Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency by Nanis S. Marzuki, Firman P. Idris, Hannie D. Kartapradja, Alida R. Harahap, Jose R. L. Batubara

“…Those containing harmful mutations exhibited more severe phenotypes with median external genitalia masculinisation scores (EMS) of 3 (1.5–9) and were more likely to be diagnosed at a later age, reared as female, and virilised at pubertal age. In addition, the respective sensitivities for detecting severe 5ARD2 cases using T/DHT (cutoff: 10) and urinary Et/An ratios (cutoff: 0.95) were 85% and 90%, whereas mild cases were only identified with 64.7% and 47.1% sensitivity, respectively. …”
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The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies by Liyuan Han, Lina Zhang, Wenhua Xing, Renjie Zhuo, XiaLu Lin, Yanhua Hao, Qunhong Wu, Jinshun Zhao

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Prevalence and risk factors of gestational diabetes mellitus among pregnant women in northern Vietnam: a cross-sectional study by Hieu Minh Le, Thi Ai Nguyen, Dang Kien Nguyen, Ditte Søndergaard Linde, Ib Christian Bygbjerg, Jens Søndergaard, Thanh Duc Nguyen, Bay Quang Nguyen, Ngoc-Anh Thi Dang, Xuan Bai Nguyen, Dan W. Meyrowitsch, Christina A. Vinter, Tine M. Gammeltoft, Vibeke Rasch

“…Multivariate logistic regression analysis showed maternal age from 25 to 34 (adjusted OR 2.0; 95%CI 1.3–2.9), maternal age ≥ 35 (adjusted OR 3.0; 95%CI 1.7–5.4), pregestational body mass index ≥ 23 (adjusted OR 1.6; 95%CI 1.1–2.3), family history of diabetes (adjusted OR 1.9; 95%CI 1.3–2.9), fertility treatment (adjusted OR 2.3; 95%CI 1.3–3.8), and previous GDM (adjusted OR 3.1; 95%CI 1.4–6.9) were associated with increased odds of GDM. …”
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Candidate vaccine construction against tick-born encephalitis based on hybrid recombinant flagG-protE-protein by P. A. Belavin, D. A. Kunyk, E. V. Protopopova, V. B. Loktev, E. V. Deineko

“…The recombinant protein protE comprises the tick­borne encephalitis virus envelope protein and the flagGprotE recombinant protein has an additional flagG domain encoding flagellin G of Salmonella typhi. …”
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ALL-Net: integrating CNN and explainable-AI for enhanced diagnosis and interpretation of acute lymphoblastic leukemia by Abhiram Thiriveedhi, Swetha Ghanta, Sujit Biswas, Ashok K. Pradhan

“…Along with accuracy, we have considered other evaluation metrics and the results illustrate the potential of ALLNet with an average precision of 99.35%, recall of 99.33%, and F1 score of 99.58%. Additionally, XAI techniques, specifically the Local Interpretable Model-Agnostic Explanations (LIME) algorithm is employed to interpret the model’s predictions, providing insights into the decision-making process of our ALL-Net CNN. …”
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Effect of blade inclination angle for straight-bladed vertical-axis wind turbines by L. Morgan, A. K. Amiri, W. Leithead, J. Carroll

“…This indicates the potential of V-rotors to reduce the cost of energy compared to H-rotors in traditional VAWT designs. Additionally, inclined blades are shown to increase the operational tip-speed ratio, demonstrating their applicability to turbines using secondary rotors, such as the X-rotor, where high tip-speed ratios are required for efficient power conversion between primary and secondary rotors.…”
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Mitigation of PFOA/PFOS toxicity in zebrafish (Danio rerio) by oxidative stress modulation and gut microbial metabolism through the use of aquatic probiotic Lactobacillus rhamnosus by Chun Wang, Guanyi Li, Sibao Chen, Ruixuan Li, Mengyan Wang, Xia Wang, Ning Ding, Yingxue Sun

“…The impact of PFOA and PFOS on intestinal tissue damage followed the order: PFOA + PFOS > PFOS > PFOA. Additionally, L. rhamnosus exhibited significant reparative effects on damaged intestinal tissues, as evidenced by the restoration of damaged intestinal villi and an increase in lymphocyte count. …”
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Rhopalurus junceus scorpion venom induces G2/M cell cycle arrest and apoptotic cell death in human non-small lung cancer cell lines by Alexis Díaz-García, Ángel Garrido, Jenny Laura Ruiz-Fuentes, Tamara Hermosilla, Diego Varela

“…Likewise, the scorpion venom treatment did not affect p-ERK, p-AKT, or p-38MAPK protein levels. …”
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Recent Developments and Present Status of Telepathology by K. Kayser, M. Beyer, S. Blum, G. Kayser

“…The image quality, transfer rates, and screen resolution of active and passive telepathology systems are sufficient for an additional or primary judgment of histological slides and cytological smears. …”
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Availability of Zinc, Copper, Iron, Manganese, and Selenium in Feed Ingredients and Sources in Pigs by Yohan Choi, Junseon Hong, Jihwan Lee, Minju Kim

