Exploring nanocomposite materials in clinical dermatology: Innovations for treating skin diseases by Sandipan Dasgupta, Subhasundar Maji, Sanjay Dey, Moitreyee Chattopadhyay, Ananya Chanda, Satarupa Acharjee, Kousik Santra, Kazi Asraf Ali

“…Silver and curcumin-based nanocomposites provide controlled release of active ingredients over extended periods, protecting bioactive compounds from degradation. Additionally, hydroxyapatite-based nanocomposites enhance mechanical properties and bioactivity through chemical bonding with the polymer matrix. …”
Get full text

Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model by Emma Steijvers, Yunshong Shi, Hong Lu, Weixin Zhang, Yitian Zhang, Feihu Zhao, Baichuan Wang, Louise Hughes, Jake E. Barralet, Giulia Degli-Alessandrini, Igor Kraev, Richard Johnston, Zengwu Shao, Frank H. Ebetino, James T. Triffitt, R. Graham G. Russell, Davide Deganello, Xu Cao, Zhidao Xia

“…Rapid intramembranous bone formation was observed at 14 days, with 4- to 8-fold increases in bone thickness and callus volume in comparison with sham-operated animals (p < 0.0001), followed by bone remodelling and a new layer of cortical bone formation by 28 days after implantation. The addition of zoledronate, a clinically-utilised bisphosphonate, to HAA, promoted significantly more new bone formation than HAA alone over 28 days (p < 0.01). …”
Get full text

Investigating the response mechanisms of the intertidal seagrass Zostera japonica to increased UVB radiation through physiological, transcriptomic, and metabolomic analyses by Jiayi Xin, Song Xue, Hongzhen Wang, Xinqi Li, Yu Zang, Lei Liu, Xuexi Tang, Jun Chen

“…Notably, flavonoids are the preferred compounds synthesized by Z. japonica, in contrast to other plant species. In addition, the weighted gene coexpression network analysis (WGCNA) method was employed to identify genes that may play important roles in the response of Z. japonica to increased UVB radiation. …”
Get full text

NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome by Vancheswaran Gopalakrishnan, Ben Sparklin, Jung Hwan Kim, Jerome Bouquet, Margaret Kehl, Tara Kenny, Christopher Morehouse, Carolina Caceres, Paul Warrener, Ventzislava A. Hristova, Susan Wilson, Harini Shandilya, Arnita Barnes, Alexey Ruzin, Junmin Wang, Lisa Oberg, Bastian Angermann, Christopher McCrae, Adam Platt, Daniel Muthas, Sonja Hess, Christine Tkaczyk, Bret R. Sellman, Kristoffer Ostridge, Maria G. Belvisi, Tom M. A. Wilkinson, Karl J. Staples, Antonio DiGiandomenico, on behalf of the MICA II Study Group

“…Microbial composition, proteomics and NTHi killing activity was analyzed using bronchoalveolar lavage fluid (BALF). In addition, antigen–antibody titers in sera to COPD pathogens were determined using a multiplex assay. …”
Get full text

Screening of Efficient Antifreeze Agents to Prevent Low-Temperature Stress in Vines by Yali Zhang, Mengyao Han, Langjie Wu, Haoyu Wang, Yanying Liang, Xianhang Wang, Zhumei Xi

“…This suggests that all four antifreeze agents effectively improve grapevine cold resistance, with better results observed when applied 24 h before frost. Additionally, the antifreeze agents significantly increased the soluble solid content in berries and enhanced the levels of anthocyanins, total phenols, total tannins, total flavonoids, and total flavonols in the berries’ skin. …”
Get full text

Species-specific mercury speciation in billfishes and its implications for food safety monitoring and dietary advice by Anaïs Médieu, David Point, Valérie Allain, Nathalie Bodin, Mélanie Lemire, Pierre Ayotte, Zahirah Dhurmeea, Matthieu Waeles, Laure Laffont, Antoine Le Gohalen, François Roupsard, Anne Lorrain

“…This study calls for additional characterization of mercury speciation and bioavailability in billfishes to better understand the mechanisms driving species-specific differences of methylmercury detoxification, and to refine dietary advices associated to marine top predators consumption.…”
Get full text

