The Anticancer Activity of Lycium barbarum Polysaccharide by Inhibiting Autophagy in Human Skin Squamous Cell Carcinoma Cells In Vitro and In Vivo by Meihua Zeng, Qingtao Kong, Fang Liu, Jun Chen, Hong Sang

“…At the same time, the regulation of Beclin1, LC3II, Bcl-2, and cl-caspase-3 by LBP was effectively reversed by the cotreatment of SP600125. In addition, LBP increased the survival rate of transplanted nude mice, reduced tumor volume and weight, and downregulated the expression of Ki67 and MMP-2. …”
Get full text

Allele-specific PCR with fluorescently labeled probes: criteria for selecting primers for genotyping by V. A. Devyatkin, A. A. Shklyar, A. Zh. Fursova, Yu. V. Rumyantseva, O. S. Kozhevnikova

“…It makes it possible to distinguish alleles in a genome with high accuracy without additional manipulations with DNA samples or PCR products; hence the popularity of this method in genetic association studies in molecular genetics and medicine. …”
Get full text

Life Cycle Assessment of Methanol Production from Municipal Solid Waste: Environmental Comparison with Landfilling and Incineration by Cristiano Queiroz Cerqueira, Electo Eduardo Silva Lora, Lidiane La Picirelli de Souza, Márcio Montagnana Vicente Leme, Regina Mambeli Barros, Osvaldo José Venturini

“…The results reveal that methanol production from MSW significantly reduces global warming potential (GWP) by 87% compared to landfilling and 56% compared to incineration. Additionally, the process demonstrates high energy efficiency in electricity generation, achieving 80% of the output of incineration. …”
Get full text

0.5 V Digitally-Tunable Filters for Biomedical Applications Exploiting Segmented Duty-Cycled Resistors by Alessandro Fava, Francesco Centurelli, Giuseppe Scotti

“…In this paper, we present the design and the experimental validation of a biquad filter for biomedical applications that takes advantage of segmented duty-cycled resistors to allow for digital tuning over a wide range of the cutoff frequency (<inline-formula> <tex-math notation="LaTeX">$f_{0}$ </tex-math></inline-formula>), quality factor (Q), and gain (K). Additionally, we report on the experimental findings for an 8th-order band pass filter that was created to extract the epilepsy biomarker, related to the fast ripple band (250 Hz&#x2013;500 Hz). …”
Get full text

Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…Analyses of TCGA datasets and tissue arrays showed that CREB5 mRNA and protein expression levels were higher in liver cancer tissues than in paired normal tissues. In addition, overexpression of CREB5 was associated with poor prognosis and an aggressive phenotype in patients with HCC. …”
Get full text

Pre-emergent herbicides during the off-season of irrigated rice to control weedy rice and reduce the soil seed bank by Tilio Adan Lucas, Simone Puntel, Rafaella Boemo Mario, Leonardo da Silva Bolson, Arícia Ritter Corrêa, Pedro Henrique Folharini, Murilo Vieira Loro, André da Rosa Ulguim

“…The herbicides s-metolachlor, sulfentrazone + diuron, and flumioxazin exhibited the highest injury values; however, they did not significantly affect crop productivity. …”
Get full text

Useful Reduction Mammoplasty Technique in Oncoplastic Breast Surgery and Reconstruction by Jong Ho Lee, Jeong Yeop Ryu, Kang Young Choi, Jung Dug Yang, Ho Yun Chung, Byung Chae Cho, Byeongju Kang, Jeeyeon Lee, Ho Yong Park, Joon Seok Lee

“…Among the patients who underwent a partial mastectomy, the mean age was 45.18 ± 11.05 years, the mean body mass index (BMI) was 26.74 ± 3.53 kg/m2, and the mean preoperative right and left breast volumes were 663.85 (±28.12) cc and 664.34 (±37.13) cc, respectively, and the mean excised mass weight was 177.74 (±213.93) g. …”
Get full text

Economic evaluation of tranexamic acid for the treatment of acute gastrointestinal bleeding: a cost-effectiveness analysis using data from the HALT-IT randomised controlled trial by Ian Roberts, Vipul Jairath, Alec Miners, Jack Williams, Haleema Shakur-Still, Nuha Bazeer

“…The model used data of the treatment effectiveness from the HALT-IT trial, which showed that TXA administration for acute gastrointestinal bleeding did not reduce all-cause mortality (risk ratio 1.03, 95% CI 0.92 to 1.16) compared with no-TXA. …”
Get full text

A Systematic Review and Network Meta-Analysis of Biomedical Mg Alloy and Surface Coatings in Orthopedic Application by XinYue Lu, HongXin Cai, Yu Ru Li, Xinru Zheng, Jiahao Yun, Wenhui Li, XiaoYu Geng, Jae-Sung Kwon, Heng Bo Jiang

“…In the quantitative analysis, 21 articles were subjected to network meta-analysis, with 16 articles on implant degradation and 8 articles for new bone formation. Additionally, SUCRA indicated that Ca-P coating exhibited the highest corrosion resistance, followed by FLU treatment. …”
Get full text

A Novel Nomogram for Early Identification of CFS-Like Symptoms in University Students with Infectious Mononucleosis by Deping Sun, Yanan Liang, Fuwei Yang, Lan Liu, Yuqin Yan

