Impact of Timing the Combination of Radiotherapy and PD-1 Inhibitors on Outcomes in Patients with Hepatocellular Carcinoma by Zhong L, Peng W, Sun J, Luo Y, Sheng H, Wu Y, Zhou T, Zhou C, Cao C

“…This study aimed to evaluate and compare the efficacy and treatment-related adverse events (TRAEs) of synchronously administered radiotherapy and programmed cell death protein (PD)-1 inhibitors and sequential administration in patients with HCC.Patients and Methods: We retrospectively enrolled 67 patients with HCC who were undergoing liver radiotherapy and PD-1 inhibitor therapy at two medical centers between July 2017 and April 2023. Additionally, we created an experimental tumor model using 6-week-old female mice to validate our findings.Results: In the concurrent group, the median overall survival was indefinite; however, it was 13 months in the sequential group (95% confidence interval [CI] 6.7– 19.3 months, P=0.010). …”
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Identifying the Dimensions and Consequences of Digital Customer Experience: A Phenomenological Study by Fatemeh Eslahi, Seyed Mohammad Reza Mirahmadi, Mojtaba Aghajani

“…Today, customers are not only accessing and searching for information on the Internet but also engaging in interactions, uploading, and sharing content themselves. In addition, by creating the online virtual world, social media has transformed communication from traditional methods into a large and online social phenomenon. …”
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An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan by Rabea Basri, Muslim Bin Aqeel, Faryal Mehwish Awan, Sadiq Noor Khan, Ayesha Obaid, Rubina Parveen, Muhammad Mohsin, Wajeeha Akhtar, Abdal Hussain Shah, Tahira Sher Afghan, Amir Alam, Saira Khan, Anam Naz

“…Based on statistical analysis, the percentage allele frequency of IL-10 (rs1800871) variant was 0.2112% and the FcγRIIA (rs1801274) variant is 0.1128% in the current study. Additionally, this study reflects that screening of genetic variants associated with susceptibility and protection in a population gives better insights into organizing public health awareness campaigns to control diseases.…”
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Preventing epileptogenesis by interaction between inositol isomers and proteins by Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia

“…A critical, unexplored area is how inositols interact with proteins. Additionally, the antiepileptogenic capabilities of SCI and DCHI have yet to be determined. …”
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Accuracy of artificial intelligence algorithms in predicting acute respiratory distress syndrome: a systematic review and meta-analysis by Yaxin Xiong, Yuan Gao, Yucheng Qi, Yingfei Zhi, Jia Xu, Kuo Wang, Qiuyue Yang, Changsong Wang, Mingyan Zhao, Xianglin Meng

“…In the subgroup analysis, the pooled AUC of the AI models ANN, CNN, LR, RF, SVM, and XGB were 0.86 (0.83–0.89), 0.91 (0.88–0.93), 0.86 (0.83–0.89), and 0.89 (0.86–0.91), 0.90 (0.87–0.92), 0.93 (0.90–0.95), respectively. In an additional subgroup analysis, we evaluated the predictive performance of the AI models trained using different predictors. …”
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Human–nature connectedness and sustainability across lifetimes: A comparative cross‐sectional study in France and Colombia by Gladys Barragan‐Jason, Maxime Cauchoix, Paula A. Diaz‐Valencia, Arielle Syssau‐Vaccarella, Solène Hemet, Camilo Cardozo, Suzanne M. Skevington, Philipp Heeb, Camille Parmesan

“…Our study indicates that enhancing human–nature connectedness could provide an additional tool for achieving sustainable targets globally, not just in highly developed northern‐hemisphere countries. …”
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The impact of bleaching using 15% carbamide peroxide on surface properties of CAD-CAM composite structures by Rasha A. Alamoush, Jiawei Yang, Abdulaziz Alhotan, Julfikar Haider, Burak Yilmaz, Alaaeldin Elraggal

“…Similar trends in hardness reduction were observed at 24 h and 1 month post-bleaching. Additionally, hardness was significantly reduced after polishing for all materials. …”
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The Consequences of Digital Storytelling-Based Customer Engagement in Social Media for the Tourism Industry by Meysam Ahmadnia, Taher Roshandel Arbatani, Abbas Nargesian, Seyed Mahdi Sharifi, Khabat Derafshi

“…Such actions may significantly affect customer retention and prevent defection, prompting managers to consider the implications of positive customer interactions in enhancing the adoption of effective engagement techniques. Additionally, this approach can help acquire and retain new clientele, ultimately fostering increased economic value and profitability for the enterprise.…”
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Pressurised water flow in fractured permafrost rocks revealed by borehole temperature, electrical resistivity tomography, and piezometric pressure by M. Offer, M. Offer, S. Weber, S. Weber, M. Krautblatter, I. Hartmeyer, M. Keuschnig

“…This study shows that, in addition to slow thermal heat conduction, permafrost rocks are subjected to sudden push-like warming events and long-lasting rock temperature regime changes, favouring accelerated bottom-up permafrost degradation and contributing to the build-up of hydrostatic pressure, potentially leading to slope instability.…”
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Analysis of the CHS Gene Family Reveals Its Functional Responses to Hormones, Salinity, and Drought Stress in Moso Bamboo (<i>Phyllostachys edulis</i>) by Shiying Su, Xueyun Xuan, Jiaqi Tan, Zhen Yu, Yang Jiao, Zhijun Zhang, Muthusamy Ramakrishnan

