Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation by Soukaina Essadssi, Al Mehdi Krami, Lamiae Elkhattabi, Zouhair Elkarhat, Ghita Amalou, Houria Abdelghaffar, Hassan Rouba, Abdelhamid Barakat

“…The results of ConSurf’s analysis revealed that all these nsSNPs are localised in the highly conserved positions and affect the structure of the native proteins. In addition, our computational analysis showed that the H15D, G140E, G216R, and S291L mutations identified as being associated with severe combined immunodeficiency affect protein structure. …”
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Recent global patterns in skin cancer incidence, mortality, and prevalence by Mingyue Wang, Xinghua Gao, Li Zhang, Lishao Guo, Xiangxiang Pan

“…These data were analyzed and the characteristics of incidence and mortality across five continents and top five countries and regions in each continent are presented. In addition, correlations between Human Development Index (HDI) and age-standardized incidence and mortality rates of these two skin cancers are described. …”
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Bacterial reduction in river water using nanocellulose membrane from pineapple biomass with ferrous-ferric oxide reinforcement by D. Syukri, H. Suryanto, F. Kurniawan, P.D. Hari, R.M. Fiana, . Rini

“…The ferrous-ferric oxide reinforcement enhanced the effectiveness of the membrane on bacteria and dye reduction. The addition of ferrous-ferric oxide resulted in a greater amount of dye degradation, and the presence of ≥0.75 percent ferrous-ferric oxide indicated an optimum ability to kill bacteria.CONCLUSION: Ferrous-ferric oxide yielded good results in reducing the number of microbes and anionic dyes in the water samples tested. …”
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Compliant flooring to prevent fall-related injuries in older adults: A scoping review of biomechanical efficacy, clinical effectiveness, cost-effectiveness, and workplace safety. by Chantelle C Lachance, Michal P Jurkowski, Ania C Dymarz, Stephen N Robinovitch, Fabio Feldman, Andrew C Laing, Dawn C Mackey

“…<h4>Conclusions</h4>In summary, compliant flooring is a promising strategy for preventing fall-related injuries from a biomechanical perspective. Additional research is warranted to confirm whether compliant flooring (i) prevents fall-related injuries in real-world settings, (ii) is a cost-effective intervention strategy, and (iii) can be installed without negatively impacting workplace safety. …”
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Effects of Soursop flowers (Annona muricata L.) extract on chemical changes of refined palm olein stored at frying temperature by Tonfack Djikeng Fabrice, Womeni Hilaire Macaire, Bala Krishna Marrapu, Mallampalli Sri Lakshmi Karuna, Rachapudi Badari Narayana Prasad, Linder Michel

“…Peroxide, para-anisidine, TOTOX, thiobarbituric acid and iodine values were the parameters evaluated. Additionally, the evolution of the fatty acid composition of each oil sample during the storage was assessed by gas-chromatography using a flame ionization detector (GC/FID). …”
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Swasthya Pahal (Health for All) Using a Sustainable, Multisector, Accessible, Affordable, Reimbursable, and Tailored Informatics Framework in Rural and Urban Areas of Chennai, Tami... by Ashish Joshi, Krishna Mohan Surapaneni, Ashoo Grover, Harpreet Kaur, Sofia Rani Saggu, Doilyn Oliveira

“…Objective assessments such as weight, blood pressure, and random blood sugar levels will be measured. In addition, the usefulness, acceptance, and effectiveness of the Swasthya Pahal program will be determined. …”
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Circ-ADAM9 Promotes High Glucose-Induced Retinal Pigment Epithelial Cell Injury in DR via Regulating miR-338-3p/CARM1 Axis by Zeyu Liang, Chengzhe Lu, Tingting Feng, Xiang Gao, Yongfang Tu, Wenchao Yang, Yipeng Wang

“…Also, MDA level and SOD activity were determined to assess cell oxidative stress. In addition, the interaction between miR-338-3p and circ-ADAM9 or CARM1 was confirmed by dual-luciferase reporter assay and RIP assay. …”
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Design and expression of a chimeric recombinant antigen (SsIR-Ss1a) for the serodiagnosis of human strongyloidiasis: Evaluation of performance, sensitivity, and specificity. by Mostafa Omidian, Zohreh Mostafavi-Pour, Marzieh Asadi, Meysam Sharifdini, Navid Nezafat, Ali Pouryousef, Amir Savardashtaki, Mortaza Taheri-Anganeh, Fattaneh Mikaeili, Bahador Sarkari

“…Using bioinformatics analysis, the regions with the highest antigenicity that did not overlap with other parasite antigens were selected. …”
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A Study on Excavation Characteristics of Tunnel with Upper-Soft Lower-Hard Stratum by Jun Feng, Hui-juan Yang, Yu Zhang

“…In general, the deformation and stress in the positive benching method construction were less than those in the other two methods. In addition, the positive benching method was convenient for mechanized operation, the construction progress was fast, and the cost was relatively low. …”
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IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy by Dylan Krajewski, Saurav Ranjitkar, Nathan Jordan, Sallie S. Schneider, Clinton B. Mathias

