Seed priming and abiotic stress tolerance in carrot: Unraveling the mechanisms of improved germination. by Marcin Nowicki, Marzena Nowakowska, Katarzyna Nowak, Wojciech Szczechura, Piotr Kaminski

“…., water, NaCl, PEG, GA3) on germination rates and seedling vigor. Additionally, we investigated the impact of inhibitors (actinomycin D-inhibitor of transcription, cycloheximide-inhibitor of translation, hydroxyurea-inhibitor of DNA synthesis, cytochalasin-inhibitor of actin polymerization) on seed germination under stress conditions. …”
Get full text

Transfer of optogenetic vectors into the brain of neonatal animals to study neuron functions during subsequent periods of development by D. A. Lanshakov, U. S. Drozd, T. A. Zapara, N. N. Dygalo

“…Thus, neonatal administration of a viral vector carrying an opto-channel gene is suitable for the study of brain neurons in rats of juvenile age, and requires additional control for gene expression during subsequent periods of development.…”
Get full text

Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…ATAC-seq analysis revealed that glycolysis in BC cells enhanced chromatin accessibility. Additionally, we confirmed that HDAC2 and HDAC3 act as “erasers” for H3 lysine lactylation. …”
Get full text

Habitat associations of six‐lined racerunners in longleaf pine managed with a short fire rotation for northern bobwhites by Isaiah W. Samek, Steven J. Price, Theron M. Terhune II, Darin J. McNeil

“…Although bobwhite management in these systems is mostly synonymous with longleaf pine restoration, additional conservation practices aimed at game birds (promoting fallow fields, supplemental feeding, meso‐carnivore control, cross sectional mowing, etc.) might affect the extent to which squamates benefit from habitat management. …”
Get full text

Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6 by Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer

“…Remarkably, it restored nicotinic modulation in neurons of α5SNP rats, while no such effect was observed in α5KO rats. Additionally, galantamine functioned as a positive allosteric modulator of α5*nAChRs in RS neurons, both in rat and human cortical L6, but did not affect burst spiking (BS) neurons. …”
Get full text

Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…The objective of the current research was to explore the potential connections between immune characteristics and the development of HF, as well as to ascertain the nature of the causality between these factors.MethodsTo assess the causal association of immunological profiles with HF based on publicly available genome-wide studies, we employed a two-sample Mendelian randomization technique, utilizing the inverse variance weighted (IVW) method as our primary analytical approach. In addition, we assessed heterogeneity and cross-sectional pleiotropy through sensitivity analyses.ResultsA two-sample Mendelian randomization (MR) analysis was conducted using IVW as the primary method. …”
Get full text

Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex by Jason S. Hauptman, Joseph Antonios, Gary W. Mathern, Michael S. Levine, Carlos Cepeda

“…These results support the concept that Pten deletion results in significant changes in inhibitory inputs onto CPNs, and these alterations can be prevented with chronic rapamycin treatment. In addition, normal mice treated with rapamycin also display altered membrane and synaptic properties. …”
Get full text

Decomposition of skill scores for conditional verification: impact of Atlantic Multidecadal Oscillation phases on the predictability of decadal temperature forecasts by A. Richling, J. Grieger, H. W. Rust

“…Compared to the low-resolution system (preop-LR), no overall performance benefits are made in this region, but positive contributions are achieved for initialization in neutral AMO phases. Additionally, the decomposition reveals a strong imbalance among the subsets (defined by AMO phases) in terms of reference weighting, allowing for insightful interpretation and conclusions. …”
Get full text

Long-Term Surgical Outcomes of Glaucoma Drainage Implants in Eyes with Preoperative Intraocular Pressure Less than 19 mmHg by Shahin Hallaj, Jae-Chiang Wong, Lauren E. Hock, Natasha Nayak Kolomeyer, Aakriti G. Shukla, Michael J. Pro, Marlene R. Moster, Jonathan S. Myers, Reza Razeghinejad, Daniel Lee

“…Clinical data of 67 eyes of 67 patients were collected from patients’ charts, and the outcomes of GDI were evaluated until 7 years. GDI failure was defined as IOP reduction of less than 20% from the baseline at two consecutive visits three months after surgery, decline to no light perception, or if additional glaucoma surgery was performed. …”
Get full text

Physiological and molecular mechanisms of exogenous salicylic acid in enhancing salt tolerance in tobacco seedlings by regulating antioxidant defence system and gene expression by Xiliang Song, Jian Chen, Can Xu, Xianjie Cai, Wenjing Song, Aixia Chang, Yu Zhang, Chenggang Luo

“…The plant hormone salicylic acid (SA) has notable potential in mitigating salt toxicity, yet its mechanism in enhancing the salinity tolerance of tobacco plants is not well explored.MethodsThis study aimed to assess the potential benefits of exogenous SA application (1.0 mM) on tobacco seedlings subjected to saline soil conditions.ResultsThe foliar spray of SA partially mitigated these salt-induced effects, as evidenced by a reduction of malondialdehyde content, and improvements of leaf K+/Na+ ratios, pigment biosynthesis, and electron transport efficiency under NaCl stress. Additionally, SA increased the contents of total phenolic compound and soluble protein by 16.2% and 28.7% to alleviate NaCl-induced oxidative damage. …”
Get full text

In-Situ Polymerization for Catalytic Graphitization of Boronated PAN Using Aluminum and Zirconium Containing Co-Catalysts by Taewoo Kim, Byoung-Suhk Kim, Tae Hoon Ko, Hak Yong Kim