Research on the Ground Vacuum Shortwave Calibration of Moon-Based Earth Radiation Budget Detector by Jieling Yu, Wei Fang, Duo Wu, Silong Wang, Zhitao Luo, Yuwei Wang, Yisu Zhang, Xin Ye

“…Where, SWCLS is designed with a electrically variable slit and a 12-hole narrow-band filter wheel to achieve continuous broad-spectrum radiance output and discrete narrow-spectrum band tuning, respectively. Additionally, wide dynamic range output is from the introduction of elliptic land spherical mirrors for bilateral highly efficient focusing structure. …”
Get full text

Increased positive tree species mixture effects on the abundance and richness of Collembola with stand development in Canadian boreal forests by Yakun Zhang, Sai Peng, Zilong Ma, Chen Chen, Bilei Gao, Xinli Chen, Han Y.H. Chen

“…Our results showed significant effects of stand types on Collembola with higher abundance and richness in conifer and mixed stands than in broadleaf stands. Additionally, with stand development, we observed increased Collembola abundance and richness. …”
Get full text

Cutting performance and surface integrity during rotary ultrasonic elliptical milling of cast Ni-based superalloy by Zhefei Sun, Yihang Liu, Daxi Geng, Deyuan Zhang, Enze Ying, Runze Liu, Xinggang Jiang

“…The findings reveal that RUEM exhibits superior machinability with a maximum force reduction of 25.74% in feed direction and 27.25% in radial cutting depth direction, respectively, compared to that of CM. Additionally, RUEM generates unique microstructure characteristics on the machined surface instead of the obvious feed marks and material flow in CM. …”
Get full text

The use of Specim IQ, a hyperspectral camera, for plant analysis by V. V. Alt, T. A. Gurova, O. V. Elkin, D. N. Klimenko, L. V. Maximov, I. A. Pestunov, O. A. Dubrovskaya, M. A. Genaev, T. V. Erst, K. A. Genaev, E. G. Komyshev, V. K. Khlestkin, D. А. Afonnikov

“…It was shown that according to the characteristics of the spectrum, the samples studied are divided into three groups, each characterized by increased or reduced intensity levels for the specified parts of the spectrum. In addition, minima in the reflection spectra corresponding to chlorophyll a were found for a number of varieties. …”
Get full text

The Use of Digital Microscopy to Compare the Thicknesses of Normal Corneas and Ex Vivo Rejected Corneal Grafts with a Focus on the Descemet’s Membrane by Taíse Tognon, Sabrina Bergeron, Christina Mastromonaco, Kleyton Barella, Adriano Pasqualotti, Laura Nunez, Francisco Murta, Luciene Barbosa de Sousa, Mauro Campos, Miguel Noel Nascentes Burnier

“…Normal corneas have a thinner epithelium in the central region than the FGR group. In addition, the stroma and DM thicknesses of the nasal and temporal periphery were significantly higher in normal corneas than in those from the FGR group. …”
Get full text

Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29 by Xue Bai, Liu-Lin Xiong, Chang-Le Fang, Hao-Li Zhou, Lu-Lu Xue, Yue Hu, Qing-Jie Xia, Jia Liu, Jun-Yan Zhang, Ting-Hua Wang, Si-Jin Yang

“…The results demonstrated that the IL-10 expression was markedly increased after HI and IL-10 were colocalized with neurons and astrocytes which were badly injured by HI insult. In addition, Bcl-2 and ERp29 were remarkably decreased following IL-10 mRNA interference compared with the NC group. …”
Get full text

Applying the Dempster–Shafer Fusion Theory to Combine Independent Land-Use Maps: A Case Study on the Mapping of Oil Palm Plantations in Sumatra, Indonesia by Carl Bethuel, Damien Arvor, Thomas Corpetti, Julia Hélie, Adrià Descals, David Gaveau, Cécile Chéron-Bessou, Jérémie Gignoux, Samuel Corgne

“…The best result was reached by considering the probabilities of pixels to belong to the OP class associated with DESCALS map. In addition, the belief (i.e., confidence) and conflict (i.e., uncertainty) maps produced by DST evidenced that industrial plantations were detected with higher confidence than smallholder plantations. …”
Get full text

