Effect of Fish Meal Substitution with Black Soldier Fly (Hermetia illucens) on Growth Performance, Feed Stability, Blood Biochemistry, and Liver and Gut Morphology of Siamese Fight... by Zulhisyam Abdul Kari, Guillermo Téllez-Isaías, Noor Khalidah Abdul Hamid, Nor Dini Rusli, Khairiyah Mat, Suniza Anis Mohamad Sukri, Muhammad Anamul Kabir, Ahmad Razali Ishak, Nazri Che Dom, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Martina Irwan Khoo, Faizuan Abdullah, Md Shahjahan, Md Fazle Rohani, Simon J. Davies, Lee Seong Wei

“…Similar blood haematology and biochemical properties, including corpuscular volume, lymphocytes, white blood cells, red blood cells, haematocrit, albumin, and alkaline phosphatase, were the highest (p<0.05) in the 13% BSFL diet group compared to the other treatment groups. In addition, BSFL had a significant impact (p<0.05) on villus length, width, and crypt depth for the anterior and posterior guts of B. splendens. …”
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A Case Study Identified a New Mutation in the TTN Gene for Inherited Hypertrophic Cardiomyopathy by Dong J, Liu M, Chen Q, Zha L

“…Candidate variants obtained by WES were verified using Sanger sequencing, pathogenic mutation screening was conducted among family members, and the mutations were systematically analyzed using bioinformatics.Results: WES revealed a novel heterozygous missense mutation, c.20233 C>T (p.R6745C), located in exon 80 of the HCM-related gene TTN, which may be a pathogenic mutation in the family. In addition, this mutation was predicted to damage protein function. …”
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Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype by Niloufar Rasaei, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Mahsa Samadi, Mohammad Keshavarz Mohammadian, Elnaz Daneshzad, Khadijeh Mirzaei

“…Results We found significant interactions between GRS and N6/N3 in the adjusted model controlling for confounding factors (age, body mass index, energy, and physical activity) (β = 2.26, 95% CI: 0.008 to 4.52, P = 0.049). …”
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Association among high blood pressure health literacy, social support and health-related quality of life among a community population with hypertension: a community-based cross-sec... by Ting Chen, Wei Gan, Li Song, Yujie Wang, Huan Qi, Qinghua Zhang, Jinyu Yin

“…In multiple linear regression models, HRQoL was significantly associated with ‘Print HL’ and ‘Medication Label’ of HBP-HL (p&lt;0.05) and all three dimensions of SS (p&lt;0.05). In addition, The bootstrap method was used to examine the indirect effect among variables. …”
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Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain by Christian Kirschneck, Erika Calvano Küchler, Michael Wolf, Gerrit Spanier, Peter Proff, Agnes Schröder

“…Clinically dosed etoricoxib, that is, a highly selective COX-2 inhibition, did not have substantial effects on hPDL fibroblast-mediated periodontal inflammation, extracellular matrix remodeling, RANK-L/OPG expression, and osteoclastogenesis during simulated orthodontic compressive strain.…”
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Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients by Raffaele Pezzani, Loris Bertazza, Elisabetta Cavedon, Simona Censi, Jacopo Manso, Sara Watutantrige-Fernando, Gianmaria Pennelli, Francesca Galuppini, Susi Barollo, Caterina Mian

“…We found a significant correlation between the expressions of AURKA and PTTG1 (p<0.0002, r=0.5298) and between the expressions of PTTG1 and Ki-67 (p=0.01). Ki-67 levels were statistically different among the groups with or without metastatic lymph nodes (p=0.01) or distant metastases (p=0.003). …”
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Influence of bottled salad dressings on the development of enamel erosion in the presence or absence of salivary pellicle – An in vitro study by Aishwarya Lakshmi Billa, Jagadeeswara Rao Sukhabogi, Dolar Doshi, Prashant Sharma, T.V.S. Subrahmanyam, Sasikala Jummala

