Anti-PLA2R1 Antibodies Containing Sera Induce In Vitro Cytotoxicity Mediated by Complement Activation by Maël Lateb, Hajar Ouahmi, Christine Payré, Vesna Brglez, Kevin Zorzi, Guillaume Dolla, Mohamad Zaidan, Sonia Boyer-Suavet, Bertrand Knebelmann, Thomas Crépin, Cécile Courivaud, Noémie Jourde-Chiche, Vincent Esnault, Gérard Lambeau, Barbara Seitz-Polski

“…Mean cytotoxicity of anti-PLA2R1 sera for HEK293 cells overexpressing PLA2R1 was 2±2%, which increased to 24±6% after addition of rabbit complement (p<0.001) (n=48). GVB-EDTA, which inhibits all complement activation pathways, completely blocked cell cytotoxicity, whereas Mg-EGTA, which only inhibits the classical and lectin pathways, highly decreased suggesting a limited role of the alternative pathway. …”
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Fact-finding and risk factor analysis of chemotherapy-induced nausea and vomiting in children with solid tumors: a prospective observational study by Miaomiao Shao, Ying Li, Jing Qin, Yuchen Zhou, Yixin Sun, Peiyi Yang, Xisi Wang, Cheng Huang, Yan Su, Wen Zhao

“…Abstract Objective The aim of the study was to describe the control of acute chemotherapy-induced nausea and vomiting (CINV) in children with solid tumors receiving highly emetogenic chemotherapy (HEC) at our center. Additionally, the study aimed to explore the risk factors for chemotherapy-induced vomiting (CIV) with the ultimate goal of enhancing CINV management for children. …”
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Clinicopathological and molecular characterization of astrocytoma by Xiaoyan Wu, Wenfeng Peng, Xu Zhang, Tao Tang, Ling Deng, Yuxia Xu, Xiaoyun Liu, Fang Wang, Wujian Peng, Jianrong Huang, Xiaoni Zhong

“…Immunohistochemical staining revealed that all four patients expressed OLIG2, EMA, and vimentin, while three patients also expressed GFAP and S-100. The Ki-67 positivity index was approximately 15% in three cases and 10% in one case. …”
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Sex differences in murine MASH induced by a fructose-palmitate-cholesterol-enriched diet by Lakshmi Arivazhagan, Sofie Delbare, Robin A. Wilson, Michaele B. Manigrasso, Boyan Zhou, Henry H. Ruiz, Kaamashri Mangar, Ryoko Higa, Emily Brown, Huilin Li, Michael J. Garabedian, Ravichandran Ramasamy, Kathryn J. Moore, Edward A. Fisher, Neil D. Theise, Ann Marie Schmidt

“…Impact and implications:: Despite the importance of metabolic dysfunction-associated steatohepatitis (MASH) in impairment of human health, the potential for and mechanisms of sex-dependent responses have yet to be well-studied, particularly with respect to the possible influence of high-fructose corn syrup additives to the diet, which has been linked to metabolic and hepatic disturbances. …”
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The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats by Xiaoyun Fan, Qing Zhang, Weiling Guo, Qi Wu, Jinpeng Hu, Wenjian Cheng, Xucong Lü, Pingfan Rao, Li Ni, Youting Chen, Lijiao Chen

“…Furthermore, liver metabolomics analysis demonstrated that L. brevis FZU0713 had a significant regulatory effect on the composition of liver metabolites in hyperlipidemic rats, especially the levels of some important biomarkers involved in the metabolic pathways of arachidonic acid metabolism, primary bile acid biosynthesis, amino sugar and nucleotide sugar metabolism, taurine and hypotaurine metabolism, biosynthesis of unsaturated fatty acid, fructose and mannose metabolism, tyrosine metabolism, etc. Additionally, oral administration of L. brevis FZU0713 significantly regulated the mRNA levels of liver genes (including Acat2, Acox1, Hmgcr, Cd36, Srebp-1c and Cyp7a1) involved in lipid metabolism and bile acid homeostasis. …”
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Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults by Jung Hyuk Lee, Yuna Shin, Kwang-Soo Shin, Ju Yeon Park, Mi Sun Kim, Young-Shin Park, Wuhyun Kim, Joon Young Song, Ji Yun Noh, Hee Jin Cheong, Chang-Yuil Kang, Sang Hwan Seo, Jae-Ouk Kim, Deok Ryun Kim, Nathaniel S. Hwang, Jae Seung Yang, Jerome H. Kim, Byoung-Shik Shim, Manki Song

