Preparation of Nutmeg Gel and Evaluation of its Efficacy as Local Drug Delivery in Stage II Grade A Periodontitis Patients: A Prospective Interventional Study by Vazeeha Afrin Syed, AS Pavithra, Arvina Rajasekar, Rajeshkumar Shanmugam

“…Conclusion: The developed nutmeg gel was found to be effective when used in addition to SRP as a Local Drug (LD) among patients with stage II grade A periodontitis.…”
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Effect of Lamotrigine on Refractory Epilepsy: Clinical Outcomes and EEG Changes by Li Z, Wu P, Chen Q, Tong X, Yang Q

“…Based on the treatment interventions received, patients were divided into a control group (n=46, treated with valproate) and an observation group (n=47, treated with lamotrigine in addition to valproate). The clinical treatment effects, EEG (δ, θ, α, β) power levels, neurological function indicators [brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), pro-apoptotic protein Bcl-2, Bax], inflammatory response indicators [interleukin-1β (IL-1β), interleukin-6 (IL-6), prostaglandin E2 (PGE2)], and the incidence of adverse reactions were compared between the two groups.Results: The clinical treatment effect in the observation group was significantly better than that in the control group, with a higher total effective rate (93.62% vs 76.09%, P< 0.05). …”
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Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study by Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel

“…Conclusions Treatment with upadacitinib demonstrated consistent improvement and maintenance of treatment effect across efficacy endpoints through 2 years; no new safety signals were identified with additional exposure. Trial registration NCT04169373.…”
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Activated CD27+PD-1+ CD8 T Cells and CD4 T Regulatory Cells Dominate the Tumor Microenvironment in Refractory Celiac Disease Type II by Tessa Dieckman, Mette Schreurs, Ciska Lindelauf, Ahmed Mahfouz, Caroline R. Meijer, Louise Pigeaud, Vincent van Unen, Gerd Bouma, Frits Koning

“…Methods: We applied mass cytometry on CD45+ duodenal cells derived from intestinal biopsies (n = 23) and blood samples (n = 20) from RCDII patients and controls. Additionally, we analyzed intestinal biopsies from celiac disease (n = 11) and RCDI (n = 2) patients. …”
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Comparative analysis of inflammatory biomarkers for the diagnosis of neonatal sepsis: IL-6, IL-8, SAA, CRP, and PCT by Chen Ying, Yan Aixia, Zhang Li, Hu Xiaoming, Chen Liang, Cui Jun, Fan Zichuan, Li Ying

“…When the CRP cut-off value was 13.18 mg/L, the smallest AUC for the diagnosis of NS-TIs was for CRP (AUC = 0.762, 95% CI 0.667–0.857; P < 0.001). Additionally, according to the AUC value, the best combination was SAA and PCT for NS-PI diagnosis, and the best combination was PCT and IL-6 for NS-TI. …”
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Effect of intermittent infusion hemodiafiltration on cerebral and hepatic oxygenation by Susumu Ookawara, Kiyonori Ito, Kazuma Fukuda, Tomoko Iida, Kazumi Yahagi, Haruhisa Miyazawa, Keiji Hirai, Mamoru Yoshizawa, Yoshiyuki Morishita

“…The percentage (%) change in hepatic rSO2 after the seventh dialysate infusion was significantly greater than those after the first, third, and fifth infusions. Additionally, percentage changes in hepatic rSO2 were negatively correlated with %ΔBV (ρ = −0.394, p < 0.001) and positively correlated with the ratio of the dialysate infusion volume to circulating BV just before infusion (ρ = 0.387, p < 0.001). …”
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Genetic Polymorphisms in RNF138, ABCA1 and ESRRG-GPATCH2 Genes and their Role in Insulin Resistance Risk among Normal BMI Individuals in Indian Population: A Case-control Study by Sabitha Thummala, Sarah Fathima, Nithya Kruthi, Junaid Ahmed Khan Ghori, Katherine Saikia, Vivek Belde, Balamurali Andiyakkal Rajendran, Rahul Ranganathan

“…Statistical analyses, including Odds Ratios (ORs), 95% Confidence Intervals (CIs), and inheritance model analysis, were conducted to assess the association between genotypes and IR. …”
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The prolonged health sequelae “of the COVID-19 pandemic” in sub-Saharan Africa: a systematic review and meta-analysis by Melsew Setegn Alie, Getayeneh Antehunegn Tesema, Getayeneh Antehunegn Tesema, Gossa Fetene Abebe, Desalegn Girma

“…This situation has placed additional strain on global healthcare systems, underscoring the urgent need for ongoing clinical management of these patients. …”
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The Effect of Laboratory Parameters on the Hospital Stay and Mortality in Pediatric Patients Who Underwent Lobectomy and Pneumonectomy by Ahmet Ulusan, Hilal Zehra Kumbasar Danaci, Bekir Elma, Maruf Sanli, Ahmet Feridun Isik

“…Laboratory results were obtained from the patients’ most recent blood samples before surgery. In addition, derived ratios such as platelet-to-lymphocyte ratio (PLR), MPV-to-PLT ratio (MPR), MPV-to-monocyte ratio (MMR), MPV-to-lymphocyte ratio (MPVLR), monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR), and Pan-Immune-Inflammation Value (PIV) were calculated and their potential prognostic values were evaluated. …”
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Legal Disputes of Emigrant Periodical Publishers from the End of the 19th Century to 1904 by Remigijus Misiūnas

