The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) results suggested that the pharmacodynamic mechanism of XFC may be closely related to the regulation of the PI3K/AKT signaling pathway. Additionally, network pharmacology and molecular docking results show that the main active components of XFC, namely, calycosin-7-O-beta-D-glucoside, calycosin, and formononetin, exhibit excellent docking with the core targets HIF1A, PTGS2, and MMP9. …”
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Health Care Professionals and Data Scientists’ Perspectives on a Machine Learning System to Anticipate and Manage the Risk of Decompensation From Patients With Heart Failure: Quali... by Joana Seringa, Anna Hirata, Ana Rita Pedro, Rui Santana, Teresa Magalhães

“…Adequate variable selection, risk stratification, and response models were identified as essential components for the effective implementation of ML models in health care. In addition, the study identified technical, regulatory and ethical, and adoption and acceptance challenges that need to be overcome for the successful integration of ML models into clinical workflows. …”
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Corneal nerve abnormalities in early-stage diabetic retinopathy evaluated by corneal confocal microscopy by Yi Zhou, Xiangchen Li, Suhan Shi, Ziwei Guo, Beibei Shan, Linlin Xu, Yixiao Li, Jianxin Guo

“…We collected the clinical data (gender, age, body mass index), laboratory indicators (fasting blood glucose, glycosylated hemoglobin), and confocal laser scanning microscopy images for further analysis. …”
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Telomerase inhibiting phytochemicals derived from Blumea eriantha for cancer treatment: A comprehensive computational analysis by Rahil Ummar Faruk Abbu, Shaik Mohammad Abdul Fayaz, Divyashree M S, Raghu Chandrashekhar H, Prasanna Kumar Reddy Gayam, Archana Mahadev Rao

“…The phytochemical also exhibited a robust binding affinity mediated by consistent magnesium metal ion interactions involving key residues such as Asp251, Asp252, Ile252, and Asp343, along with additional hydrogen bonding and water-mediated contacts that enhance its stability and selectivity. …”
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MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data by Katarzyna Arturi, Eliza J. Harris, Lilian Gasser, Beate I. Escher, Georg Braun, Robin Bosshard, Juliane Hollender

“…While the original proof of concept study was accompanied by the release of a MLinvitroTox v1 KNIME workflow, in this study, we release a Python MLinvitroTox v2 package, which, in addition to automation, expands functionality to include predicting toxicity from structures, cleaning up and generating chemical fingerprints, customizing models, and retraining on custom data. …”
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Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing by Johanna Graue, Melanie Timmen, Katharina Schmitz, Daniel Kronenberg, Markus Böhm, Kishor K. Sivaraj, M. Gabriele Bixel, Richard Stange

“…Bone tissue is significantly affected in inflammatory joint diseases. Additionally, inflammatory signaling is essential -in bone regeneration during fracture healing. …”
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Three-dimensional evaluation of tongue position and volume in adult patients with different skeletal malocclusions by CHIOU Wei-Cho, MEN Xinrui, ZHANG Kaiwen, JIANG Xiaoge, CHEN Song

“…Tongue volume was positively correlated with U1-SN and negatively correlated with overbite and overjet (<i>P </i>&lt; 0.05). Additionally, tongue volume showed a significant positive correlation with Go-Gn and Pg-Np (<i>P </i>&lt; 0.01), as well as with maxillary and mandibular dental arch width and basal bone arch width (<i>P </i>&lt; 0.01). …”
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BananaImageBD: A comprehensive banana image dataset for classification of banana varieties and detection of ripeness stages in BangladeshMendeley Data by Md Hasanul Ferdaus, Rizvee Hassan Prito, Ahmed Abdal Shafi Rasel, Masud Ahmed, Md. Jahid Hassan Saykot, Shanjida Sultan Shanta, Sonali Akter, Ankan Chandra Das, Mohammad Manzurul Islam, Mahamudul Hasan, Md Sawkat Ali

