Functional differentiation of human dental pulp stem cells into neuron-like cells exhibiting electrophysiological activity by B. Pardo-Rodríguez, A. M. Baraibar, I. Manero-Roig, J. Luzuriaga, J. Salvador-Moya, Y. Polo, R. Basanta-Torres, F. Unda, S. Mato, Gaskon Ibarretxe, Jose Ramon Pineda

“…Results We found that neural markers like Nestin, GFAP, S100β and p75NTR were expressed differently in neurodifferentiated hDPSC cultures depending on the presence or absence of serum during the initial cell expansion phase. In addition, hDPSCs previously grown as spheroids in serum-free medium exhibited in vitro expression of neuronal markers such as doublecortin (DCX), neuronal nuclear antigen (NeuN), Ankyrin-G and MAP2 after neurodifferentiation. …”
Get full text

Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome by Manjula Nandakumar, Priya Das, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin

“…In BMI-matched (overweight/obese, BMI ≥ 26 kg/m²) subset analysis, six CVRPs were common to the whole set: ANGPT1 and IL-1Ra were upregulated; and sRAGE, BMP6, GDF2, and Mn-SOD were downregulated. In addition, lymphotactin (XCL1) was upregulated and placenta growth factor (PIGF), alpha-L-iduronidase (IDUA), angiopoietin-1 receptor, and soluble (sTie-2) and macrophage metalloelastase (MMP12) were downregulated. …”
Get full text

The Effect of Rosuvastatin on a murine model of deep vein thrombosis by Megan E. Barney, Shenghao Zhou, Anh Le-Cook, Naly Setthavongsack, Gabriel Nager, Jennifer M. Loftis, Randy L. Woltjer, Monica Hinds, Khanh P. Nguyen

“…Conclusions: After DVT, rosuvastatin did not accelerate thrombus resolution nor did it affect thrombus formation. …”
Get full text

Localized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions by Hasan AM, Cavalu S, Kira AY, Hamad RS, Abdel-Reheim MA, Elmorsy EA, El-kott AF, Morsy K, AlSheri AS, Negm S, Saber S

“…Finally, the review discusses in detail the recent therapeutic and diagnostic applications of NDDs that have been conducted in oral, esophageal, gastric, colon, and liver cancers, aiming to offer valuable insights into the current and future state of utilizing NDDs for the local treatment of GI cancers. …”
Get full text

Oleanolic Acid Cubic Liquid Crystal Nanoparticle-Based Thermosensitive Gel Attenuates Depression Symptoms in Chronic Unpredictable Mild Stress Rats by Shi Z, Wang Q, Li Q, Jia F, Xu W

“…Zhiqi Shi,1,2,* Qing Wang,1,* Qing Li,1,3 Fan Jia,1,3 Weifeng Xu1 1Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, Jiangsu, People’s Republic of China; 2Liangxi District Hospital of Traditional Chinese Medicine, Wuxi, Jiangsu, People’s Republic of China; 3Wuxi Institute of Traditional Chinese Medicine, Wuxi, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiqi Shi, Chinese Medicine Research Department, Wuxi, Jiangsu, 214071, People’s Republic of China, Tel +86 510-82725693, Email shi_mars@foxmail.com Weifeng Xu, Drug Clinical Trial Facility Office, Wuxi, Jiangsu, 214071, People’s Republic of China, Tel +86 510-82725693, Email 13585028501@163.comPurpose: Major depressive disorder (MDD) is a global health concern. Studies have demonstrated that oleanolic acid (OA) has a regulatory effect on MDD. …”
Get full text

Identification of mesenchymal stem cell populations with high osteogenic potential using difference in cell division rate by Maya Watanabe, Yukiyo Asawa, Dan Riu, Tomoaki Sakamoto, Kazuto Hoshi, Atsuhiko Hikita

“…Furthermore, real-time qPCR analysis showed that osteocalcin expression was higher in the slow cell group in cells immediately after preparative differentiation. In addition, the expression of osteocalcin and sclerostin were higher in the slow cells after osteogenic differentiation. …”
Get full text

