New acorane-sesequiterpenes and anti-retinoblastoma constituents from the marine algicolous fungus Trichoderma harzianum NTU2180 guided by molecular networking strategy by Andrea Gu, Fan-Li Lin, Chung-Kuang Lu, Tz-Wei Yeh, Yih-Fung Chen, Ho-Cheng Wu, Tzong-Huei Lee

“…Among them, six compounds (1, 2, 3, 4, 5, and 11) were annotated as terpenoids by the NPClassifier on FBMN. 5-Hydroxy-3-hydroxmethyl-2-methyl-7-methoxychromone (7) and ergosterol peroxide (11) showed significant anti-angiogenic activity in ex vivo experiments with respective 0.57 ± 0.12- and 0.20 ± 0.12-fold changes. In addition, compound 11 displayed cytotoxicity against Y79 retinoblastoma cells with IC50 value of 35.3 ± 6.9 µM. …”
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Study on the protective effect of naringin-regulated lncRNA GAS5 against mitochondrial apoptosis in osteoarthritic chondrocytes by LIN Qin, ZHU Yingkai, LIN Yanming, LAN Shujie, CHEN Changxing, FU Changlong

“…In vitro experiments, Lenti-lncRNA GAS5 was used to infect sodium nitroprusside (SNP)-induced chondrocytes, and the expression of lncRNA GAS5 was detected by fluorescence in situ hybridization in rat chondrocytes; after silencing of lncRNA GAS5, the expression level of lncRNA GAS5 in rat chondrocytes was detected by Real-time PCR; Western blot detected the protein levels of Caspase-3, Bax, MMP-13 and Cyt-C.Results① Pathological changes of cartilage tissue: The articular cartilage matrix in naringenin group was relatively complete, the surface was relatively smooth, the structure was clear, the tide line was more complete, the number of chondrocytes was more full, the arrangement was more orderly, the cartilage staining was more uniform, and the structure was significantly restored than that in the model group. ② lncRNA GAS5 expression in cartilage tissue: Compared with model group, lncRNA GAS5 expression in naringin group was decreased (<italic>P</italic>&lt;0.01). ③ Expression of proteins related to mitochondrial apoptosis in cartilage tissues: Compared with model group, the expressions of Caspase-3, Bax, MMP-13 and Cyt-C in cartilage tissues of naringin group were decreased (<italic>P</italic>&lt;0.01). ④ Fluorescence expression of lncRNA GAS5 in chondrocytes: FISH results showed that the fluorescence expression of lncRNA GAS5 was decreased after naringin treatment of SNP-induced chondrocytes (<italic>P</italic>&lt;0.01). ⑤ The protein expressions of Caspase-3, Bax, MMP-13 and Cyt-C in chondrocytes: Compared with the model group, the protein expressions of Caspase-3, Bax, MMP-13 and Cyt-C in naringin group were significantly decreased (<italic>P</italic>&lt; 0.01). In addition, silencing lncRNA GAS5 will weaken the therapeutic effect of naringin on OA.ConclusionNaringin inhibits chondrocyte mitochondrial apoptosis and protects degraded cartilage tissues by down-regulating the expression of lncRNA GAS5, which has therapeutic value for OA diseases.…”
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Human exploitation of adult horseshoe crab and public awareness campaign in Hong Kong SAR, China by Pui Yi Tang, Hei Wut Fong, Shan Yee Lee, Wing Tung Chang, Lee Yan Pang, Tin Yan Hui, Kelvin Jun Yin So

“…The market survey recorded a total of 80 adult horseshoe crabs for sale in seafood restaurants or fish stalls out of the 98 shops surveyed. In addition, phone interviews revealed a low level of awareness among Hong Kong citizens (N = 1005 respondents), with 53 % having no prior knowledge and never heard of “horseshoe crab”. …”
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Domestic sewage irrigation on dynamics of nutrients and heavy metals in soil and wheat (Triticum aestivum L.) production by S. R. Salakinkop, C. S. Hunshal

“…None of the treatments did show accumulation of these heavy metals in wheat plant parts more than normal range found in food plants. …”
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L-shaped association between dietary iron intake and HPV infection: a cross-sectional analysis based on national health and nutrition examination survey 2005–2016 by Xiaotong Chen, Haiwei Chen, Yuling Chen, Lixin Tang, Jiaqi Liu, Yu-Hua Ou

“…To statistically assess this relationship, we utilized weighted multivariate logistic regression models. Additionally, we implemented smooth curve fitting and threshold effect analysis, to delineate the complex, nonlinear association between iron intake and HPV infection. …”
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Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives by Hafez Hend N., El-Gazzar Abdel-Rhman B. A.

