Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma by Masahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Saya Ozaki, Hideaki Watanabe, Hajime Yano, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda

“…Here, we investigated the existence and functions of GSCs in the tumor periphery, which is considered to constitute the invasion niche for GSCs in GBM, by analyzing expression of stem cell markers and stem cell-related molecules and measuring particular activities of cultured GSCs. In addition, the relationship between GSCs expressing particular stem cell markers and pathological features on MRI and prognosis in GBM patients was analyzed. …”
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Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD by Seong Mi Lee, Yura Choi, Dayeon Kim, Ha Jin Jeong, Young Ho Do, Sohee Jung, Bomee Lee, Hyung Jun Choi, Suhyeon Kim, Jung-Min Oh, Songhee Jeon, Jinju Han, Yeni Kim

“…In Clcn4 KO cortical neurons, the phosphorylation of SYNAPSIN and PSD95 expressions also decreased compared to WT, indicating disrupted synaptic function. Additionally, Sholl analysis revealed a reduction in dendritic branching and neuronal projection length in both mouse and human CLCN4 KD neurons. …”
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New insights into the effects of Aspergillus oryzae administration during the transition period in Bubalus bubalis by Sameh A. Abdelnour, Walaa M. Essawi, Nasser Ghanem, Ibrahim T. El-Ratel, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Ahmed N. F. Neamat-Allah, Shimaa A. Amer, Simon J. Davies, Ali Ali El-Raghi

“…We examined the potential effect of Aspergillus oryzae (ASG) on blood biochemistry, adaptive immunity, milk yield and composition, dry matter intake, inflammation markers, and oxidative stress in buffalo cows. …”
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Structural characterization and immunomodulatory activity of polysaccharides from the flowers of Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb by Honglin He, Haijun Huang, Yunheng Yang, Yi Liu, Ailing Liang, Yao Lei, Chenghuai Tang, Ling Yao, Zhiwei Chen

“…They were characterized by FT-IR, HPGPC, and SEM, with FIC-1 undergoing additional methylation and NMR analysis. FIC-1 was a neutral polysaccharide with a molecular weight of 5.3 kDa, while FIC-2 was an acidic polysaccharide with a molecular weight of 23.3 kDa. …”
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A High-Salt Diet Disturbs the Development and Function of Natural Killer Cells in Mice by Xiaokang Zeng, Yan Li, Weibiao Lv, Xinhuai Dong, Chong Zeng, Liming Zeng, Zibo Wei, Xu Lin, Yanning Ma, Qiang Xiao

“…Therefore, the purpose of the present study was to understand the effects of HSD on the development and function of NK cells, in addition to investigating the underlying molecular mechanism. …”
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Dendriform pulmonary ossification in military combat veterans: A case series by Jeremy T. Hua, Carlyne D. Cool, Tami J. Bang, Silpa D. Krefft, Richard C. Kraus, Cecile S. Rose

“…A high index of clinical suspicion combined with a detailed occupational history may reveal additional exposure-related associations with DPO. Access to large medical databases of military veterans with linkage to exposure histories may further elucidate risk factors for lung injury with ossification, paving the way for targeted prevention.…”
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High-dose dual therapy for Helicobacter pylori eradication inducing less impact on the gut microbiota by Jia-Lun Guan, Ting-Ting Xu, Ya Lin, Yan-Shuai Mo, Bi-Yu He, Ying-Ying Han, Ji-Yan Li, Su-Hong Xia, Ya-Ni Zhou, Jia-Zhi Liao, Pei-Yuan Li

“…Additionally, a greater number of species had alterations in their abundances in the BQT group compared to the HDDT group at week 2. …”
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Role of postoperative radiotherapy in pT3N0 rectal cancer: A risk‐stratification system based on population analyses by Yun‐xia Huang, Yan‐zong Lin, Jin‐luan Li, Xue‐qing Zhang, Li‐rui Tang, Qing‐yang Zhuang, Fei‐fei Lin, Xi‐jin Lin, Jun‐xin Wu

