Inhibition of the anti-apoptotic protein BCL2 in EML4-ALK cell models as a second proposed therapeutic target for non-small cell lung cancer. by Richard Junior Zapata Dongo, Diletta Fontana, Luca Mologni, Juan Enrique Faya Castillo, Stefany Fiorella Infante Varillas

“…We treated these cells with ABT-199, a selective BCL2 inhibitor, and found that models with high BCL2 expression exhibited resistance, while those with lower expression showed sensitivity to BCL2 inhibition. In addition, our analysis using bioinformatics indicated that ABT-199 not only targets BCL2 but also binds to the active site of all ALK mutants, it was contrasted by in vitro ALK kinase activity inhibition by ABT-199 (5.5 μM). …”
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Third Trimester Lower Extremity Lymphorrhea by Kaori Morimoto, Luke O’Rourke

“…Lifestyle modifications were recommended, but the patient did not comply. At her 31-week office visit, the patient presented with anasarca and clear, slightly viscous fluid seeping through the atraumatic skin of her lower extremities. …”
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Combining habitat selection, behavioural states, and individual variation to predict fish spatial usage near a barrier by Rachel Mawer, Jelger Elings, Stijn P. Bruneel, Ine S. Pauwels, Eliezer Pickholtz, Renanel Pickholtz, Johan Coeck, Peter L.M. Goethals

“…Under the tested flow conditions, high spatial usage was predicted in the area directly downstream of the barrier. In addition, barbel usage was high in the area by and downstream of the fish pass entrance but not for grayling, which may indicate a need to improve pass attractiveness for grayling. …”
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Geospatial digital mapping of soil organic carbon using machine learning and geostatistical methods in different land uses by Yahya Parvizi, Shahrokh Fatehi

“…The SOC changes were simulated using multivariate analysis and machine learning methods including generalized linear model (GLM), linear additive model (LAM), cubist, random forest (RF), and support vector machine (SVM) models. …”
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What are the Thoughts of Women Whose Husbands’ Frozen Testicular Sperm Is Thawed for in vitro Fertilization on the Day of Oocyte Retrieval? A Qualitative Study by He Y, Wei Q, Chen X, Zhang C, Wang Z

“….; b. shared expectations for children help couples establish a common goal).Conclusion: It is recommended that healthcare practitioners implement strategies to enhance patient education and awareness surrounding assisted reproductive technology. Additionally, establishing and strengthening social support, reinforcing privacy protections and safety measures, promoting effective communication between partners, and managing treatment outcome expectations are crucial steps forward.Immediate Practical Implications: Women prioritize treatment efficacy, privacy preservation, and the necessity of acquiring comprehensive professional knowledge when employing their partner’s testicular sperm for in vitro fertilization. …”
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Quantitative profiling of the vaginal microbiota improves resolution of the microbiota-immune axis by Eric Armstrong, Rachel Liu, James Pollock, Sanja Huibner, Suji Udayakumar, Erastus Irungu, Pauline Ngurukiri, Peter Muthoga, Wendy Adhiambo, Sergey Yegorov, Joshua Kimani, Tara Beattie, Bryan Coburn, Rupert Kaul

“…We hypothesized that the addition of absolute abundance data would provide a more complete picture of host-microbe interactions in the female genital tract. …”
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Associations between the intake of single and multiple dietary vitamins and depression risk among populations with chronic kidney disease by Chunli Yu, Kun Liu, Weiguo Yao, Dingzhong Tang

“…Weighted multivariate logistic regression models were utilized to analyze the associations of individual dietary vitamin intakes with depression risk. Additionally, Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression were performed to evaluate the joint effect of the intake of the nine vitamins on depression risk.ResultsThe overall prevalence of depression was approximately 11.3% in the study participants. …”
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Deaths during Sexual Activity by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…The cause of death was determined to be suffocation due to neck compression by a ligature, compounded by significant alcohol intoxication, with additional postmortem burns covering 30% of the body surface area likely occurring after death. …”
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Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis by Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu, Fei Xu, Fei Xu

“…Analysis revealed that FAE administration reversed the carbon tetrachloride (CCl4)-induced dysbiosis by increasing the abundance of Akkermansia and reducing that of Cyanobacteria. Additionally, metabolomic analysis showed that FAE treatment reversed the CCl4-induced metabolic disorders by regulating amino and nucleotide sugar metabolism. …”
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Rapid landslide detection from free optical satellite imagery using a robust change detection technique by Rosa Coluzzi, Angela Perrone, Caterina Samela, Vito Imbrenda, Salvatore Manfreda, Letizia Pace, Maria Lanfredi

