Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Much of the logistical burden falls on those living with SMI to educate themselves and initiate the completion of a PAD.[11] However, many of those living with SMI already face additional burdens that prevent their successful navigation of a complex healthcare system, including poverty, marginal housing, and food insecurity.[12] In addition, individuals with SMI tend to be more socially isolated, with few others to trust besides their providers.[13] Efforts to promote the uptake of PADs by those living with SMI that neglect these additional burdens risk exacerbating health inequities faced by those with SMI. …”
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ITER NBI operational window and power availability constraints due to shine-through losses by P. Vincenzi, M. Schneider, P. Veltri, J.F. Artaud, A. Loarte, S. Nicolici, C. Poggi, A.R. Polevoi, A. Snicker

“…This allows for establishing operational limits for Hydrogen and Deuterium NBI in Hydrogen, Deuterium, and Deuterium–Tritium plasmas. Additionally, we compare commonly used beam ionisation codes for ITER and tokamak simulations, evaluating their reliability in the investigated parameter space. …”
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Effect of Cd–Zn compound contamination on the physiological response of broad bean and aphids by Liya Chen, Sijing Wan, Qintian Shen, Keting Zhao, Yanlan He, Yexin Xie, Shiyu Tao, Shuchang Zheng, Yi Zhang, Shigui Wang, Bin Tang, Yan Li, Yan Li

“…Cd and Zn can be transferred through the food chain, while broad beans can resist complex stress by regulating the content of total soluble sugars and photosynthetic pigments in the body, as well as accumulating proline. In addition, in the first generation of adult aphids, treatment with Cd (12.5 mg/kg) + Zn (100 mg/kg) significantly affected the expression of trehalase (TRE) and trehalose-6-phosphate synthase (TPS) genes and influenced the carbohydrate content and trehalase activity in the aphids.DiscussionThe number of offspring produced by the second-generation aphids was significantly reduced under mixed heavy metal treatment, but it was not caused by changes in the vitellogenin (Vg) content. …”
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Advantageous Extraction, Cleanup, and UHPLC-MS/MS Detection of Patulin Mycotoxin in Dietary Supplements and Herbal Blends Containing Hawberry from Crataegus spp. by Anna Przybylska, Grzegorz Bazylak, Robert Kosicki, Iwona Altyn, Magdalena Twaruzek, Jan Grajewski, Anna Soltys-Lelek

“…PAT was detected in all (n=14) commercial single-component dietary supplements formulated with dried hawberry belonging to Crataegus monogyna and/or Crataegus laevigata. …”
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Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer by Yuwei Yao, Jiarui Zhang, Kexin Huang, Yingying Peng, Shuangshuang Cheng, Shuangge Liu, Ting Zhou, Jinhua Chen, Haojia Li, Yingchao Zhao, Hongbo Wang

“…Abstract Background The efficacy of current therapies for ovarian cancer is limited due to the multilevel and complex tumor microenvironment (TME), which induces drug resistance and tumor progression in a single treatment regimen. Additionally, poor targeting and insufficient tissue penetration are important constraints in ovarian cancer treatment. …”
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Chinese medicine for headaches in emergency department: a retrospective analysis of real-world electronic medical records by Zhenhui Mao, Shirong Wu, Yuzhen Fan, Jingbo Sun, Shaohua Lyu, Qiaozhen Su

“…Conversely, over one-third of the patients utilized headache-specific patented Chinese herbal medicine products. Additionally, oral and topical Chinese herbal medicine treatments were also administered for headaches in the emergency departments.ConclusionThe majority of headaches consulting in the EDs were non-urgent and treated with various forms of Chinese medicine, alone or in conjunction of western medicine. …”
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Visceral Adipose Tissue Inflammation and Vascular Complications in a Rat Model with Severe Dyslipidemia: Sex Differences and PAI-1 Tissue Involvement by Irena Markova, Martina Hüttl, Natalie Gayova, Denisa Miklankova, Kristyna Cerna, Martina Kavanova, Petra Skaroupkova, Sona Cacanyiova, Hana Malinska

