Evaluation of Rivaroxaban Exposure via Anti-Xa Levels During VTE Prophylaxis in Hospitalized Patients by Kaitlin Blotske PharmD, Toral Patel PharmD, BCPS, Toby Trujillo PharmD, FCCP, FAHA, BCPS, Matthew Marlar MLS (ASCP), Stuart Lind MD, Henry Kramer MD, Kathryn Hassell MD, Tyree H. Kiser PharmD, FCCM, FCCP, BCCCP, BCPS

“…Characterizing the high correlation between anti-Xa levels and rivaroxaban plasma concentrations at 10 mg daily doses, provides additional insight to rivaroxaban's anticoagulant effects in clinical practice. …”
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Future-proofing quality education using integrated assessment systems by Lucy Tambudzai Chamba, Namatirai Chikusvura

“…However, coding the data manually allowed the researchers to be fully immersed in the emerging themes enriching the study with additional data. This means that in-depth data engagement was ensured. …”
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Exploring the impact of deleterious missense nonsynonymous single nucleotide polymorphisms in the DRD4 gene using computational approaches by Dipto Kumer Sarker, Pallobi Ray, Fayad Bin Abdus Salam, Shaikh Jamal Uddin

“…By contrast, while interacting with nemonapride, the impact of the I156T and L65P mutations was highly deleterious; both showed lower stability, higher flexibility, and higher motions. Additionally, nemonapride significantly lost interactions with the active site, notably in the I156T variant. …”
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The Essential Role of Monte Carlo Simulations for Lung Dosimetry in Liver Radioembolization—Part B: ¹⁶⁶Ho Microspheres by Edoardo d’Andrea, Andrea Politano, Bartolomeo Cassano, Nico Lanconelli, Marta Cremonesi, Vincenzo Patera, Massimiliano Pacilio

“…Given the high heterogeneity of lung tissue, standard dosimetric approaches cannot accurately estimate the AD. Additionally, MC results for ¹⁶⁶Ho showed notable spatial absorbed dose inhomogeneity, highlighting the need for tailored lung dosimetry in Ho-TARE accounting for the patient-specific lung density distribution. …”
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Design of a new model yeast consortium for ecological studies of enological fermentation by Pourcelot, Eléonore, Vigna, Audrey, Marlin, Thérèse, Galeote, Virginie, Nidelet, Thibault

“…We have carried out a complete analysis of this consortium, studying the evolution of populations over time and examining factors such as metabolite production and fermentation kinetics. In addition, the yeast consortium was used to test the diversity-function relationship as a proof of concept. …”
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Effects of Light Intensity and Irrigation Method on Growth, Quality, and Anthocyanin Content of Red Oak Lettuce (<i>Lactuca sativa</i> var. <i>cripspa</i> L.) Cultivated in a Plant... by Thanit Ruangsangaram, Pariyanuj Chulaka, Kriengkrai Mosaleeyanon, Panita Chutimanukul, Michiko Takagaki, Na Lu

“…The results indicated that plants grown with circulating irrigation exhibited significantly higher fresh and dry weights than those grown under non-circulating conditions, regardless of light intensity. …”
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Short bouts and long-term exercise reduce sedentary-induced bone loss and microstructural changes by modulating bone formation and resorption in healthy young male rats by L.Y. Wang, L.M. Liang, X.X. Zhang, H. Chi, F. L. Peng

“…In the trabecular bone, parameters such as trabecular separation (Tb.Sp), trabecular number (Tb.N), BS, connectivity density (Conn.D), BS/BV, bone volume/tissue volume (BV/TV), degree of anisotropy (DA), and structural model index (SMI) were also significantly reduced. In addition, we detected an increase in serum tartrate-resistant acid phosphatase (TRAP) levels in SED rats at both 4 and 8 weeks. …”
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Lymph Node Adiposity and Metabolic Dysfunction-Associated Steatotic Liver Disease by Jessica M. Rubino, Natalie Yanzi Ring, Krishna Patel, Xiaoqing Xia, Todd A. MacKenzie, Roberta M. diFlorio-Alexander

“…<b>Results</b>: We found a significant association between MASLD and mammographic LNA, defined as lymph node (LN) length > 16 mm (<i>p</i> = 0.0004) that remained significant after adjusting for clinical factors, including body mass index (BMI). We additionally found a significant association between LNA and metabolic dysfunction-associated steatohepatitis (MASH), identified via liver biopsy (<i>p</i> = 0.0048). …”
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Influence of Pretreatments on Microwave Vacuum Drying Kinetics, Physicochemical Properties and Sensory Quality of Apple Slices by Yingqiang Wang, Hongxiao Zhao, Huiwen Deng, Xi Song, Wenjie Zhang, Sirui Wu, Jing Wang

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The predictive value of optic nerve sheath diameter measurement via ultrasound for intracerebral hemorrhage complicated by cerebral-cardiac syndrome by Wei-Ze Fan, Jun-Rong Jiang, Hui-Ling Zang, Hui Cheng, Xiao-Hui Shen, Wen-Juan Yang, Hui Wang, Li-Xing Jing