“…On the other hand, compound 2 was used to synthesize ethyl-[(3-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[ 3,2-d]pyrimidin-4-yl)-oxy]acetate (10), 2-hydrazinyl- -3-methyl-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (11), 3-methyl-2-(methyl-sulfanyl)-6-phenyl-thieno[3,2-d]pyrimidin- 4(3H)-one (12) and N-(phenyl)/4-chlorophenyl or methoxy- phenyl)-2-[(3-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[ 3,2-d]pyrimidin-2-yl)-sulfanyl]-acetamide (13a-c). In addition, compound 12 was used to synthesize thieno[1,2,4] triazolopyrimidine derivatives 14 and 15 and 3-methyl-2-(methyl-sulfonyl)-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (16) through the reaction with the respective reagents. …”
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Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis by Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B

“…Kaplan–Meier curves and Cox regression analyses were used to evaluate the relationship between CD73+T cells and infections; meanwhile, multiple logistic regression analysis was used to analyze differences among infection groups. In addition, a 5/6 nephrectomy (5/6 Nx) rat model and cecal ligation and puncture (CLP) were used to verify the effect of chronic kidney disease (CKD) and sepsis on CD73-adenosine signaling.Results: Decreased CD73+ T cells were independently associated with increased infection risk over one and three years. …”
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Daily time series of 12 human thermal stress indices in Greece, aggregated at commune level (1998–2022)Zenodo by Georgios Charvalis, Michalis Koureas, Chloe Brimicombe, Chara Bogogiannidou, Fani Kalala, Varbara Mouchtouri, Christos Hadjichristodoulou

“…The execution of a built-in QGIS function was implemented to geospatially aggregate the NetCDF files of 12 daily mean, maximum and minimum, indices to 326 Greek communes for 9131 days.The high spatial and temporal resolution of the data, makes the dataset appropriate for analysis and comparison of climate change impacts, heatwave patterns, and the development of climate adaptation strategies at a regional scale in Greece. Additionally, it can be used as a basis of a system to inform and devise targeted interventions and policies aimed at mitigating the effects of extreme heat events. …”
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Health effects of astaxanthin in the intestinal tract of yellow-feathered broilers by Yu-Yun Gao, Zhi-Xin Lin, Min Zhang, Rui Yang, Ping-Ting Guo, Jing Zhang, Chang-Kang Wang, Ling Jin

“…The results showed that compared with the CON group, the villus height and the villus-to-crypt ratio of broiler jejunum in the astaxanthin-added group increased, while the crypt depth decreased (P < 0.05). In addition, IL-1β content and gene expression in broiler jejunal mucosa decreased, IL-6 gene expression decreased, and IL-4 content and gene expression increased (P < 0.05). …”
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Formation and fate of freshwater on an ice floe in the Central Arctic by M. M. Smith, N. Fuchs, E. Salganik, D. K. Perovich, I. Raphael, M. A. Granskog, K. Schulz, M. D. Shupe, M. D. Shupe, M. Webster

“…Our freshwater budget analyses suggest that a relatively high fraction (58 %) is derived from surface melt. Additionally, the contribution from stored precipitation (snowmelt) outweighs by 5 times the input from in situ summer precipitation (rain). …”
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Source and Ecological Risk Assessment of Potentially Toxic Metals in Urban Riverine Sediments Using Multivariate Analytical and Statistical Tools by Xiaojun Zheng, Abdul Rehman, Shan Zhong, Shah Faisal, Muhammad Mahroz Hussain, Syeda Urooj Fatima, Daolin Du

“…For this, riverine sediments from 25 locations along urban banksides of the River Ravi, Pakistan, were collected and analyzed to explore the distribution, pollution, ecological, and toxicity risk indices of PTMs like Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Sb, Sn, Sr, V, and Zn using Inductively Coupled Plasma–Optical Emission Spectrometry (ICP-OES) technique. Additionally, techniques such as X-ray Diffraction (XRD) and Scanning Electron Microscopy–Energy Dispersive X-ray Spectroscopy (SEM-EDS) were employed to investigate the mineralogical and morphological aspects. …”
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Investigating the effects of basil (Ocimum basilicum L.)c mucilage and cellulose nanofiber-based edible films with post-probiotics on fish fillet shelf life by Leila Mokhtaran, Sahar Sabahi, Mohammad Noshad, Seyyed Mohammad Ali Noori