“…Low‐risk patients had better CSS than high‐risk patients (92.13% vs 72.55%, P < 0.001). The addition of radiotherapy to surgery doubled the CSS among the high‐risk patients (42.06% vs 91.26%, P = 0.001) but produced no survival benefit among the low‐risk patients (93.36% vs 96.38%, P = 0.182). …”
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Study of the corrosion behavior of cast Ti2AlNb alloy in HF–HNO3 solution by Yunyun Liu, Xianfei Ding, Lihong Wu, Xin Feng, Jiabin Zuo, Yunan Zhang, Lei Wen

“…Scanning Kelvin probe atomic force microscopy (SKPFM) combined with microstructural analysis revealed that the electrochemical system consisting of matrix B2 phase and secondary phase governs the high localized dissolution rate of Ti2AlNb alloy. Additionally, the segregation of elements at grain boundaries accelerates corrosion, leading to more severe degradation in those regions. …”
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Adult hypophosphatasia presenting with recurrent acute joint pain by Hayao Yoshida, Takaaki Murakami, Atsubumi Ogawa, Takashi Sunouchi, Naoko Hidaka, Nobuaki Ito, Hiromi Murakami, Hidenori Kawasaki, Tomoyuki Akiyama, Katsumi Nakajima, Daisuke Yabe, Taizo Yamamoto

“…., c.979T>C (p.Phe327Leu) and c.1559del (p.Leu520Argfs), confirming HPP. Additional genetic testing of his parents showed a heterozygous c.1559del variant in his father and a heterozygous c.979T>C variant in his mother. …”
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Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2 by Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang

“…Mechanistically, SUMOylation of microglial TRPC1 exacerbated neutrophil infiltration into the peri-infarct area. Additionally, SUMOylated TRPC1 activates the Nod-like receptor protein (NLRP) 3 signaling pathway in microglia and stimulates multiple CC-chemokine ligands and C-X-C motif ligand chemokines after MCAO/R. …”
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Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study by Zhuyuan Zheng, Shaojie Yang, Wanlin Dai, Yang Sun, Jingnan Wang, Xiaolin Zhang, Yiming Zheng, Jing Kong

“…A two-sample MR analysis was conducted to infer causality. Additionally, multiple sensitivity analyses were conducted to assess the heterogeneity, horizontal pleiotropy, and robustness of the MR findings. …”
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Navigating the future of agri-food supply chain: A conceptual framework using bibliometric review by Abdul Kafi, Nizamuddin bin Zainuddin, Mohd Fitri Mansor, Mohamed Najib Bin Salleh, Adam bin Mohd Saifudin, Nurhaizal Azam Arif, Syairah Aimi Shahron, Ravi Ramasamy, Ibrahim Hassan mohamud

“…Co-occurrence analysis was conducted to identify seven core research themes, namely: agri-food supply chain system; agri-food supply chain management; agri-food supply chain industry; agri-food supply chain risk factors; agri-food supply chain information; agri-food supply chain advancement; agri-food supply chain risk management; This study makes a significant contribution by constructing a comprehensive conceptual framework that logically organizes these thematic factors, aligning future research with emerging trends. Additionally, this research highlights the imperative of global collaboration across diverse regions and fields within AFSC to build more resilient supply chains capable of adapting to evolving conditions.…”
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Exploring the Impact of Citric Acid on Mitigating Sweet Potato Soft Rot and Enhancing Postharvest Quality by Yixi Chen, Linjiang Pang, Jiacheng Bai, Wenbao Yu, Yueming Zhu, Melvin Sidikie George, Zunfu Lv, Guoquan Lu