“…Background: Acidic beverages are believed to elevate the risk of enamel surface erosion. In addition to the intake of soft drinks, the increased consumption of salad dressings has been linked to a higher prevalence of dental erosion. …”
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Perceived barriers to physical activity and their predictors among adults in the Central Region in Saudi Arabia: Gender differences and cultural aspects. by Osama Abdelhay, Mohammad Altamimi, Qusai Abdelhay, Marwan Manajrah, Ayla M Tourkmani, Mutaz Altamimi, Taghreed Altamimi

“…Multivariate analysis revealed that females were 14% more likely than males to report external barriers to physical activity (OR = 1.14; 95% CI: 1.04-1.25; p = 0.018), suggesting gender plays a role in perceived external obstacles. Additionally, older age, higher body mass index, higher education level, marriage, certain employment statuses, and chronic diseases were significantly associated with increased reported internal and external barriers. …”
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Development and effectiveness evaluation of an interactive e-learning environment to enhance digital health literacy in cancer patients: study protocol for a randomized controlled... by Lukas Lange-Drenth, Hellena Willemer, Mirjam Banse, Anke Ernst, Anne Daubmann, Anja Holz, Christiane Bleich, Susanne Weg-Remers, Holger Schulz

“…However, the quality of online information varies widely and is often inaccurate or does not provide all the details patients need to make informed decisions. Additionally, patients’ often limited ability to find and evaluate cancer-related online information can lead to misinformation.ObjectiveAn interactive e-learning environment to promote digital health literacy will be developed and evaluated for effectiveness.Primary hypothesisCancer patients who use the e-learning environment (IG1.1–IG1.3) or the content of the environment as a non-interactive PDF file (IG2) will show greater improvement in their digital health literacy from baseline to 8 weeks after baseline compared to patients who receive no such intervention, but are referred to a standard information brochure.MethodsThe hypothesis will be tested in a stratified randomized controlled superiority trial with five parallel groups and the primary endpoint of digital health literacy. …”
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Performance of perisel as shelter and periphyton substrate in the floating cage of Pacific white shrimp culture by Rifka Liling Palinggi, Tatag Budiardi, Daniel Djokosetiyanto

“…It was concluded that the addition of perishel inside the floating cage may contribute as natural feed source for the shrimp and thus increase the production performance of shrimp. …”
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Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy by Andy Sitoh, David Weintrob, Jacqueline F. I. Anderson, Angela R. Jackman, Marie F. O'Shea, Graeme D. Jackson, Piero Perucca, Chris Tailby

“…Significance Although the RAVLT delayed recall was the strongest predictor of left‐sided HS, PAL Hard Pairs also demonstrated excellent discriminatory capacity, offering an additional cognitive marker of left hippocampal integrity to complement word list learning in clinical assessments. …”
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Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China by Liqing Wei, Jun Chen, Zhen Deng, Zefang Zhang, Zhengbin Zhang, Qionghong Duan

“…Whole genome sequencing (WGS) was used to identify resistance-conferring mutations, examine their associations with specific Mycobacterium tuberculosis lineages or sublineages, and assess clustering profiles.ResultsAmong the 149 analyzed strains, the most prevalent mutations associated with resistance to 11 anti-tuberculosis drugs were identified as follows: rpoB Ser450Leu (59.73%, rifampicin), katG Ser315Thr (62.42%, isoniazid), embB Met306Val (42.86%, ethambutol), rpsL Lys43Arg (68.13%, streptomycin), pncA Trp68Arg (10.53%, pyrazinamide), gyrA Asp94Gly (22.50%, fluoroquinolones), and rrs 1401A &gt; G (50.00–100.00%, second-line injectable aminoglycosides). Additional mutations were detected in fabG1 c-15C &gt; T (42.86%, ethionamide) and thyX c-16C &gt; T (21.43%, p-aminosalicylic acid). …”
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Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis by Kang Yi, Shao-E He, Tao Guo, Zi-Qiang Wang, Xin Zhang, Jian-Guo Xu, Hao-Yue Zhang, Wei-Guo Liu, Tao You

