Coronary Heart Disease Risk Prediction Model Based on Machine Learning by YUE Haitao, HE Chanchan, CHENG Yuyou, ZHANG Sencheng, WU You, MA Jing

“…Among them, the XGBoost model exhibited superior performance and can be referenced for future optimization of CHD prediction models. Additionally, considering the excellent performance of the XGBoost model and the convenience and interpretability of stepwise logistic regression, a combined use of these approaches after data balancing is recommended in CHD risk prediction models.…”
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Satisfactory Evaluation of Call Service Using AI After Ureteral Stent Insertion: Randomized Controlled Trial by Ukrae Cho, Yong Nam Gwon, Seung Ryong Chong, Ji Yeon Han, Do Kyung Kim, Seung Whan Doo, Won Jae Yang, Kyeongmin Kim, Sung Ryul Shim, Jaehun Jung, Jae Heon Kim

“…ObjectiveThis study aimed to assess the effectiveness of an AI-based prediction tool in providing patients with information about potential complications from ureteroscopy and ureteric stent placement and indicating the need for early additional therapy. MethodsOverall, 28 patients (aged 20-70 years) who underwent ureteral stent insertion for the first time without a history of psychological illness were consecutively included. …”
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Approaches to modulate buffalo gut microbiome for efficient feed utilization and reduced environmental pollution by Vijit Dey, Puran C. Lailer, Tirtha K. Datta

“…At the same time, ammonia is a potent environmental pollutant and is liable for the depletion of oxygen in the body water, reduction of soil pH, and generation of harmful aerosol fine particles accompanied by the augmented menace of pulmonary diseases. …”
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The CYP4/20-HETE/GPR75 axis in the progression metabolic dysfunction-associated steatosis liver disease (MASLD) to chronic liver disease by James P. Hardwick, Byoung-Joon Song, Paul Rote, Charles Leahy, Yoon Kwang Lee, Alexandra Rudi Wolf, Danielle Diegisser, Victor Garcia

“…To address the role of the CYP4/20-HETE/GPR75 axis, we measured the amount and the synthesis of 20-HETE in patients with CLD, specifically during the progression of MASLD. Additionally, we evaluated gene expression and protein levels of GPR75, a high-affinity receptor for 20-HETE across CLD patient samples.ResultsWe observed an increase in 20-HETE levels and synthesis during the progression of MASLD. …”
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Exploring agronomic diversity and disease tolerance in soybeans to combat Cowpea mild mottle virus by H. Kuswantoro, S. Zubaidah, E. Uge, K. Rozana, P. Purwantoro, J. Purnomo

“…The variation in soybean characteristics can be attributed mainly to factors such as seed yield, the quantity of filled pods, and the number of productive pods per plant. Additionally, plant height showed the strongest correlation among these traits. …”
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Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…According to the composite reference standards, the accuracy of tNGS in the detection of responsible pathogens was 0.852 (95% confidence interval 0.786– 0.918), which resembled that of mNGS and remarkably exceeded that of CMTs. In addition, 81 AMR genes associated with responsible pathogens were reported, and 75.8% (25/33) priority drug-resistant pathogens could be directly identified. …”
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Lattes/Lattara (Hérault), comptoir étrusque du littoral languedocien by Éric Gailledrat, Ariane Vacheret

“…The associated material remains, in addition to the significant presence of indigenous pottery exhibiting a great diversity, confirmed the predominance of Tyrrhenian contributions during this period. …”
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Climats et origines des grands singes et des hommes by Brigitte Senut

“…En ce qui concerne nos origines, il est largement admis que notre lignée a émergé en Afrique (comme cela avait été prédit par Darwin au XIXe siècle), tout comme celles de nos cousins (les gorilles et les chimpanzés). …”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …”
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HbA1c Cutoff Point of 5.9% Better Identifies High Risk of Progression to Diabetes among Chinese Adults: Results from a Retrospective Cohort Study by Kai Liang, Chuan Wang, Fei Yan, Lingshu Wang, Tianyi He, Xiuping Zhang, Chengqiao Li, Weifang Yang, Zeqiang Ma, Aixia Ma, Xinguo Hou, Li Chen

“…However, the RRs for subjects with HbA1c ranging from 5.7 to 5.8% and those with HbA1c ≤ 5.6% did not differ significantly (p=0.615). The AUCs for predicting diabetes after 3 years by FPG, 2hPG, and HbA1c were 0.752 (95% confidence interval 0.718–0.787), 0.710 (95% confidence interval 0.671–0.748), and 0.756 (95% confidence interval 0.720–0.793), respectively. …”
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A Three-Stage-Concatenated Non-Linear MMSE Interference Rejection Combining Aided MIMO-OFDM Receiver and its EXIT-Chart Analysis by Jue Chen, Siyao Lu, Tsang-Yi Wang, Jwo-Yuh Wu, Chih-Peng Li, Soon Xin Ng, Robert G. Maunder, Lajos Hanzo

“…Hence, we propose a novel receiver for interference-constrained MIMO-OFDM systems, relying on a linear MMSE-IRC detector intrinsically amalgamated with an additional NL equalizer. In this way, we may achieve the best of both worlds, retaining the interference rejection capability of the MMSE-IRC detector and the superior performance of the NL equalizer. …”
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The effect of groundwater depth on topsoil organic matter mineralization during a simulated dry summer in northwestern Europe by A. Françoys, A. Françoys, O. Mendoza, J. Hu, P. Boeckx, W. Cornelis, S. De Neve, S. Sleutel

