Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease by Yue Xu, Yue Xu, Durong Chen, Meiqi Dong, Yun Zhang, Yun Zhang, Hongmei Yu, Hongmei Yu, Hongmei Yu, Yanqing Han, Yanqing Han, Yanqing Han

“…Then, we explored the mediating role of cognitive function in the bidirectional relationship between depression and ADL in patients with PD, and the mediation effect test was carried out using a bias-corrected nonparametric percentile bootstrap approach.ResultsDepression in patients with PD predicted their subsequent ADL (β = 0.079, p < 0.01), and ADL also predicted their subsequent depression (β = 0.069, p < 0.05), In addition, Bootstrap analysis showed that cognitive function played a significant mediating role in prediction of depression to ADL in patients with PD (β = 0.006, p = 0.074, 95%CI = 0.001 ~ 0.014), and cognitive function also played a significant mediating role in prediction of depression to ADL (β = 0.006, p = 0.067, 95%CI = 0.001 ~ 0.013).ConclusionThere is a bidirectional relationship between depression and ADL in patients with PD. …”
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Ganciclovir Resistance-Linked Mutations in the HCMV <i>UL97</i> Gene: Sanger Sequencing Analysis in Samples from Transplant Recipients at a Tertiary Hospital in Southern Brazil by Anna Caroline Avila da Rocha, Grazielle Motta Rodrigues, Alessandra Helena da Silva Hellwig, Dariane Castro Pereira, Fabiana Caroline Zempulski Volpato, Afonso Luís Barth, Fernanda de-Paris

“…Notably, the A594V and C603W mutations, associated with GCV resistance, were identified in four samples. Additionally, three mutations with unknown phenotypic impact (P509L, A628T, and H662Y) and two viral polymorphisms (N510S and D605E) were detected. …”
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Reconstruction for Time-Domain In Vivo EPR 3D Multigradient Oximetric Imaging—A Parallel Processing Perspective by Christopher D. Dharmaraj, Kishan Thadikonda, Anthony R. Fletcher, Phuc N. Doan, Nallathamby Devasahayam, Shingo Matsumoto, Calvin A. Johnson, John A. Cook, James B. Mitchell, Sankaran Subramanian, Murali C. Krishna

“…The results show that the parallel code for filtration has achieved a speed up factor of 46.66 as against the equivalent serial MATLAB code. In addition, a parallel MATLAB code has been developed to perform 3D Fourier reconstruction. …”
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Cost-efficient assignment panel for ducks. Setup of a cost-efficient assignment panel for duck populations.  by Chapuis, Hervé, Brard-Fudulea, Sophie, Hazard, Azélie, Vignal, Alain, Demars, Julie, Rouger, Romuald, Teissier, Marc, Gilbert, Hélène

“…This new design impacted the population structure, creating more sire x dam combinations, offering possibilities for a better estimation of non-additive genetic effects, which could prove relevant in the foie gras sector. …”
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Organizational readiness and implementation of colorectal cancer screening evidence-based interventions in federally qualified health centers: A cross-sectional study by Emanuelle M. Dias, Timothy J. Walker, Bijal A. Balasubramanian, Paula M. Cuccaro, Lauren Workman, Abraham Wandersman, Maria E. Fernandez

“…Future research should examine these associations using a larger sample size to explore additional relations between organizational readiness and implementation outcomes. …”
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A Simple Machine Learning-Based Quantitative Structure–Activity Relationship Model for Predicting pIC₅₀ Inhibition Values of FLT3 Tyrosine Kinase by Jackson J. Alcázar, Ignacio Sánchez, Cristian Merino, Bruno Monasterio, Gaspar Sajuria, Diego Miranda, Felipe Díaz, Paola R. Campodónico

