Phosphate-modified CpG oligonucleotides induce in vitro maturation of human myeloid dendritic cells by A. A. Ostanin, O. Y. Leplina, E. A. Burakova, T. V. Tyrinova, A. A. Fokina, A. S. Proskurina, S. S. Bogachev, D. A. Stetsenko, E. R. Chernykh

“…Interestingly, the characteristic ability of LPS to enhance the expression of the co-stimulatory molecule OX40L on DCs was revealed only for the μ-analogue SD-101M. In addition, CpG-ODNs (SD-101 and SD-101M) had a stimulatory effect on IFN-γ production comparable to the action of LPS. …”
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Anthelmintic Resistance in Sheep Across Ireland and the UK: a literature review of the in vivo versus in vitro methods by Megan Tumulty

“…It was concluded that many flock owners have become complacent with incorrect dosing and a lack of calibrating of dosing equipment, as seen in 69% and 63% respectively. In addition, the prevalence of N. battus is becoming more evident on farms across Ireland and the UK, with 62% of farms having an outbreak of N. battus infection on the farm within the last five years. …”
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Exploring the anticancer potential of extracts and compounds from the heartwood of Cotinus coggygria Scop. wild growing in Serbia by Ivana Pašić, Miroslav Novaković, Vele Tešević, Slobodan Milosavljević, Nina Petrović, Tatjana Stanojković, Ivana Z. Matić

“…Conclusions This research might suggest promising anticancer effects and underscores the need for additional research on C. coggygria extracts and compounds to assess their potential in cancer prevention and therapy.…”
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Factors Influencing Telemedicine Adoption Among Health Care Professionals: Qualitative Interview Study by Fiona Schürmann, Daniel Westmattelmann, Gerhard Schewe

“…Transparency emerged as a critical antecedent of trust across different referents, comprising disclosure, clarity, and accuracy. In addition, the study highlighted the importance of context-specific variables such as symptom characteristics (10/14, 71%) and prior professional experience with telemedicine (11/14, 79%). …”
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Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study by Rafael Scaf de Molon, Rogier M. Thurlings, Birgitte Walgreen, Monique M. Helsen, Peter M. van der Kraan, Joni Augusto Cirelli, Marije I. Koenders

“…Prophylactic and therapeutic RvE1 regimens did not ameliorate CIA incidence and severity. Anti-TNF treatment significantly abrogated signs of joint inflammation, bone erosion, and proteoglycan depletion, but additional RvE1 treatment did not further reduce the anti-TNF-mediated suppression of the disease. …”
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A Novel, Patient-Specific Mathematical Pathology Approach for Assessment of Surgical Volume: Application to Ductal Carcinoma in situ of The Breast by Mary E. Edgerton, Yao-Li Chuang, Paul Macklin, Wei Yang, Elaine L. Bearer, Vittorio Cristini

“…We tested this idea in a retrospective study of 17 patients by staining breast tumor specimens containing ductal carcinoma in situ for mitosis with Ki-67 and for apoptosis with cleaved caspase-3 and counting cells positive for each marker. …”
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Korean patients with hereditary cancer: a prospective multicentre cohort study protocol exploring psychosocial and health outcomes by Boyoung Park, Sun-young Kong, Dongju Won, Jong Eun Park, Jun-Kyu Kim, Mi-Ae Jang, Jung-Sook Ha, Kyoung-Bo Kim

“…Data were collected using 11 validated surveys. In addition, information on the chronic diseases, cancer diagnoses, medical history and treatment history of participants will be extracted from their electronic medical records to analyse their health status and cancer treatment experiences. …”
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A Local Adversarial Attack with a Maximum Aggregated Region Sparseness Strategy for 3D Objects by Ling Zhao, Xun Lv, Lili Zhu, Binyan Luo, Hang Cao, Jiahao Cui, Haifeng Li, Jian Peng

“…To minimize the attack camouflage regions, a sparseness regularization is designed to make the mask weights tend toward a U-shaped distribution and limit extreme values. Additionally, neural rendering is used to obtain gradient-propagating multi-angle augmented data and suppress the model’s detection to locate universal critical decision regions from multiple angles. …”
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How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review by Luke Gray, Peter Ladlow, Russell J Coppack, Robyn P Cassidy, Lynn Kelly, Sarah Lewis, Nick Caplan, Robert Barker-Davies, Alexander N Bennett, Luke Hughes

“…The management of persistent pain and utility of adjunct therapies has become a clinical and research priority within numerous healthcare settings, including defence medical services. Main Body Blood flow restriction (BFR) exercise has demonstrated beneficial morphological and physiological adaptions in load-compromised populations, as well as being able to elicit acute hypoalgesia. …”
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(Study on Stomach Contents of Opudi Fish (Telmatherina celebensis) in Towuti Lake, South Sulawesi) by . Sulistiono, A. Furkon, R. Affandi

“…The fish (N=273) was consisted of 141 males and 132 females, varied in total body length (55.8-94.7 mm).  Stomach content was analyzed using Index of preponderance.  …”
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PROSPECTS FOR THE DEVELOPMENT OF BIODIESEL PRODUCTION IN UKRAINE WITH CONSIDERATION OF SOCIO-ECONOMIC AND ENVIRONMENTAL EFFICIENCY by Ihor Kupchuk, Tatiana Yemchyk, Yaroslav Gontaruk

