dunxian She, Gangsheng Wang, Liping Zhang, Zhaoxia Jing, Zhihong Song, Jun Xia

“…Here we developed a spatiotemporal matching framework to identify propagation processes among meteorological, soil, and evaporative flash droughts from a three-dimensional perspective, applying it to the middle and lower reaches of Yangtze River Basin (MLRYRB) from 2000 to 2022. Additionally, we utilized the random forest model to identify critical factors influencing flash drought propagation. …”
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Choosing the most suitable NGS technology to combine with a standardized viral enrichment protocol for obtaining complete avian orthoreovirus genomes from metagenomic samples by Sonsiray Álvarez-Narváez, Sonsiray Álvarez-Narváez, Telvin L. Harrell, Islam Nour, Sujit K. Mohanty, Steven J. Conrad

“…We used eight clinical isolates of ARV, each previously processed using our published viral genome enrichment protocol. Additionally, we evaluate three assembly methods to determine which provided the most complete and reliable whole genomes: De novo, reference-guided or hybrid. …”
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A New Risk Prediction Model for the Assessment of Myocardial Injury in Elderly Patients Undergoing Non-Elective Surgery by Vedat Cicek, Mert Babaoglu, Faysal Saylik, Samet Yavuz, Ahmet Furkan Mazlum, Mahmut Salih Genc, Hatice Altinisik, Mustafa Oguz, Berke Cenktug Korucu, Mert Ilker Hayiroglu, Tufan Cinar, Ulas Bagci

“…The study cohort was divided into two groups: patients who had MINS and those who did not. <b>Results:</b> In total, 13% (48 out of 370 patients) of the patients developed MINS. …”
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Gastroprotective Effects of Aqueous Extracts of Broccoli Stems on Acute Injury in Rats: A Comprehensive Evaluation of Gastric Function and Inflammatory Responses by Jihye Choi, Yuseong Jang, Hyeon-Gi Paik, Melissa Hyun-Joo Ha, Jungkee Kwon

“…<i>Results</i>: The BSE 250 mg/kg group exhibited significant relief of clinical signs compared to the negative control group. In addition, the BSE 250 mg/kg group showed significant improvements in gastric tissue, including macroscopic reductions in ulcer size and improved overall gastric morphology as assessed through gross examination, as well as microscopic improvements such as reduced inflammation and the restoration of mucosal integrity observed in histopathological analysis. …”
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The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver by Chunmei Gan, Mi Leng, Yu Liu, Zhaoyue Zheng, Siwu He, Wen Qiao, Lin Xiao, Yao Xiao, Jingya Ye, Lixing Zhou, Jiao Zhou, Boduan Xiao, Wenxin Zhao, Jiamei Yang, Aohan Wu, Huiyuan Zhang, Hongbo Hu, Xiaobo Cen, Zhiyong Qian, Haohao Dong, C. Alexander Valencia, Lunzhi Dai, Hoi Yee Chow, Lei Zhang, Biao Dong

“…We showed successful but low efficient triple trafficking by LNP-rAAV2 carrying EGFP, human factor IX (hFIX), and luciferase (luc), due to its encapsulation characteristic. Additionally, sustained TAC treatment, which dose-dependently downregulated the anti-rAAV2 antibodies, permitted rAAV2 re-administration at dosages of ≥45 mg/kg/3 days. …”
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Integrating biodiversity assessments into local conservation planning: the importance of assessing suitable data sources by Ferraille, Thibaut, Kerbiriou, Christian, Bigard, Charlotte, Claireau, Fabien, Thompson, John D.

“…Despite the paradigm of “garbage in - garbage out” that emphasises the importance of testing the suitability of data for SDM and priority conservation areas, the assessment of database sources remains relatively rare. In addition, the lack of practical recommendations for the use of open-access databases by SEA stakeholders remains a problem. …”
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Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study by Jing Qian, Jiahao Zhu, Yifan Wang, Ruoqi Dai, Jingyou Miao, Ye Yang, Wenxia Zhao, Jing Wang, Lilu Ding, Dan Zhou, Min Yu, Yingjun Li

“…Cox models assessed associations between air pollution exposure and OA incidence, joint replacement, and survival. Additionally, using genome-wide association statistics, we examined the potential causal associations between air pollution-related DNA methylation (DNAm) and OA risk. …”
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Factors affecting the implementation of guideline-based prophylactic antiemetic therapy for chemotherapy-induced nausea and vomiting in Japan: a protocol for a hospital-based quali... by Yosuke Uchitomi, Junko Saito, Maiko Fujimori, Taichi Shimazu, Ayako Okuyama, Sadamoto Zenda, Ayumu Matsuoka, Akiko Yaguchi-Saito, Yuki Kaji, Miyuki Odawara, Aki Otsuki

“…We will also create new codes inductively, as required. In addition, we will refer to the aggregate results of the Quality Indicator survey to determine the implementation of recommended antiemetic prescriptions for each hospital and discuss the relationship with influencing factors.Ethics and dissemination This study has been approved by the National Cancer Centre Ethics Approval Committee (approval number: 2020-305). …”
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Designing multi-function rapid right angle set slurry compositions for a high pressure-high temperature well by Pooria Kianoush, Mostafa Gomar, Nasser Keshavarz Faraj Khah, Seyednooroldin Hosseini, Ali Kadkhodaie, Shahaab Varkouhi

“…The thermal gradient was 1.62 °F/100 ft, significantly impacting cement performance; elevated temperatures can accelerate hydration reactions, potentially causing strength retrogression. A blend of additives—including 3 % boric acid as a dual-functioning dispersant and 1 % latex materials—enhanced dispersing properties, compressive strength, and gas migration resistance. …”
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Effect of soil-groundwater system on migration and transformation of organochlorine pesticides: A review by Haohao Li, Lin Huo, Rui Zhang, Xuefan Gu, Gang Chen, Ying Yuan, Wenbing Tan, Kunlong Hui, Yu Jiang

“…However, most studies on the pollution of OCPs have focused on the aboveground or surface water environment, and little consideration has been given to the pollution and hazards of OCPs to the deep soil and groundwater environment, especially the effects of different environmental factors on the transport and transformation of OCPs in soil-groundwater. Moreover, in addition to the influence of a single factor on it, the interactions that arise between different factors cannot be ignored. …”
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Establishing a preoperative predictive model for gallbladder adenoma and cholesterol polyps based on machine learning: a multicentre retrospective study by Yubing Wang, Chao Qu, Jiange Zeng, Yumin Jiang, Ruitao Sun, Changlei Li, Jian Li, Chengzhi Xing, Bin Tan, Kui Liu, Qing Liu, Dianpeng Zhao, Jingyu Cao, Weiyu Hu

“…Evaluation through external cohort validation, calibration curves, and clinical decision curves further confirmed its excellent predictive ability for distinguishing gallbladder adenomas from cholesterol polyps. Additionally, this study identified age, adenosine deaminase level, and metabolic syndrome as potential predictive factors for gallbladder adenomas. …”
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