“…<b>Results:</b> Key molecular descriptors influencing the inhibitor potency were identified, thereby improving the interpretability of structural requirements. Additionally, a user-friendly computational tool was developed to enable rapid prediction of pIC₅₀ values and facilitate ligand-based virtual screening, leading to the identification of promising FLT3 inhibitors. …”
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The Late Orchid Catches the Bee: Frost Damage and Pollination Success in the Face of Global Warming in a European Terrestrial Orchid by Florian P. Schiestl, Beat A. Wartmann, Ruth Bänziger, Brigitte Györög‐Kobi, Klaus Hess, Jürg Luder, Edith Merz, Beat Peter, Max Reutlinger, Tobias Richter, Heinz Senn, Thomas Ulrich, Beate Waldeck, Claudia Wartmann, Roland Wüest, Walter Wüest, Quint Rusman

“…Our study shows that the orchid, despite being limited to warm habitats in central Europe, suffers under global warming by increased frost damage caused by earlier flowering. We did not detect an effect of accelerated flowering on desynchronization in flowering time and pollinator activity in this orchid species.…”
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Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study by Jiayu Qiu, Yueming Yu, Dingwei Liu, Sihai Chen, Youhua Wang, Jianxiang Peng, Jinliang Xie, Chengyun Wu, Feng Zhou, Hui Fang, Qirui Lai, Yong Xie

“…In subgroup analysis, the adjusted association between three IR surrogate markers and H. pylori infection were more likely to be observed in female and Non-Hispanic White. Additionally, the RCS curve revealed a positive linear correlation between TyG index and H. pylori infection across all three models, and between METS-IR and H. pylori infection in Model 3. …”
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Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in <i>Penicillium expansum</i> and <i>Penicillium chrysogenum</i> by Holly P. Bartholomew, Christopher Gottschalk, Bret Cooper, Michael R. Bukowski, Ronghui Yang, Verneta L. Gaskins, Dianiris Luciano-Rosario, Jorge M. Fonseca, Wayne M. Jurick

“…This included the absence of an intact patulin gene cluster in <i>P. chrysogenum</i>, which corroborates the metabolomic data regarding its inability to produce patulin. Additionally, a core subset of <i>P. expansum</i> virulence gene homologues were identified in <i>P. chrysogenum</i> and were similarly transcriptionally regulated in vitro. …”
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Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 201... by Zhen Junhai, Meng Yang, Tan Zongbiao, Yan Wenxuan, Li Tiange, Wu Yanrui, Liu Chuan, Dong Weiguo

“…Diet low in milk, diet low in calcium, alcohol use, and high body-mass index were the main contributors to deaths and DALYs. …”
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RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose by Chenlin Gao, Jiao Chen, Fang Fan, Yang Long, Shi Tang, Chunxia Jiang, Jiying Wang, Youhua Xu, Yong Xu

“…High glucose upregulated RIPK2 and LC3 in GMCs during short periods (0-12 h) (p<0.01), while RIPK2 and LC3 were significantly downregulated in the long term (12-72 h) (p<0.01); these changes were positively correlated with glucose concentration (p<0.01). In addition, levels of ROS, caspase1, and IL-1β increased in a time- and dose-dependent manner in the high glucose group, even with an increased expression of LC3 (p<0.01). …”
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Current Status, Challenges, and Perspectives in the Conservation of Native Honeybees and Beekeeping in Cambodia by Eric Guerin, Chhouk Chheang, Chainarong Sinpoo, Korrawat Attasopa, Nuttapol Noirungsee, Huoqing Zheng, Tial C. Ling, Patcharin Phokasem, Terd Disayathanoowat

“…Key strategies for the development of beekeeping are documenting and conserving bee floral resources and habitats, reducing the use of bee-toxic pesticides, developing research and training capacities in beekeeping, regulating bee imports, and enhancing quality and authenticity testing facilities. Additionally, building capacity among honey value chain stakeholders in areas such as quality control, authenticity, processing, packaging, and marketing is essential.…”
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Salt Stress Enhanced Bioactivity of Quinoa Leaf Extracts: An In Vitro and In Silico Study of Acetylcholinesterase and Tyrosinase Inhibition for Sustainable Drug Development by Narmine Slimani, Soumaya Arraouadi, Hafedh Hajlaoui, Antonio Cid-Samamed, Mohamed Ali Borgi, Mejdi Snoussi

