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  1. 50161

    Effect of Matrine on growth performance, gut health, and gut microbiota in chickens infected with avian pathogenic Escherichia coli by Ningning Mao, Yaming Yu, Jiqin Cui, Jin He, Yang Yang, Deyun Wang

    Published 2025-01-01
    “…Results indicated that pretreatment with matrine alleviated the symptoms of APEC infection in chickens, improving survival rates and promoting weight gain. Additionally, pretreatment with matrine reduced the secretion and gene expression of IL-1β, IL-6, and TNF-α in intestinal tissues, while enhancing serum SOD, GSH, and CAT activity, as well as gene expression levels in the intestine. …”
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  2. 50162

    Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma by Xiwen Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Jianxin Chen, Linying Chen, Lianhuang Li

    Published 2025-02-01
    “…We identified eight distinct tumor-associated collagen signatures (TACS1-8) from multiphoton images of PDAC tissues and developed an optical biomarker, TACS-score, based on the TACS1-8 using ridge regression analysis. Additionally, we also extracted 142 microscopic TACS (M-TACS) from second-harmonic generation (SHG) images and constructed a new robust biomarker, M-TACS-score, using the least absolute shrinkage and selection operator (LASSO) regression analysis. …”
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  3. 50163
  4. 50164

    Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes by Congshan Jiang, Jing Xu, Wenhua Zhu, Yongsong Cai, Si Wang, Yuanxu Guo, Ke Xu, Manman Geng, Nazim Hussain, Yan Han, Fujun Zhang, Qilan Ning, Liesu Meng, Shemin Lu

    Published 2019-01-01
    “…Moreover, DICER1 deficiency could also reduce apoptosis, while DICER1 overexpression was found to decrease the proliferation and enhance apoptosis. In addition, DICER1 deficiency could lower the expression of multiple RA-related miRNAs such as miR-155. …”
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  5. 50165

    Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies by Ray Wagiu Basrowi, Ray Wagiu Basrowi, Ray Wagiu Basrowi, Tonny Sundjaya, Tonny Sundjaya, Dessy Pratiwi, Nurlinah Amalia, Nurlinah Amalia, Nurlinah Amalia, Yosi Yohanes Putra Tandi, Muhammad Yasir Syafa’atulloh, Garuda Nusantara Putra Utomo, Muhammad Abdir Rahman Albarok, Fahrul Nurkolis

    Published 2025-01-01
    “…These miRNA-protein interactions suggest targeted therapies such as protein-based miRNA modulators could optimize erythropoiesis, advancing IDA management. Additionally, the review emphasizes the potential of leveraging protein-miRNA interactions for precision medicine, especially in resource-limited settings where anemia’s burden is profound. …”
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  6. 50166

    How fast is the frequency of precipitation extremes doubling in global land regions? by Guillaume Chagnaud, Juliette Blanchet, Guillaume Evin, Benoit Hingray, Thierry Lebel, Geremy Panthou, Théo Vischel

    Published 2024-01-01
    “…The fastest frequency doubling, in the coming two decades, is found in the highly vulnerable tropical regions of Western and South Eastern Africa, with strong implications for hydrological risk management there. In addition, the rarest events are found to have smaller FDT compared to more ‘common’ extremes; infrastructures designed to withstand the strongest events are thus more exposed to premature obsolescence.…”
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  7. 50167

    High-performance UWB Vivaldi antenna on FR4: A cost-effective solution for wearable technologies by Sahar Saleh, Tale Saeidi, Nick Timmons, Bader Alali, Faroq Razzaz, Ayman A. Althuwayb

    Published 2025-03-01
    “…The antenna's suitability for wearable applications was validated through testing on flat and curved human phantoms made of skin, fat, and muscle, showing low Specific Absorption Rate (SAR) values across the UWB spectrum, confirming its safety for body-centric use. Measured results include S11 values below -10.56 dB over the 3.66–20.42 GHz range, a peak gain of 8.1 dBi, stable radiation patterns, and an average group delay of 0.83 ns. …”
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  8. 50168

    The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis by Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu

    Published 2025-02-01
    “…Specifically, NSUN2 could stabilize PKM2 mRNA by increasing the m5C level of the m5C site C773 in the 3′-UTR of PKM2 mRNA. In addition, rescue assays revealed that NSUN2 promotes HCC glycolysis and progression by upregulating PKM2. …”
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  9. 50169

    Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction by Montserrat Guadalupe Garza-Reyes, Mónica Daniela Mora-Ruíz, Luis Chávez-Sánchez, Alejandra Madrid-Miller, Alberto Jose Cabrera-Quintero, José Luis Maravillas-Montero, Alejandro Zentella-Dehesa, Luis Moreno-Ruíz, Selene Pastor-Salgado, Erick Ramírez-Arias, Nataly Pérez-Velázquez, Adriana Karina Chávez-Rueda, Francisco Blanco-Favela, Wendy Guadalupe Vazquez-Gonzalez, Alicia Contreras-Rodríguez

    Published 2020-01-01
    “…A gradual increase in IL-17 was found in STEMI and post-STEMI patients. Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. …”
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  10. 50170

    Effect of cooling medium temperature on cooling curve and microstructure of Ti65 alloy by DONG Xiaolin, LI Wenyuan, TAN Haibing, LIU Jianrong, LIU Qiaomu, CHEN Yulong, WANG Lei, WANG Qingjiang

    Published 2025-01-01
    “…When the oil temperature rises to 80 ℃, the vapor stage disappears. In addition, the microstructure shows a transition trend from α+β dual-phase microstructure to martensitic microstructure with the increase in oil temperature. …”
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  11. 50171

    Boosting disassembly of π–π stacked supramolecular nanodrugs under tumor microenvironment by introducing stimuli‐responsive drug‐mates by Wenzhe Xu, Ruixu Yang, Yingke Xue, Yang Chen, Shuwei Liu, Songling Zhang, Yonggang Wang, Yi Liu, Hao Zhang

    Published 2025-01-01
    “…Meaningfully, the ΔEdis is the sum of a series of activation energy according to the specific stimuli of TME. …”
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  12. 50172

    LMF-Net: A Learnable Multimodal Fusion Network for Semantic Segmentation of Remote Sensing Data by Jihao Li, Wenkai Zhang, Weihang Zhang, Ruixue Zhou, Chongyang Li, Boyuan Tong, Xian Sun, Kun Fu

    Published 2025-01-01
    “…The further mining for cross-modal features is comparatively insufficient in heterogeneous data fusion. In addition, complex structures also lead to relatively heavy computation burden. …”
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  13. 50173

    Robotic pedicle screw placement for minimal invasive thoracolumbar spine surgery: a technical note by Luthfi Gatam, Luthfi Gatam, Luthfi Gatam, Phedy Phedy, Phedy Phedy, Syafruddin Husin, Harmantya Mahadhipta, Asrafi Rizki Gatam, Asrafi Rizki Gatam, Asrafi Rizki Gatam, Mitchel Mitchel, Karina Sylvana Gani, Erica Kholinne, Erica Kholinne

    Published 2025-01-01
    “…It also covers the surgical process, including patient positioning, dynamic reference placement, intraoperative cone-beam tomography, screw planning, exposure, and insertion techniques for spinal stabilization.DiscussionA meta-analysis highlighted the significant advantages of robotic spine surgery over traditional freehand techniques, including a notably lower complication rate (4.83% vs. 14.97%) and up to a tenfold reduction in surgeon radiation exposure compared to fluoroscopy. Additionally, robotic systems enhance pedicle screw placement accuracy, achieving a 91.7% success rate. …”
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  14. 50174

    The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target by Reem Alharthi, Monica Sueiro-Olivares, Isabelle Storer, Hajer Bin Shuraym, Jennifer Scott, Reem Al-Shidhani, Rachael Fortune-Grant, Elaine Bignell, Lydia Tabernero, Michael Bromley, Can Zhao, Jorge Amich

    Published 2025-12-01
    “…Indeed, the role of 5 of the 15 genes has previously been empirically validated, supporting the likelihood that the remaining candidates are relevant. In addition, the analysis of gene expression dynamics at early (16 h), mid (24 h), and late (72 h) time-points uncovered potential disease initiation and progression factors. …”
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  15. 50175

    Effect of sleep quality on the severity of perimenstrual symptoms in Japanese female students: a cross-sectional, online survey by Yukio Urabe, Makoto Komiya, Noriaki Maeda, Satoshi Arima, Tsubasa Tashiro, Rami Mizuta, Sakura Oda, Takaaki Nagasawa, Koichi Naito

    Published 2025-02-01
    “…The MDQ scores were compared between two groups (normal-sleep quality and low-sleep quality) using Mann-Whitney U test. In addition, multiple logistic regression analysis was performed, and the MDQ subscales that showed significant differences between the groups were used as independent variables. …”
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  16. 50176

    Primary aldosteronism patients with previous cardiovascular and cerebrovascular events have high aldosterone responsiveness to ACTH stimulation by Eriko Nakano, Kosuke Mukai, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura, Takamasa Ichijo, Mika Tsuiki, Norio Wada, Takashi Yoneda, Yoshiyu Takeda, Kenji Oki, Tetsuya Yamada, Yoshihiro Ogawa, Daisuke Yabe, Miki Kakutani, Masakatsu Sone, Takuyuki Katabami, Akiyo Tanabe, Mitsuhide Naruse, JPAS/JRAS Study Group