“…A total of 64 barrows (Yorkshire × Landrace × Duroc crossbreds) with an average initial body weight of 26.61 ± 4.12 kg were housed individually in metabolic cages. …”
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A Review of Needle Navigation Technologies in Minimally Invasive Cardiovascular Surgeries—Toward a More Effective and Easy-to-Apply Process by Katharina Steeg, Gabriele Anja Krombach, Michael Horst Friebe

“…For instance, fusion technologies overlay information from multiple visual approaches within a single interface to overcome individual limitations. Additionally, emerging diagnostic methods like vibroacoustic sensing or optical fiber needles offer information from complementary sensory channels, augmenting visual approaches with insights into tissue integrity and structure, thereby paving the way for enhanced needle navigation systems in MICS.…”
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Long-Term Comparative Outcomes of Short Implants Versus Maxillary Sinus Elevation in Posterior Maxilla Rehabilitation by Eduardo Anitua, Laura Piñas, Mohammad Hamdan Alkhraisat

“…In the LSEG, two cases of mucositis were identified, attributed to improper use of an interdental brush. Additionally, two cases of prosthetic screw fracture were reported in the LSEG as technical complications. …”
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The biological control agent for bacterial canker of kiwifruit, in Aureo® Gold, is a strain of Aureobasidium pullulans identifiable by novel SCAR marker primers by Deirdre A. Cornish, Magan M. Schipper, Jenny M. Oldham, Janet Yu, Joel L. Vanneste

“…One set of primers designed on this SCAR marker gave a unique amplicon only with CG163 and not with any of the 164 strains of A. pullulans tested. In addition, an in silico analysis revealed that none of the 75 strains of A. pullulans for which the whole genome sequence is available had the same sequence as either one of those primers. …”
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Assessment of RANS Models for Milli-Channel Turbulent Flow in Drip Irrigation Emitter by Qi Feng, Qingzheng Li, Yaojun Li, Xuefeng Qiu, Jiandong Wang, Xingfa Huang

“…Furthermore, computations using SWF failed to capture the asymptotic characteristics of flow parameters in the near-wall region, resulting in an overestimation of turbulent kinetic energy and turbulence intensity. Additionally, the magnitude of wall shear stress in the channel corners fell below the threshold required for self-cleaning, underscoring the necessity for optimizing channel structures to enhance the anti-clogging performance of the emitter.…”
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Spatiotemporal changes of ecosystem health and the impact of its driving factors on the Loess Plateau in China by Xuepeng Zhang, Taixia Wu, Qiqi Du, Ninglei Ouyang, Wei Nie, Yang Liu, Peng Gou, Guangchao Li

“…The efficient machine learning model (light gradient boosting machine model) and the variable explanation model (SHapley Additive exPlanation model) are combined to quantify the functional relationships between various driving factors and EH, thereby exploring the impacts of climatic factors, socioeconomic development (SED), and ecological restoration projects (ERP) on EH. …”
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Long-read 16S rRNA amplicon sequencing reveals microbial characteristics in patients with colorectal adenomas and carcinoma lesions in Egypt by Asmaa A. El Leithy, Amira Salah El-Din Youssef, Auhood Nassar, Ramy K. Aziz, Nadin M. Khaled, Mina T. Mahrous, Ghobrial N. Farahat, Aya H. Mohamed, Yasser Mabrouk Bakr

“…The Enterococcus spp. were significantly overabundant in patients with rectal cancer and early-onset CRC, while Staphylococcus spp. were significantly higher in patients with sigmoid cancer and late-onset CRC. In addition, the relative abundance of Fusobacterium nucleatum was significantly higher in CRC patients. …”
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The effects of training female students in emotion regulation techniques on their social problem-solving skills and social anxiety: a randomized controlled trial by Ashraf Akbari, Camellia Torabizadeh, Narjes Nick, Giti Setoodeh, Parvin Ghaemmaghami

“…Abstract Background Social anxiety is one of the most prevalent anxiety-related disorders among adolescents with many adverse effects on the social and academic lives of this population. In addition, poor social problem-solving skills can aggravate anxiety in individuals suffering from anxiety. …”
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PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells by Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li

“…Moreover, PAX6 enhances the enrichment of the ALDEFLUOR+ and CD133+ population and promotes sphere formation in SCLC cells. Additionally, upregulation or downregulation of PAX6 expression does not induce apoptosis in SCLC cells. …”
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Cost-effectiveness of oral versus injectable disease modifying therapies in relapsing multiple sclerosis: a systematic review analysis by Mehdi Rezaee, Ramin Ravangard, Seyyed Morteza Mojtabaeian, Abdosaleh Jafari

“…However, despite the difference in the results, Cladribine tablets were cost-effective in all studies compared with injectable drugs. In addition, the present study could be of great importance for policymakers and other beneficiaries regarding the cost-effectiveness of the aforementioned drugs.…”
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Corrosion inhibition effects of eco-friendly clarithromycin molecules on aluminium in hydrochloric acid solution via experimental, theoretical and optimization approach by O.D. Onukwuli, I.A. Nnanwube, F.O. Ochili, M. Omotioma, J.I. Obibuenyi

“…FTIR results reveal that the inhibitor contained heteroatoms. Additional analysis with GC–MS indicated that heteroatoms-carrying compounds were contained in the inhibitor. …”
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