Cartilage structure-inspired nanofiber-hydrogel composite with robust proliferation and stable chondral lineage-specific differentiation function to orchestrate cartilage regenerat... by Yaqiang Li, Xiaowei Xun, Liang Duan, Erji Gao, Jiaxin Li, Lei Lin, Xinping Li, Aijuan He, Haiyong Ao, Yong Xu, Huitang Xia

“…To address these issues, we developed a nanofiber-hydrogel composite with superior mechanical performance by incorporating fragment oxidized bacterial cellulose (BC) nanofibers into a gelatin methacryloyl (GelMA) hydrogel network. Additionally, a biomaterial system was developed based on this composite, featuring dual-release functionality of fibroblast growth factor (FGF) and transforming growth factor beta (TGF-β) to facilitate step-wise maturation of neo-cartilage tissue. …”
Get full text

Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice by Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang

“…Inflammatory factors (TNF-α, IL-1β, and IL-6) in the intestinal tissue were examined by ELISA and RT-PCR. In addition, expressions of autophagy markers (microtubule-associated light chain 3 (LC3) and Beclin-1) were detected by western blot and RT-PCR. …”
Get full text

Possible accumulation of emerging contaminants of concern in treated wastewater on the soil plant system of a processing tomato-wheat succession by Giuseppe Gatta, Federica Carucci, Anna Gagliardi, Michele Perniola, Michele Denora, Francesco De Mastro, Gennaro Brunetti, Sapia Murgolo, Cristina De Ceglie, Alfieri Pollice, Marcella Michela Giuliani

“…However, its use can pose significant risks due to the potential presence of emerging contaminants of concern (ECCs), including personal care products, pesticides, food additives, and pharmaceuticals. This study aimed to evaluate the impact of irrigation with TWW on the accumulation of ECCs within the soil-plant system during a processing tomato (Solanum lycopersicum L.)…”
Get full text

AI-based carbon peak prediction and energy transition optimization for thermal power industry in energy-intensive regions of China by Chenhao Huang, Zhongyang Lin, Jian Wu, Penghan Li, Chaofeng Zhang, Yanzhao Liu, Weirong Chen, Xin Xu, Jinsong Deng

“…The results showed that, compared to the baseline, the carbon peak under the Economic Development Scenario will be delayed by three years, with an additional 92.74 Mt CO2; while under the Environmental Protection and Energy Transition Scenarios, the peak will be advanced by five and three years, with 106.48 and 73.86 Mt CO2 reductions, respectively. …”
Get full text

Reverberation Evidence for Stream Collision and Delayed Disk Formation in Tidal Disruption Events by Hengxiao Guo, Jingbo Sun, Shuangliang Li, Yan-Fei Jiang, Tinggui Wang, Defu Bu, Ning Jiang, Yanan Wang, Yuhan Yao, Rongfeng Shen, Minfeng Gu, Mouyuan Sun

“…Moreover, X-ray emissions are not only significantly delayed relative to the primary UV/optical peak but also lag behind the rebrightening bump by up to several tens of days, completely different from the X-ray illumination reprocessing. Additionally, the anticorrelated UV−optical continuum in ASASSN-15lh further disfavors the reprocessing scenario. …”
Get full text

Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial by Mark Conaway, David R Boulware, Scott K Heysell, Stellah G Mpagama, Christopher C Moore, Alphonce Liyoyo, Conrad Muzoora, Catherine Gitige, Bibie Said, Edwin Nuwagira, Rinah Arinaitwe, Rhina Mushagara, Peter Buzaare, Anna Chongolo, Samuel Jjunju, Precious Twesigye, Megan Null, Tania A Thomas

“…Accordingly, this multisite randomised clinical trial aims to determine whether immediate and/or increased dose anti-TB therapy improves 28-day mortality for participants with HIV and sepsis in Tanzania or Uganda.Methods and analysis This is a phase 3, multisite, open-label, randomised controlled clinical 2×2 factorial superiority trial of (1) immediate initiation of anti-TB therapy and (2) sepsis-specific dose anti-TB therapy in addition to standard of care antibacterials for adults with HIV and sepsis admitted to hospital in Tanzania or Uganda. …”
Get full text

