Immunosuppressive Phenotype of Esophagus Tumors Stroma by Olga V. Kovaleva, Madina A. Rashidova, Daria V. Samoilova, Polina A. Podlesnaya, Valeria V. Mochalnikova, Alexei Gratchev

“…We found that FOXP3 expression was associated with age (p=0.042) and iNOS expression was associated with the disease stage (p=0.044). In addition, FOXP3 and CD163 appeared to be markers of good prognosis (HR=0.4420, p=0.0325, and HR=0.4447, p=0.0456, respectively). …”
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Evaluation of Biocoagulant “Opuntia ficus-indica and Chitosan” to Improve the Removal of Contaminants in Dairy Effluents through Electrocoagulation by Naysha Y. M. Elguera, Stephanie E. S. Pulcha, Edgar M. M. Ballon, Miriam R. F. Castro, Lilia M. M. Ramos, Victor L. A. Tohalino, Pavel K. D. Sarmiento, Vitor C. Almeida, Hugo G. J. Pacheco

“…A monopolar glass reactor with aluminum electrodes was assembled by applying the response surface approach methodology. Additionally, using the Box–Behnken mathematical model for the removal of TB and COD, the effects and interactions of the factors and experimental design levels (considering control formulations using triplicates) were evaluated. …”
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Effect of HBeAg/anti-HBe coexistence on HBeAg seroconversion in treatment-naïve chronic hepatitis B patients with peginterferon-α by Kaimin Song, Huitong Wang, Dawu Zeng, Yunyun Qian, Zhixiang Guo, Huatang Zhang, Yijuan Zheng, Yongjun Zhou, Xueping Yu, Zhijun Su

“…Clinical characteristics of the HBeAg/anti-HBe coexistence group were compared with those of the anti-HBe-negative group. In addition, univariate and multivariate logistic regression analyses were performed to identify independent risk factors for HBeAg seroconversion. …”
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All-Cause Mortality Prediction in Subjects with Diabetes Mellitus Using a Machine Learning Model and Shapley Values by Oana Mirea, Mostafa Ghelich Oghli, Oana Neagoe, Mihaela Berceanu, Eugen Țieranu, Liviu Moraru, Victor Raicea, Ionuț Donoiu

“…Methods: We included 1969 consecutive patients with DM type 1 (T1DM, <i>n</i> = 255) and type 2 (T2DM, <i>n</i> = 1714). eXtreme Gradient Boosting (XGBoost) was used for the prediction of all-cause mortality in this cohort and the Shapley additive explanation (SHAP) was used to assess the importance of each feature of the classifier. …”
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VICTIM OF AN OFFENCE: LEGAL AND ECONOMIC ANALYSIS IN AN INTERJURISDICTIONAL CONTEXT by Andrii Borovyk, Oleksandr Golovach, Oleksandr Shyra

“…The study places particular emphasis on the economic impact of crimes on victims and society as a whole. In addition to direct costs such as medical expenses, it also analyses indirect consequences including psychological trauma. …”
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Integrative physiological and transcriptome analysis unravels the mechanism of low nitrogen use efficiency in burley tobacco by Yuqing Feng, Yuanyuan Zhao, Yanjun Ma, Xiaolong Chen, Hongzhi Shi

“…Three nitrate transporter genes in the leaves (NPF2.11, NPF2.13, and NPF3.1) and three nitrate transporter genes (NPF6.3, NRT2.1, and NRT2.4) in roots were down‐regulated by nitrogen starvation, all of which showed lower expression in TN90 than in K326. In addition, the protein–protein interaction (PPI) network diagram identified eight key genes (TPIP1, GAPB, HEMB, PGK3, PSBO, PSBP2, PSAG, and GLN2) that may affect NUE. …”
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The association between dietary sodium density and Hashimoto’s thyroiditis in US adults by Peilin An, Silin Wang, Lingyun Liu, Xuelin Li, Xin Lv, Xin Lv

“…Restricted cubic spline (RCS) analyses were performed to explore non-linear relationships.ResultsA total of 6,258 participants were included, with 576 (9.20%) diagnosed with HT. An additional unit of dietary sodium density was associated with a 24% increased risk of HT (OR 1.24, 95% CI 1.01–1.50) in adjusted model. …”
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Regulation of ER stress-induced apoptotic and inflammatory responses via YAP/TAZ-mediated control of the TRAIL-R2/DR5 signaling pathway by Y. El Yousfi, F. J. Fernández-Farrán, F. J. Oliver, A. López-Rivas, R. Yerbes

“…On the other hand, it inhibits cFLIP down-regulation in tumor cells experiencing ER stress. In addition, YAP/TAZ controls the expression of pro-inflammatory interleukin-8 (IL-8/CXCL8) in tumor cells undergoing ER stress by a TRAIL-R2/DR5/caspase-8-dependent mechanism. …”
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Does sociality affect evolutionary speed? by Socias-Martínez, Lluís, Peckre, Louise Rachel

“…Social selection strength and Ne consequences need to be assessed using 4) as many axes of social variation as possible and 5) in both sexes. 6) Considering the evolutionary covariances in communicative systems might improve the validity of tests for the current framework. In addition, we develop predictions for how variation in each social dimension and component might affect evolutionary speed. …”
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Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages by Diana Martínez-Saucedo, Juan de Dios Ruíz-Rosado, César Terrazas, Blanca E. Callejas, Abhay R. Satoskar, Santiago Partida-Sánchez, Luis I. Terrazas