“…Such ML and DL models can be leveraged to develop automated systems to determine the optimal harvest time, establish standards for quality control of bananas, develop products and marketing strategies through analysis of consumer preferences for various banana varieties and ripeness levels, and streamline the banana supply chain through improvements in harvesting, sorting, packaging, and inventory management. Additionally, researchers aiming to contribute to developing Computer Vision technologies in food and agricultural sciences will find this dataset valuable in advancing precision farming and food processing mechanisms. …”
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Association Between Diurnal Temperature Range and Risk of Cardiomyopathy-Induced Hospitalisation in Henan, China: A Time-Series Study by Zhang Z, Wang Y, Zhou Y, Pei J, Zhao G, Dong P, Yang K, Liu H, Xie N, Li X, Zang X, Lin F, Chen Z

“…Zhaolin Zhang,1,&ast; Yongbin Wang,2,&ast; Yifeng Zhou,1 Jiachao Pei,1 Guoan Zhao,1,3 Pingshuan Dong,4 Kan Yang,5 Hui Liu,6 Na Xie,7 Xuefang Li,3 Xiayan Zang,3 Fei Lin,1,3 Zhigang Chen1 1Department of Cardiology,The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, People’s Republic of China; 2Department of Epidemiology and Health Statistics, Xinxiang Medical University, Xinxiang, 453003, People’s Republic of China; 3Henan Engineering Technology Research Center of Environmental Meteorological Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, People’s Republic of China; 4Department of Cardiology,The First Affiliated Hospital of Henan University of Science and Technology, Luoyan, 471000, People’s Republic of China; 5Department of Cardiology,Nanyang Central Hospital, Nanyang, 473005, People’s Republic of China; 6Department of Cardiology,Anyang District Hospital, Anyang, 455000, People’s Republic of China; 7Department of Cardiology,The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fei Lin; Zhigang Chen, Department of Cardiology,The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, Henan, People’s Republic of China, Tel +86 18567557937, Email 1fy2000129@xxmu.edu.cn; 1fy2015157@xxmu.edu.cnPurpose: The effect of the diurnal temperature range (DTR) on human health in diverse geographic areas and the potential confounding factors are not fully understood. Additionally, while a robust association has been reported between temperature and cardiomyopathy (CM), evidence of the impact of DTR is relatively limited. …”
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Research on the impact of land use and land cover changes on local meteorological conditions and surface ozone in the north China plain from 2001 to 2020 by Chunsheng Fang, Xinlong Li, Juan Li, Jiaqi Tian, Ju Wang

“…Below 500 m, vertical transport increased O3 concentrations, while horizontal transport decreased O3 concentrations. Additionally, the meteorological and chemical processes induced by LULCC showed enhanced effects above the surface, whereas the dry deposition process had a smaller impact on O3 concentrations above the surface. …”
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Modeling Stock High-Low Price Range: Fractional Cointegrating VAR Approach (FCVAR) by Elham Farzanegan

“…ObjectiveThis paper seeks to employ fractional cointegration methodology to model high and low stock prices, as well as the range series, indicating the difference between high and low stock prices. Additionally, it tries to examine the regime-switching characteristic in the cointegrating relationship between price series. …”
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Syntheses and structures of two coordination polymers formed by Ni(cyclam)2+ cations and sulfate anions by Liudmyla V. Tsymbal, Irina L. Andriichuk, Lucian G. Bahrin, Yaroslaw D. Lampeka

“…In II it includes additionally a molecule of the undissociated acid (2,2′,4,4′,6,6′-hexamethyl[1,1′-biphenyl]-3,3′,5,5′-tetrayl)tetra(benzoic acid) located on a crystallographic twofold axis and nine highly disordered water molecules of crystallization. …”
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Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study by Yuhui Chen, Li Chen, Liang Xian, Haibing Liu, Jiaxing Wang, Shaohuai Xia, Liangfeng Wei, Xuewei Xia, Shousen Wang

