Metal-free production of natural blue colorants through anthocyanin–protein interactions by Wenxin Wang, Peiqing Yang, Fuqing Gao, Yongtao Wang, Zhenzhen Xu, Xiaojun Liao

“…Methods: Using human serum albumin (HSA) as a model protein, we investigated the structural influences of ACNs on their blue color generation using visible absorption spectroscopy, fluorescence quenching, and molecular simulations. Additionally, we examined the bluing effects of six proteins derived from milk and egg and identified the remarkable roles of bovine serum albumin (BSA) and lysozyme (LYS). …”
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Impact of Polystyrene Microplastics on Soil Properties, Microbial Diversity and <i>Solanum lycopersicum</i> L. Growth in Meadow Soils by Shuming Liu, Yan Suo, Jinghuizi Wang, Binglin Chen, Kaili Wang, Xiaoyu Yang, Yaokun Zhu, Jiaxing Zhang, Mengchu Lu, Yunqing Liu

“…The results showed that the PS0510 treatment significantly increased plant height (93.70 cm, +40.83%) and dry weight (2.98 g, +100%). Additionally, antioxidant enzyme activities improved across treatments for <i>S. lycopersicum</i> L. roots. …”
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Sociodemographic factors associated with dental students knowledge and attitudes regarding disinfection as a control measure to reduce the spread of COVID-19 by Geanella Silva-Robles, Gissela Briceño-Vergel, Rosa Aroste-Andía, Emily Hernández-Huamaní, Marysela Ladera-Castañeda, Miriam Castro-Rojas, Percy Gavilán-Chávez, Luis Cervantes-Ganoza, César Cayo-Rojas

“…A minority of dental students presented sufficient knowledge, while the majority presented positive attitudes regarding disinfection as a control measure to reduce the spread of COVID-19. In addition, being from the capital city was a limiting factor for sufficient knowledge. …”
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Comparing propofol anaesthesia guided by Bispectral Index monitoring and frontal EEG wave analysis with standard monitoring in laparoscopic surgery: protocol for the ‘EEG in Genera... by Luzius A Steiner, Salome Dell-Kuster, Bettina U Gruber, Valerie Girsberger, Lukas Kusstatscher, Simon Funk, Anita Luethy, Lien Jakus, Julien Maillard, Christoph S Burkhart

“…However, these monitors are vulnerable to artefacts. In addition to the processed number, the raw frontal electroencephalogram (EEG) can be displayed as a curve on the same monitor. …”
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Impact of mango peel pectin and Bacillus iranensis on growth, immunity, and gene expression in Nile tilapia (Oreochromis niloticus) by Anisa Rilla Lubis, Nguyen Vu Linh, Khambou Tayyamath, Supreya Wannavijit, Punika Ninyamasiri, Chanagun Chitmanat, Wanaporn Tapingkae, Einar Ringø, Hien Van Doan, Maria Ángeles Esteban

“…This highlights their potential as effective feed additives for improving fish health and supporting sustainable aquaculture practices.…”
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Comparative genomics analysis of the reason for 12C6+ heavy-ion irradiation in improving Fe3O4 nanoparticle yield of Acidithiobacillus ferrooxidans by Jiani Yang, Shuang Zhang, Lirong Geng, Dan Zhao, Siyu Xing, Xinyue Ji, Lei Yan

“…We further annotated the genes involved in the mutation, such as hcp, hsdM, yghU, K7B00_11365, and K7B00_11355, which are responsible for the substantial changes in the Fe3O4 nanoparticle yield of A. ferrooxidans. Additionally, we performed a pan-genome analysis to understand how these genes regulate Fe3O4 nanoparticle synthesis. …”
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Unusual congenital polydactyly in mini-pigs from the breeding group of the Institute of Cytology and Genetics (Novosibirsk, Russia) by S. V. Nikitin, S. P. Knyazev, V. A. Trifonov, A. A. Proskuryakova, Yu. D. Shmidt, K. S. Shatokhin, V. I. Zaporozhets, D. S. Bashur, E. V. Korshunova, V. I. Ermolaev

