Differential responses of soil C, N, and P ecological stoichiometric characteristics to different configurations of edge-locked forests in the Kubuqi Desert by Xue Chen, Hejun Zuo, Hejun Zuo, Min Yan, Min Yan, Haibing Wang, Haibing Wang, Cheng Xi, Yinchao Chai

“…This study’s findings offer a scientific reference and foundation for restoring vegetation and enhancing the ecological environment in desert regions. In addition, they provide a theoretical foundation for establishing and managing edge-locked forests.…”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…We also carried out additional validations including colocalization, linkage disequilibrium check and host–pathogen interactome predictions. …”
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3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study by Yurong Jiang, Jiawei Zhang, Zhaochen Liu, Jinxiong Zhang, Xiangrong Yu, Danyan Lin, Dandan Dong, Mingyue Cai, Chongyang Duan, Shuyi Liu, Wenhui Wang, Yuan Chen, Qiyang Li, Weiguo Xu, Meiyan Huang, Sirui Fu

“…Abstract Background Besides tumorous information, synergistic liver parenchyma assessments may provide additional insights into the prognosis of hepatocellular carcinoma (HCC). …”
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Interaction between 24 h Urinary Free Cortisol and Obesity in Hypertension-Mediated Organ Damage in Patients with Untreated Hypertension by Gao-Zhen Cao, Jia-Yi Huang, Qing-Shan Lin, Cong Chen, Min Wu, Run Wang, Ming-Yen Ng, Kai-Hang Yiu, Jian-Cheng Xiu

“…In the obese group, elevated 24 h UFC was significantly associated with LVH (odds ratio (OR) = 2.53; 95% CI: 1.02–6.31, p = 0.044) and albuminuria (OR = 3.13; 95% CI: 1.31–7.43, p = 0.01), after multivariate adjusting. …”
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Spirituality-Based Intervention in Hypertension: EFfects on Blood PrEssure and EndotheliaL Function—FEEL Trial Results by Maria Emília Figueiredo Teixeira, Weimar Kunz Sebba Barroso, Andréa Araújo Brandão, Ana Luiza Lima Sousa, Roberto Esporcatte, Mário Henrique Elesbão de Borba, Ana Clara Neri Ávila Baleeiro, Beatriz Caldas Gonçalves, Enzo Inumaru, Enzo Mata de Sousa, Giovana Barros Leal, Henrique Soares de Araújo Pereira Farias, Juliana Alves de Souza, Lure Emilly Barreto da Silva, Matheus Canguçu de Paiva Queiroz, Frederico Rafael Moreira, Priscila Valverde de Oliveira Vitorino, John Eikelboom, Álvaro Avezum

“…Main outcomes were between group difference in change from baseline to 12 weeks in office and central BP, HBPM and FMD, using t-tests, analyses of covariance (ANCOVA) adjusting for baseline differences, and, in addition, missing data imputation as a sensitivity analysis. …”
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Muhâsebede Hata ve Hilelerin Önlenmesinde Mali Hizmet Çalışanlarının Sorumluluğunun Tespitine Yönelik Bir Araştırma by Onur Açıkgöz, Enis Baha Biçer

“…Muhasebenin sağlamış olduğu finansal bilgiler göz ardı edilemeyecek kadar büyük bir öneme sahiptir. …”
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TAME 2.0: expanding and improving online data science training for environmental health research by Alexis Payton, Alexis Payton, Alexis Payton, Elise Hickman, Elise Hickman, Elise Hickman, Jessie Chappel, Jessie Chappel, Jessie Chappel, Kyle Roell, Kyle Roell, Lauren E. Koval, Lauren E. Koval, Lauren A. Eaves, Lauren A. Eaves, Chloe K. Chou, Chloe K. Chou, Chloe K. Chou, Allison Spring, Allison Spring, Sarah L. Miller, Sarah L. Miller, Sarah L. Miller, Oyemwenosa N. Avenbuan, Oyemwenosa N. Avenbuan, Oyemwenosa N. Avenbuan, Rebecca Boyles, Rebecca Boyles, Paul Kruse, Cynthia V. Rider, Grace Patlewicz, Caroline Ring, Cavin Ward-Caviness, David M. Reif, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Rebecca C. Fry, Rebecca C. Fry, Rebecca C. Fry, Julia E. Rager, Julia E. Rager, Julia E. Rager, Julia E. Rager