“…We examined (1) upward moisture flow by capillary action along the soil profile, specifically into the top 20 cm of soil, and (2) the effect of the GWT on the decomposition of an added <span class="inline-formula">¹³C</span>-enriched substrate (ryegrass) over a period of 10 weeks, with limited wetting events representing a dry summer. A 50 cm difference in the GWT depth (<span class="inline-formula">−165</span> vs. …”
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Predictors of recurrence of ventricular tachycardia and the effectiveness of endocardial ablation at the patients with sudden cardiac death and history of myocardial infarction by O. M. Grytsay, Ya. V. Skybchyk

“…At 12 months after the procedure, the following parameters were associated with relapses of ventricular tachycardia with the greatest statistical significance: left ventricular systolic dysfunction (additive relative risk (ARR) – 43.0 %, relative risk (RR) – 2.57 [1.14–5.82], odds ratio (OR) – 6.50 [7.00–30.70], p < 0.05), arterial hypertension (ARR – 41.0 %, RR – 2.75 [1.08–6.90], OR – 5.96 [1.33–26.70], p < 0.05), diabetes mellitus (ARR – 43.0 %, RR – 2.83 [1.10–7.30], OR – 6.50 [1.25–33.60], p < 0.05), duration of arrhythmic history (ARR – 40.0 %, OR – 5.71 [7.00–28.10], p < 0.05), electrical storm episode at the time of ablation (ARR – 38.0 %, RR – 1.89 [1.27–4.99], OR – 8.57 [7.00–51.50], p < 0.05). …”
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Effect of breathing exercises combined with behavioral intervention in nursing of patients with asthma (呼吸训练联合行为干预在哮喘患者护理中的应用效果观察) by TIAN Shuijing (田水静), ZHANG Wenzheng (张文峥), WANG Yan (王燕)

“…The total effective rate of nursing and nursing satisfaction of patients in the observation group were higher than those of the control group (P＜0. 05). Conclusion In addition to routine care, breathing exercises and behavioral interventions may improve patients' quality of life, reduce the duration of oxygen intake, increase the nursing efficiency, and is conductive asthma control. …”
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SMART SPECIALISATION AS A BASIC COMPONENT OF SOCIO-ECONOMIC DEVELOPMENT by Olena Guzenko, Svitlana Nikolaichuk, Dmytro Ivanenko

“…Furthermore, the implementation of these strategies can also generate additional financial opportunities to support regional development. …”
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Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic... by Partha Ray, Tomoko Hayashi, Karen Messer, Stephen Schoenberger, Aaron Miller, Dennis Carson, Sara McArdle, Zbigniew Mikulski, Jayanth S Shankara Narayanan, Suna Erdem, Herve Tiriac, Minya Pu, Rebekah R White

“…Addition of CD40Ab to IRE improved dendritic cell activation and neoantigen recognition, while generating a strong systemic antitumor T-cell response that inhibited metastatic disease progression.…”
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Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development by G. F. Korytina, L. Z. Akhmadishina, V. A. Markelov, Y. G. Aznabaeva, O. V. Kochetova, T. R. Nasibullin, A. P. Larkina, N. N. Khusnutdinova, N. Sh. Zagidullin, T. V. Victorova

“…Significant associations with COPD were identified for SIRT1 (rs3818292) (P = 0.001, OR = 1.51 for AG), SIRT3 (rs3782116) (P = 0.0055, OR = 0.69) and SIRT3 (rs536715) (P = 0.00001, OR = 0.50) under the dominant model, SIRT6 (rs107251) (P = 0.00001, OR = 0.55 for СT), PIK3R1: (rs10515070 (P = 0.0023, OR = 1.47 for AT), rs831125 (P = 0.00001, OR = 2.28 for AG), rs3730089 (P = 0.0007, OR = 1.73 for GG)), PTEN: (rs701848 (P = 0.0015, OR = 1.35 under the log-additive model), and rs2735343 (P = 0.0001, OR = 1.64 for GC)). …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…In addition, conditional knockout mice for Nrf2 and p62 were used to detect these markers, together with the monitoring of in vivo tumor growth. …”
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NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder by Bin Gong, Chenxu Xiao, Yu Feng, Yu Feng, Jing Shen

“…Additionally, NEK4 was notably linked to BD type 1 (βbrain=0.123, P FDR=2.97E-05; βblood=1.018, P FDR=0.002), but showed no significant association with BD type 2.Moreover, TSMR analysis identified four proteins (BMP1, F9, ITIH3, and SIGIRR) affecting the risk of BD, and PSMB4 affecting the risk of MDD.ConclusionOur study identified NEK4 as a key gene linked to both bipolar disorder (BD) and major depressive disorder (MDD), suggesting its potential as a drug target and a biomarker for differentiating BD subtypes. …”
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Subclinical Plasmodium spp. Infections in a Community Setting in Bangui, Central African Republic by Nzoumbou-Boko R, Denissio Morissi Nalingbo MCI, Yambiyo BM, Detol R, Moussa ERF, Nalinga D, Namsenei-Dankpea LJVDLG, Manirakiza A, Ayong L, Boum II Y

“…Proportions of positives were 32.45% by PCR, 27.59% by mRDT, and 23.51% by Giemsa-based thick blood smear microscopy, representing the burden of subclinical malaria. In addition, a 9.56% prevalence of submicroscopic infections was observed. …”
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