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51741
Provision of Managerial Skills by Micro Credit Institutions and Sustainability of MSMEs During COVID-19 Pandemic in Kigezi Region South Western Uganda
Published 2022“…Descriptive and cross-sectional surveys, as well as an additional interview, were used in the study to collect data from various MSMEs records and panel procedures. …”
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51742
Systematic Review and Meta-Analysis on Human African Trypanocide Resistance
Published 2023“…Results: Pentamidine/melarsoprol/nifurtimox cross-resistance is associated with loss of the T. brucei adenosine transporter 1/purine 2 gene (TbAT1/P2), aquaglyceroporins (TbAQP) 2 and 3, followed by the high affinity pentamidine melarsoprol transporter (HAPT) 1. In addition, the loss of the amino acid transporter (AAT) 6 is associated with eflornithine resistance. …”
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51743
Agricultural Innovation Characteristics and Their Utilisation: A Case of National Agricultural Research Organization
Published 2023“…The results also indicated that that there was a positive significant relationship between the attribute/characteristics of the varieties and the extent of utilization of varieties. In addition, regression results indicated that innovation characteristics such as relative xii advantage, compatibility, triability and, other variables such as gender, age, education had a significant effect (p<0.05) on innovation utilization by farming communities. …”
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51744
Combining a WT1 Vaccine (Galinpepimut-S) With Checkpoint Inhibition (Nivolumab) in Patients With WT1–Expressing Diffuse Pleural Mesothelioma: A Phase 1 Study
Published 2025-01-01“…Patients received two doses of GPS followed by six doses of GPS with intravenous nivolumab every 2 weeks, and up to six additional cycles until disease progression or unacceptable toxicity. …”
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51745
Multi-environmental traits selection and farmer's participatory assessment of mean performance and stability of orange-fleshed sweet potato genotypes in Benin
Published 2025-01-01“…The PVS revealed that farmers assigned high importance to yield performance for field evaluation and root dry matter content. In addition, they prioritized many different traits, such as the attractiveness of orange flesh colour and the lower fibrousness of boiled roots. …”
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51746
Theoretical Study of Sphingomyelinases from <i>Entamoeba histolytica</i> and <i>Trichomonas vaginalis</i> Sheds Light on the Evolution of Enzymes Needed for Survival and Colonizati...
Published 2025-01-01“…Cavity blind docking showed that the substrate is pushed outward of the active site when cobalt is bound instead of magnesium ions. Additionally, the structural models of the aSMase6 of <i>E. histolytica</i> showed a loop that is absent from the rest of the aSMases, suggesting that it may be involved in hemolytic activity, as demonstrated experimentally using the recombinant proteins of aSMase4 and aSMase6. …”
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51747
RfxCas13d-mediated inhibition of Circ1647 alleviates renal fibrosis via PI3K/AKT signaling pathway
Published 2024-12-01“…Meanwhile, Immunohistochemistry, qRT-PCR and Western blot were conducted to assess the degree of fibrosis. In addition, overexpressing of Circ1647 in renal tubular epithelial cells (TCMK1) was performed to investigate the underlying mechanisms of Circ1647.Results Our results displayed that electroporation-mediated knockdown of Circ1647 by RfxCas13d knockdown plasmid significantly inhibited renal fibrosis in UUO mice as evidenced by reduced expression of fibronectin and α-SMA (alpha-smooth muscle actin). …”
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51748
Long-term effect of island industrial construction on groundwater health risk
Published 2025-01-01“…The analysis revealed that the contributions of indicators D and L to the uncertainty were the highest. In addition, the diffusion of chemical oxygen demand in the vicinity of pollution sources has a significant impact on uncertainty. …”
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51749
Billing models for measuring nursing care in inpatient and outpatient settings: a scoping review
Published 2025-01-01“…We consulted MEDLINE (Pubmed), CINAHL (EBSCOhost), Web of Science (Clarivate), SCOPUS (Elsevier), ProQuest and Google Scholar, government sites and major international bodies (e.g., National Health Service NHS, World Health Organization WHO). …”
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51750
Efficacy comparison of optimal natural orifice specimen extraction for robotic middle rectal cancer resection in women: transanal or transvaginal orifice
Published 2025-01-01“…Results Anal function, assessed by the Wexner score, was better in the RATV group than in the RATA group (P = 0.034). Additionally, pre-menopausal women in RATV group exhibited superior anal function over those in RATA group (P = 0.031). …”