“…HPLC-DAD-ESI-MS/MS was employed to identify the major compounds in the water extract. Additionally, antioxidants (ABTS and FRAP), anti-tyrosinase, and anti-acetylcholinesterase effects were assessed using in vitro and in silico approaches. …”
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Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

“…Simultaneous screening of positive control patients on all six assays revealed distinct phenotypic profiles. In addition, individuals with VUS(es) in well-known disease genes showed distinct – but similar—phenotypic profiles compared to patients with pathogenic variants in the same gene.. …”
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Effect of ISPAD Anaerobic Digestion on Ammonia Volatilization from Soil Applied Swine Manure by Susan King, Michael Schwalb, David Giard, Joann Whalen, Suzelle Barrington

“…Accordingly, ISPAD effluent can offer a higher fertilizer value during land application, as compared to manure of similar age stored in an open tank. However, this additional nitrogen can also be lost by volatilization during land application. …”
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Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung by Yuanyuan Jia, Xuehong You, Ningxia Ma, Hui Li, Guopan Liu, Ying Wang, Jing Xue, Juan Shi, Jun Wei, Yong Li, Jiali Yang, Xiaoming Liu

“…The results showed a pseudostratified mucociliary epithelium comprised of basal, ciliated, goblet, and columnar cells in the conducting airway of a porcine lung. In addition, the majority of primary epithelial cells able to proliferate in vitro expressed keratin 5, a subpopulation of these keratin 5-positive cells, also expressed CD117 (c-Kit) or CD49f (integrin alpha 6, ITGA6), implying that they might be potential epithelial stem/progenitor cells in conducting airway of a porcine lung. …”
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High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression by Zhengyi Wu, Chao Li, Shouhua Zhang, Liang Sun, Junwen Hu, Bingbing Qiu, Shuiqiu Liu, Yiran Hong, Tianxiang Chen, Kai Wang, Xiangbao Yin, Jinlong Yan

“…In vitro experiments replicated the HIFP environment to observe changes in HCC cell behavior and protein expression, while in vivo studies involved mice portal hypertension to create an orthotopic liver cancer model, allowing for the evaluation of tumor progression. Additionally, clinical samples from HCC patients were analyzed for consistency with the experimental findings. …”
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The multi-omics signatures of telomere length in childhood by Congrong Wang, Dries S. Martens, Mariona Bustamante, Rossella Alfano, Michelle Plusquin, Lea Maitre, John Wright, Rosemary R. C. McEachan, Johanna Lepeule, Remy Slama, Marina Vafeiadi, Leda Chatzi, Regina Grazuleviciene, Kristine B. Gutzkow, Hector Keun, Eva Borràs, Eduard Sabidó, Angel Carracedo, Georgia Escarami, Augusto Anguita-Ruiz, Dolors Pelegrí-Sisó, Juan R. Gonzalez, Martine Vrijheid, Tim S. Nawrot

“…The association of these latent components with early-life aging risk factors (child lifestyle, body mass index (BMI), exposure to smoking, etc.), were interrogated. …”
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Risk of angioedema and thrombolytic therapy among stroke patients: An analysis of data from the FDA Adverse Event Reporting System database by Hunong Xiang, Yu Ma, Xiaochao Luo, Jian Guo, Minghong Yao, Yanmei Liu, Ke Deng, Xin Sun, Ling Li

“…., alteplase or tenecteplase) were identified, and the associations with angioedema were explored using disproportionality analysis and time-to-onset analysis. Additionally, we used adapted Bradford Hill criteria to confirm these associations. …”
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The associations between single nucleotide polymorphisms and diabetic retinopathy risk: an umbrella review by Shaofen Huang, Yonghui Feng, Ying Sun, Jiazi Liu, Pu Wang, Jingrong Yu, Xin Su, Shasha Han, Shiqi Huang, Haokun Huang, Shiyun Chen, Ying Xu, Fangfang Zeng

“…The TCF7L2 C/T variant could be identified as a definitive genetic risk factor for the development and progression of DR. Data from additional in-depth studies are needed to establish robust evidence for the associations between polymorphisms of IL-6 or VEGF and DR.…”
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