“…The minimum thickness was observed in the basil seed mucilage sample, measuring 0.081 ± 0.01 mm, while the maximum thickness was recorded for the Basil seed mucilage+cellulose nanofiber+1.5 % postbiotic sample at 0.164 ± 0.01 mm. Additionally, the film with 0.5 % postbiotic showed the lowest water vapor permeability. …”
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The Value of Serum YKL-40 and TNF-α in the Diagnosis of Acute ST-Segment Elevation Myocardial Infarction by Caoyang Fang, Zhenfei Chen, Jing Zhang, Jianyuan Pan, Xiaoqin Jin, Mengsi Yang, Luyao Huang

“…Model B predicted STEMI with an AUC of 0.851. The addition of serum YKL-40 and serum TNF-α to the traditional diagnostic model composed of cTnI constituted a new diagnostic model; that is, the AUC of model C for predicting the occurrence of STEMI was 0.930. …”
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The relationship between social support and psychological crisis vulnerability among family impoverished undergraduates: the intermediary role of psychological resilience by Weimin Yuan, Jinhui Ning, Mengke Huo, Yiwei Feng

“…Factors significantly associated with the psychological crisis vulnerability of family impoverished undergraduates included being a student from a financially disadvantaged background, coming from a single-parent family, and having experienced being a left-behind child. Additionally, the participants had a social support score of 60.29 ± 11.31, indicating that individual social support was significantly correlated with family support, friend support, and support from significant others. …”
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Resilience of Fishery Economy in Fujian Coastal Areas from the Perspective of Institutional Evolution by Leng Yun, Wei Suqiong, You Xiaojun, Ren Zhihuang

“…This study highlights the importance of regional institutional change in the formation of fishery resilience, provides a new perspective on how institutional change affects economic activity, and uses quantitative methods to investigate the relationship between institutional change and industrial resilience. In addition, this study has important implications for disaster response and risk management, helping firms and governments better prepare for and respond to potential economic shocks.…”
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Study on Anaerobic Digestion and the Treatment of Livestock and Poultry Waste Liquid by Nanoparticles and Antibiotics in the Context of Carbon Neutrality and Microbial Ecosystems by Xiaofei Zhen, Han Zhan, Ke Li, Ruonan Jiao, Lei Feng, Tie Du

“…Chicken manure was selected as the research object, and nanoparticle nano-Fe₂O₃, nano-C₆₀, antibiotics enrofloxacin, sulfamethoxazole, and oxytetracycin were selected as additives to carry out medium-temperature sequential batch anaerobic digestion experiment. …”
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Variations of microbiota and metabolites in rhizosphere soil of Carmona microphylla at the co-contaminated site with polycyclic aromatic hydrocarbons and heavy metals by Ying Zhang, Fanghan Qian, Yanyu Bao

“…As the results showed, among three pollution levels, a medium level of pollution was favorable to increase the richness and diversity of soil bacterial community, while high level of pollution greatly decreased special OTUs number. In addition, HMs were the most significant factors driving bacterial community structure, especially for Cd. …”
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Contribution of Short-Time Occlusion of the Amblyopic Eye to a Passive Dichoptic Video Treatment for Amblyopia beyond the Critical Period by Lauren Sauvan, Natacha Stolowy, Danièle Denis, Frédéric Matonti, Frédéric Chavane, Robert F. Hess, Alexandre Reynaud

“…This passive dichoptic movie training approach is shown to significantly improve visual acuity of subjects beyond the critical period. The addition of a short-term monocular occlusion to the dichoptic training shows promising trends but was not significant for the sample size used here. …”
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Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

“…Further analysis demonstrated that the administration of allicin has the potential to ameliorate intestinal flora disorder following AMI by modulating the abundance of beneficial bacteria, such as g_Lactobacillus, g_Prevotella, g_Alistipes, and g_Limosilactobacillus, while reducing the abundance of harmful bacteria g_Parasutterella. Additionally, it exhibits the ability to enhance myocardial energy metabolism flexibility through modulating metabolites and key enzymes associated with the fatty acid metabolic pathway. …”
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Quantification of Soil–Water Erosion Using the RUSLE Method in the Mékrou Watershed (Middle Niger River) by Rachid Abdourahamane Attoubounou, Hamidou Diawara, Ralf Ludwig, Julien Adounkpe

“…Even though these average soil losses in the Mékrou basin are below the tolerable threshold of 10 t/ha/yr, mitigation actions are needed for prevention. In addition, the spatial dynamics of water erosion are noticeably heterogeneous. …”
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