“…Calibration curves revealed a close match between predicted and observed probabilities. Additionally, decision curve analysis showed positive net benefits across a broad spectrum of threshold probabilities, underscoring the nomogram’s clinical applicability. …”
Get full text

Thermally Conductive Shape-Stabilized Phase Change Materials Enabled by Paraffin Wax and Nanoporous Structural Expanded Graphite by Yilin Zhao, Shuhui Huang, Zhaoguo Jin, Zhongnan Xie, Hong Guo, Haofeng Xie

“….%, and the residual mass fraction was greater than 99% after 50 cycles of high and low temperature. In addition, due to the excellent thermal management capability of PW/EG, the operating temperature of electronic components can be stably maintained at 68–71 °C for about 15 min and the peak temperature can be reduced by at least 23 °C when the heating power of the electronic components is 10 w. …”
Get full text

Comparative analysis of harmonic sensitivity for stator fault diagnosis in induction motors by Allal Abderrahim, Lamouchi Zakaria, Abderrahmane Khechekhouche, Antonio Marcos de Oliveira Siqueira, Julio César Costa Campos, Kheireddine Lamamra

“…Continuous monitoring of the RSH frequency component enables the prompt detection and localization of stator faults, along with an assessment of their severity. Additionally, this diagnostic methodology proves effective in identifying micro short-circuits between stator coils, allowing for a proactive strategy in predictive maintenance. …”
Get full text

Multi-layered electrospun grafts for surgical repair: Biomimicking physiological ascending aortic compliance by Julia Krammer, Maximilian Pichlmaier, Jan Stana, Christian Hagl, Sven Peterss, Maximilian Grab, Linda Grefen

“…Therefore, the aim of this project was to develop an innovative graft that additionally exhibits physiological aortic compliance. …”
Get full text

What's the role of kindness in the healthcare context? A scoping review by Angela Greco, Laura G. González-Ortiz, Luca Gabutti, Daniel Lumera

“…Conclusions The need for additional research on kindness in healthcare arises from a complex and dynamic healthcare environment, where the concept of kindness holds the potential to revolutionize the quality of care and the well-being of healthcare providers. …”
Get full text

Association between 24-hour urine volume and 28-day intensive care unit mortality in sepsis patients: a multi-center retrospective cohort study by Yuzhan Lin, Weiguo Lin, Cheng Fu, Ruixue Sun, WeiLi Hong, Xinglin Chen, Shaorong Yan

“…Logistic regression models and generalized additive models were used to examine the relationship between 24-hour urine volume and 28-day ICU mortality.ResultsA negative correlation was found between 24-hour urine volume and ICU 28-day mortality. …”
Get full text

Assessing Mitigation Strategies to Reduce Potential Exposures to Indoor Particle Release Events by Katie Van Valkinburgh, Ali Mohammadi Nafchi, Ehsan Mousavi, Vincent Blouin, Nigel Kaye, Andrew R. Metcalf

“…We then assess how quickly the particles were removed by ventilation systems with varying conditions, including the addition of both high- and low-cost portable mitigation devices into the classroom. …”
Get full text

Plant Coping with Cold Stress: Molecular and Physiological Adaptive Mechanisms with Future Perspectives by Yan Feng, Zengqiang Li, Xiangjun Kong, Aziz Khan, Najeeb Ullah, Xin Zhang

“…This review also highlights the analysis of those transcription factors such as bHLH, especially bHLH-type transcription factors ICE, and discusses their functions as phytohormone-responsive elements binding proteins in the promoter region under cold stress. In addition, a theoretical framework outlining plant responses to cold stress tolerance has been proposed. …”
Get full text

US Deterrence against Russia and China (based on strategic documents of J. Biden administration) by V. I. Batyuk

“…The main role in containing the PRC should be played by a system of military-political alliances with the countries of Southeast and South Asia located along the perimeter of its borders. In addition to the alliances inherited from the Cold War, the Biden administration is seeking to develop new ‘bloc structures’ in the Indo-Pacific region, in particular the Quadrilateral Security Dialogue (QUAD). …”
Get full text

Distinguishing benign and malignant myxoid soft tissue tumors: Performance of radiomics vs. radiologists. by Joshua M Lawrenz, Can Cui, Samuel R Johnson, Katherine S Hajdu, Stephen W Chenard, Akhil Rekulapelli, Cullen P Moran, John J Block, Nicholson S Chadwick, Joanna L Shechtel, Brian Bingham, Leo Y Luo, Jennifer L Halpern, Herbert S Schwartz, Ginger E Holt, David S Smith, Benoit Dawant, Hakmook Kang

“…Five ML models were trained to classify tumors as benign or malignant in 40 tumors and then tested with an additional 50 tumors using cross validation. The accuracy of the best ML model based on area under the receiver operating characteristic curve (AUC) was compared to the consensus diagnosis of three musculoskeletal radiologists. …”
Get full text

A Case of Status Epilepticus in a Patient Experiencing an Acute Attack of Hereditary Angioedema by Danielle Weinberg, Steven Gayda, Kyle Hultz, Hanan Atia, Brian Kohen, Eric Boccio

“…The patient’s mental status did not return to baseline, and she experienced two additional seizures. …”
Get full text