“…To further define the anti-inflammatory effect of TcES in the response of LPS-stimulated macrophages, we performed transcriptomic array analyses of mRNA and microRNA to evaluate their levels. Although the addition of TcES to LPS-stimulated BMDM induced modest changes in the inflammatory mRNA profile, it induced the production of mRNAs associated with the activation of different receptors, phagocytosis, and M2-like phenotype. …”
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Pimavanserin Treatment for Parkinson’s Disease Psychosis in Clinical Practice by Khashayar Dashtipour, Fiona Gupta, Robert A. Hauser, Cherian A. Karunapuzha, John C. Morgan

“…Effective treatment of PDP may reduce disturbing symptoms of psychosis, thus improving patient function and quality of life. In addition, effective pharmacotherapy for PDP may also facilitate the use of other medications needed to treat neurological symptoms of PD (e.g., tremor, bradykinesia, and dyskinesia), although they may also have adverse effects that contribute to symptoms of PDP.…”
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That “darned Dorsiceratus case” (Copepoda, Harpacticoida, Cletodidae T. Scott)—an attempt of a systematic approach, including the description of three new species by Kai Horst George, Lukas Tönjes, Songül Yurtdaş

“…In order to obtain a most realistic assessment of this, taxonomic studies are essential in addition to faunistic ones. They reveal that particularly rare deep-sea groups can be characterised by a large number of different species even from the same location. …”
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Innovative applications and future trends of multiparametric PET in the assessment of immunotherapy efficacy by Tingting Qiao, Tingting Qiao, Zhaoping Cheng, Yanhua Duan

“…Review articles and meta-analyses were consulted for additional references but excluded from quantitative analysis. …”
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Estimation of 1 km Dawn–Dusk All-Sky Land Surface Temperature Using a Random Forest-Based Reanalysis and Thermal Infrared Remote Sensing Data Merging (RFRTM) Method by Yaohai Dong, Xiaodong Zhang, Xiuqing Hu, Jian Shang, Feng Zhao

“…However, as only the Moderate Resolution Imaging Spectroradiometer (MODIS) is adopted as the TIR source for merging, current 1 km all-sky LST products are limited to the MODIS observation time. …”
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Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans by Loredana Bergandi, Oleksii A Skorokhod, Rosalba La Grotta, Evelin Schwarzer, Raffaele Nuzzi

“…The consequently higher lipoperoxide-dependent 4-HNE production in synchysis scintillans was detectable in aqueous and vitreous humors as a significant increased accumulation of 4-HNE-protein conjugates vs nonsynchysis vitreoretinal disorders. Additionally, hyaluronic acid (HA) was significantly decreased in the vitreous body of synchysis scintillans patients. …”
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Revamping field practicum: insights for future health services management professionals by Fatemeh Mohabati, Marzieh Arefi, Seyed Pouria Hedayati

“…To achieve desirable outcomes through a fundamental revision strategy, it was decided that, in addition to students’ presence in hospitals (including the office of senior hospital managers and the quality improvement and accreditation unit), students should also be present in the deputyships and central units of Zabol University of Medical Sciences (treatment, resource development and management, food and drug administration, and the center for management of medical emergencies). …”
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Macrophage Infiltration and ITGB2 Expression in ESCC: A Novel Correlation by Tao Huang, Longqian Wei, Huafu Zhou, Jun Liu

“…The higher the expression of ITGB2, the more feasible it is to target macrophages. Additionally, we found that evaluating immune therapy responses in ESCC patients through ITGB2 expression is a viable approach. …”
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Refined Urban Functional Zones Identification via Empirical Bayesian Kriging: A POI-Weighted Scoring Innovation by Xuan Du, Yisha Pan, Xiaoyan Yang, Longgao Chen, Liangchen Liu, Ying Lin

“…Results indicate that: 1) The EBK interpolation method not only accounts for the spatial and directional distance relationships between known and unknown sample points, but also produces more accurate raster images and provides more precise estimates in unmeasured ranges. 2) The method successfully identifies UFZs for 99.5% of the buildings in the central urban area of Xuzhou. Additionally, the incorporation of multi-source data enables the extraction of traffic and ecological zones, facilitating the identification of non-building-reliant zones within the city, thereby enhancing the completeness and comprehensiveness of urban spatial recognition. 3) The overall accuracy achieved is 84.4%, with a Kappa coefficient of 0.804 for the classification results, which represents a significant improvement in UFZs identification accuracy compared to traditional methods and offers a robust scientific basis for urban planning and resource optimization.…”
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A holistic physics-informed neural network solution for precise destruction of breast tumors using focused ultrasound on a realistic breast model by Salman Lari, Hossein Rajabzadeh, Mohammad Kohandel, Hyock Ju Kwon

“…Our PINN-based solution operated efficiently in a mesh-free domain, achieving remarkable accuracy with significantly reduced computational demands, compared to conventional FEM techniques. Additionally, employing PINN for estimating partial differential equations (PDE) solutions can notably decrease the enormous number of discretized elements needed. …”
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Healthcare Workers (HCWs)’ Perceptions and Current Practice of Managing Cognitively Impaired Patients with Chronic Obstructive Pulmonary Disease (COPD) by Rayan A. Siraj

“…Physical and respiratory therapists were more likely to identify cognitive impairment compared to nurses. Additionally, having more years of experience (≥10 years, OR: 1.63; 95% CI: 1.02 to 2.61; <i>p</i> = 0.001) and adequate knowledge of cognitive impairment (OR: 6.23; 95% CI: 4.18 to 9.29; <i>p</i> = 0.001) were strongly associated with better recognition. …”
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