“…Using male and female hereditary hypertriglyceridemic (HHTg) rats—a nonobese prediabetic model featuring dyslipidemia, hepatic steatosis, and insulin resistance—we found that HHTg females exhibited more pronounced hypertriglyceridemia than males, while HHTg males had higher non-fasting glucose levels. Additionally, HHTg females had higher platelet counts, larger platelet volumes, and lower antithrombin inhibitory activity. …”
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Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and ne... by Juan Li, Jie Yang, Fan-rong Liang, Jun Zhou, Gui-Xing Xu, Han Yang, Yan-qun Xiao, Jia-jia Liu, Zhi-yong Xiao, Xiao-yan Zheng, Li-ying Liu, Zheng Yu

“…Therefore, it is necessary to conduct a systematic review and network meta-analysis (NMA) to rank these non-pharmacological interventions in terms of effect and determine which one is more effective for clinical application.Methods and analysis We will retrieve eight databases including Cochrane Library, Medline, Embase, PsycINFO, Chinese National Knowledge Infrastructure, WanFang Data, the Chongqing VIP Database and China Biology Medicine disc from their inceptions onwards. In addition, four clinical trial registries and the related references will be manually retrieved. …”
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A Systematic Review on the Performance Characteristics of Sustainable, Unfired Admixed Soil Blocks for Agricultural and Industrial Waste Management by Tarun Sharma, Sandeep Singh, Parteek Singh Thind, Jasgurpreet Singh Chohan, Raman Kumar, Shubham Sharma, Wojciech Kaplonek, Nima Khalilpoor, Alibek Issakhov

“…It was found that of the total 9 parameters considered for discussion, most of the studies using different admixtures (binder and fibers) in soil blocks were focused on compressive strength testing of blocks, water absorption, and durability by wetting drying cycles. However, other parameters like bulk density, maximum dry density and optimum water content, thermal conductivity, tensile strength, and flexural strength examined in recent studies are also reported in this paper. …”
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NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton by Van Thai Ha, Heung Soo Beak, Eunji Kim, Kwang-Soo Baek, Muhammad Jahangir Hossen, Woo Seok Yang, Yong Kim, Jun Ho Kim, Sungjae Yang, Jeong-Hwan Kim, Yung Hyup Joo, Chang Seok Lee, Joonho Choi, Hong-Ju Shin, Sungyoul Hong, Song Seok Shin, Jae Youl Cho

“…AP736 was found to strongly inhibit the production of both NO and PGE2 in lipopolysaccharide- (LPS-) treated RAW264.7 cells. In addition, AP736 strongly inhibited both LPS-induced morphological changes and FITC-dextran-induced phagocytic uptake. …”
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Study on the Mechanism of Organic Matter Enrichment in Early Cambrian Marine Shales in the Lower Yangtze Area, South China: An Example Using Well JXY1 by Sihong Cheng, Bin Li, Kun Zhang, Weiwei Liu, Jun Peng, Mingcai Hou, Ming Wen, Qingsong Xia, Xin Wang, Xiaoxue Liu, Li Zhong, Yizhou Huang, Yongyang Liu, Muhe Yuan, Yue Yao

“…In the middle stages of the Wangyinpu sedimentary period, the water body had the strongest reducibility and the highest biological productivity. …”
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Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system by Georgios Tsekas, Cornel Zachiu, Gijsbert H. Bol, Jochem R.N. van der Voort van Zyp, Sandrine M.G. van de Pol, Johannes C.J. de Boer, Bas W. Raaymakers

“…Sub-fractions with insufficient CTV dose can be explained by the presence of intrafraction rotations and deformations that were not taken into account during intrafraction corrections. Additionally, for no sub-fraction the dose to the organs-at-risk exceeded the clinical constraints. …”
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Barriers and facilitators to data-based decision making in Australian early childhood education and care: A qualitative study by Shauna Sherker, Karen Villanueva, Ruth Beatson, Caitlin M. Macmillan, Wan Yi Lee, Olivia Hilton, Carly Molloy, Sharon Goldfeld

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Proteomic profiling of serum in cats with naturally occurring degenerative joint disease and co-morbid conditions by B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, Rakesh Ponnala, Steven G. Kamerling, Tracey Williams