“…These findings underscore the importance of considering diverse humoral immune responses when evaluating vaccine efficacy and provide insights for optimizing adenovirus vector-based SARS-CoV-2 vaccine doses.IMPORTANCEOptimization of vaccine dose is crucial for eliciting effective immune responses. In addition to neutralizing antibodies, non-neutralizing antibodies that mediate Fc-dependent effector functions play a key role in protection against various infectious diseases, including coronavirus disease 2019. …”
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Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis by Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Nanhao Yin, Liyan Zhou, Liyan Zhou, Jianxin Xue, Jianxin Xue, Jianxin Xue, Min Ren

“…Furthermore, patients with MSS RC underwent neoadjuvant treatment with anti-PD-1 inhibitors demonstrated higher pooled pCR, MPR, cCR compared to those receiving PD-L1 inhibitors. Additionally, yielded improved pooled MPR and anal preservation rates compared to sequential immuno-radiotherapy (63.4% vs 51.2% and 88.5% vs 69.9%), without raising the incidence of irAEs≥3 grade. …”
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Climate change policies reduce air pollution and increase physical activity: Benefits, costs, inequalities, and indoor exposures by Sean Beevers, Nosha Assareh, Andrew Beddows, Gregor Stewart, Mike Holland, Daniela Fecht, Yunzhe Liu, Anna Goodman, Heather Walton, Christian Brand, Dimitris Evangelopoulos, Dylan Wood, Tuan Vu, David Dajnak

“…NZ building sector operating costs did not achieve break-even via efficiency savings, but with Greenhouse Gas (GHG) (lower benefits) break-even was achieved in 2052. …”
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Identifying the predictors of ultra early neurological improvement and its role in functional outcome after endovascular thrombectomy in acute ischemic stroke by Yuzheng Lai, Mohammad Mofatteh, José Fidel Baizabal-Carvallo, José Fidel Baizabal-Carvallo, Jianfeng He, Wenhao Wu, Daohong Wang, Wenshan Yan, Jicai Ma, Sijie Zhou, Yu Sun, Yu Sun, Yi He, Shumei Li, Hao Sun

“…While 82.79% of the patients with UENI achieved favorable functional outcomes at 3-months, only 32.36% of patients without UENI had favorable functional outcome (p &lt; 0.0001). In addition, lower hospitalization costs were associated with patients who had UENI, compared to No-UENI (p = 0.003). …”
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Comparative evaluation of sensititre YeastOne and VITEK2 antifungal susceptibility tests with CLSI broth microdilution method of clinical Cryptococcus isolates in Taiwan by Tzu-Ping Weng, Shin-Wei Wang, Shih-Ting Lo, Shu-Li Su, Ming-I Hsieh, Pei-Jane Tsai, Pei-Fang Tsai, Chi-Jung Wu, Nan-Yao Lee, Wen-Chien Ko, Po-Lin Chen

“…Non-wild-type (non-WT) strains to amphotericin B (AMB) were observed in 11 isolates with the CLSI BMD method and 8 with SYO among 44 C. neoformans isolates, but only 1 isolate was classified as non-WT by both methods. Additionally, all C. neoformans isolates were susceptible to AMB with their MIC ≤1 µg/mL according to the clinical breakpoint defined by EUCAST. …”
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Transfer of aflatoxin M1 and sterigmatocystin from buffalo milk to soft cheeses by Maurizio Cossu, Andrea Sanna, Giannina Chessa, Stefano Sdogati, Ivan Pecorelli, Ilaria Di Marco Pisciottano, Sara Lambiase, Pasquale Gallo, Stefania Massafra, Elena Torres, Marilena Gili, Giovanni Lo Cascio, Antonio Vella, Roberto Condoleo, Bruno Neri, Guglielmo Militello, Gilberto Giangolini, Carlo Boselli

“…AFM1 is a toxic molecule classified by the IARC as “potentially carcinogenic to humans” in Group 1. In addition to the four aflatoxins (AFB1, AFB2, AFG1, and AFG2), these fungi also produce other toxins such as Sterigmatocystin (STC), while Aflatoxicol (AFL) is a metabolite of AFB1. …”
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Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study by Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Ezza Jalil, Jayati Khattar, Nicole R. Palmer, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan

