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50761
Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic Opportunities
Published 2025-01-01“…COX-2 inhibitors, Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway blockers, and NF-kB inhibitors have shown potential in preclinical studies, while immune checkpoint inhibitors targeting PD-1/PD-L1 and CTLA-4 have been explored with mixed results in OC. Additionally, emerging research on the microbiome and inflammation-related biomarkers, such as microRNAs (miRNAs) and exosomes, points to new opportunities for early detection and precision medicine. …”
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50762
Olfactory disorders in patients with chronic rhinosinusitis in Kinshasa, Democratic Republic of the Congo: A cross-sectional study
Published 2025-01-01“…All mean scores for subjective and objective olfactory assessments were significantly higher (p < 0.001) among CRS patients with OD compared to those without. Additionally, the mean VAS level for loss of smell was higher in CRS patients with OD (p < 0.001). …”
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50763
Extracellular electron shuttles induced transformation and mobilization of Fe/As with the occurrence of biogenic vivianite
Published 2025-01-01“…The results showed that the amount of Fe(II) released and precipitated in the Gt-As group with the addition of 9,10-anthraquinone-2,6-disulfonic acid (AQDS) and phosphate was the highest. …”
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50764
Research on the movement process of erosion-denudation type debris flow in middle-low mountains based on particle algorithm model
Published 2025-01-01“…Regarding movement speed, the debris flow initially accelerated and then decelerated, with the extreme condition resulting in a greater travel distance compared to the normal condition. Additionally, the debris flow exhibited greater erosion depth and volume under normal conditions. …”
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50765
Cell-free supernatants from plant growth-promoting rhizobacteria Bacillus albus strains control Aspergillus flavus disease in peanut and maize seedlings
Published 2025-01-01“…Both CFSs strongly suppressed the harmful effects of A. flavus AF1 and seed-borne A. flavus on peanut and maize seedlings, reducing disease incidence (DI) and disease severity index (DSI) compared to controls. …”
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50766
Survival Status and Predictors of Mortality among Newborns Admitted with Neonatal Sepsis at Public Hospitals in Ethiopia
Published 2020-01-01“…The cumulative proportion of surviving at the end of the fourth day was 99.5%, and it was 98.2% at the end of the fifth day. In addition, it was 96.6%, 93.5%, and 91.1% at the end of the sixth, seventh, and eighth day, respectively. …”
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50767
Population structure, selection signal and introgression of gamecocks revealed by whole genome sequencing
Published 2025-02-01“…Results The population structure analysis revealed that gamecocks have multiple origins. In addition, we used Fst, π-Ratio and XP-EHH methods to explore the candidate signatures of positive selection in gamecocks. …”
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50768
Cell Wall Protein 2 as a Vaccine Candidate Protects Mice Against <i>Clostridioides difficile</i> Infection
Published 2024-12-01Subjects: “…<i>Clostridioides difficile</i> infection (CDI)…”
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50769
Shenkang injection for the treatment of acute kidney injury: a systematic review and meta-analysis
Published 2024-12-01“…The incidence of adverse reactions did not differ from that in the control group. Additional rigorous clinical trials will be necessary in the future to thoroughly evaluate and establish the effectiveness of SKI in the treatment of AKI.…”
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50770
Improving the Quality of Total Hip Arthroplasty Operative Notes: A Clinical Audit Study
Published 2024-01-01“…The notes were audited keeping in mind the guidelines set by the Royal College of Surgeons of England Good Surgical Practice with some additional points which was related to hip arthroplasty making up 21 points which is described in table below. …”
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50771
The extremely halotolerant black yeast Hortaea werneckii - a model for intraspecific hybridization in clonal fungi
Published 2019-07-01“…Here, we report that addition of NaCl to culture media expands the growth range of H. werneckii to 37 °C, which explains its colonisation of human skin, with its increased salinity. …”
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50772
EEG electrode setup optimization using feature extraction techniques for neonatal sleep state classification
Published 2025-01-01“…An imbalance between classes is solved using the SMOTE technique. In addition, the most significant features are identified and prioritized using principal component analysis (PCA). …”
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50773
Association of N-terminal pro-brain natriuretic peptide with cognitive function and depression in elderly people with type 2 diabetes.
Published 2012-01-01“…The prospective phases of the ET2DS will help determine whether or not NT-proBNP can be considered a risk marker for subsequent cognitive impairment and incident depression and whether it provides additional information over and above traditional risk factors for these conditions.…”
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50774
Electronegative LDL from Rabbits Fed with Atherogenic Diet Is Highly Proinflammatory
Published 2019-01-01“…Knockdown of lectin-type oxidized LDL receptor- (LOX-) 1 resulted in significant reduction in LDL(-)-induced IL-1β, IL-6, and TNF-α. In addition, these LDL(-) effects were also markedly attenuated by inhibition of NF-κB and ERK1/2. …”
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50775
Tailoring traditional Chinese medicine in cancer therapy
Published 2025-01-01“…Specifically, leveraging TCM pharmaceutic components can not only directly impact tumor biology at the molecular level, but regulate the tumor immune environment through distinct pathways. Additionally, the administration of external TCM treatments such as acupuncture and moxibustion also demonstrates beneficial effects in cancer patients. …”
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50776
Retrospective evaluation of autotransfusion using a cell saver device versus allotransfusion in the perioperative management of acute hemoperitoneum in 43 dogs (2017–2021)
Published 2025-02-01“…And therefore may emphasize its further application as an addition or alternative to traditional allogenic blood transfusions.…”
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50777
Astigmatism and maternal myopia as important factors affecting success rate of DIMS lens treatment
Published 2024-05-01“…Quality of life assessments were conducted at baseline, at 2 weeks, and 3, 6, 9 and 12 months. Additionally, parental myopic dioptre was recorded when applicable.Results At the 12-month mark, myopia progression in patients (mean±SE: −0.40±0.05) mirrored findings from prior European DIMS studies, but with 50% of patients showing no progression. …”
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50778
Heat transportation of 3D chemically reactive flow of Jeffrey nanofluid over a porous frame with variable thermal conductivity
Published 2025-01-01“…The numerical analysis is performed via the finite difference approach, which consists of a three-stage Lobatto scheme using MATLAB package. Additionally, important engineering parameters under different constraints-like skin friction, Nusselt number, and Sherwood number—are given in a thorough manner using tabular and graphical representations. …”
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50779
Toll-Like Receptor Homolog CD180 Expression Is Diminished on Natural Autoantibody-Producing B Cells of Patients with Autoimmune CNS Disorders
Published 2021-01-01“…Furthermore, the anti-CS IgM natural autoantibody serum level was lower in both NMOSD and MS. In addition, we found a tendency of higher anti-CS IgG natural autoantibody levels only in anti-Chlamydia IgG antibody-positive NMOSD and MS patients. …”
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50780
Clinical Utility of a Structured Program to Reduce the Risk of Health-Related Quality of Life Impairment after Discharge from Intensive Care Unit: A Real-World Experience
Published 2018-01-01“…The main endpoint was the occurrence of PICS at the 6-month follow-up visitation, defined as an abnormal physical or mental score in the SF-12 questionnaire in the presence of clinical evidence of new or worsening impairment in physical, cognitive, or mental health status. An additional questionnaire was administered, to assess the effects of ICU-related memories. …”
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