“…Results ONSD measurements differed significantly between males and females, with males exhibiting larger ONSD values. Additionally, significant differences were observed in ONSD, hematoma volume, midline shift, and GCS scores between the CCS and non-CCS groups. …”
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NIH funding for the pediatric surgeon-scientist: An analysis of current trends by Colton D. Wayne, MD, Zachary Dumbauld, BS, Ethan Mills, BS, Diana L. Farmer, MD, Gail E. Besner, MD

“…Academic productivity was assessed by PubMed publications. In addition, a survey was distributed to Regular/Associate APSA members. …”
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Comparative analysis of phytonutrients of Moringa oleifera leaves from South Africa and Nigeria, and their antimicrobial and antioxidant potentials by UPLC-ESI-QToF-MS and OPLS-DA... by Jonathan Kayembe, Cosa Sekelwa, Kokoette Bassey

“…Whereas the antioxidant potentials of the extracts were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide scavenging assays, the antimicrobial potentials of the extracts were evaluated using minimum inhibitory concentrations protocol.ResultsThe chemometric analysis with a line regression (R2) = 0.97 revealed 70% significant similarities in the phytonutrients of samples between the two regions and an intriguing 30% variation within the same plant species. In addition, kaempferol, quercetin, luteolin, tangutorid E, and podophyllotoxin, among others were annotated as the major phytonutrients in the samples. …”
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Risk factors of gallbladder cancer in Nepal: A case control study. by Chanda Thakur, Roshan Kumar Mahato, Sabina Marasini, Dinesh Timalsena, Krishna Sagar Sharma, Biraj Man Karmacharya

“…The risk factors for GBC were assessed by using unconditional logistic regression to find odds ratios and 95% confidence level for bivariate and multivariate analysis. …”
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Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer by Elizabeth T. Evans, Emily F. Page, Alex Seok Choi, Zainab Shonibare, Andrea G. Kahn, Rebecca C. Arend, Karthikeyan Mythreye

“…Results Gene expression levels of components of the activin signaling pathway were elevated within EOC when compared to a benign cohort, with differences in activin type I/II receptor gene profiles identified. Additionally, INHBA gene expression was linked to lymphocytic immune markers in EOC samples. …”
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Characterization of the First Marine Pestivirus, Phocoena Pestivirus (PhoPeV) by Lars Söder, Denise Meyer, Olaf Isken, Norbert Tautz, Matthias König, Alexander Postel, Paul Becher

“…To further characterize this unique pestivirus, its host cell tropism and growth kinetics were determined in different cell lines. In addition, the interaction of PhoPeV with innate immunity in porcine epithelial cells and the role of selected cellular factors involved in the viral entry and RNA replication of PhoPeV were investigated in comparison to closely and distantly related pestiviruses. …”
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Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoE−/− mice by Yaze Wang, Hifumi Ohishi, Rongji Wu, Hui Liu, Rong Xu

“…Serum lipid levels were measured and monitored for body weight and food consumption alterations in murine models. …”
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A Study of the Solid-Liquid-Gas Three-Phase Coupling Relationship of Coal, Water and Gas by Anying Yuan, Chunhui Huang, Junling Hou, Zhaomin Zhang, Weihui Pan, Lei Duan, Quansen Wu

“…It was found that with the increases in water content, the desorption speeds, initial desorption speeds, and desorption amount of gas in the coal bodies continuously decreased. In other words, the water content levels in the coal bodies were negatively correlated with the gas desorption speeds and desorption amounts of the coal bodies. …”
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Multifield Coupling Mechanism of Unloading Deformation and Fracture of Composite Coal-Rock by Zhen Yang, Yan Li, Xin Li, Jiayu Zhuang, Hao Li, Xue Wang, Yuning Wang

“…The composite coal-rock deforms and ruptures under unloading, and the brittle failure of the rock body becomes more sudden when the confining pressure is unloaded. …”
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Expression of CSTF2 in oral squamous cell carcinoma and its relationship with immune infiltration and poor prognosis by Zumulaiti Aierken, Muertiza Muhetaer, Zhang Lei, Ainiwaerjiang Abudourousuli, Ainiwaerjiang Abudourousuli

“…Functional enrichment analysis indicated that CSTF2 plays a role in epidermal development and differentiation, immunoglobulin complexes, peptidases and endopeptidase inhibitor activity, and cytochrome P450 metabolic processes. Additionally, the overexpression of CSTF2 exhibited a negative correlation with the infiltration of immature dendritic cells (iDCs), cytotoxic cells, and plasmacytoid dendritic cells (pDCs). …”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…The MARCKSL1 gene was predominantly expressed in MVI-positive malignant cells and may contribute to MVI progression by interacting with the PTN signalling network. Additionally, MARCKSL1 is linked to tumour resistance to multiple anticancer drugs.DiscussionThis study sheds light on the molecular characteristics and functional heterogeneity of MVI-associated malignant cell subpopulations. …”
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