The bergen 4-day treatment for panic disorder: a longer-term follow-up by Thorstein Olsen Eide, Bjarne Hansen, Kay Morten Hjelle, Stian Solem, Michael G. Wheaton, Thröstur Björgvinsson, Gerd Kvale, Kristen Hagen

“…Previous studies have shown B4DT to be a promising treatment format for panic disorder (PD), although the long-term stability of treatment gains requires additional study. Aim The aim of the current study was to evaluate the longer-term effectiveness of B4DT for patients with panic disorder with or without agoraphobia. …”
Get full text

Impact of mild hypothermic circulatory arrest on surgical outcomes in acute type a aortic dissection patients: a single-centre study by Zhenxiong Li, Hao Tang, Chao Deng, Kangjun Shen, Jingyu Li, Song Tian, WenYao Zhan, Ling Tan

“…In the multivariable logistic regression analysis, MI-HCA was identified as an independent protective factor for AKI (OR = 0.354, 95% CI 0.177–0.689; p = 0.003). Additionally, compared with MHCA, MI-HCA was not associated with an increased incidence of stroke, spinal cord injury, or in-hospital mortality. …”
Get full text

Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients With Essential Hypertension Uncontrolled by Amlodipine: A Phase III, Multicenter, Double‐Blind, Parallel‐Group, R... by Hongjie Chi, Xin Zhang, Shumei Ma, Gang Pan, Xiaojuan Lian, Yan Chen, Haotian Pei, Zichen Liu, Xiangmin Lin

“…. –5.6 and –3.8 mmHg) were more pronounced in the ALI/AML group. Additionally, a higher proportion of patients achieved both a BP response and target office BP in the ALI/AML group compared to the AML group (51.4% vs. 37.4%, 42.5% vs. 30.6%, both p < 0.05). …”
Get full text

Transplantation of mitochondria from human malignant tumor cells as a method of tumor growth formation in the lungs of laboratory animals by O. I. Kit, E. M. Frantsiyants, A. I. Shikhlyarova, I. V. Neskubina

“…Respiratory problems in mice with mitochondrial transplantation occurred between days 113 and 123, when a drop in body weight ≥ 25 % was observed. A uniform formation of tumor nodes together with an active filling of the lung space with blood was clearly visible on lung preparations of a Balb/c Nude male mouse after intravenous transplantation of mitochondria from the lung of a patient with non-keratinizing squamous cell carcinoma. …”
Get full text

Fatty Acid Content and Profile in <i>Ulva lactuca</i> in Response to Exposure to Variable Growth Conditions in Indoor Photobioreactors by Nabeel Gnayem, Razan Unis, Rima Gnaim, Alexander Chemodanov, Álvaro Israel, Jallal Gnaim, Alexander Golberg

“…This study assessed their influence on <i>U. lactuca</i>’s biomass production rate (BPR), dry weight (DW), ash content (AC), and FA composition after 7 and 21 days. …”
Get full text

The potential utility of synovial C-reactive protein, interleukin-6, and presepsin in diagnostics of periprosthetic joint infection by Lyudmila V. Lyubimova, Svetlana I. Pavlova, Nikolay S. Nikolaev, Evgeniy A. Lyubimov, Nadezhda N. Pchelova, Vladimir Y. Emelianov

“…In cases where synovial leukocyte counts are at borderline levels, the additional assessment of synovial fluid cellular composition and simple, cost-effective markers such as synovial CRP and IL-6 may be recommended to confirm PJI.…”
Get full text

‘I no longer worry about money for transport to the health centre’ - economic empowerment of caregivers of children living with HIV through Village Savings and Loan Associations: e... by Joseph Rujumba, Carmen Roebersen, Susan Namara, Richard Ochen, Sharon Eva Ahumuza, Allen Tushabe, Mathias Akugizibwe, David Bitira, Innocent Mwesigye, Stella Kentusi, Henry Zakumumpa, Japheth Kwiringira, Merian Natukwatsa Musinguzi

“…Data were collected through 31 focus group discussions (FGDs) with VSLA members, children and adolescents living with HIV, networks of people living with HIV and Village Health Team members (VHTs). In addition, we conducted 11 interviews with children and their caregivers at TAFU supported health facilities as well as 43 interviews with health workers and district officials involved in HIV programming. …”
Get full text