Molybdate delays sulphide formation in the sediment and transfer to the bulk liquid in a model shrimp pond by Torun, Funda, Hostins, Barbara, De Schryver, Peter, Boon, Nico, De Vrieze, Jo

“…Sodium molybdate (5 and 25 mg/L Na2MoO4.2H2O) was applied as a preventive strategy to control sulphide production before oxygen depletion. Molybdate addition partially mitigated H2S production in the sediment, and delayed its transfer to the bulk liquid by pushing the higher sulphide concentration zone towards deeper sediment layers. …”
Get full text

TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…In a cell line-derived xenograft (CDX) mouse model, TMEM45A knockdown significantly restores sensitivity to palbociclib and suppresses tumor growth. Additionally, the use of engineered exosomes loaded with siRNA targeting TMEM45A presents a promising strategy for enhancing CDK4/6 inhibitor sensitivity without observable toxic side effects in a patient-derived xenograft (PDX) model. …”
Get full text

Fosab, but not fosaa, plays important role in learning and memory in fish—insights from zebrafish gene knockout study by Qiuling Wang, Qiuling Wang, Qiuling Wang, Lixin Zhang, Lixin Zhang, Lixin Zhang, Chenyuan Zhu, Chenyuan Zhu, Chenyuan Zhu, Ke Lu, Ke Lu, Ke Lu, Jiaqi Wu, Jiaqi Wu, Jiaqi Wu, Xu-Fang Liang, Xu-Fang Liang, Xu-Fang Liang

“…In the T-maze behavioral assay, the fosab−/− zebrafish took significantly more than the average time to complete the assigned trial as the increase in the days compared to WT zebrafish, while the fosaa−/− zebrafish did not show a notable variance. The average time to complete the trial in fosab−/− zebrafish was significantly higher than in WT zebrafish. …”
Get full text

Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…Intriguingly, ARV infection significantly upregulated PRPS2 expression levels. Additionally, PRPS2 was shown to have a substantial impact on ARV replication; overexpression of PRPS2 increased ARV replication while knockdown of PRPS2 resulted in decreased quantities of ARV particles. …”
Get full text

PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway by Xiangyu Kong, Ganghao Ai, Dai Wang, Renzhen Chen, Dongbei Guo, Youliang Yao, Kai Wang, Guiye Liang, Fengjie Qi, Wenzhi Liu, Yongxing Zhang

“…To assess the expression levels of exchange protein 1 directly activated by cAMP (Epac1) and phosphodiesterase 4 (PDE4) in rectal carcinoma, and their associations with clinicopathological indexes. In addition, the associations of PDE4 and Epac1 with A-kinase anchor protein 95, connexin 43, cyclin D1, and cyclin E1 were evaluated. …”
Get full text

Age-related differences in borderline personality disorder traits and childhood maltreatment: a cross-sectional study by GuoRong Li, Yong Lin, Yun Xu, Yong Zhou, YanYan Wei, LiHua Xu, XiaoChen Tang, Zixuan Wang, Qiang Hu, JiJun Wang, HaiSu Wu, ZhengHui Yi, TianHong Zhang

“…Specifically, identity disturbance and impulsivity were more pronounced in adolescents (p&lt;0.001). Additionally, adolescents reported higher levels of emotional (F=15.987, p&lt;0.001) and physical abuse (F=12.942, p=0.002), while older adults reported higher levels of emotional and physical neglect. …”
Get full text

Green and Innovative Extraction: Phenolic Profiles and Biological Activities of Underutilized Plant Extracts Using Pulsed Electric Fields and Maceration by Noelia Pallarés, Houda Berrada, Emilia Ferrer, Wahiba Rached, José Pinela, Filipa Mandim, Tania C. S. P. Pires, Tiane C. Finimundy, Francisco J. Barba, Lillian Barros

“…These species present an untapped source of bioactive compounds with significant applications in the food and pharmaceutical industries, including the development of functional foods and additives. Recent advances in food processing have introduced innovative methods, such as pulsed electric fields (PEFs), to enhance the extraction of valuable compounds without compromising their integrity or quality. …”
Get full text