Elucidating stearoyl metabolism and NCOA4-mediated ferroptosis in gastric cancer liver metastasis through multi-omics single-cell integrative mendelian analysis: advancing personal... by Zhongqiu Yang, Yuquan Chen, Yaping Miao, Haisheng Yan, Kexin Chen, Yaoqin Xu, Lanqian Su, Lanyue Zhang, Yalan Yan, Hao Chi, Jin Fu, Lexin Wang

“…Conclusion This study enhances the understanding of the relationship between stearoyl metabolism and ferroptosis in promoting liver metastasis of gastric cancer and its role in the regulation of tumor heterogeneity. In addition, this study contributes to a deeper understanding of the dynamics of gastric cancer tumor microenvironment (TME) and provides a basis for the development of better interventions to combat cancer metastasis.…”
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A Lightweight YOLO Model for Rice Panicle Detection in Fields Based on UAV Aerial Images by Zixuan Song, Songtao Ban, Dong Hu, Mengyuan Xu, Tao Yuan, Xiuguo Zheng, Huifeng Sun, Sheng Zhou, Minglu Tian, Linyi Li

“…However, intensive planting, complex growth environments, and the overlapping of rice panicles and leaves in paddy fields pose significant challenges for precise panicle detection. …”
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Control of two-spotted spider mite, Tetranychus urticae, on strawberry by integrating with cyetpyrafen and Phytoseiulus persimilis by Shan Zhao, Qiuyu Zhao, Xiaoyan Dai, Bing Lv, Ruijuan Wang, Zhenjuan Yin, Feng Zhang, Yan Liu, Long Su, Hao Chen, Li Zheng, Hongmei Li, Lixia Xie, Yifan Zhai

“…The results suggested that cyetpyrafen revealed no substantial differences in prey consumption or longevity when compared to the control, though minor effects on the development durations of protonymphs and deutonymphs were noted in the subsequent generation. Additionally, cyetpyrafen's toxicity on key pollinators, such as Apis mellifera and Bombus terrestris, was found to be low. …”
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Machine Learning Model Reveals Land Use and Climate’s Role in Caatinga Wildfires: Present and Future Scenarios by Rodrigo N. Vasconcelos, Mariana M. M. de Santana, Diego P. Costa, Soltan G. Duverger, Jefferson Ferreira-Ferreira, Mariana Oliveira, Leonardo da Silva Barbosa, Carlos Leandro Cordeiro, Washington J. S. Franca Rocha

“…Future research should incorporate additional variables, such as vegetation recovery and socio-economic factors, to refine predictions. …”
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A comprehensive review on eutectic phase change materials: Development, thermophysical properties, thermal stability, reliability, and applications by Abhishek Anand, Muhamad Mansor, Kamal Sharma, Amritanshu Shukla, Atul Sharma, Md Irfanul Haque Siddiqui, Kishor Kumar Sadasivuni, Neeraj Priyadarshi, Bhekisipho Twala

“…The low thermal conductivity of organic eutectics can be eliminated with suitable nanoparticle additives. The leakage issue can be eliminated by providing shape stabilization to the PCMs. …”
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Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis by Shuji Kanmura, Akihito Tanaka, Kazuki Yutsudou, Kosuke Kuwazuru, Fukiko Komaki, Yuga Komaki, Hiromichi Iwaya, Shiho Arima, Fumisato Sasaki, Shiroh Tanoue, Shinichi Hashimoto, Akio Ido

“…We assessed the correlation between orange-like color lesion (defined as LCI-scarlet color lesions) and clinical relapse rate (requiring additional treatment for UC) during the 1-year follow-up period. …”
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Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation by Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu

“…The co-occurrence of keywords and co-cited references were analyzed using CiteSpace6.1.R6 software to generate visualization maps. Additionally, burst detection was applied to keywords and cited references to forecast research hotspots and future trends.Results Our search yielded 7462 publications, with the American Journal of Physiology-Renal Physiology contributing the most articles. …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Results We observed a significant reduction in CD8αα + IELs, accompanied by a marked increase in CD8αβ + IELs in Lpr mice. Additionally, subsets of CD8 + IELs exhibiting significantly enhanced effector functions were found to be markedly enriched in Lpr mice. …”
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Effect of custom-designed transfection buffer on delivery of genome modification components into primary cells of buffalo, cattle, goats, and sheep by Shreya Malhotra, Priyanka Singh, Aseem Tara, Bosco Jose, Devika Gautam, Ram Prasad, Gaurav Tripathi, Sacchinandan De, Naresh L. Selokar

“…We also noticed that cell viability and proliferation rates were better in the case of goats, sheep, and cattle cells; also, these cells have less vacuolation than buffalo cells. In addition, we also generated MSTN (myostatin) KO (Knockout) cell clones from these cell populations, in which the efficiency of single-cell clone generation was high for goats and sheep cells. …”
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Occupational exposure to flame retardants following production replacement and their effect on thyroid function indicators by Ling Meng, Tingting Guo, Yizhi Liu, Han Wu, Kang An, Xizhu Xu, Yuancheng Li

“…The results showed that the detection frequencies of only triphenyl phosphate (TPHP), BDE-138 and BDE-197 (82.4 %, 61.2 % and 60.6 %, respectively) exceeded 60 % among the 34 compounds of interest, while the median concentrations of BDE-138 and BDE-197 were much higher than TPHP (medians of 103.6, 60.6 and 20.5 ng/g lw, respectively). In addition, the concentrations of these compounds in exposed group are higher than those in the control group (P < 0.05). …”
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Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations by Lucas Tricoli, Sunetra Sase, Julia L. Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife Roche, John Everett, Frederic Bushman, Peter Kurre, Rebecca Ahrens-Nicklas, Laura A. Adang, Adeline L. Vanderver, Stefano Rivella

“…To address this need, we increased the expression of ARSA cDNA at single integration by generating novel LVs, optimizing ARSA expression and enhancing safety. In addition, our vectors achieved optimal transduction in mouse and human hematopoietic stem cells (HSCs) with minimal multiplicity of infection (MOI). …”
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Association of multiple environmental exposures with rhinitis and asthma symptoms in preschool children: Identifying critical risk factor by Shuang Du, Hao Tang, Han Chen, Yang Shen, Zhiping Niu, Tianyi Chen, Jing Wei, Xia Meng, Wen Su, Qun Wu, Yongqiang Tan, Jing Cai, Zhuohui Zhao

“…Random forest ranking analysis further corroborated the most significant environmental exposure for rhinitis alone was PM1, and for wheezing symptoms (both wheezing &amp; rhinitis and wheezing alone) was NO2. Significant additive and multiplicative interactions were examined between indoor dampness and PM1 exposure on rhinitis alone. …”
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Cognitive control in individuals with heroin use disorder after prolonged methadone maintenance treatment by Wei Zhao, Fan Duan, Xiangyu Li, Junda Li, Lingling Xia, Zixuan Ren, Yegang Li, Li Song, Peipei Song, Linlin Mu, Lijin Wang, Jing Zhang, Xun Song, Ze Wang, Jinxuan Chen, Xiaochu Zhang, Dongliang Jiao

“…Results HUD individuals exhibited worse saccade error rate and executive dysfunction but showed no significant impairment in prospective memory. Additionally, the relapsers performed worse in terms of antisaccade amplitude and velocity at higher difficulty gradients (11° or 16°). …”
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Patients’ acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualita... by Tempei Miyaji, Yosuke Uchitomi, Hiroyuki Okada, Masatoshi Inagaki, Maiko Fujimori, Taichi Shimazu, Masaki Fujiwara, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Hirokazu Takahashi, Naoki Nakaya, Shiro Hinotsu, Keita Harada, Norihito Yamada, Yuto Yamada, Tsuyoshi Etoh

