Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease by Kyung In Woo, Suk-Woo Yang, Jeong Kyu Lee, Sang In Khwarg, Jin Sook Yoon, Sehyun Baek, Jae Wook Yang, JaeSang Ko, Koung Hoon Kook, Sang Duck Kim, Jun Hyuk Son, Helen Lew, Sung Bok Lee, Jae Woo Jang, Hee Young Choi, Mi Jung Chi

“…In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels and course of disease activity and severity over time.Design This was a multicentre, prospective, observational study.Setting Fifteen tertiary care oculoplastic service centres in Korea.Participants Seventy-six patients with newly diagnosed TED were included and followed up for 12 months.Methods We evaluated clinical characteristics and serum TRAb levels at baseline, 6 and 12 months of TED diagnosis. Additionally, we analysed longitudinal associations between the serum TRAb levels and clinical activity score (CAS), no signs or symptoms, only signs, soft tissue involvement, proptosis, extraocular muscle involvement, corneal involvement, sight loss (NOSPECS) score and proptosis.Results Thyroid-stimulating immunoglobulin (TSI) and TSH-binding inhibitory immunoglobulin (TBII) levels decreased during the 1-year follow-up, whereas disease activity measured using CAS decreased mainly in the first 6 months. …”
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A Study on Dust Storm Pollution and Source Identification in Northwestern China by Hongfei Meng, Feiteng Wang, Guangzu Bai, Huilin Li

“…Backward trajectory analysis using the HYSPLIT model was employed to trace the origins of the dust, while FY-2H satellite data provided high-resolution dust distribution patterns. Additionally, the MAIAC AOD product was used to analyze Aerosol Optical Depth, and concentration-weighted trajectory (CWT) analysis was used to identify key dust source regions. …”
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Comprehensive analysis of causal pathogens and determinants influencing black rot disease development in MD2 pineapples by Manori Kuruppu, Yasmeen Siddiqui, Hala Badr Khalil, Hala Badr Khalil

“…This study was conducted to identify the principal causative pathogen of black rot disease in pineapple from three different regions. In addition, critical factors influencing black rot disease were investigated, such as the minimum inoculum concentration, appropriate storage temperature, and maturity index required to initiate infection. …”
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Choosing the most suitable NGS technology to combine with a standardized viral enrichment protocol for obtaining complete avian orthoreovirus genomes from metagenomic samples by Sonsiray Álvarez-Narváez, Sonsiray Álvarez-Narváez, Telvin L. Harrell, Islam Nour, Sujit K. Mohanty, Steven J. Conrad

“…We used eight clinical isolates of ARV, each previously processed using our published viral genome enrichment protocol. Additionally, we evaluate three assembly methods to determine which provided the most complete and reliable whole genomes: De novo, reference-guided or hybrid. …”
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Valorisation et sauvegarde de l’identité socio-culturelle fang de Guinée Équatoriale et du Gabon dans les romans Herencia de Binendee et le pacte d’Afia by Hope ODIGUI NTOUTOUME & Hubert EDZODZOMO ONDO

“…Bien que complexe, l’identité culturelle fang du Gabon et de Guinée Équatoriale ne déroge pas à ce mécanisme de transmission communément admis dans toute société. Le fang à la fois langue et ethnie transnationale du Gabon, de la Guinée Équatoriale, du Cameroun et de la République Populaire du Congo pour ne citer que ces Nations, est un vecteur essentiel qui unit et consolide les liens socio-culturels prétendument anéantis par la colonisation. …”
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Gastroprotective Effects of Aqueous Extracts of Broccoli Stems on Acute Injury in Rats: A Comprehensive Evaluation of Gastric Function and Inflammatory Responses by Jihye Choi, Yuseong Jang, Hyeon-Gi Paik, Melissa Hyun-Joo Ha, Jungkee Kwon

“…<i>Results</i>: The BSE 250 mg/kg group exhibited significant relief of clinical signs compared to the negative control group. In addition, the BSE 250 mg/kg group showed significant improvements in gastric tissue, including macroscopic reductions in ulcer size and improved overall gastric morphology as assessed through gross examination, as well as microscopic improvements such as reduced inflammation and the restoration of mucosal integrity observed in histopathological analysis. …”
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Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing by Anwen Huang, Jinxiu Wu, Jiakuan Wang, Chengwen Jiao, Yunfei Yang, Huaiwen Xiao, Li Yao

“…Moreover, we pinpointed prognostic genes from immune-related gene (IRGs) sets, developed a prognostic risk model, and executed survival analysis, receiver operating characteristic (ROC) curve analysis, and independent prognostic analysis. Additionally, we assessed the risk for patients categorized into high- and low-risk groups based on the model. …”
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Assessment of stress hyperglycemia ratio to predict all-cause mortality in patients with critical cerebrovascular disease: a retrospective cohort study from the MIMIC-IV database by Yuwen Chen, Jian Xu, Fan He, An’an Huang, Jie Wang, Bingchen Liu, Qucheng Wei

“…Subgroup analysis indicated the association was more pronounced in non-diabetic individuals. Additionally, incorporating SHR into existing models improved both discrimination and reclassification performance. …”
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In vitro evaluation of the immunomodulatory and antibacterial activities of calcitriol (1,25-dihydroxy-vitamin D3) as a potential application for aerobic vaginitis treatment - prel... by Anna Tomusiak-Plebanek, Grażyna Więcek, Edyta Golińska, Magdalena Strus