“…While ST2-/- mice also exhibited a profound suppression of MC responses, IL-10 depletion had no additional effects. However, ST2-/-/IL-10-/- mice exhibited further decreases in OVA-IgE and antigen-specific MC activation compared to ST2-/- mice.ConclusionOur data demonstrates that IL-10 can enhance MC responses in both WT and ST2-/- mice, further corroborating its proinflammatory effects on MCs and suggesting that they are not regulated by IL-33 signaling.…”
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On Transformation and Stress–Strain–Temperature Behavior of Fine-Grained Ni-Rich NiTi Wire vs. Aging Mode by Elena Ryklina, Kristina Polyakova, Victor Komarov, Semen Murygin, Anton Konopatsky, Vladimir Andreev, Adilet Ulanov

“…The aging mode strongly affects the stress–temperature behavior: (i) a dramatical expansion of the temperature range of realization of the transformation yield stress (σ_tr); and (ii) the magnitude of σ_tr at a chosen test temperature is generally determined by the position of the M_s temperature. An additional contribution of competing factors is discussed. …”
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Perceptions of Cardiovascular Healthcare Professionals Regarding Clinical Trials: A Survey-Based Study from the Middle East by Zainab Atiyah Dakhil, Hasan Ali Farhan, Mohammed Dheyaa Marsool, Mohammed Saad Qasim, Michele Peters, Jose Leal

“…The most common barriers to respondents’ participation in trials were lack of electronic health records (52.2% of those surveyed) and time (51.4%), followed by the requirement of additional follow-up visits or investigations (34.1%). …”
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Factors influencing breast milk donation to a human milk bank in Iran: implications for policymakers and planners by Leila Doshmangir, Maryam Naghshi, Kamal Gholipour, Ayat Ahmadi, Hosein Azizi, Vladimir Sergeevich Gordeev

“…Logistic regression analysis was performed to examine the relationships between breast milk donation and these factors. Additionally, qualitative data were collected through face-to-face interviews with HMB senior staff and mothers. …”
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A thermo-responsive chitosan-based injectable hydrogel for delivery of curcumin-loaded polycaprolactone microspheres to articular cartilage: in-vitro and in-vivo assessments by Farnoosh Kalantarnia, Sasan Maleki, Amir Shamloo, Kazem Akbarnataj, Sayed Navid Tavoosi

“…The degradation rate of ∼55 % over 30 days was tailored to match the timeline of cartilage repair. Additionally, polycaprolactone microspheres, prepared by solid/oil/water method, were used to enhance the bio-availability of curcumin and its sustained delivery. …”
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Barlow Twins deep neural network for advanced 1D drug–target interaction prediction by Maximilian G. Schuh, Davide Boldini, Annkathrin I. Bohne, Stephan A. Sieber

“…In addition, we further benchmark new baselines against existing methods. …”
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Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy by Esra Kızıldağ Özbay, Şenol Sabancı, Mehmet Fatih Küçük, Muhammet Kazım Erol

“…<b>Results:</b> Patients with persistent SRF exhibited significant increases in RNFL thickness in the inferior and nasal quadrants compared to healthy controls (<i>p</i> = 0.003 and <i>p</i> = 0.014, respectively). Additionally, RPC vessel density in the small vessel disc area (%) was significantly lower in the persistent SRF group compared to controls (<i>p</i> = 0.021). …”
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Genome sequence and evaluation of safety and probiotic potential of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89 by Ting Chen, Yunjiao Zhao, Yunjiao Zhao, Yixuan Fan, Yao Dong, Zhonghui Gai

“…We tested various properties of the two strains, included tolerance, cell adhesion, hemolytic activity, catalase activity, gelatin hydrolysis, arginine hydrolysis ability, bile salt hydrolysis capacity, mucin degradation, bioamine, D-/L-lactic acid production and antibiotic susceptibility, to confirm the safety of LC86 and LC89 both in vitro and in vivo. Additionally, we studied the acute toxicity of LC86 and LC89 in mice through a 14-day oral gavage experiment.ResultsThe two strains selected were identified as Lacticaseibacillus paracasei and Lacticaseibacillus casei. …”
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Rapid and simple detection of Candida albicans using closed dumbbell-mediated isothermal amplification by Yanli Zhang, Xuhan Chen, Yeling Zhong, Fei Guo, Guifang Ouyang, Rui Mao

“…IntroductionCandida albicans, a human fungal pathogen, multiplies to invade body cells and causes fungal diseases in the condition of insufficient body's immune function. …”
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Effect of Preservation Methods on Physicochemical Quality, Phenolic Content, and Antioxidant Activity of Stevia Leaves by Nadia Hidar, Abdelhamid Noufid, Ayoub Mourjan, El Mustapha El Adnany, Safa Mghazli, Mohammed Mouhib, Abderrahim Jaouad, Mostafa Mahrouz

“…The effect of freeze-drying and gamma irradiation at 0.5, 1, and 2 kGy on the physicochemical composition (moisture, fat, ash, mineral, and chlorophyll contents), microstructure, total phenolic content, and antioxidant capacity of stevia leaves was investigated in the present study. …”
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Comprehensive Metabolomic Profiling in Adults with X-Linked Hypophosphatemia: A Case-Control Study by Luis Carlos López-Romero, José Jesús Broseta, Marta Roca-Marugán, Noemí Máñez Ramírez, Julio Hernández-Jaras

“…Enrichment analysis identified disturbances in key metabolic pathways, including phosphatidylethanolamine biosynthesis, sphingolipid metabolism, and phosphatidylcholine biosynthesis. Additionally, pathways related to cysteine metabolism, glycolysis, and pyruvate metabolism. …”
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