“…Citric acid (CAC) is a ubiquitous, odorless, and non-toxic food additive. Soft rot, caused by the pathogen <i>Rhizopus stolonifer</i>, is a major postharvest disease affecting sweet potato (<i>Ipomoea batatas</i> (L.) …”
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Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice by Qi Li, Chenyi Wu, Zhenlong Liu, Huiqing Zhang, Yuna Du, Yuxiang Liu, Kuangyu Song, Qiaofa Shi, Rong Li

“…Our results showed more aggravated kidney damage in CD38−/− mice than in WT mice, accompanied with an increase of proinflammatory cytokine expression. In addition, compared with CD38−/−TLR4mut mice, we found an increase of TLR4 expression and mRNA expression of these cytokines in the kidney of CD38−/− mice, although only increased IFN-γ level was detected in the serum. …”
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Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1 by Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete

“…We determined that the observed pro-inflammatory effect was ALPK1-dependent in both HEK293 and HT-29 cells and that the released F. nucleatum molecule had characteristics that match those of the pro-inflammatory ALPK1 ligand ADP-heptose or related heptose phosphates. In addition, we determined that not only F. nucleatum promoted an ALPK1-dependent pro-inflammatory environment but also other Fusobacterium species such as F. varium, F. necrophorum and F. gonidiaformans generated similar effects, indicating that ADP-heptose or related heptose phosphate secretion is a conserved feature of the Fusobacterium genus. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…In vitro, HG treatment increased the migration of HK-2 cells while reducing their viability and proliferation rate, and treatment with Ori reversed these changes. Additionally, the knockdown of β-catenin arrested cell migration and reduced the expression levels of Wnt/β-catenin signaling-related molecules (Wnt4, p-GSK3β and β-catenin) and fibrosis-related molecules (α-smooth muscle actin, collagen I and fibronectin), and Ori treatment exerted an effect similar to that observed after the knockdown of β-catenin. …”
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Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

“…Further experiments indicate that AKT inhibition can reverse the lipid metabolism disorders and inflammatory responses caused by MT1B downregulation. Additionally, Zinc can promote the nuclear translocation of MTF1, leading to its binding to the MT1B promoter, thereby upregulating MT1B expression and ultimately mitigating MASH progression. …”
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Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis by José Alberto Choreño-Parra, Luis Armando Jiménez-Álvarez, Ellis Daniela Maldonado-Díaz, Graciela Cárdenas, Luis Alejandro Fernández-Lopez, José Luis Soto-Hernandez, Marcela Muñoz-Torrico, Gustavo Ramírez-Martínez, Alfredo Cruz-Lagunas, Armando Vega-López, María Lilia Domínguez-López, Carlos Sánchez-Garibay, Parménides Guadarrama-Ortíz, Silvia Giono, Luis Antonio Jiménez-Zamudio, Shabaana A. Khader, Ethel A. García-Latorre, Citlaltepetl Salinas-Lara, Joaquín Zúñiga

“…We found that NK cells from TBM patients showed lower absolute frequencies, higher CD69 expression, and poor expansion of the CD45RO+ memory-like subpopulation upon Mtb exposure in vitro compared to LTBI individuals. In addition, a reduction in the frequency of CD56brightCD16- NK cells characterized TBM patients but not LTBI or PTB subjects. …”
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Prediction of microvascular obstruction from angio-based microvascular resistance and available clinical data in percutaneous coronary intervention: an explainable machine learning... by Zhe Zhang, Yang Dai, Peng Xue, Xue Bao, Xinbo Bai, Shiyang Qiao, Yuan Gao, Xuemei Guo, Yanan Xue, Qing Dai, Biao Xu, Lina Kang

“…The ML workflow comprised feature selection using the Boruta algorithm, model construction with seven classifiers, hyperparameter optimization via ten-fold cross-validation, model comparison based on the area under the curve (AUC), and a Shapley additive explanations (SHAP) analysis to analyze the significance of different features. 32.29% of patients showed inconsistency between AMR and MVO, but we successfully constructed a predictive model for MVO. …”
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