Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences by Pål Møller, Aysel Ahadova, Matthias Kloor, Toni T. Seppälä, John Burn, Saskia Haupt, Finlay Macrae, Mev Dominguez-Valentin, Gabriela Möslein, Annika Lindblom, Lone sunde, Ingrid Winship, Gabriel Capella, Kevin Monahan, Daniel D. Buchanan, D. Gareth Evans, Eivind Hovig, Julian R. Sampson

“…In path_APC carriers, second hits result in the development of multiple adenomas, with CRC typically emerging after an additional 20 years. In path_MLH1 and path_MSH2 carriers, second hits lead to the formation of microscopically detectable, microsatellite unstable (MSI) crypts, from which CRC develops in about half of carriers over their lifetime, often without progressing through a diagnosable adenoma stage. …”
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Dysmenorrhea Among Women Living in Saudi Arabia: Prevalence, Determinants, and Impact by Mohammad A. Jareebi, Saja A. Almraysi, Dhiyaa A. H. Otayf, Ghadeer A. Alneel, Areej H. Zughaibi, Sarah J. Mobarki, Imtenan A. Oberi, Hayam A. Alzahrani, Shatha A. Aldhowaihi, Zainab A. Alramadhan, Majed A. Ryani, Ahmed A. Bahri, Nuha H. Abutalib, Nada M. Makein, Ahmad Y. Alqassim

“…Descriptive and inferential statistics were utilized to evaluate the prevalence, severity, and associated symptoms of dysmenorrhea. Additionally, multiple logistic regression was employed to identify the determinants of dysmenorrhea within the sample. …”
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Postmortem Analysis of Ethyl Alcohol Concentration in Blood, Urine, Muscle and Bile by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Gabija Laubner-Sakalauskienė, Robertas Badaras, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“… Introduction: The determination of ethyl alcohol concentration in body fluids is an important investigation in forensic practice. …”
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Dynamic Detection of Monocyte Subsets in Peripheral Blood of Patients with Acute Hypertriglyceridemic Pancreatitis by Junyuan Zheng, Junjie Fan, Chunlan Huang, Yingying Lu, Zehua Huang, Xingpeng Wang, Yue Zeng

“…In severe HTGP, M1 monocyte count and percentage rose to the highest point while M2 were the lowest on day 3. Additionally, the level of M1 monocytes showed a positive correlation with plasma triglyceride and Ranson score of HTGP patients. …”
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Synergistic effects of PGPRs and fertilizer amendments on improving the yield and productivity of Canola (Brassica napus L.) by Haji Muhammad, Muhammad Ijaz, Abdul Sattar, Sami Ul-Allah, Ahmad Sher, Muhammad Asif, Muhammad Dilshad, Khalid Mahmood, Muhammad Waheed Riaz, Muhammad Saqlain Zaheer, Muhammad Rizwan, Salim Manoharadas

“…Results Canola yield and agronomic traits were enhanced by the combination of Bacillus subtilis with the fully recommended N: P:K ratio (140:55:40 kg/ha). Additionally, the application of Bacillus subtilis with biochar at 2 tons/ha improved the yield and quality of canola, as well as the structure and nutrient regulation of the soil. …”
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Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A. Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G. Karlsson, Anne Marie Lynge Pedersen

“…MS2 fragmentation analysis of salivary O-glycans suggests that altered sulfation, fucosylation, sialylation and distribution of core types may all contribute to the observed alteration, directly or indirectly. Additionally, the short disaccharide sialyl-Tn was most abundant in the saliva samples from patients with pSS. …”
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Dwelling overheating in risk in cool climates: Assessing the risk in the context of retrofit and climate change in Ireland by M. Mulville, S. Harrington, C. Li, K. Raushan, E. Essien-Thompson, C. Ahern

“…Building upon this, the paper makes the case for the use of robust Dynamic Simulation Modelling supported by localised weather files accounting for the Urban Heat Island effect and occupant behaviour. In addition, the paper, for the first time, reviews the future building simulation weather files from Ireland’s National Meteorological service highlighting the potential impact of climate change on overheating projections. …”
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Effect of probiotics on the growth, blood profile, and nutritional-metabolic profile of feedlot cattle by Flavia I. Mansilla, María C. Aristimuño Ficoseco, María H. Miranda, Marcela D’Urso Villar, Graciela M. Vignolo, María E. F. Nader-Macías

“…Analysis of clinical parameters showed optimal animal body condition and sensorium state. Isolated nasal discharges and the absence of diarrhea were observed at 105 days in the group administered with multistrain and Lim. fermentum CRL2085 probiotics. …”
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Traditional Knowledge and Efficacy Analysis of an Emerging Medicinal Food Plant: <i>Disporopsis aspersa</i> by Qingyu Chen, Miaomiao Wang, Xian Hu, Jihai Zhang, Qing Zhang, Congli Xu, Chunlin Long

“…The IC₅₀ for nitric oxide (NO) scavenging activity was 72.7 ± 7.43 μg/mL, showing dose dependence. Additionally, the ethanolic extract also exhibited ABTS⁺· scavenging capacity and total antioxidant capacity. …”
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Structural Response Prediction of Floating Offshore Wind Turbines Based on Force-to-Motion Transfer Functions and State-Space Models by Jie Xu, Changjie Li, Wei Jiang, Fei Lin, Shi Liu, Hongchao Lu, Hongbo Wang