“…On one hand, the hyperbolization of problems and ills in the emigrant life attracted readers with engaging texts, but on the other, it was interpreted as propaganda for a dissolute lifestyle and rejection of religious norms, dismissing the satirical aspect. Additionally, the defense of freedom of speech became a cornerstone in the litigation between Olšauskas and priest Kriaučiūnas. …”
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Defining “Giant” Mediastinal Tumors: Proposal of a New Clinical–Radiological Classification and Case Report by Emanuel Palade, George Bucur Delaca, Ioana-Medeea Titu, Sergiu Adrian Ciulic, Gabriel Cismaru, Adrian Stef, Simona Manole

“…This classification integrates clinical presentation and cross-sectional imaging findings, offering a standardized framework for tumor reporting. In addition, it provides a precise definition of “giant” mediastinal tumors. …”
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Synthesizing Local Capacities, Multi-Source Remote Sensing and Meta-Learning to Optimize Forest Carbon Assessment in Data-Poor Regions by Kamaldeen Mohammed, Daniel Kpienbaareh, Jinfei Wang, David Goldblum, Isaac Luginaah, Esther Lupafya, Laifolo Dakishoni

“…Notably, a stacking ensemble of support vector machines and random forest achieved the highest accuracy (R² = 0.84, RMSE = 1.36), followed by an ensemble of all base learners (R² = 0.83, RMSE = 1.39). Additionally, our results demonstrate that factors such as the diversity of base learners and the sensitivity of meta-leaners to optimization can influence stacking performance.…”
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Integrated transcriptomic hypothalamic-pituitary-ovarian axis network analysis reveals the role of energy availability on egg production in layers by Jianling Peng, Yong Cui, Haiping Liang, Shenyijun Xu, Linjian Weng, Meng Ru, Ramlat Ali, Qing Wei, Jiming Ruan, Jianzhen Huang

“…The study found that energy deprivation significantly decreased reproductive performance such as egg laying rate, ovarian index, number of small yellow follicles (SYF), and normal hierarchical follicles (NHIE) (P < 0.05), which recovered after refeeding, indicating the importance of energy availability for sustained ovulation in layers. In addition, estradiol (E2), estradiol to progesterone (E2/P4) ratio, and luteinizing hormone (LH) displayed changes similar to follicle number, whereas follicle-stimulating hormone (FSH) exhibited a contrasting pattern. …”
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Application of Minimally Invasive Oral Swab Samples for qPCR-Based Sexing in Neognathae Birds by Maria-Carmen Turcu, Anamaria Ioana Paștiu, Lucia-Victoria Bel, Anca-Alexandra Doboși, Dana Liana Pusta

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Within- and between-day test–retest reliability of responses to rapid bilateral anterolateral magnetic phrenic nerve stimulation in healthy humans (ReStim) by Kyle G. P. J. M. Boyle, Andrea A. Beglinger, Heinrich Häusler, Anna Stahel, Esther I. Schwarz, Esther I. Schwarz, Christina M. Spengler, Christina M. Spengler

“…Mean transdiaphragmatic pressure (Pdi,mean), tidal volume (VT), discomfort, pain, and paresthesia were recorded for each rBAMPS. …”
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Villa d’époque romaine et habitat médiéval à Mont-Saint-Jean (Sarthe) : bilan des recherches 2008-2020 by Florian Sarreste, Paul-André Besombes, Phaedra Bouvet, Chloé Genies, Étienne Jaffrot, Florian Jedrusiak, Thomas Jubeau, Anthony Ledauphin, Annaïg Le Martret, Christophe Loiseau, Hugo Meunier, Aurore Noël, Sandrine Paradis-Grenouillet, Boris Robin

“…In total, 58 test trenches were excavated, spread over 3.7 ha, and corresponding to a cumulative area of just over 5,000 m². In addition, 7.4 ha were surveyed using a variety of methods (electrical resistance, magnetic and ground-penetrating radar). …”
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Call for Papers: Constitutions and Intergenerational Justice by IF and FRFG

“…The 2016 (2) edition will have the additional help of Professor Bruce Auerbach of Albright College, Reading PA, who will be serving as a guest editor. …”
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Designing a model for the development of questioning skills based on the school context in primary school students by motahare Khosravi Rad, Ahmad Akbari, Mohammad karimi, Moslem Cherabin

“…In addition, instructors will find out how well students actually understand the material they show their students in class. …”
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Designing the entrepreneurial government model in attracting and selecting public sector human resources by Atieh sarayani, Vahid Pourshahabi, Nourmohammad yaghobi, Amin reza kamaliyan

“…Hasanzade et al, (2020) showed that all recruitment processes in government organizations should have scientific and legal processes, so that in addition to reducing administrative corruption, employment justice is also established in the government departments of the province. …”
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Possible scenarios of sustainable supply chain in dairy industry with future research approach by Meysam Abedini, Narges Mohammadalipour, Ashraf Shahmansouri, Mahnaz Rabiei

“…Therefore, the dairy industry needs a change in the entire supply chain in order to enjoy environmental and social sustainability in addition to cost effectiveness. Experts believe that this industry needs innovation in order to achieve sustainability. …”
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