“…Abstract Background We did this study to better clarify the correlations of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1)-G1958A (rs2236225) gene polymorphism with the risk of congenital heart diseases (CHD) and its subgroups. …”
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Defining geosciences research data through metadata reuse: by Alexandre Ribas Semeler, Luana Farias Sales, Adilson Luiz Pinto, Roberta Pereira da Silva de Paula, Valquer Cleyton Paes Gandra, Heloisa Costa

“…The data come from a range of disciplines, including geochemistry, atmospheric science, paleontology, oceanography, geophysics, and hydrology, using technologies such as satellites, electronics microscopes, climate sensors, ships, computer modeling, and others. In addition, the data are augmented by other sources related to the study of the Earth and its processes. …”
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Are Saudi Radiological Sciences Students Prepared for Emergencies? Exploring Knowledge, and Attitudes Towards Basic Life Support and Cardiopulmonary Resuscitation by Alshamrani KM, Alkhayyat AA, Arif RN, Alahmadi AAS, Aldahery ST, Alsharif WM, Qurashi AA

“…Notably, 80.8% of students without BLS training lacked knowledge of cardiac massage, compared to only 30.4% of those with training. Additionally, 30.6% of students were familiar with defibrillators, and 44.1% knew AED locations (P = 0.0007). …”
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Predictive value of peripheral blood SNORD55 for prognosis of atrial fibrillation patients by WANG Yu, WANG Yu, WU Na, YANG Lanqing

“…In predicting the outcomes of all-cause mortality and stroke， the addition of relative expression SNORD55 level with the CHA2DS2-VASc score obtained higher AUC value ［0.80 （95%CI： 0.67~0.93） vs 0.67 （95%CI： 0.53~0.81）， P<0.05］. …”
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Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia by Huijuan Wang MD, Dong Chen MD, Ming He MD

“…The Group R required significantly fewer red blood cell transfusions compared to the Group C and did not require Plt suspension ( P  < 0.05). No significant differences were found between the groups in terms of mechanical ventilation time, intensive care unit (ICU) length of stay, and total hospital stay ( P  > 0.05). …”
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Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds by K. Grimm, A. Fiedler, C. Kröger

“…Results B: Two-step regression analysis for the outcome category at evaluation day (with exclusion of the first baseline evaluation) showed that during the trial, compared with the treatment group, odds of having a lesion rather than none was 4 times higher in the control group and the odds of having an active lesion compared with an inactive one were almost 6 times higher in the control group. …”
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Defining ecological thresholds to detect potential ecological risks of offshore wind power using macrobenthic biodiversity and indicator species in Cangnan, China by Wanhong Han, Chen Song, Yurong Zhang, Weiwei Zhou, Yushu Yang, Danyi Ke, Aoxiang Huang, Xiaobo Wang, Qingxi Han

“…Community responses were analyzed via the Shannon–Wiener diversity index, taxonomic β diversity, and conditional probability analysis (CPA) to evaluate the probability of biodiversity damage on the basis of chlorophyll-a (Chl-a) and suspended solids concentrations. Additionally, the pruned exact linear time (PELT) algorithm was applied to detect key CPA change points, and threshold indicator taxa analysis (TITAN) was used to confirm reliable ecological thresholds. …”
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Application of Biochar-Immobilized <i>Bacillus megaterium</i> for Enhancing Phosphorus Uptake and Growth in Rice by Keru Yu, Zhenyu Wang, Wenyan Yang, Shuai Li, Dongtao Wu, Hongtao Zheng, Zhengqian Ye, Shaona Yang, Dan Liu

“…Furthermore, the bioavailable P reservoir (H₂O–Pi and NaHCO₃–Pi) in soil was greatly increased through the fertilizer input and microbial turnover, with the highest H₂O–Pi (3.66 mg kg⁻¹) in OF treatment and the highest NaHCO₃–Pi (52.65 mg kg⁻¹) in MOF treatment. Additionally, carbon utilization analysis was applied using the commercial Biolog system, revealing that the MOF treatment significantly increased the utilization of carbohydrates, polymers, and amino acid carbon sources. …”
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