“…Panelists rated the relevance and wording of each consideration on a 7-point Likert scale and provided free-text comments during both phases. Considerations that did not meet predetermined thresholds were excluded. …”
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Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications by Jiayi He, Huiqian Zhang, Hehua Quan, Qingyuan Wang, Congcong Wen, Yiyan Wang, Yang Zhu, Ren-Shan Ge, Xiaoheng Li

“…The results demonstrated that BPB significantly decreased testosterone output, which was counteracted by GSK-J4 to reverse BPB-mediated testosterone suppression. Additionally, BPB significantly elevated the levels of EEF1A1, EEF1A2, EED, H3K27me3, and H3K9me3 in vitro. …”
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Overexpression of the <i>GmPM35</i> Gene Significantly Enhances Drought Tolerance in Transgenic Arabidopsis and Soybean by Xinyu Wang, Yao Sun, Rui Wang, Xinyang Li, Yongyi Li, Tianyu Wang, Zhaohao Guo, Yan Li, Wenxi Qiu, Shuyan Guan, Qi Zhang, Piwu Wang, Mingze Li, Siyan Liu, Xuhong Fan

“…The improvement of these indexes helped to reduce the accumulation of reactive oxygen species (ROS) in the plants. In addition, we found that under drought stress, the MDA content was reduced by an average of 18.8%, and the Pro content was increased by an average of 60.14% in soybean plants overexpressing the <i>GmPM35</i> gene, and the changes in these indexes indicated that the plants had stronger antioxidant and osmoregulatory capacities in response to drought stress. …”
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Resilience Based on Community-Oriented Capacities in Crisis Conditions by Mohammad Jalali, Mahdi Mahmoodzadeh Vashan, Nour Mohammad Yaghoubi, Mohammad Mohammadi

“…But in Iran, the evidence indicates that this change of approach and outlook has not yet happened in the country, and currently the government-oriented approach is trying to formulate and implement centralized and downward strategies to increase resilience in crisis situations. In addition, few studies have been conducted in the field of identifying and explaining factors affecting resilience based on community-oriented capacities in crisis conditions in our country; So far, a comprehensive model has not been presented as a road map for the country's crisis management managers. …”
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Innovación en sueño by Laura Vigil, Toni Zapata, Andrea Grau, Marta Bonet, Montserrat Montaña, María Piñar

“…These advances make it possible to improve the efficiency of sleep labs and to personalize OSA treatment. In addition, techniques such as cluster analysis are used to identify symptomatic patterns and phenotypes, which improves understanding of OSA pathophysiology and optimizes CPAP treatment.However, implementation of AI in hospitals faces technological, ethical, and legal barriers. …”
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Usefulness of a personalized algorithm‐based discharge checklist in patients hospitalized for acute heart failure by Florent Allain, Virginie Loizeau, Laure Chaufourier, Maya Hallouche, Laurence Herrou, Amir Hodzic, Katrien Blanchart, Annette Belin, Alain Manrique, Paul Milliez, Rémi Sabatier, Damien Legallois

“…Conclusions In this preliminary study, the use of a PCL did not improve outcomes at 6 months in patients hospitalized for acute HF. …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…Functional assays showed that lnc-MAP3K13-3:1 overexpression inhibited proliferation in HuH-7 and Li-7 cells, promoted apoptosis, reduced migration in Li-7 cells, but enhanced migration in HuH-7 cells. Additionally, lnc-MAP3K13-3:1 overexpression significantly increased the proportion of HuH-7 cells in the G2/M phase and Li-7 cells in the S phase. …”
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Analisis Sentimen Kebijakan Penerapan Kurikulum Merdeka Sekolah Dasar dan Sekolah Menengah pada Media Sosial Twitter dengan Menggunakan Metode Word Embedding dan Long Short Term Me... by Alif Rizal Maulana, Satrio Hadi Wijoyo, Yusi Tyroni Mursityo

“…Analisis sentimen dilakukan pada opini siswa yang diutarakan di media sosial Twitter dengan menggunakan pendekatan machine learning. …”
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Reducing dietary crude protein levels while meeting metabolizable protein requirements: Performance of dairy cows over a full lactation period by A. Lavery, A. Craig, A.W. Gordon, A. White, N. Barkley, C.P. Ferris

“…Decreasing dietary CP concentration from 170 to 150 g CP/kg DM did not affect DMI, milk yield, milk fat or protein yield in early lactation (8–181 DIM), but reduced MUN and the ratio of n-6 to n-3 fatty acids in milk, as well as serum albumin, globulin, total protein, and urea concentrations. …”
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