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51751
Full-length transcriptome analysis of male and female gonads in Japanese Eel (Anguilla japonica)
Published 2025-01-01“…A total of 24,661 unigenes were identified in ovaries and 15,023 in testes, along with genomic regulatory elements such as transcription factors, simple sequence repeats, and long non-coding RNAs. Additionally, 1,210 differentially expressed genes were detected. …”
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51752
Visual and High-Efficiency Secretion of SARS-CoV-2 Nanobodies with <i>Escherichia coli</i>
Published 2025-01-01“…The novel nanobody production system enhances the efficiency of nanobody expression and streamlines the downstream purification process, enabling large-scale, cost-effective nanobody production. In addition, <i>E. coli</i> cells secreting the nanobodies on their surface facilitates screening and characterization of antigen-binding clones.…”
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51753
Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin
Published 2024-07-01“…Our results show that G6-CAR-NK92 cells can effectively kill various tumor cell lines in vitro on which ERp57 is induced or intrinsically expressed, and also exhibit potent antitumor effects in cancer cell-derived xenograft and patient-derived xenograft mouse models. Additionally, the antitumor activity of G6-CAR-NK92 cells is synergistically enhanced by the low-dose ICD-inducible drug OXP.Conclusion Collectively, our findings suggest that ERp57 can be leveraged as a new tumor antigen for CAR-NK targeting, and the resultant CAR-NK cells have the potential to be applied as a broad-spectrum immune cell therapy for various cancers by combining with ICD inducer drugs.…”
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51754
Case report: Chest radiotherapy-induced vertebral fractures in lung cancer patients: a case series and literature review
Published 2025-02-01“…These patients shared common characteristics, including advanced age, a history of heavy smoking, and high radiation doses. Additionally, hypermetabolic activity at the fracture sites necessitated MRI to differentiate these fractures from bone metastases. …”
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51755
Cellular and immune landscape of chronic liver diseases: insights from immunophenotyping
Published 2025-01-01“…Viral hepatitis and peri-tumor samples exhibited higher hepatic B cell counts compared to alcohol-related liver disease. Additionally, chronic liver disease patients showed higher levels of CD57+ T cells, suggestive of T cell differentiation. …”
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51756
Immediate results of the еndovascular aneurysm repair in abdominal aortic aneurysm patients with an unfavorable proximal neck
Published 2020-12-01“…The postoperative period did not differ between the groups. Conclusions. …”
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51757
Broad-line Region Characterization in Dozens of Active Galactic Nuclei Using Small-aperture Telescopes
Published 2025-01-01“…We obtain robust delays for 33/80 objects, allowing us to estimate the broad-line region (BLR) size. Additionally, we measure multiepoch delays for six objects whose scatter per source is smaller than the scatter in the BLR size–luminosity relation. …”
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51758
ViT-Based Face Diagnosis Images Analysis for Schizophrenia Detection
Published 2024-12-01“…The experimental results demonstrate that our method significantly improves SZ detection performance with a 3–10% increase in accuracy scores. Additionally, it is found that facial regions rank in descending order according to importance in SZ detection as eyes, mouth, forehead, cheeks, and nose, which is exactly consistent with the clinical traditional Chinese medicine experience. …”
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51759
Characterization of two iron bullets from the royal ammunition factory of Eugi (Spain)
Published 2018-01-01“…Based on the physical characteristics of the bullets and on the obtained results, it can be concluded that one of the bullets could have been used as a grapeshot projectile and the other one as a bullet for ribauldequins. In addition, calcined ore and slag found in this factory were also analysed. …”
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51760
Hyperosmotic Stress Induces a Specific Pattern for Stress Granule Formation in Human-Induced Pluripotent Stem Cells
Published 2021-01-01“…Moreover, the formation of hyperosmotic SGs in hiPSCs/IMR90-1 was independent of eIF2α phosphorylation and was associated with low apoptosis levels. In addition, a comprehensive proteomics analysis was performed to identify proteins involved in regulating this specific pattern of hyperosmotic SG formation in hiPSCs/IMR90-1. …”
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