    Published 2024-05-01
    “…Aldosterone secretion in primary aldosteronism (PA) is often regulated by adrenocorticotropic hormone (ACTH) in addition to its autonomous secretion. However, the clinical characteristics and risk of cardiovascular and cerebrovascular (CCV) events in PA patients with aldosterone responsiveness to ACTH stimulation remain unclear. …”
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  17. 50177

    Mosquito‐derived ingested DNA as a tool for monitoring terrestrial vertebrates within a peri‐urban environment by Christine Chivas, Adam Stow, Andrew Harford, Thomas J. Mooney, David Loewensteiner, Kate Montgomery, Anthony Chariton

    Published 2025-01-01
    “…The overall diversity retrieved reveals a broad diversity of species with 10 avian taxa and six mammalian taxa, including both native and non‐native species of varying body sizes and behavioral characteristics. Both the multi‐locus approach and the use of a human blocking primer revealed additional diversity. …”
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  18. 50178

    Optimizing winged-bean meal through oven and autoclave heating as viable alternative for plant-based aquafeed by Shobrina Silmi Qori Tartila, Tholibah Mujtahidah, Muh. Azril, Anjali Apta Pramudita, Lusi Septiani, Bagas Putra Satria, Ignatius Abel Cristanto, Muhammad Abizar Sakti Oktavian, Sultan Jibran Risqulloh, Santika Dewi Astuti

    Published 2024-07-01
    “…Heating treatments improved in vitro trypsin activity (1300 units/O and 1135 units/A vs. 835 units) but reduced protein (29.05±1.96%/A and 31.73±1.52%/O vs. 35.17±0.38%) and moisture contents. Additionally, the O treatment met the standards for aquafeed protein content (27-45%) and potentially fulfilled the protein requirements for catfish (25-40%), Nile tilapia (30-35%), and Java barb (30-32%). …”
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  19. 50179

    Study of Long-term Spectral Evolution and X-Ray and γ-Ray Correlation of Blazars Seen by HAWC by R. Alfaro, C. Alvarez, A. Andrés, J.C. Arteaga-Velázquez, D. Avila Rojas, H.A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K.S. Caballero-Mora, T. Capistrán, A. Carramiñana, F. Carreón, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño de León, E. De la Fuente, D. Depaoli, N. Di Lalla, R. Diaz Hernandez, B.L. Dingus, M.A. DuVernois, M. Durocher, J.C. Díaz-Vélez, K. Engel, C. Espinoza, K.L. Fan, N. Fraija, S. Fraija, J.A. García-González, F. Garfias, A. Gonzalez Muñoz, M.M. González, J.A. Goodman, S. Groetsch, J.P. Harding, S. Hernández-Cadena, I. Herzog, D. Huang, F. Hueyotl-Zahuantitla, A. Iriarte, V. Joshi, S. Kaufmann, D. Kieda, A. Lara, W.H. Lee, J. Lee, H. León Vargas, J.T. Linnemann, A.L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, I. Martinez-Castellanos, J. Martínez-Castro, J.A. Matthews, P. Miranda-Romagnoli, J.A. Montes, E. Moreno, M. Mostafá, A. Nayerhoda, L. Nellen, M.U. Nisa, R. Noriega-Papaqui, N. Omodei, M. Osorio, Y. Pérez Araujo, E.G. Pérez-Pérez, C.D. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, J. Serna-Franco, A.J. Smith, Y. Son, R.W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Ureña-Mena, E. Varela, L. Villaseñor, X. Wang, I.J. Watson, K. Whitaker, E. Willox, S. Yun-Cárcamo, H. Zhou, C. de León, HAWC collaboration, Abraham D. Falcone, Fredric Hancock

    Published 2025-01-01
    “…For Mrk 501, we found evidence of a long-term correlation. Additionally, we identified a period in the light curve where the flux was very low for more than 2 yr. …”
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  20. 50180

    Oral dydrogesterone versus oral micronized progesterone in threatened miscarriage: protocol paper for a randomized controlled trial by Alka Kriplani, Gouri Shankar Kamilya, T Ramani Devi, Ashima Taneja, Amol Pawar, Gayathri Karthik Nagesh, Tapan Pattanaik, Tanusree Gupta, Mahima Jain, Monjori Mitra

    Published 2025-02-01
    “…Scheduled visits after enrollment will be conducted during 6–13, 8–14, 18–20 and 24–26 weeks of gestation, in addition to a visit at the end of treatment at 14 weeks and another after parturition. …”
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