“…The planned biodiesel production of 450 kg per tonne requires an additional investment of 2,050 UAH. By-product revenues are estimated at 5,900 UAH, resulting in biodiesel production costs of 33 UAH per kg or 28.44 UAH per litre. …”
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Insomnia, cardiorespiratory function and quality of life in individuals with post-COVID-19 fatigue by Nathalea Spode de Arruda, Alessandra Hofstadler Deiques Fleig, Charles Rech, Carine Cristina Callegaro

“…Results: Individuals with post-COVID-19 fatigue demonstrated a higher prevalence of insomnia (80% vs. 49%) and excessive daytime sleepiness (45% vs. 7%), as well as lower MIP, shorter distance covered in the 6MWT, and lower FEV1/FVC (forced expired volume in the first second divided by forced vital capacity), and FEV1/FVC% of predicted. Additionally, they exhibited poorer quality of life in the physical and environmental domains. …”
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miRNA-541-5p regulates myocardial ischemia–reperfusion injury by targeting ferroptosis by ZhiYu Zhao, BoXia Li, DianWei Cheng, YuFang Leng

“…Subsequently, by constructing H9C2 cell lines with miRNA-541-5p overexpression and miRNA-541-5p expression inhibition, miRNA-541-5p expression was inversely correlated with the survival of H9C2 cells after hypoxia-reoxygenation injury. miRNA-541-5p up-regulation led to a decrease in SOD and GSH, an increase in ferritin and MDA, and an accumulation of ROS. wb and qRT-PCT demonstrated that high miRNA-541-5p expression up-regulated the expression of protein/mRNA expression of ACSL-4, HO-1, ferritin, and TFR-1, but down-regulated protein/mRNA expression of GPX-4. In addition, ADAM 7, FNIP 2, HOXD 10, HCCS and STK 3 were preliminarily identified as potential candidate target genes for miRNA-541-5p by bioinformatics analysis. …”
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Artificial-Intelligence-Based Investigation on Land Use and Land Cover (LULC) Changes in Response to Population Growth in South Punjab, Pakistan by Tanweer Abbas, Muhammad Shoaib, Raffaele Albano, Muhammad Azhar Inam Baig, Irfan Ali, Hafiz Umar Farid, Muhammad Usman Ali

“…LULC was classified into built-up, vegetation, water, and barren classes in Multan and Bahawalpur, with an additional “rock” class included for Dera Ghazi Khan due to its unique topography. …”
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Integrating Hybrid Team-Based and Case-Based Learning in Dental Education Transformation by Sidra Abid, Humna Rafiq

“…They enjoy intense teamwork and group discussions because these activities are productive. In addition, they positively affect clinical knowledge and experience.4 The combination of TBL and CBL methodologies in the dental curriculum at the Medical University of Pakistan demonstrates a major move forward in dental education. …”
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New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach by Yin Guan, Xiaoqian Zhao, Yun Lu, Yue Zhang, Yan Lu, Yue Wang

“…Subsequent experiments confirmed that NBTL inhibited VEGF and its receptors, VEGFR1 and VEGFR2, along with HIF-1α (hypoxia-inducible factor 1-alpha), thereby reducing angiogenesis. Additionally, NBTL upregulated miR-20a-5p and miR-223-3p, contributing to its anti-angiogenic effects.ConclusionNBTL exhibits significant therapeutic potential in RA by modulating gut microbiota and inhibiting the VEGF signaling pathway. …”
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Investigating the Use of Generative Adversarial Networks-Based Deep Learning for Reducing Motion Artifacts in Cardiac Magnetic Resonance by Ma ZP, Zhu YM, Zhang XD, Zhao YX, Zheng W, Yuan SR, Li GY, Zhang TL

“…These metrics increased from initial values of 23.85± 2.85, 0.71± 0.08, and 4.56± 0.67, respectively, to 27.91± 1.74, 0.83± 0.05, and 7.74± 0.39 post-optimization. Additionally, the subjective assessment scores significantly improved from 2.44± 1.08 to 4.44± 0.66 (P< 0.001). …”
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Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation by Chaowang Zhou, Ruqian Zhong, Lei Zhang, Renyi Yang, Yuxin Luo, Huijun Lei, Liang Li, Jianzhong Cao, Zhiying Yuan, Xiaoning Tan, Mengzhou Xie, Haoyu Qu, Zuomei He

“…In vivo experimental results showed that RosA could inhibit the growth of transplanted tumors in nude mice bearing tumors of lung cancer cells, reduce the positive expression of Ki67 in lung tumor tissue, and hinder the proliferation of lung tumor cells. …”
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Effects of Dietary Supplementation with <i>Lactobacillus reuteri</i> Postbiotics on Growth Performance, Intestinal Flora Structure and Plasma Metabolome of Weaned Piglets by Dongfeng Sun, Wenfei Tong, Shaochen Han, Mengjun Wu, Peng Li, Youguo Li, Yunxiang Liang

“…The fecal flora sequencing results show that the relative abundance of Firmicutes and monoglobus was upregulated, and the relative abundance of Bacteroides was downregulated with <i>Lactobacillus reuteri</i> postbiotics-treated piglets (<i>p</i> < 0.05). In addition, the levels of propionic acid and butyric acid in the feces were positively correlated with the relative abundance of Firmicutes and negatively correlated with the relative abundance of Bacteroides (<i>p</i> < 0.05). …”
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Characteristics and combustion kinetics of fuel pellets composed of waste of polyethylene terephthalate and biomass by K. Manatura, U. Samaksaman

“…Functional groups of the pellets were contributed by terephthalate and lignocellulose. The addition of a small amount of biomass in pellets could improve their thermal decomposition behavior. …”
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