“…With the added co-morbidity of CKD, similar pathways were identified, with the addition of IL-12 signaling and production in macrophages.DiscussionWe identified differentially abundant proteins associated with DJD, pain and CKD and future work should evaluate these proteins as potential biomarkers of disease (individually or as clusters). …”
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Impact of Ag Coating Thickness on the Electrochemical Behavior of Super Duplex Stainless Steel SAF2507 for Enhanced Li-Ion Battery Cases by Hyeongho Jo, Jung-Woo Ok, Yoon-Seok Lee, Sanghun Lee, Yonghun Je, Shinho Kim, Seongjun Kim, Jinyong Park, Jonggi Hong, Taekyu Lee, Byung-Hyun Shin, Jang-Hee Yoon, Yangdo Kim

“…SAF30400 offers excellent strength and corrosion resistance but suffers from work hardening and low high-temperature strength at 700 °C. Additionally, Ni used for plating has a low current density of 25% international copper alloy standard (ICAS). …”
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Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support by Tae Higuchi, Tomomi Ide, Takeo Fujino, Takeshi Tohyama, Yuta Nagatomi, Tomoyuki Nezu, Masataka Ikeda, Toru Hashimoto, Shouji Matsushima, Keisuke Shinohara, Masaaki Nishihara, Takeshi Iyonaga, Tomohiko Akahoshi, Tomoki Ushijima, Akira Shiose, Shintaro Kinugawa, Hiroyuki Tsutsui, Kohtaro Abe

“…ICU-AW occurred 52% of patients with CS using MCS, indicating the significance of recognizing and managing this complication for those patients. In addition, IL-15 can be a potential biomarker for the early prediction of ICU-AW.…”
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Cell-free fat extract improves embryo development and clinical outcomes in older women with previous in-vitro fertilization failure by Xiaowei Zhou, Hanfei Zhu, Jingru Duan, Lan Xia, Shen Zhao, Huihui Xu, Xian Wu, Xiaoling Wang, Bufang Xu, Yi Cao, Aijun Zhang

“…We assessed the model’s efficacy in influencing embryo development and pregnancy rates in older women with in vitro fertilization failure. In addition, we performed immunofluorescence staining, multiplex immunoassay, whole-genome amplification and DNA sequencing, time-lapse embryo monitoring, and in vitro experiments. …”
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5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation by Jinque Luo, Jinque Luo, Xin Li, Xin Li, Li Zhang, Li Zhang, Meijing Deng, Jieyang Zhao, Jinghuan Zhang, Wenyu Tang, Qinghua Guo, Ling Wang

“…Further western blotting analysis showed 5-DR decreased the levels of NLRP3, cleaved caspase-1, and mature IL-1β in mice and J774A.1 cells exposed to LPS. Additionally, NF-κB pathway activation significantly diminished the inhibition of the NLRP3 inflammasome by 5-DR.DiscussionOur findings highlight the therapeutic potential of 5-DR as a promising candidate for treating LPS-induced ALI, offering insights into its underlying mechanism that targets NLRP3 inflammasome-mediated inflammation.…”
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A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…Pathogenic potential was assessed using disease phenotype predictors and CADD scores, while allele frequency data from gnomAD contextualized mutation prevalence. Additionally, aggregation propensity, frustration analysis, and post-translational modification sites were analyzed for functional disruptions.ResultsOf the 184 substitutions analyzed, 50 were identified as deleterious, with 41 predicted to be pathogenic. …”
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S, Se-Codoped Dual Carbon Coating and Se Substitution in Co-Alkoxide-Derived CoS₂ Through SeS₂ Triggered Selenization for High-Performance Sodium-Ion Batterie... by Kaiqin Li, Yuqi Kang, Chengjiang Deng, Yanfeng Wang, Haocun Ba, Qi An, Xiaoyan Han, Shaozhuan Huang

“…The dual carbon–graphene matrix not only improves the electronic conductivity but also stabilizes the electrode material effectively. In addition, the Se substitution within the CoS₂ lattice further improves the electrical conductivity and promotes the Na⁺ reaction kinetics. …”
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