Identification of new genes regulating nodule development in Medicago truncatula: an in-silico approach by Mahboobeh Azarakhsh, Sara Eslami, Maryam Moghadas, Zahra Ataei

“…Our results on potential regulators of nodule organogenesis will pave the way for additional researches.…”
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Performance outcomes from a DMEK peeling and preparation wet lab by Sajjad Ahmad, Vito Romano, Mohit Parekh, Stefano Ferrari, Alessandro Ruzza, Matteo Airaldi, Alexander George Wallace

“…A significant correlation was found between longer peeling times and higher TBPC % (p<0.001) with a 0.7% endothelial mortality increase for each additional minute required to complete the peel.Conclusions DMEK wet labs provide a controlled risk-free learning opportunity for trainee surgeons to improve confidence and competence. …”
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Challenges and Barriers of Online Teaching: Perspective of Faculty in a Private Medical College of Lahore by Naureen Omar, Ifra Aslam, Syeda Mahnoor Nadeem, Ramsha Batool, Umbreen Navied, Muhammad Subhan Feroze

“…Conclusion: Lack of face to face interaction, connectivity, software and power failure issues, in addition to finances and time management were major challenges and barriers faced during initiation of online teaching by the faculty. …”
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Development of Extrudable Hydrogels Based on Carboxymethyl Cellulose–Gelatin Complex Coacervates by Hamid Gharanjig, Hossein Najaf Zadeh, Campbell Stevens, Pram Abhayawardhana, Tim Huber, Ali Reza Nazmi

“…Rheological characterization demonstrated that all CMC–gelatin hydrogels exhibited pseudoplastic behavior, with an inverse correlation between increased coacervation and decreased shear viscosity. Additionally, the coacervates displayed lower tackiness compared to gelatin hydrogels, with the maximum tackiness normal force for various CMC–gelatin ratios ranging from 1 to 15 N, notably lower than the 29 N observed for gelatin hydrogels. …”
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Association between C-reactive protein and chronic pain in US adults: A nationwide cross-sectional study. by Chunsheng Huang, Qizhen Tong, Qiaoling Tong

“…Individuals exhibiting elevated levels of CRP demonstrated a heightened propensity for experiencing chronic pain in comparison to individuals with lower CRP levels. Additional investigation is necessary to explore the presence of a causal association between the two variables, as well as the potential underlying mechanisms.…”
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Thermodynamic Analysis of Supercritical CO2 Power Cycle with Fluidized Bed Coal Combustion by Chenchen Geng, Yingjuan Shao, Wenqi Zhong, Xuejiao Liu

“…The influences of two stages split flow on system performance have been investigated in detail. In addition, thermodynamic analysis of critical operating parameters has been carried out, including terminal temperature difference, turbine inlet pressure/temperature, reheat stages, and parameters as well as compressor inlet pressure/temperature. …”
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Measuring the Average Peak Timing of Kinematic Variables in Youth and Adolescent Baseball Pitchers by Mark Boland, Daniel Zambanini, Ivan Mulligan, Sean Donegan

“…Mean and standard deviations were identified for peak kinematic variables of shoulder external rotation ROM (158.71°, ±9.32), shoulder internal rotation velocity (92.26 rad/sec, ±19.29), trunk rotation velocity (15.94 rad/sec, ±1.68), trunk rotation ROM (23.57°, ±8.14), and average stride length (81.97% height ±4.57). Additionally, mean and standard deviations of peak kinematic variables were expressed as percentages to reflect when they occurred in the pitching cycle and included trunk rotation ROM (8.45%, ±12.72), pelvic rotation velocity (33.26%, ±16.42), trunk rotation velocity (41.59%, ±9.27), shoulder external rotation ROM (71.34%, ±6.61), and shoulder internal rotation velocity (86.93%, ±6.45)…”
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Predicting pregnancy loss and its determinants among reproductive-aged women using supervised machine learning algorithms in Sub-Saharan Africa by Tirualem Zeleke Yehuala, Sara Beyene Mengesha, Nebebe Demis Baykemagn

“…Women from lower-income backgrounds may face challenges in accessing prenatal care or safe reproductive health services, leading to higher risks of loss. Additionally, higher levels of education are often correlated with increased awareness of family planning methods and better access to healthcare, which can reduce the likelihood of unintended pregnancy loss.ConclusionThe Random Forest machine learning model demonstrates greater predictive power in estimating pregnancy loss risk factors. …”
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A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data reveal... by Zhou An, Meichun Zeng, Xianhua Wang

“…Results: Multivariable Mendelian randomization showed an association between smoking per day (odds ratio = 1.2, 95% confidence interval: 1.038–1.38, p  = 0.014) or current smoking (odds ratio = 2.41, 95% confidence interval: 1.06–5.5, p  = 0.037) and Barrett’s esophagus. …”
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A compact and highly isolated integrated 8-port MIMO antenna for sub-6 GHz and mm-wave 5G-NR applications by Manumula Srinubabu, Nuthakki Venkata Rajasekhar

“…The antenna demonstrates excellent isolation and gain, with S21 values below -25 dB and peak gains of 11.75 dBi and 12 dBi for the sub-6 GHz and mm-wave bands, respectively. …”
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MOMAST^® Downregulates AQP3 Expression and Function in Human Colon Cells by Ines Angelini, Mariangela Centrone, Giusy Rita Caponio, Annarita Di Mise, Andrea Gerbino, Marianna Ranieri, Giovanna Valenti, Grazia Tamma