“…Motif and gene structure analyses confirmed high structural similarity, suggesting shared functional characteristics. Additionally, <i>cis</i>-acting element analysis demonstrated that <i>PeCHS</i> genes are involved in hormonal regulation and abiotic stress responses. …”
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Peran Interaktivitas dalam Penggunaan E-learning: Perluasan Model UTAUT by Yuni Marlina Saragih, Erwin Setiawan Panjaitan, Roni Yunis

“… Perubahan proses belajar mengajar menjadi daring dilaksanakan oleh STMIK Mikroskil untuk mematuhi kebijakan yang dibuat Menteri Pendidikan dan Kebudayaan dalam masa darurat penyebaran covid-19 di Indonesia. Sebelum covid-19 terjadi, STMIK Mikroskil telah menerapkan E-learning yaitu moodle. …”
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Multi-Class Guided GAN for Remote-Sensing Image Synthesis Based on Semantic Labels by Zhenye Niu, Yuxia Li, Yushu Gong, Bowei Zhang, Yuan He, Jinglin Zhang, Mengyu Tian, Lei He

“…To integrate these generators, we design a shared-parameter encoder for consistent feature encoding across two branches, and a spatial decoder that synthesizes outputs from the class generators, preventing overlap and confusion. Additionally, we employ perceptual loss (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>L</mi></mrow><mrow><mi>V</mi><mi>G</mi><mi>G</mi></mrow></msub></mrow></semantics></math></inline-formula>) to assess perceptual similarity between generated and real images, and texture matching loss (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>L</mi></mrow><mrow><mi>T</mi></mrow></msub></mrow></semantics></math></inline-formula>) to capture fine texture details. …”
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Are the acute phase proteins related to anestrus in primiparous water buffaloes? Preliminary results by Frank Díaz-Huerta, Anthony Meléndez-Becerra, Justin Dijak, Héctor Nava-Trujillo

“…All the means were compared by T-test using R studio; additionally, a correlation analysis was carried out. …”
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Autistic and transgender/gender diverse people’s experiences of health and healthcare by Kate Green, Elizabeth Weir, Lily Wright, Carrie Allison, Simon Baron-Cohen

“…All individuals whose sex assigned at birth did not match their current gender identity were categorized as transgender/gender diverse; this was possible to determine, as the survey asked about sex assigned at birth and gender in separate questions. …”
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Physiological arterial pressure improves renal performance during normothermic machine perfusion in a porcine kidney DCD model by Yitian Fang, Gisela Ambagtsheer, Lin Xia, Marian C. Clahsen-van Groningen, Robert C. Minnee, Ron W.F. de Bruin

“…Conclusions: For kidneys with high IRR, both 95 mmHg and 115 mmHg perfusion pressures enable an early improvement in renal hemodynamics and function compared to 75 mmHg during NMP, while a high physiological perfusion can cause additional injury.…”
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Trade-Off Between Enzymatic Antioxidant Defense and Accumulation of Organic Metabolite Affects Salt Tolerance of White Clover Associated with Redox, Water, and Metabolic Homeostase... by Min Zhou, Yuting Wu, Yuchen Yang, Yan Yuan, Junnan Lin, Long Lin, Zhou Li

“…These findings indicated a trade-off relationship between antioxidant enzymes and nonenzymatic antioxidants in different white clover genotypes adapting to salt stress. In addition, Trp004 accumulated more organic acids (glycolic acid, succinic acid, fumaric acid, malic acid, linolenic acid, and cis-sinapic acid), amino acids (serine, l-allothreonine, and 4-aminobutyric acid), sugars (tagatose, fructose, glucoheptose, cellobiose, and melezitose), and other metabolites (<i>myo</i>-inositol, arabitol, galactinol, cellobiotol, and stigmasterol) than KL when they suffered from the same salt concentration and duration of stress. …”
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Serum metabolic profiles in quails: Effects of age, breed, and sex by Qin He, Hanle Shang, Yizhong Huang, Lizhi Li, Zhuomin Wu, Huihui Ran, Jiguo Xu, Xinwei Xiong

“…At 20 days of age (D20), quails had high levels of serum thymidine and alpha-D-glucose, while at 70 days of age (D70), the lipids, including 3-isothujone, 15-deoxy-d-12,14-PGJ2, and 2-aminobut-2-enoate dominated the serum. Additionally, xanthine, hypoxanthine, diaminopimelic acid, and 2-deoxy-scyllo-inosose appeared to be specific metabolites of Japanese quail (JAPQ). …”
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Temperature, violent crime, climate change, and vulnerability factors in 44 United States cities by Seulkee Heo, Hayon Michelle Choi, Jesse D. Berman, Michelle L. Bell

“…The Uniform Crime Reporting Program data were used to calculate daily city-specific number of violent crimes (n = 2,447,458 incidents). Generalized additive modeling was used to estimate relative risks (RRs) of violent crime. …”
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Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

“…Oxidative stress parameters and nuclear factor erythroid 2-related factor 2 (Nrf2)/ heme oxygenase-1 (HO-1) pathway, pro-inflammatory cytokines and nuclear factor-kappa B (NF-κB) pathway were also evaluated. Additionally, HK-2 cells were treated with LPS in vitro, and cell viability and apoptosis were detected using CCK-8 kit and flow cytometer, respectively. …”
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Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…Venous thromboembolism/all-cause mortality IRs were generally comparable across regions. DAS28-4(CRP)/HAQ-DI improvements were generally lowest in North America. …”
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