Epigallocatechin gallate (EGCG) modulates senescent endothelial cell-monocyte communication in age-related vascular inflammation by Sarvatit Patel, Kai Ellis, Kai Ellis, Corey A. Scipione, Jason E. Fish, Jason E. Fish, Jason E. Fish, Jason E. Fish, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe

“…Monocytes co-cultured with EGCG-treated senescent ECs showed decreased pro-inflammatory responses compared to those co-cultured with untreated senescent ECs. Additionally, senescent ECs produced more EVs than non-senescent ECs. …”
Get full text

Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal Cancer Patients by Yushi Nagaki, MD, PhD, Satoru Motoyama, MD, PhD, Yusuke Sato, MD, PhD, Akiyuki Wakita, MD, PhD, Hiromu Fujita, MD, PhD, Kohei Kemuriyama, MD, Ryohei Sasamori, MD, Shu Nozaki, MD, Kyoko Nomura, MD, PhD, Yoshihiro Minamiya, MD, PhD

“…There have been several recent reports showing the efficacy of immune check-point inhibitors (ICIs) against esophageal cancer, especially immunologically hot tumors. In addition, several studies have suggested that chemotherapy and radiotherapy may convert cold tumors to hot tumors. …”
Get full text

Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer by Yaojun Ren, Min Xue, Xinhui Hui, Xiuyu Liu, Muhammad Asad Farooq, Yiran Chen, Yuzhou Ji, Yixin Duan, Iqra Ajmal, Jie Yao, Wenzheng Jiang

“…Natural killer (NK) cells play a crucial role in the body’s anti-cancer defense, and chimeric antigen receptor (CAR)–NK cell therapy is gaining attention as a cutting-edge and promising treatment method. …”
Get full text

Ion beam induced secondary electron tomography of acrylonitrile-styrene-acrylate/polycarbonate polymer blends for fused filament fabrication and injection moulding by J. Hernández-Saz, D. Moreno-Sanchez, L. M. Valencia, Y. Gómez, S. I. Molina, M. Herrera

“…For this, ion beam induced secondary electron (iSE) images show the capability to distinguish unequivocally the two phases in the blend, providing enough contrasts to perform the 3D experiment. Additionally, Monte Carlo simulations show that the lateral spread for incident electrons in PC is 61.7 nm and for Ga+ ions of 26.2 nm, evidencing a better spatial resolution in iSE imaging. …”
Get full text

Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelinationResearch in context by Jian Huang, Jinyi Che, Michelle Z.L. Kee, Ai Peng Tan, Evelyn C. Law, Patricia Pelufo Silveira, Irina Pokhvisneva, Sachin Patel, Keith M. Godfrey, Lourdes Mary Daniel, Kok Hian Tan, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Dennis Wang, Jonathan Yinhao Huang

“…Polygenic risk for obesity was nominally associated with EFNA4 and VWC2 expression. However, we did not find support for mediating mechanisms via these proteins. …”
Get full text

Cost-Effectiveness of Bariatric Surgery versus Medication Therapy for Obese Patients with Type 2 Diabetes in China: A Markov Analysis by Bin Wan, Nan Fang, Wei Guan, Haixia Ding, Ying Wang, Xin Ge, Hui Liang, Xin Li, Yiyang Zhan

“…Bariatric surgery was associated with a mean health-care savings of 26,869.39 CNY and 2.51 additional QALYs per patient compared to medication therapy. …”
Get full text

Adaptive Autophagy Offers Cardiorenal Protection in Rats with Acute Myocardial Infarction by Zhendong Feng, Han Xue Jiang, Huiyang Chen, Yu Ning Liu, Yahui Wang, Rui Bing Yang, Xueting Han, Chen Hui Xia, Ze Bing Zhu, Hongcai Shang, Aiming Wu, Wei Jing Liu

“…In addition, 3-MA markedly increased KIM1, NGAL, and the activity of caspase-3 in the hypoxic HK-2 and AC16 cell. …”
Get full text

Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer by Anne Meunier, Javier Alejandro Hernández-Castro, Nicholas Chahley, Laudine Communal, Sara Kheireddine, Newsha Koushki, Nadia Davoudvandi, Sara Al Habyan, Benjamin Péant, Anthoula Lazaris, Andy Ng, Teodor Veres, Luke McCaffrey, Diane Provencher, Peter Metrakos, Anne-Marie Mes-Masson, David Juncker