“…Such highly graphitized materials can be effectively obtained through in-situ polymerization. The addition of external catalysts during in-situ polymerization not only enhances the polymerization rate but also facilitates the degree of graphitization and quality of graphitic carbon upon graphitization at moderate temperatures. …”
Get full text

Effectiveness of deliberate practices versus conventional lecture in trauma training for medical students by Suksan Kanoksin, Bhapapak Na Songkhla, Amarit Tansawet, Issaree Laopeamthong, Pakkapol Sukhvibul, Suphakarn Techapongsatorn

“…Additionally, the deliberate practice group had no clear failures or seven good passes, whereas the conventional lecture group had five clear failures and no good passes. …”
Get full text

Psychometric Properties of the Persian Version of the Frontal Assessment Battery in Patients With Traumatic Brain Injury by Ramin Banimahdi, Seyed Majid Akhavan Hejazi, Seyed Ali Hosseini, Nazila Akbarfahimi, Mohsen Vahedi

“…This included the number of categories achieved in the WCST (r=0.745, P<0.001) and perseverative errors (r=0.307, P<0.05) in addition to all items of the Stroop test (P<0.001), with exception of the interference score (P>0.05). …”
Get full text

Revealing speckle obscured living human retinal cells with artificial intelligence assisted adaptive optics optical coherence tomography by Vineeta Das, Furu Zhang, Andrew J. Bower, Joanne Li, Tao Liu, Nancy Aguilera, Bruno Alvisio, Zhuolin Liu, Daniel X. Hammer, Johnny Tam

“…The combination of two parallel discriminators in P-GAN provides additional feedback to the generator to more faithfully recover both local and global cellular structures. …”
Get full text

Physical Activity Types Among School-Aged Children During COVID-19 Pandemic in Saudi Arabia: A Cross-Sectional Study by Mshari Alghadier, Reem M. Basuodan, Afnan Gmmash, Reem A. Albesher

“…Results: Parents reported that children (<i>n</i> = 361, mean age 7.7 ± 1.1 years) selected different PA types pre-COVID-19 pandemic more often than during the COVID-19 lockdown, such as swimming (16.9% vs. 12.8%), high-intensity jumping (9.8% vs. 6.6%), cycling (12.8% vs. 9.6%), football (14.3% vs. 6.1%), running (9.3% vs. 5.5%), virtual gaming exercise (5% vs. 3.2%), and playground activity (11.3% vs. 5.8%) (<i>p</i> < 0.05). Additionally, PA type was shown to be influenced by gender and residence type, with girls being 55% more likely to be physically active during COVID-19 compared to boys, and participants living in houses without private yards being less physically active compared to those who lived in houses with private yards. …”
Get full text

Cost-effectiveness Analysis of Lorlatinib in Patients Previously Treated with Anaplastic Lymphoma Kinase Inhibitors for Non-small Cell Lung Cancer in Greece by George Gourzoulidis, Oresteia Zisimopoulou, Nadia Boubouchairopoulou, Christina Michailidi, Chrissy Lowry, Charalampos Tzanetakos, Georgia Kourlaba

“…**Conclusion:** The present analysis suggests that lorlatinib may be considered as a cost-effective option compared with P-ChT in Greece for the treatment of patients with advanced, ALK-positive NSCLC whose disease has progressed after at least one second-generation ALK tyrosine kinase inhibitor. In addition, this option addresses a significant unmet medical need.…”
Get full text

Self-management behavior and its influencing factors among adults with chronic obstructive pulmonary disease in Colombo, Sri Lanka: A cross-sectional study by Kanchana Warnakula Royal Weerasooriya, Niphawan Samartkit, Khemaradee Masingboon, Pachanok Witheethamasak

“…Conclusion: The study shows evidence that a program to intervene targeting COPD knowledge and perceived social support, in addition to reducing dyspnea and perceived stress, can be beneficial in promoting better self-management behaviors among adults with mild to moderate COPD. …”
Get full text

A systematic literature review of forecasting and predictive models for enterococci intrusion in aquatic ecosystems by Philomina Onyedikachi Peter, Edoardo Bertone, Rodney A. Stewart

“…This systematic review explores the existing body of research on water quality modeling by analyzing various model types, their applications, and their effectiveness. …”
Get full text

Interactions of Self-Assembled <i>Bletilla Striata</i> Polysaccharide Nanoparticles with Bovine Serum Albumin and Biodistribution of Its Docetaxel-Loaded Nanoparticles by Guangyuan Zhang, Jin Qiao, Xin Liu, Yuran Liu, Ji Wu, Long Huang, Danyang Ji, Qingxiang Guan

“…The ultraviolet and fluorescence results exhibited a strong binding affinity between BSPs-SA nanoparticles and bovine serum albumin, but the conformation of bovine serum albumin was not altered. Additionally, the area under the concentration–time curve (AUC_0–∞) of DTX-loaded BSPs-SA nanoparticles was about 1.42-fold higher compared with Duopafei^® in tumor-bearing mice. …”
Get full text

The divergent histories of Bose-Einstein statistics and the forgotten achievements of Władysław Natanson (1864–1937) by Michał Kokowski

“…Also shown is his strategy to quote reliably the bibliography with regard to the explanation of the distribution of blackbody radiation and related issues. Additionally, a list of scientists who knew Natanson’s publications has been supplemented in the article and the precursorship of Natanson’s achievements is explained. …”
Get full text