The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries by Xi Xie, Chen Chen, Cang-Bao Xu, Jie Lin, Lei Cao, Gen Chen, Jie Li

“…The dose-effect curve of endothelin-1- (ET-1-) induced mesenteric artery contraction was measured using myography, while ETA receptor mRNA expression was detected using real-time polymerase chain reactions, and the protein levels of the ETA receptor, class III PI3K, Beclin-1, LC3 II/I, p62, NF-κB, and p-NF-κB were observed using Western blot analysis. mmLDL significantly strengthened ET-1-induced contraction (the Emax value increased from 184.87 ± 7.46% in the NS group to 319.91 ± 20.31% in the mmLDL group (P<0.001), and the pEC50 value increased from 8.05 ± 0.05 to 9.11 ± 0.09 (P<0.01). In addition to upregulating the protein levels of Class III PI3K, Beclin-1, and LC3 II/I and downregulating that of p62, mmLDL significantly increased the mRNA expression and protein level of the ETA receptor and increased the protein level of p-NF-κB. …”
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Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…The therapeutic impacts of QAFF were assessed in dextran sulfate sodium (DSS)-induced UC mice, focusing on the changes in body weight, disease activity index (DAI), colon length, histological assessment of colonic tissues, levels of pro-inflammatory cytokines, and expression of tight junction proteins. …”
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RISET PRAKTIK EKSPERIMENTAL LAS BUSUR DENGAN MATERIAL AS STAINLESS STEEL UNTUK PENCIPTAAN BENTUK KATAK POHON by Miky Endro Santoso

“…Selain itu, hasil riset ini juga dapat berpartisipasi dan memberikan sumbangan keragaman ide, bentuk, dan material pada perkembangan produk kriya dan seni dalam industri kreatif di Indonesia.   Kata kunci: bentuk tiga dimensi, katak pohon, las busur, riset praktik eksperimental…”
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Genome-Wide Identification and Expression Analysis of the <i>GRF</i> and <i>GIF</i> Gene Families in <i>Prunus avium</i> by Hongxu Chen, Yangang Pei, Wanjia Tang, Hongfen Li, Yidi Huang, Yizhe Chu, Guanqiong Kou, Wenyi Niu, Runmei He, Ronggao Gong

“…Additionally, miR396 could bind to the <i>PavGRFs</i>, thereby regulating the expression level of <i>PavGIF</i> after transcription. …”
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Reintroducing Autochthonous Minor Grapevine Varieties to Improve Wine Quality and Viticulture Sustainability in a Climate Change Scenario by Tommaso Frioni, Elia Romanini, Silvia Pagani, Filippo Del Zozzo, Milena Lambri, Alberto Vercesi, Matteo Gatti, Stefano Poni, Mario Gabrielli

“…Furthermore, we compared the composition, aromatic, and sensory profiles of wines obtained from ORT and BRB grapes picked on the same date and, in addition, of a second Barbesino wine from late harvest (BRB-LH). …”
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An efficient decoupled 3-D axial anisotropic resistivity inversion for magnetotelluric data with OpenMP parallelization by Wisart Thongyoy, Weerachai Siripunvaraporn, Puwis Amatayakul, Tawat Rung-Arunwan, Kiyoshi Baba

“…The decoupled inversion achieved significantly faster processing, requiring just 32 min per iteration or a total of 96 min to finish the inversion. In addition, the decoupled inversion requires just a fraction of the memory used in the full axial inversion. …”
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Weaving oral health provider perspectives to guide future dental therapy advocacy and implementation efforts by Amanda J. Llaneza, Amanda J. Llaneza, Kara A. Stone, Julie Seward

“…., particularly in areas with underserved communities. Additionally, most providers felt this could be done with ease and no providers indicated opposition in open-ended remarks. …”
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Options of improvement of efficacy of gastroesophageal reflux disease treatment by dioctaedric smectite by O. A. Storonova, A. S. Trukhmanov, N. Yu. Ivashkina, V. T. Ivashkin

“…In the first group weakly acidic refluxes disappeared in 2 (67%), in the second — in 1 (50%), in the third – in 9 (69%) cases, weakly alkaline refluxes: in 4 (80%), in 2 (40%) and in 100% of cases respectively.Conclusions. Addition of Smecta in treatment mode at erosive form of GERD essentially increases treatment response rate, significantly reducing terms of clinical improvement onset. …”
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The Effects of Self-Monitoring Using a Smartwatch and Smartphone App on Stress Awareness, Self-Efficacy, and Well-Being–Related Outcomes in Police Officers: Longitudinal Mixed Desi... by Herman Jaap de Vries, Roos Delahaij, Marianne van Zwieten, Helen Verhoef, Wim Kamphuis

“…Complementing the basic “off-the-shelf” wearable-based intervention with additional EMA questionnaires, weekly personalized feedback reports, and peer support groups did not appear to improve the effectiveness of the intervention. …”
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Seroprevalence and Associated Risk Factors of Infectious Bovine Rhinotracheitis (IBR) and Animal Owners’ Knowledge, Attitude and Practice (KAP) Towards the Disease in Selected Dist... by Abdisa Mitiku Danu, Abriham Kebede Deresa, Chala Guyassa Dinagde

“…The significant association (p <0.05) was found for breed, age, body condition and herd size but not for district and sex as risk factors. …”
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Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study by Xiaoqin Wang, Zhaozhao Hui, Jiaru Sun, Paul D Terry, Xiaohan Ren, Shuangyan Lei, Caihua Wang, Mingxu Wang