“…The article describes a new phenomenon in the breeding group of mini-pigs at the Institute of Cytology and Genetics (ICG, Novosibirsk): polydactyly (extra digits), which is unusual because the additional digits are situated at the lateral surface of legs or at the lateral and medial ones. …”
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Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension by Jia-Yong Qiu, Shen-Shen Huang, Chao Liu, Dong Ding, Yan-Hong Xu, Yi-Min Mao, Ya-Dong Yuan

“…Sensitivity analysis did not reveal significant pleiotropy or heterogeneity. …”
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Multiplexed SSR marker analysis of Diplocarpon coronariae reveals clonality within samples from Middle Europe and genetic distance from Asian and North American isolates by Thomas Oberhänsli, Anna Dalbosco, Virginie Leschenne, Anne Bohr, Sascha Buchleither, Lucius Tamm, Lukas Wille, Srđan G. Aćimović, Fatemeh Khodadadi, Young-Hyun Ryu, Bruno Studer, Hans-Jakob Schärer, Andrea Patocchi

“…Results We found 31 distinct multilocus genotypes (MLGs) in European samples, and seven additional MLGs in the Asian and USA samples. The European samples had the typical genetic signature of a recently introduced species including high clonality, a low number of private alleles and one dominant MLG across all the sampling sites. …”
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Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study by Elisa Russo, Francesca Viazzi, Roberto Pontremoli, Fabio Angeli, Carlo Maria Barbagallo, Bruno Berardino, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Lanfranco D’Elia, Giovambattista Desideri, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Egidio Imbalzano, Luciano Lippa, Francesca Mallamaci, Alessandro Maloberti, Stefano Masi, Maria Masulli, Alberto Mazza, Alessandro Mengozzi, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Agostino Virdis, Massimo Volpe, Claudio Borghi, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

“…Finally, IR and GFR-adjusted hyperuricemia showed an additive effect on CV mortality. Conclusions Both IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. …”
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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…Mechanistically, sorafenib promoted the effect and fatty acid uptake ability of MDSCs and modulated peroxisome proliferator-activated receptor α (PPARα)-mediated fatty acid oxidation (FAO). In addition, tumor-bearing mice fed a high-fat diet (HFD) at the beginning of sorafenib administration had worse outcomes than mice fed a regular diet. …”
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Autoantibodies in type 1 diabetes: Prevalence and clinical profiles by Raja Hazime, Saad Lamjadli, Morad Guennouni, Mounir Belkrachni, Fatima-Ezzohra Eddehbi, Ider Oujamaa, Lahcen Elmoumou, Aicha Bourrahouate, Imane Ait Sab, Hicham Baizri, Nawal El Ansari, Brahim Admou

“…Among the positive cases, GAD65 antibodies were the most prevalent at 37.31 %, followed by anti-insulin and anti-ZnT8 antibodies, each at 36.59 %, and anti-IA2 at 28.62 %. Additionally, 45,67 % of patients had one a-Abs, 28.36 % had a two, 21.15 % had three, and 4.8 % had all four a-Abs.A statistically significant difference was observed between the seropositive and seronegative groups regarding the presence of associated autoimmune diseases (p = 0.005). …”
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Activated B Lymphocyte Inhibited the Osteoblastogenesis of Bone Mesenchymal Stem Cells by Notch Signaling by Mengxue Pan, Wei Hong, Ye Yao, Xiaoxue Gao, Yi Zhou, Guoxiang Fu, Yuanchuang Li, Qiang Guo, Xinxin Rao, Peiyuan Tang, Shengzhi Chen, Weifang Jin, Guoqiang Hua, Jianjun Gao, Xiaoya Xu

“…Osteoporosis happened in OVX rats, more serious in SPX-OVX rats, B lymphocytes increased in OVX rats, and sharply higher in SPX-OVX rats. Osteoporosis did not happen in SPX rats which is still companied with a high increase of B lymphocytes. …”
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Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations by Hannah Schmieg, Hermann Ferling, Karina Annika Bucher, Stefanie Jacob, Julia Regnery, Hannah Schrader, Julia Schwaiger, Anton Friesen