“…Results Multivariable logistic regression analysis identified OTBI classification type C (p < 0.001), a Glasgow Coma Scale score (GCS) ≤ 8 (p < 0.001), subarachnoid hemorrhage (SAH) (p = 0.004), subdural hematoma (SDH) (p = 0.011), and coagulopathy (p = 0.020) as independent risk factors for poor prognosis. The addition of the OTBI classification to a model containing all the other identified prognostic factors improved the predictive ability of the model (Z = 1.983; p = 0.047). …”
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Measuring Fear and Greed Index in Stock Market: Evidence from the Tehran Stock Exchange by Mojtaba Rostami Noroozabad, Ali Golbabaei Pasandi, Milad Shahrazi, Somayeh Esfandyari

“…Conversely, in 2012 and 2017, the Tehran Stock Exchange demonstrated a neutral sentiment on most trading days. Additionally, in 2013, the Tehran Stock Exchange displayed a greedy sentiment on the majority of its trading days. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

“…To test the model, different concentrations of in vitro digested broccoli (BD) were added to the apical section of the model.ResultsSupernatants from the basolateral compartment were collected and analyzed for cytokines production (IL-6, TNF-α, IL-12p70, IL-18 and IL-8) using automated ELISA (ELLA). Additionally, ZO-1 protein from the tight junctions of epithelial cells was analyzed by flow cytometry. …”
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Breast myopathy co-occurrence and its impact on carcass and meat quality attributes in broiler chickens by Míriam Muñoz-Lapeira, Maria Font-i-Furnols, Albert Brun, Anna Jofré, Marcos Botella, Cristina Zomeño

“…A 54.8 % of the affected breasts presented multiple myopathies, and within them, a correlation between WB and WS was found (Kendall's tau = 0.24; P < 0.01). Additionally, myopathies were more prevalent in the breast cranial region (P < 0.05). …”
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Effect of Moderate Red Meat Intake Compared With Plant-Based Meat Alternative on Psychological Well-Being: A 10-Wk Cluster Randomized Intervention in Healthy Young Adults by Tamlin S Conner, Nicola A Gillies, Anna Worthington, Emma N Bermingham, Jillian J Haszard, Scott O Knowles, Daniel R Bernstein, David Cameron-Smith, Andrea J Braakhuis

“…Background: A healthy diet has been proposed to support good mental health, but the addition of either red meat or meat alternatives is nuanced. …”
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Pregnancy Complications and Outcomes in Obese Women with Gestational Diabetes by Gitana Ramonienė, Laura Malakauskienė, Eglė Savukynė, Laima Maleckienė, Greta Gruzdaitė

“…<i>Results</i>: Fasting glycaemia was significantly higher in obese women with GDM than in normal-weight women with GDM (<i>p</i> < 0.001). In addition, fasting glycaemia was higher in obese women with GDM requiring insulin correction than in normal-weight women (<i>p</i> = 0.006). …”
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Rumen DNA virome and its relationship with feed efficiency in dairy cows by Xiaohan Liu, Yifan Tang, Hongyi Chen, Jian-Xin Liu, Hui-Zeng Sun

“…The study annotated 2,382 auxiliary metabolic genes (AMGs), comprising 1,752 lytic virus-associated AMGs across 51 functional categories and 589 temperate virus-associated AMGs across 29 categories. Additionally, 2,232 vOTU-host metagenome-assembled genome (hMAG) linkages were predicted, with Firmicutes_A (33.60%) and Bacteroidota (33.24%) being the most prevalent host phyla. …”
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CeRNA profiling and the role in regulating gonadal development in gold pompano by Changcan Yang, Yijun Zhao, Wendong Zhao, Hai Huang, Quanqi Zhang, Jinxiang Liu

“…Results Overall, a total of 96 differentially expressed microRNAs (DE-miRNAs), 2,338 differentially expressed messenger RNAs (DE-mRNAs), 973 differentially expressed long non-coding RNAs (DE-lncRNAs), and 94 differentially expressed circular RNAs (DE-circRNAs) were identified. Additionally, a ceRNA network was constructed, and enrichment analysis confirmed the involvement of numerous pathways in reproduction and gonadal development, including the TGF-β signaling pathway and GnRH signaling pathway. …”
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