“…Multiplicative interaction measures were statistically significant in overweight/obesity and drinking/light drinking/heavy drinking categories in men (p&lt;0.05). Additive interactions were observed between high BMI and drinking in men (relative excess risk due to interaction=1.75, 95% CI 0.85 to 2.65, attributable proportion due to interaction=0.56, 95% CI 0.36 to 0.76, synergy index=6.43, 95% CI 1.02 to 28.84).Conclusions Measures of body weight and size, particularly BMI and WC, appear to interact synergistically with alcohol consumption to increase the risk of hypertension in the Chinese population. …”
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Association between Circulating B-Type Natriuretic Peptide and Diabetic Peripheral Neuropathy: A Cross-Sectional Study of a Chinese Type 2 Diabetic Population by Pijun Yan, Qin Wan, Zhihong Zhang, Yong Xu, Ying Miao, Pan Chen, Chenlin Gao

“…Circulating levels of BNP were significantly and positively associated with systolic blood pressure (P=0.035), neutrophil-to-lymphocyte ratio (P=0.007), creatinine (P=0.030), vibration perception threshold values (P=0.021), and the prevalence of diabetic foot ulceration (P=0.039), peripheral arterial disease (P=0.013), DPN (P=0.032), and diabetic nephropathy (P=0.020) and negatively with lymphocyte count (P=0.003) and ankle-brachial index (P=0.038), irrespective of age, sex, and body mass index. Moreover, circulating levels of BNP was an independent decisive factor for the presence of DPN after multivariate adjustment (odds ratio, 1.044; 95% confidence interval, 1.006-1.084; P=0.024). …”
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Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice by Mengjie Liu, Zhenlin Li, Jie Li, Guorong Yan, Chaoqi Liu, Qingqiang Yin, Yeqiang Liu, Xiaoxiang Xu

“…Further investigations revealed that COS modulated the expressions of pro-inflammatory cytokines and anti-apoptotic proteins through stimulation of the Nrf2/HO-1 signaling pathway and suppression of the NF-κB signaling pathway. Additionally, COS inhibited ferroptosis by modulating the SLC7A11/GSH/GPX4 pathway and the expression of FTH1 and FLC proteins, thereby reducing lipid peroxidation accumulation and iron overload. …”
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Prevalence and factors associated with adverse pregnancy outcomes in South Africa: Evidence from the 2016 Demographic and Health Survey by L Mpolokeng, A Musekiwa

“…Women who were currently in a union/living with a man (aOR 1.85, 95% CI 1.41 - 2.43) or formerly in a union/living with a man (aOR 2.66, 95% CI 1.64 - 4.29), compared with those who had never been in a union, had higher odds of adverse pregnancy outcomes. Contrarily, adverse pregnancy outcomes were lower with each additional child delivered or ever born (aOR 0.66, 95% CI 0.58 - 0.75). …”
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The e-STROKE Study: The Design of a Prospective Observational Multicentral Study by Kateřina Dvorníková, Veronika Kunešová, Svatopluk Ostrý, Robert Mikulík, Michal Bar

“…The secondary aim is to evaluate whether multimodal CT examination leads to an increase in the number of patients eligible for recanalization therapy. Additionally, this study seeks to assess the specificity and sensitivity of multimodal CT in distinguishing stroke mimics from actual strokes. …”
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Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model by Liu RJ, Li M, Zhu Q, Liu HY, Zhang XX, Han XY, Yu MJ, Zhou JW, Han CY

“…The BE hydrogel that was created showed persistent drug release. Additionally, it demonstrated an enhanced flow of 4.374 ± 0.12 μg/cm2/hour, permeability coefficient was 3.65 ± 0.09 cm/h× 10− 3, and apparent skin deposition was 17.77 ± 1.13 μg/cm2. …”
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RCE-IFE: recursive cluster elimination with intra-cluster feature elimination by Cihan Kuzudisli, Burcu Bakir-Gungor, Bahjat Qaqish, Malik Yousef

“…The comparability of RCE-IFE is also verified with other biological domain knowledge-based Grouping-Scoring-Modeling (G-S-M) tools, including mirGediNET, 3Mint, and miRcorrNet. Additionally, the biological relevance of the selected features by RCE-IFE is evaluated. …”
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Risk Factors for the Occurrence of Rebound Pain After Intercostal Nerves Block in Three-Port Thoracoscopic Surgery: A Case-Control Study by Wan C, Kong M, Shen Q, Lu W, Shen X

“…In addition, the proportion of female patients with RP was significantly higher. …”
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Phytotoxicity and phytoremediation potential of Lemna minor exposed to perfluorooctanoic acid by Azam Noori, Lorena Corbelli, Erin Lincoln, Sara Thomas, Jasmine Jones, Sara L. Nason, Jason C. White, Riley Lewis, Christy L. Haynes

“…The concentration of essential elements K, Cu, Fe, Mn, Zn, Mo were reduced in L. minor exposed to PFOA compared with the controls by 39.6, 33.4, 42.1, 35.2, 31.9, 40.2%, respectively. Additionally, PFOA accumulated in L. minor fronds and roots with an average bioaccumulation factor of 56 ± 7. …”
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Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2): protocol for a historical cohort study by David Jenkins, Mark H Stoler, Anne Hammer, Torben Steiniche, Lone Kjeld Petersen, Patti E Gravitt, Rikke Kamp Damgaard, Maurits NC de Koning, Wim GV Quint, John Doorbar, Johnny Kahlert

“…Tissue samples from women included will be sectioned for p16INK4a and HPV E4 immunohistochemical staining in addition to conventional hematoxylin and eosin (H&amp;E) staining. …”
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