“…Further validation involved a numerical model of a spar-type floating offshore wind turbine, showing high accuracy in predicting responses to both regular and irregular wave conditions, closely aligning with results from conventional methods. Additionally, we assessed the efficiency of our algorithm over various simulation durations, confirming its superior performance compared to traditional time-domain methods. …”
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Verbal fluency and semantic association deficits in children with in birth nonprogressive neuromuscular diseases by Maria Koriakina, Maria Koriakina, Olga E. Agranovich, Ioannis Ntoumanis, Maxim Ulanov, Isak B. Blank, Anna Shestakova, Evgeny Blagovechtchenski

“…Interestingly, MD children with unilateral limb impairment outperformed those with bilateral impairment on semantic association tasks.DiscussionThese results suggest that the cognitive deficits observed in children with motor impairments can be attributed to less engagement with their physical environment, which influences their ability to perceive and manipulate objects differently based on their level of impairment. Additionally, the findings underscore how social and cultural contexts may be affected by motor impairments. …”
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H3K4 methylation regulates development, DNA repair, and virulence in Mucorales by Macario Osorio-Concepción, Carlos Lax, Damaris Lorenzo-Gutiérrez, José Tomás Cánovas-Márquez, Ghizlane Tahiri, Eusebio Navarro, Ulrike Binder, Francisco Esteban Nicolás, Victoriano Garre

“…These strains also showed a significant reduction in vegetative growth and sporulation. Additionally, set1 null strains were more sensitive to SDS, EMS, and UV light, indicating severe impairment in the repair process of the cell wall and DNA lesions and a correlation between Set1 and these processes. …”
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Abnormal characteristics of inferior vena cava and abdominal aorta among neonates with early onset septic shock by Lanlan Mi, Yiman Liu, Fei Bei, Jianhua Sun, Jun Bu, Yuqi Zhang, Weiwei Guo

“…Results Among the control newborns, IVC and AO were significantly increased with GA and BW (P < 0.05) but IVC-CI and IVC/AO did not correlate with GA, BW, day of age, and PDA. …”
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Fabrication and Performance Analysis of Novel HTV Silicon Rubber Nanocomposites for High Voltage Insulation in Outdoor Environment by Aqeel Ur Rehman, Muhammad Salman Khan, Abraiz Khattak, Yasin Khan, Khalid Hamad Alkhalid

“…The extraordinarily high resistive nature of silicon rubber nanocomposites displays the insulation levels attained by nano-filler addition to the base matrix. The most considerable band gap energy was found in Silicone Rubber with 1% silica nano-composite filling, followed by 3% and 7% nanocomposites with an improvement of 71% and 76%, respectively. 1% silica nanocomposites have the highest DC resistance value among all nanocomposites. …”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…Secondary objectives include assessment of overall survival, response rate, safety and quality of life measures. Two additional therapeutic arms are currently in development.Ethics and dissemination Central ethics approval was obtained from the Sydney Local Health District Ethics Review Committee, Royal Prince Alfred Hospital Zone, Sydney, Australia (Approval: 2022/ETH02230). …”
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Comment faire sortir les villages de leur immobilité ? by Jeremy Hayhoe

“…Cependant l’auteur montre que des études nouvelles et approfondies amènent à reconsidérer des questions aussi cruciales que celles de l’affaiblissement de la seigneurie, communément admis dans les années 1990, de l’efficacité des justices seigneuriales. …”
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Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (<i>Pinus densiflora</i>) in Sprague-Dawley Rats with Loperamide-Induced Constipation by Hee-Jin Song, Ayun Seol, Jumin Park, Ji-Eun Kim, Tae-Ryeol Kim, Ki-Ho Park, Eun-Seo Park, Su-Jeong Lim, Su-Ha Wang, Ji-Eun Sung, Youngwoo Choi, Heeseob Lee, Dae-Youn Hwang

“…MPC contained several bioactive compounds, including diterpenoid compounds such as dehydroabietic acid, taxodone, and ferruginol. In addition, it exhibited high scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals. …”
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Effectiveness of a harmonica-integrated, tele-supervised home-based pulmonary rehabilitation program on lung function and comprehensive health outcomes in patients with chronic obs... by Qiuxuan Zeng, Xiaohong Lin, Wenli Chen, Daniel Yee Tak Fong, Junxin Li, Jiaying Li, Jiaying Li

“…The intervention will incorporate harmonica sessions in addition to standard PR exercises (breathing and physical exercises). …”
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Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center st... by Shuhei Suzuki, Yoshiyuki Nagumo, Kosuke Kojo, Atsushi Ikeda, Bunpei Isoda, Akane Yamaguchi, Kozaburo Tanuma, Satoshi Nitta, Masanobu Shiga, Takashi Kawahara, Shuya Kandori, Akio Hoshi, Hiromitsu Negoro, Bryan J. Mathis, Hiroyuki Nishiyama

“…The second-year surgeons had significantly higher accuracy rates than first-year surgeons (81.5 % vs. 69.0 %, p = 0.013), while PDD experience did not significantly affect accuracy rates (76.5, 75.5, and 69.0 %). …”
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A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats by Sabrina Salberg, Matthew Macowan, Angela Doshen, Glenn R. Yamakawa, Marissa Sgro, Benjamin Marsland, Luke A. Henderson, Richelle Mychasiuk

“…Therefore, we investigated how daily consumption of a HFHS diet modified the development of PPSP, brain structure and function, and the microbiome. In addition, we identified significant correlations between the microbiome and brain in animals with PPSP. …”
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