“…Indeed, the H₂O₂ transport was partially but significantly reduced in the presence of MOMAST^® or DFP00173, a selective inhibitor of AQP3. In addition, the MOMAST^®-induced AQP3 decrease was associated with reduced epithelial-mesenchymal transition (EMT)-related proteins such as vimentin and β-catenin. …”
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Screening Selected Solanum Plants as Potential Rootstocks for the Management of Root-Knot Nematodes (Meloidogyne incognita) by Benjamin A. Okorley, Charles Agyeman, Naalamle Amissah, Seloame T. Nyaku

“…They advance a complex parasitic relationship with roots of tomato plants leading to modification of host structural and physiological functions in addition to significant yield loss. Resistance in solanaceous plants to RKNs has been identified and associated with the possession of Mi gene. …”
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Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma by Wei An, Kai Zhang, Guangbing Li, Shunzhen Zheng, Yukun Cao, Jun Liu

“…In terms of molecular mechanism, we found that HY-PDT induced ferroptosis by decreasing GPX4 expression via suppression of the AKT/mTORC1 signaling pathway. In addition, we also found that HY-PDT inhibit cholangiocarcinoma cells migration and the EMT process by inhibiting the AKT/mTORC1 pathway. …”
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A Cost-Effective and Robust Cell-Based Bioassay Method for Evaluating the Bioactivity of Trastuzumab-like Antibodies by Pooja Bharali, Subhash Chand, Harish Chander

“…The biological activity of trastuzumab was determined using the inhibition of proliferation (IOP) assay on the SKBR3, which was optimized based on the parameters of cell seeding density, drug dilution range, and incubation time, and it was further validated as per the compendial guidelines and found valid for the parameters of specificity, accuracy (% relative bias = 0.0067%), precision (repeatability: % GCV = 1.21%), linearity (R2 = 0.99), and range (50% to 200%). Additionally, the biological activity of different trastuzumab biosimilars was assessed using the validated IOP assay and compared to the HER2 binding assay performed by flow cytometry. …”
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Fuzzy Random Characterization of Pore Structure in Frozen Sandstone: Applying Improved Niche Genetic Algorithm by Yao Ya-feng, Lin Jian, Ge Jian, Peng Shi-long, Yin Jian-chao, Ouyang Li-na

“…Compared with the previous least square fitting method, it provides a more accurate approach in characterizing complicated pore structures in frozen rock and soil masses. In addition, the improved niche genetic algorithm effectively overcomes the shortcomings of the traditional genetic algorithm, such as low effectiveness, slow convergence, and weak controllability, which provides an effective way for parameter inversion in the section of frozen geotechnical engineering. …”
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Development of a GIS-based register of biogas plant sites in Lower Saxony, Germany: a foundation for identifying P2G potential by Mareike Plinke, Jonas Berndmeyer, Jochen Hack

“…Spatial data on existing biogas plants in Lower Saxony were selected from the Digital Landscape Model (DLM) data, with additional information coming inter alia from the Marktstammdatenregister, the Germany-wide core energy market data register. …”
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QAR Data Imputation Using Generative Adversarial Network with Self-Attention Mechanism by Jingqi Zhao, Chuitian Rong, Xin Dang, Huabo Sun

“…The improved gated recurrent unit is then introduced as the neural unit of GAN, which can successfully capture the temporal relationships in QAR data. In addition, we modify the basic structure of GAN by using an autoencoder as the generator and a recurrent neural network as the discriminator. …”
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Extreme-phenotype genome-wide association study (XP-GWAS) of powdery mildew race 2 W tolerance in the USDA Citrullus germplasm collection by Sandra E. Branham, Venkata Rao Ganaparthi, W. Patrick Wechter, Younghoon Park, Todd Wehner, Angela Davis, Antonia Tetteh, Laura Massey, Sue Hammar, Rebecca Grumet, Shaker Kousik, Amnon Levi

“…Two adjacent SNPs on chromosome 7 were significantly associated with P. xanthii race 2 W tolerance in the bulks and two additional SNPs had a strong signal in the XP-GWAS analysis. …”
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Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells by Sasi Kumar Jagadeesan, Ahmad Galuta, Ryan Vimukthi Sandarage, Eve Chung Tsai

“…Functional assays corroborated the transcriptomic findings, demonstrating superior neurogenic potential in iPSC-Br NSPCs. Additionally, we assessed donor-specific influences on NSPC behavior by analyzing gene expression and differentiation outcomes across syngeneic populations from multiple individuals. …”
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Rational metabolic engineering of <i>Corynebacterium glutamicum</i> to create a producer of L-valine by M. E. Sheremetieva, K. E. Anufriev, T. M. Khlebodarova, N. A. Kolchanov, A. S. Yanenko

“…L-Valine is used in the food and pharmaceutical industries, medicine and cosmetics, but primarily as an animal feed additive. Adding L-valine to feed, alone or mixed with other essential amino acids, allows for feeds with lower crude protein content, increases the quality and quantity of pig meat and broiler chicken meat, as well as improves reproductive functions of farm animals. …”
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