“…Due to the complexity of the phenomenon which might involve the displacement of massive rocks, soil, and both wet and dry vegetation from hillslopes, and the significant impact on the safety of the population and road infrastructure, the development of specific procedures for the rapid detection of landslides is extremely challenging. …”
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Primary Hyperparathyroidism-Phosphaturic Mesenchymal Tumour: An Unusual Association and a Probable Syndrome by Gwendolyn Fernandes, Avanika, Gloria Khumanthem

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Nanopore adaptive sampling accurately detects nucleotide variants and improves the characterization of large‐scale rearrangement for the diagnosis of cancer predisposition by Sandy Chevrier, Corentin Richard, Marie Mille, Denis Bertrand, Romain Boidot

“…Results In our cohort, 11 samples had large‐scale rearrangements (LSR), which were all detected with ONT sequencing. In addition to perfectly detecting the locus of the LSR, we found a known MLPA amplification of exon 13 in the BRCA1 (NM_7294) gene corresponded to a duplication in tandem of both exons 12 and 13 of the reference NM_7300. …”
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Effects of a Serratus Anterior Plane Block After Video-Assisted Lung Wedge Resection: A Single-Center, Prospective, and Randomized Controlled Trial by Seokjin Lee, Tae-Yun Sung, Choon-Kyu Cho, Gyuwon Lee, Woojin Kwon

“…<i>Materials and Methods</i>: In total, 22 patients undergoing VATS lung wedge resections were randomized into two groups (SAPB and control): both received intravenous patient-controlled analgesia (PCA), and one group received additional SAPB. The primary outcome was the cumulative intravenous fentanyl consumption at 8 h postoperatively. …”
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Frontal Plane Knee Kinematics and Kinetics During Gait in Children and Youth with Achondroplasia—Correspondence with Static X-Ray Images and Relevance to Symptoms by Matthias Hösl, Antonia Thamm, Faik Kamel Afifi, Sean Nader

“…Typically, X-rays are used to assess them, but 3D gait analysis (3DGA) may additionally be used to evaluate dynamic knee function. …”
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Bioactive Properties of <i>Pentacalia vaccinioides</i> (Kunth) Cuatrec. (Asteraceae) Essential Oils: Evaluation of Antimicrobial and Antioxidant Activities by Luis G. Sequeda-Castañeda, María A. Castellanos-Gómez, Carlos L. A. Céspedes-Acuña

“…<i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> did not show antimicrobial susceptibility to EOs. …”
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hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways by Yan Yu, Chengchun Zhu, Xiao Wang, Ying Shi, Yiping Gao, Zhiyi Yu

“…Western blotting, Ca2+ imaging and immunofluorescence assays were employed to study their antitumor mechanisms of actions.ResultsWe identified two novel hERG activators, SDUY429 and SDUY436, which effectively inhibited the proliferation and migration of MDA-MB-231 and MCF-7 cells. In addition, SDUY436 demonstrated significant anti-invasive and pro-apoptotic effects in MDA-MB-231 cells. …”
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Chronic Stress Mediates Inflammatory Cytokines Alterations and Its Role in Tumorigenesis by Liu Z, Lei M, Bai Y

“…This ongoing inflammation further enhances the activity of these transcription factors, which serve multiple roles: they act as pro-inflammatory agents in inflammatory cells, maintaining chronic inflammation; as oncogenic transcription factors in premalignant cells, promoting cancer initiation; and as pro-differentiation transcription factors in tumor-infiltrating immune cells, facilitating cancer progression. Additionally, the impact of chronic stress varies among different cancer types and individual responses to stress, highlighting the complexity of stress-related cancer mechanisms. …”
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Practices Regarding Human Papillomavirus and Cervical Cancer in A Sample of Paramedical Staff in Al- Najaf Governorate, Iraq by Alaa Mehdi Salih, Atta Ah Mousa Al –Sarray

“…Almost all paramedics work in urban areas. In addition, almost half of the participants came from medical institutions, accounting for 51.6 percent of the total, while just 2.4 percent were graduates of secondary schools. …”
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A Lightweight Mitigation Technique Against a Modified Version Number Attack in IoT Networks by Ibrahim S. Alsukayti, Mohammed Alreshoodi, Mehdi Rouissat

“…Network overhead and energy consumption were increased by more than 300% and 220%, respectively. Additionally, a reduction of over 28% and an increase of over 400% in PDR and latency, respectively, were experienced during the attack. …”
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Effect of a single rectal fecal microbiota transplantation on clinical severity and fecal microbial communities in dogs with chronic inflammatory enteropathy by Jorge Pérez‐Accino, Mazdak Salavati, Laura Glendinning, Silke Salavati Schmitz

“…Recipient microbiota composition or diversity did not change over time. Glycerol addition was associated with a difference in microbiota composition (P ≤ .001). …”
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