Decarbonizing Saudi Arabia energy and industrial sectors: Assessment of carbon capture cost by Feras Rowaihy, Ali Hamieh, Naser Odeh, Mohamad Hejazi, Mohammed Al-Juaied, Abdulkader M. Afifi, Hussein Hoteit

“…In contrast, the Western region requires additional focus on storage alternatives such as mineralization. …”
Get full text

The Upregulation of IL-1&beta; Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…In vitro BLB models, the effect of IL-1β on MMP9 expression, PI3K-AKT pathway activation, and endothelial barrier permeability were examined via Western blot, TEER value test, and FITC extraction analysis. In addition, inhibitors of IL-1β, MMP9, and PI3K-AKT were used to analyze the specific mechanisms.Results: After CDDP treatment, IL-1β upregulation in the stria vascularis disrupted tight junctions, increased BLB permeability, and led to hearing loss. …”
Get full text

Effect of KRAS mutation status on clinicopathological characteristics and overall survival in patients with rectal cancer by Shengbin Zheng, Zhijie You, Guodon Guo, Zhijing Lin, Siming Wang, Guohua Yang

“…In comparison to the wKRAS group, the overall survival duration was notably reduced in the KRASG12D group (p = 0.0482), whereas no significant difference was observed in the KRASG13D group (p = 0.1848). Additionally, a COX survival analysis was conducted, revealing that KRASG12D, along with higher TNM stage, LVI, tumor deposits, and PNI, were all associated with a decrease in survival time for patients with rectal cancer; however, these factors did not reach statistical significance (p > 0.05). …”
Get full text

Buffalo whey proteins performance at the oil/water interface: rheology characterization of the interfacial films by Leandro F. Bustos, Víctor M. Pizones Ruiz-Henestrosa, Cecilio Carrera Sánchez, Franco E. Vasile, Oscar E. Pérez

“…Then, the equilibrium interfacial pressure (πeq) was registered through the Wilhelmy plate method. Additionally, adsorption dynamics at the O/W interface at protein concentrations of 0.5 and 1% were obtained over three h with a drop tensiometer. …”
Get full text

Study of a Deep Learning Reconstruction Algorithm for Displaying Small- and Medium-sized Blood Vessels in Upper Abdominal Energy Spectrum CT by Qin WANG, Weijie YAN, Yuan YUAN, Hehan TANG, Liping DENG

“…The CT and standard deviation (SD) values of common hepatic, left gastric, splenic, and superior mesenteric arteries were measured, and the CT and SD values of the vertical spinal muscle at the same level were measured. In addition, the signal-to-noise (SNR) and contrast-to-noise (CNR) ratios of each branch vessel were calculated. …”
Get full text

Dengue dynamics, predictions, and future increase under changing monsoon climate in India by Yacob Sophia, Mathew Koll Roxy, Raghu Murtugudde, Anand Karipot, Amir Sapkota, Panini Dasgupta, Kalpana Baliwant, Sujata Saunik, Abhiyant Tiwari, Rajib Chattopadhyay, Revati K. Phalkey

“…We find that moderate rains spread over the summer monsoon season lead to an increase in dengue mortality, whereas heavy rains reduce it through the flushing effect, indicating the links between dengue and monsoon intraseasonal variability. Additionally, warm temperatures above 27°C and humidity levels between 60% and 78% elevate the risk of dengue. …”
Get full text

Influence of elevated temperature exposure on the residual compressive strength and radiation shielding efficiency of ordinary concrete incorporating granodiorite and ceramic powde... by Alaa A. Mahmoud, Alaa A. El-Sayed, Ayman M. Aboraya, Islam N. Fathy, Mohamed A. Abouelnour, Maged E. Elfakharany, Mohy S. Fattouh, Abdelmoniem E. Alahmer, Islam M. Nabil

“…The impact of these waste materials on the compressive strength and radiation shielding effectiveness of traditional concrete was evaluated under both ambient and elevated temperature conditions. Additionally, several microstructural tests like X-ray diffraction (XRD), Thermogravimetric analysis (TGA), and Energy dispersive X-ray (EDX) were conducted to assess the influence of using the optimal replacement ratios of the investigated waste powders on the studied properties of concrete. …”
Get full text