“…Conclusions GµF uncovers the unexpected prevalence and frequency of cCTCs including sometimes very large ones in epithelial ovarian cancer patients, and motivates additional studies to uncover their properties and role in disease progression.…”
Get full text

Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates by Yong Xie, Songsong Xu, Yufei Xi, Zixin Li, Erwei Zuo, Kai Xing, Lijing Bai, Kui Li

“…Interestingly, we found that the abundance of microbiota belonging to Bacteroidetes increased gradually while the members from Proteobacteria showed a decreasing trend from high‐ to low‐latitude zones, potentially contributing to vertebrate adaptation to local climate condition. Additionally, we comprehensively deciphered the common antibiotic resistomes and their potential mobility between terrestrial vertebrate gut microbiome (n = 487) and their sympatric soil biological environment samples (n = 203) by integrating metagenomic sequencing datasets. …”
Get full text

High serum CA19-9 predicts severe cholecystitis in calculous cholecystitis patients by Shouwen Wang, Dachen Zhou, Wanjin Chen, Qi Guo, Liujin Hou, Ruolin Wu, Wei Wang, Muhammad Annus Khan, Muhammad Ahmad, Fan Huang, Meijuan Zheng, Guobin Wang, Hongchuan Zhao, Xiaoping Geng, Xiaojun Yu

“…But WBC, neutrophils count, NLR, CRP level and IL-6 level is higher in high group than that of normal group. In addition, the gallbladder wall thickness, the operation duration and the operation conversion rate is also higher in high group, which is verified from second hospital. …”
Get full text

Reverberation Mapping of Two Variable Active Galactic Nuclei: Probing the Distinct Characteristics of the Inner and Outer Broad-line Regions by Hai-Cheng Feng, Sha-Sha Li, J. M. Bai, H. T. Liu, Kai-Xing Lu, Yu-Xuan Pang, Mouyuan Sun, Jian-Guo Wang, Yerong Xu, Yang-Wei Zhang, Shuying Zhou

“…We discuss these findings in the context of various BLR formation models, highlighting the importance of long-term, multiline RM campaigns in understanding of BLR structure and evolution. Additionally, our results suggest that the observed stratification in BLR geometry and kinematics may contribute to the scatter in black hole mass estimates and the rapid changes in velocity-resolved RM signatures reported in recent studies.…”
Get full text

Internet-based cognitive–behavioural therapy for insomnia (ICBT-i): a meta-analysis of randomised controlled trials by Jia Chen, Juan Liu, Yuan-yuan Ye, Ni-ka Chen, Ling Lin, Ya-zhen Liu, Ying Lang, Xun-jun Li, Xin-ju Yang, Xiao-jiang Jiang

“…The meta-analysis indicated that, at the post-test time point, SOL decreased by 18.41 min (95% CI 13.60 to 23.21), TST increased by 22.30 min (95% CI 16.38 to 28.23), SE increased by 9.58% (95% CI 7.30% to 11.85%), WASO decreased by 22.31 min (95% CI 13.50 to 31.11), NWAK decreased by 0.52 (95% CI 0.28 to 0.76), and ISI decreased by 5.88 points (95% CI 4.29 to 7.46). Additionally SOL, TST, SE, and WASO exhibited statistically significant improvements at follow-up versus before treatment.Conclusions ICBT-i is an effective treatment for adults with insomnia. …”
Get full text

Edible Coatings Enhance Storability and Preserve Quality of Kiwiberry (<i>Actinidia arguta</i> L.) cv. Ken’s Red by Adriana C. Guerreiro, Custódia Gago, Dário Passos, Jaime Martins, Sandra Cruz, Fernão Veloso, Rui Guerra, Maria D. Antunes

Subjects: “…hardy kiwi…”
Get full text

Sweet Potato Peel Pectin's Potential as a Suspending Agent in Pharmaceutical Formulations: The Effect of Extraction Technique by Frederick William Akuffo Owusu, Prince George jnr Acquah, Mariam El Boakye-Gyasi, Raphael Johnson, Marcel Tunkumgnen Bayor, Desmond Asamoah Bruce Otu, Samuel Nartey, Pearl Osei Akoto

“…The proximate composition, FTIR spectra, secondary metabolites and degree of esterification were determined. Additionally, different concentrations (1% and 2%) of the pectins were utilised in formulating paracetamol suspensions using acacia gum as the reference and assessed for pharmaceutical quality. …”
Get full text