“…Interviews were conducted with patients who received the intervention and staff from two psychiatric hospitals in Japan who delivered the intervention.Participants Of the 172 patients with schizophrenia who participated in the trial, 153 were included. In addition, three out of six providers were included.Data collection and analysis Using a structured interview, the case manager asked participants about patient acceptability and the helpful components of the intervention. …”
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AaMYB61-like and AabHLH137 jointly regulate anthocyanin biosynthesis in Actinidia arguta by Zhe Song, Yukuo Li, Xu Zhan, Xiaohan Li, Lingshuai Ye, Miaomiao Lin, Ran Wang, Leiming Sun, Jinyong Chen, Jinbao Fang, Feng Wei, Xiujuan Qi

“…Y1H and LUC assays revealed that AaMYB61-like activates the promoters of AaCHS, AaLDOX, and AaF3GT. In addition, AabHLH137 was found to be related to fruit color from the transcriptome data. …”
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Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences by Pål Møller, Aysel Ahadova, Matthias Kloor, Toni T. Seppälä, John Burn, Saskia Haupt, Finlay Macrae, Mev Dominguez-Valentin, Gabriela Möslein, Annika Lindblom, Lone sunde, Ingrid Winship, Gabriel Capella, Kevin Monahan, Daniel D. Buchanan, D. Gareth Evans, Eivind Hovig, Julian R. Sampson

“…In path_APC carriers, second hits result in the development of multiple adenomas, with CRC typically emerging after an additional 20 years. In path_MLH1 and path_MSH2 carriers, second hits lead to the formation of microscopically detectable, microsatellite unstable (MSI) crypts, from which CRC develops in about half of carriers over their lifetime, often without progressing through a diagnosable adenoma stage. …”
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Dysmenorrhea Among Women Living in Saudi Arabia: Prevalence, Determinants, and Impact by Mohammad A. Jareebi, Saja A. Almraysi, Dhiyaa A. H. Otayf, Ghadeer A. Alneel, Areej H. Zughaibi, Sarah J. Mobarki, Imtenan A. Oberi, Hayam A. Alzahrani, Shatha A. Aldhowaihi, Zainab A. Alramadhan, Majed A. Ryani, Ahmed A. Bahri, Nuha H. Abutalib, Nada M. Makein, Ahmad Y. Alqassim

“…Descriptive and inferential statistics were utilized to evaluate the prevalence, severity, and associated symptoms of dysmenorrhea. Additionally, multiple logistic regression was employed to identify the determinants of dysmenorrhea within the sample. …”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…Secondary objectives include assessment of overall survival, response rate, safety and quality of life measures. Two additional therapeutic arms are currently in development.Ethics and dissemination Central ethics approval was obtained from the Sydney Local Health District Ethics Review Committee, Royal Prince Alfred Hospital Zone, Sydney, Australia (Approval: 2022/ETH02230). …”
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Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (<i>Pinus densiflora</i>) in Sprague-Dawley Rats with Loperamide-Induced Constipation by Hee-Jin Song, Ayun Seol, Jumin Park, Ji-Eun Kim, Tae-Ryeol Kim, Ki-Ho Park, Eun-Seo Park, Su-Jeong Lim, Su-Ha Wang, Ji-Eun Sung, Youngwoo Choi, Heeseob Lee, Dae-Youn Hwang

“…MPC contained several bioactive compounds, including diterpenoid compounds such as dehydroabietic acid, taxodone, and ferruginol. In addition, it exhibited high scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals. …”
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Effectiveness of a harmonica-integrated, tele-supervised home-based pulmonary rehabilitation program on lung function and comprehensive health outcomes in patients with chronic obs... by Qiuxuan Zeng, Xiaohong Lin, Wenli Chen, Daniel Yee Tak Fong, Junxin Li, Jiaying Li, Jiaying Li

“…The intervention will incorporate harmonica sessions in addition to standard PR exercises (breathing and physical exercises). …”
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