“…Also new to TAME 2.0 are “Test Your Knowledge” activities at the end of each training module, in which participants are asked additional module-specific questions about the example datasets and apply skills introduced in the module to answer them. …”
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Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis by Zahra Moradpour, Amin Barik, Goljamal Jorjani, Mohammad Reza Taherian, Sepideh Tousizadeh, Sepideh Tousizadeh, Aram Halimi, Aram Halimi, Yaser Soleimani, Mobina Karimian, Tina Khavari, Fateme Azizi Kalankari, Fatemeh Asadipour, Mojtaba Azari, Niloofar Yousefzadeh Shakouri, Saeideh Karamian, Nasser Bahari, Alireza Mosavi Jarrahi

“…Regular health surveillance and education programs for workers in industries utilizing MWFs are also essential to mitigate risk. Additionally, regulatory agencies should consider revising exposure limits and safety guidelines to account for emerging evidence on the carcinogenic potential of newer MWF formulations.…”
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Genomic Characterization of Carbapenemase-Producing Enterobacteriaceae from Clinical and Epidemiological Human Samples by Alexander Tristancho-Baró, Laura Eva Franco-Fobe, Monica Pilar Ariza, Ana Milagro, Ana Isabel López-Calleja, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, Rosa Martínez, Carmen Torres, Antonio Rezusta

“…<b>Methods</b>: CPE isolates were the first isolate per patient, year, species, and carbapenemase from January 2021 to December 2023. Additional metadata were collected from the laboratory’s information system. …”
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Mesenchymal stem cell-mediated adipogenic transformation: a key driver of oral squamous cell carcinoma progression by Yiting Shao, Yu Du, Zheng Chen, Lei Xiang, Shaoqin Tu, Yi Feng, Yuluan Hou, Xiaoxing Kou, Hong Ai

“…Subcutaneous xenograft experiments were conducted in BALB/c-nu mice to further investigate the effects in vivo. Additionally, immunohistochemical staining was performed on clinical samples to determine the expression levels of fatty acid synthase (FASN) and the proliferation marker Ki67. …”
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Exposure to triphenyl phosphate during pregnancy: The role of gut-bile acids-liver axis on lipid metabolism in male offspring by Juntong Lin, Fuhui Yan, Longhui Liu, Ganzhong Liao, Yilei Xu, Qian Liu, Miaoliang Wu, Honghui Guo, Bai Zhi, Lianxian Guo, Xiaoshan Liu

“…No consistent correlations were observed in two treatment group. Additionally, Mantel tests did not reveal a consistent correlation between the microbiome network community and lipid metabolism or the gut-bile acids-liver axis. …”
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Eco-friendly alginate/PCL-TiO2 hybrid biocomposites: Preparation, properties, and methylene blue photodegradation by Bunga Fisikanta Bukit, Agus Wedi Pratama, Erna Frida, Bakti Berlyanto Sedayu, Dina Fransiska, Deni Purnomo, Emma Rochima, Istiqomah Rahmawati, Sona Suhartana, Firda Aulya Syamani

“…Furthermore, Ti-O-Ti bond appears at wave number 668.48 cm−1 and Ti-O-C appears at 1054.69 cm−1. The addition of TiO2 slightly reduced mechanical properties. …”
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Bottom Trawling and Multi‐Marker eDNA Metabarcoding Surveys Reveal Highly Diverse Vertebrate and Crustacean Communities: A Case Study in an Urbanized Subtropical Estuary by Jack Chi‐Ho Ip, Hai‐Xin Loke, Sam King Fung Yiu, Meihong Zhao, Yixuan Li, Yitao Lin, Chun‐Ming How, Jiezhang Mo, Meng Yan, Jinping Cheng, Vincent Chi‐Sing Lai, Leo Lai Chan, Kenneth Mei Yee Leung, Jian‐Wen Qiu

“…However, the eDNA approach could be enhanced through the development of suitable decapod‐specific primers and the expansion of the local reference database. In addition, multivariate analyses of the eDNA data revealed spatial patterns of fish and crustacean assemblages that might be associated with sediment loading, oxygen, and nutrient levels. …”
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Earliness and morphotypes of common wheat cultivars of Western and Eastern Siberia by S. E. Smolenskaya, V. M. Efimov, Y. V. Kruchinina, B. F. Nemtsev, G. Y. Chepurnov, E. S. Ovchinnikova, I. A. Belan, E. V. Zuev, Chenxi Zhou, V. V. Piskarev, N. P. Goncharov

“…However, since none of the tested cultivars had the dominant Vrn-D1 gene typical of the regions of China and Central Asia bordering Siberia, it can be considered as an additional argument in favor of the European origin of Siberian common wheat cultivars. …”
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<i>Limosilactobacillus reuteri</i> ZY15 Alleviates Intestinal Inflammation and Barrier Dysfunction via AKT/mTOR/HIF-1α/RORγt/IL-17 Signaling and the Gut Microbiota in ETEC K88-Chal... by Xin Xu, Hongwei Zhang, Kun Meng, Hongying Cai, Weiwei Liu, Liye Song, Zihan Zhang, Qijun Zhu, Xiling Han, Yunsheng Han, Peilong Yang