“…In the 60 days-experiment, brodifacoum doses ≥ 100 µg/kg body weight caused additionally discoloration, apathy, and anorexia, resulting in reduced weight gain, and ultimately mortality. …”
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Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…In MG6 cells, testosterone treatment upregulated the expression of several miRNAs enriched in male microglia, particularly those targeting genes related to fatty acid synthesis. Additionally, testosterone significantly reduced the gene expression of fatty acid synthase (FASN). …”
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Kinetic simulation of uranium migration in granite fissure media of beishan, gansu, China: A case study based on the Laplace transform and inverse transform methods by Xianzhe Duan, Cong Du, Nan Li, Jiaxin Duan, Zhenping Tang

“…The following insights were obtained: (1) After 100,000 years, U-238 has a very limited diffusion depth in the matrix domain, with a diffusion range of only a few tens of millimeters, whereas it migrates relatively quickly in the fissure domain, with a maximum migration distance of about 1500 m. (2) Under the same migration time and distance, the relative concentration of nuclide U-238 in the fissure domain increases with larger gap width, hydraulic gradient, and diffusible area ratio, but decreases with higher rock porosity. (3) In the same time range, the rock masses with larger gap widths, hydraulic gradients, and diffusible area ratios have larger migration ranges, while those with higher porosities have smaller migration ranges. (4) While selecting a site for diposal of HLWs, it is recommended to choose rock masses in the granite area of Beishan with no fissures or few fissures; additionally, areas with smaller fissure widths, hydraulic gradients, and diffusible area ratios but higher rock porosity should be prioritized. …”
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Effect of Cu content on microstructure and high-temperature oxidation behaviors of AlCuxCoCrFeNi2.1 high-entropy alloys manufactured by laser directed energy deposition by Zhaoyang Liu, Jiawei Liu, Xiaokang Fan, Tao Zou, Zhongwei Liang

“…In this study, thin-wall builds of AlCuxCoCrFeNi2.1 (x = 0.00, 0.25, 0.50, 0.75, 1.00, 1.25) high-entropy alloys were additively manufactured by laser direct energy deposition process. …”
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Identification of Alzheimer’s Disease Progression Stages Using Topological Measures of Resting-State Functional Connectivity Networks: A Comparative Study by Zhanxiong Wu, Jinhui Wu, Xumin Chen, Xun Li, Jian Shen, Hui Hong

“…A total of 54 subjects from Alzheimer’s Disease Neuroimaging Initiative (ANDI) database, divided into healthy control (HC), mild cognition impairment (MCI), and AD groups, were included in this study. …”
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Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm by Marcos Vinícius Melo de Oliveira, MD, PhD, Alexandre Malta Brandão, MD, PhD, Gina Camillo Rocha Silvestre, BS, Alexandre Queiroz Silva, BS, Michele Alberto Marques, BS, Marcia Martins Reis, PhD, Maria de Lourdes Higuchi, MD, PhD, Erasmo Simão da Silva, MD, PhD

“…Regarding immunohistochemical markers, AAA exhibited more B lymphocyte cells in the adventitia (CD20 1475.50 vs 320; P = .003) compared with PAA. Additionally, AAA demonstrated more adipogenic differentiation in the adventitia (PPARgamma 4854.50 vs 778; P = .009), whereas PAA showed more adipogenic differentiation in the intima (KLF5 283.50 vs 77.50; P = .039). …”
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Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension by Xiao‐ting Tian, Zhou‐yang‐fan Peng, Yu‐si Wu, Yuan‐yuan Cao, Xue‐chun Li, Ying Li, Si‐Yuan Tang, Alex F. Chen, Xiao‐hui Li

“…METHODS AND RESULTS NLRP3 knockout or short hairpin RNA interference of GSDME was performed in PAH animal models to investigate its effect on PAH progression. In addition, the effects of BMPR2 deficiency and restoration of BMPR2 by BMP9 (bone morphogenetic protein 9) or FK506 on pyroptosis were explored both in animal and cell models. …”
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