“…As a result, calcitriol by itself did not exhibit clinically relevant anti-bacterial activity; however, when combined with antibiotics, calcitriol significantly reduced the MIC values. …”
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Genome-wide microsatellite characterization and their marker development and transferability in Broussonetia Species by Xiaowen Jia, Hanyu Li, Ying Han, Lu Wang, Chanjuan Lai, Xi Liu, Pan Li, Zupei Lei, Yonghua Zhang

“…Among the identified genomic SSRs across the three species, short repeat sequences were more abundant, while long repeat sequences constituted a smaller proportion. Additionally, the predominant repeat motifs in the SSRs of the three Broussonetia species were composed of ‘A’ and ‘T’ repeats. …”
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Designing multi-function rapid right angle set slurry compositions for a high pressure-high temperature well by Pooria Kianoush, Mostafa Gomar, Nasser Keshavarz Faraj Khah, Seyednooroldin Hosseini, Ali Kadkhodaie, Shahaab Varkouhi

“…The thermal gradient was 1.62 °F/100 ft, significantly impacting cement performance; elevated temperatures can accelerate hydration reactions, potentially causing strength retrogression. A blend of additives—including 3 % boric acid as a dual-functioning dispersant and 1 % latex materials—enhanced dispersing properties, compressive strength, and gas migration resistance. …”
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Improvement of Citrus Yield Prediction Using UAV Multispectral Images and the CPSO Algorithm by Wenhao Xu, Xiaogang Liu, Jianhua Dong, Jiaqiao Tan, Xulei Wang, Xinle Wang, Lifeng Wu

“…Finally, the Shapley additive explanations (SHAP) method was used to reveal the importance of the normalized difference chlorophyll index (NDCI) and the red band mean feature (MEA_R) when constructing the prediction model. …”
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Anti-SARS-Cov-2 S-RBD IgG Formed after BNT162b2 Vaccination Can Bind C1q and Activate Complement by Anas H. A. Abu-Humaidan, Fatima M. Ahmad, Dima Awajan, Raba’a F. Jarrar, Nader Alaridah

“…The formation of C5b-9 was strongly correlated to C1q binding and not to MBL binding, additionally, the ratio of formed C5b-9/bound C1q was significantly higher in the BNT162b2 group. …”
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Streptococcus halichoeri: Comparative Genomics of an Emerging Pathogen by Kirsi Aaltonen, Ravi Kant, Marjut Eklund, Mirja Raunio-Saarnisto, Lars Paulin, Olli Vapalahti, Thomas Grönthal, Merja Rantala, Tarja Sironen

“…The remaining genes formed the pangenome which was highly variable and would still evolve after additional genomes. The results highlight the great adaptability of this bacterium possibly explaining the ease at which it switches hosts and environments. …”
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Dual-stream disentangled model for microvascular extraction in five datasets from multiple OCTA instruments by Xiaoyang Hu, Xiaoyang Hu, Jinkui Hao, Quanyong Yi, Yitian Zhao, Jiong Zhang

“…The method achieves more refined segmentation performance. In addition, we validated the performance of D2Net on four OCTA datasets (OCTA-500, ROSE-O, ROSE-Z, and ROSE-H) acquired using different instruments, demonstrating its robustness and generalization capabilities in retinal vessel segmentation compared to other state-of-the-art methods.…”
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A novel approach to skin disease segmentation using a visual selective state spatial model with integrated spatial constraints by Yu Bai, Hai Zhou, Hongjie Zhu, Shimin Wen, Binbin Hu, Haotian Li, Huazhang Wang, Daji Ergu, Fangyao Liu

“…Our SSR-UNet model overcomes these challenges by efficiently balancing computational load and feature extraction capabilities. Additionally, we introduce a spatially-constrained loss function that mitigates gradient stability issues by considering the distance between label and prediction boundaries. …”
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Forensic-medical determination of the severity of closed injuries of the hyoid-laryngeal complex according to the data of a specialized clinic by M.V. Gubin, V.O. Olkhovskyi, G.I. Garyuk, V.M. Gubin

“…It was determined that additional diagnostic criteria for determining the severity of injuries of the hyoid-laryngeal complex, which have to be considered are: the dynamics and terms of restoration of post-traumatic morphological-clinical, and functional changes, the occurrence of life-threatening phenomena. …”
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Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial by Judith Bellapart, Vinesh Appadurai, Melissa Lassig-Smith, Janine Stuart, Christopher Zappala, Rob Boots

“…High levels of plasma melatonin during the overnight period of intensive care cohort patients did not improve sleep nor decreased the prevalence of delirium. …”
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Effects of Dietary Protein-to-Energy Ratios on Growth, Immune Response, Antioxidative Capacity, Liver and Intestinal Histology, and Growth-Related Gene Expression in Hybrid Yellow... by Sehrish Taj, Quan Han, Xiaoyi Wu, Haoran Yin, Lixia Tian, Huijun Yang, Yongjian Liu, Junwa Huang

“…Additionally, an optimum P/E ratio improved intestinal morphology. …”
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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model by Patricia Ramos-Ramírez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petrén, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner

“…Hematoxylin and eosin, Picro-Sirius Red, and Periodic Acid-Schiff staining were performed to evaluate airway inflammation, collagen deposition, and mucus-producing cells. In addition, Astra blue and immunostaining against tryptase and chymase were used to visualize mast cells. …”
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