“…Notably, <i>L. reuteri</i> ZY15 suppressed intestinal inflammation by inhibiting AKT/mTOR/HIF-1α/RORγt/IL-17 pathway activation. Additionally, it significantly altered the structure of gut microorganisms by enriching <i>Akkermansia</i> and <i>Clostridia_UCG.014</i>, and thereby re-establishing colonization resistance and alleviating ETEC K88-induced intestinal barrier damage and inflammation in mice. …”
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Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer by Yong Zhang, Xiang‐Xiang Chen, Ruo Chen, Ling Li, Qing Ju, Dan Qiu, Yuan Wang, Peng‐Yu Jing, Ning Chang, Min Wang, Jian Zhang, Zhi‐Nan Chen, Ke Wang

“…Methods During this study, 26 bronchoalveolar lavage fluids (BALF) from advanced NSCLC participants who received immune checkpoint inhibitor monotherapy were performed 16S rRNA sequencing and untargeted metabolome sequencing to identify differentially abundant microbes and metabolic characteristics. Additionally, inflammatory cytokines and chemokines were also launched in paired BALF and serum samples by immunoassays to uncover their underlying correlations. …”
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The Pathogenic Role of Expanded CD8⁺CD28^null Angiogenic T Cells in ANCA-Associated Vasculitis by Haomiao Shen, Jinlin Miao, Haoyang Sun, Kui Zhang, Renli Liu, Zichao Li, Leyang Zhang, Peiyan Zhang, Jiawei Wang, Bei Zhang, Longyu Chen, Zhaohui Zheng, Ping Zhu

“…<b>Results</b>: CD8⁺CD28^null Tang levels were significantly higher in the peripheral blood of AAV patients compared to HCs, and their levels were further increased in AAV patients with MPO⁺, p-ANCA⁺, or interstitial lung disease compared to their respective control groups. Additionally, there was a positive correlation between both the percentage and absolute count of CD8⁺CD28^null Tang and the Birmingham Vasculitis Activity Score (BVAS). …”
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Establishment and application of a one-step multiplex real-time PCR assay for detection of A, B, and C subtypes of avian metapneumovirus by Mingjun Su, Jiongze Cheng, Xiangwen Xu, Yijia Liu, Yulin Zhao, Yutao Wang, Xiaoxu Du, Jiale Ying, Junfang Yan, Huihua Zheng, Changyong Cheng, Jing Sun

“…Moreover, the assay demonstrates reproducibility, as evidenced by intra- and inter-assay variability, with a coefficient of variation between 0.21% and 1.91%. Additionally, the receiver operating characteristic (ROC) curve analysis demonstrated that the multiplex real-time PCR assay exhibited high specificity and sensitivity (100.0% and 100.0% for aMPV-A, 90.9% and 100.0% for aMPV-B, 100% and 96.8% for aMPV-C) when compared with the classical aMPV real-time RT-PCR. …”
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Multimodal data-based longitudinal prognostic model for predicting atrial fibrillation recurrence after catheter ablation in patients with patent foramen ovale and paroxysmal atria... by Shoupeng Duan, Xujun Li, Jun Wang, Yuhong Wang, Tianyou Xu, Fuding Guo, Yijun Wang, Lingpeng Song, Zeyan Li, Xiaomeng Yang, Xiaoyu Shi, Hengyang Liu, Liping Zhou, Yueyi Wang, Hong Jiang, Lilei Yu

“…The area under the curve values of the development and validation cohorts at 1, 2, and 3 years post-catheter ablation were 0.911, 0.812, and 0.786 and 0.842, 0.761, and 0.785, respectively. Additionally, the nomogram demonstrated a significant correlation between the predicted and actual outcomes in the development and validation cohorts, indicating its excellent calibration. …”
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T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…We employed multiplex PCR to create amplicons spanning the three beta chain complementarity-determining regions (CDR) regions to enable detection of polymorphism within the germline-encoded framework and CDR1 and CDR2 regions in addition to CDR3 profiling. Resultant amplicons were sequenced via the Ion Torrent and TRBV allele profiles constructed for each individual was correlated with irAE annotations to identify haplotypes associated with severe irAEs (≥ grade 3).Results Our study included 81 patients who had irAEs when treated with immunotherapy for cancer. …”
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