Acute metabolic decompensation after liver transplant in a patient with maple syrup urine disease by Shao Ching Tu, Marium Khan, Katie Wolfe, Sakil S. Kulkarni, Elizabeth Toolan, Dorothy K. Grange

“…This case report raises awareness that patients with MSUD are still at risk of developing metabolic crisis post‐liver transplant and provides additional insight into the risk factors associated with metabolic decompensation in this patient cohort.…”
Get full text

Study on the Prosthesis Structural Design and Vibration Characteristics Based on the Conduction Effect of Human Middle Ear by Wu Ren, Huijuan Yan, Yi Yu, Jinghong Ren, Jinlong Chang, Yidong Wang, Yibo Han

“…As a bridge from the sound signal in the air to the sound perception of the inner ear auditory receptor, the tympanic membrane and ossicular chain of the middle ear transform the sound signal in the outer ear through two gas-solid and solid-liquid conversions. In addition, through the lever principle formed by three auditory ossicle structure, the sound was concentrated and amplified to the inner ear. …”
Get full text

Exosomes from Human Gingiva-Derived Mesenchymal Stem Cells Combined with Biodegradable Chitin Conduits Promote Rat Sciatic Nerve Regeneration by Feng Rao, Dianying Zhang, Tengjiaozi Fang, Changfeng Lu, Bo Wang, Xiao Ding, Shuai Wei, Yiran Zhang, Wei Pi, Hailin Xu, Yanhua Wang, Baoguo Jiang, Peixun Zhang

“…The in vivo studies showed that chitin conduit combined with exosomes from GMSCs could significantly increase the number and diameter of nerve fibers and promote myelin formation. In addition, muscle function, nerve conduction function, and motor function were also obviously recovered. …”
Get full text

Analysis of panel physician inquiries to U.S. TB Centers of Excellence, 2018–2022 by E. Leithead IV, S. Subramanian, K. Pimenta, N.D. Goswami, A. Patrawalla, A. Lardizabal, C. Haley, L. Chen, L. Armitige, B. Seaworth, B. Sylvester, R. Bhavaraju

“…Treatment tailoring inquiries involved optimizing the initial regimen (n = 89, 41.4%) or modifying existing regimens (n = 26, 12.1%). Additionally, 50 consultations (23.2%) mentioned comorbidities, while 47 (21.9%) described adverse reactions. …”
Get full text

Testing the Breakdown of the Asteroseismic Scaling Relations in Luminous Red Giants by Amanda L. Ash, Marc H. Pinsonneault, Mathieu Vrard, Joel C. Zinn

“…Mass, radius, and age can then be inferred with the addition of stellar spectroscopy. There is excellent agreement between seismic radii and fundamental data on the lower red giant branch and red clump. …”
Get full text

Research of Roof Anchorage Rock Beam Bearing Structure Model of Extra-Large Width Open-Off Cut and Its Engineering Application in a Coal Mine, China by Shengrong Xie, Qing Zhang, Dongdong Chen, En Wang, Junchao Zeng, Chunwei Ji, Xiaoyu Wu, Zaisheng Jiang, Feng Chen, Shunxing Qiao

“…The numerical results obtained in this study demonstrate that an anchorage rock beam bearing structure (ARBBS) can be formed. Additionally, the ARBBS model was also constructed. The analytical expression of the maximum shear stress (MSS) in the model was obtained under the functions of composite influencing factors. …”
Get full text

Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis by Yinuo Fan, Zhiwen Chen, Haixing Wang, Mengyu Jiang, Hongduo Lu, Yangwenxiang Wei, Yunhao Hu, Liang Mo, Yuhao Liu, Chi Zhou, Wei He, Zhenqiu Chen

“…Strikingly, restoring SIRT3 expression significantly inhibited pathological mitophagy mediated by the BNIP3/NIX pathway. Additionally, we discovered that Isovitexin, by promoting SIRT3 expression, effectively regulated mitophagy, preserved mitochondrial homeostasis in osteoblasts, suppressed ferroptosis, and restored osteogenic capacity, leading to remarkable improvements in SIONFH. …”
Get full text

Effects of ultra-processed foods on the liver: insights from gut microbiome and metabolomics studies in rats by Liping Shi, Zhuoyuan Li, Xiaojun Ma, Junru Wang, Yueping Wu, Yongbin Zhu, Yanrong Wang, Yue Yang, Minxiu Luo, Jiangping Li, Xian Sun, Xian Sun, Shulan He, Shulan He

“…Some serum biochemical indices, inflammatory factors, oxidative stress markers, hematoxylin–eosin (HE) staining of the liver, 16S ribosomal RNA (rRNA) and Liquid chromatography-mass spectrometry (LC–MS) of rat feces were detected.ResultsThe UPF diet-induced simple steatosis of the liver in rats without affecting the levels of IL-6, GSH, MDA, and SOD. Additionally, it modified the gut microbiota, increasing potentially harmful bacteria, such as norank_f__Desulfovibrionaceae and Staphylococcus, while also elevating the relative abundance of potentially beneficial bacteria, including Dubosiella and Allobaculum. …”
Get full text

Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants by Guanying Yao, Qinglin Qi, Xianchao Dou, Wen Zhou, Shun Bai, Xi Zhang, Xi Zhang

Subjects: Get full text

15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury via Redox Pathway by Xin Liu, Shuangshuang Jia, Weiyang Li, Le Yang, Lin Yang, Lin Wang, Liying Li

“…Furthermore, the repressive effect of 15d-PGJ2 was blocked by reactive oxygen species (ROS) inhibitor, but not PPARγ antagonist, and action of 15d-PGJ2 was not reproduced by PPARγ synthetic ligands. In addition, 15d-PGJ2 triggered a significant ROS production and cytoskeletal remodeling in BMSCs. …”
Get full text

Genotyping and drug susceptibility profiling of Prototheca sp. strains isolated from cases of protothecosis in dogs by Angelika Proskurnicka, Mateusz Iskra, Sylwia Wronka, Zofia Bakuła, Patrizia Danesi, Marconi Rodrigues deFarias, Fábio Vinícius Ramos Portilho, Márcio Garcia Ribeiro, Uwe Rösler, Rui Kano, Richard Malik, Tomasz Jagielski

“…Conclusions and Clinical Importance Our study identifies P. bovis as the species that most frequently causes protothecosis in dogs, which suggests the possibility of cross‐species infection from other animals, especially cows. Additionally, it indicates that EFZ could be used in the treatment of infection in the colon.…”
Get full text

Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB-Dependent Mechanism by E. K. Patterson, L. J. Yao, N. Ramic, J. F. Lewis, G. Cepinskas, L. McCaig, R. A. W. Veldhuizen, C. M. Yamashita

“…Changes in gene transcription were confirmed using qPCR for IL-6, CXCL-1, and CXCL-2. Additionally, liver tissue obtained from mice subjected to 2 hours of in vivo MV demonstrated significant increases in hepatic gene transcription of IL-6, CXCL-1, and CXCL-2 compared to nonventilated controls. …”
Get full text

Muscle metabolism in response to oxidized fish oil feed in juvenile Nile tilapia by Xinyuan Li, Lili Chen, Hua Wen, Xuan Wang, Di Peng, Jianmin Zhang, Yangyang Liu, Ming Jiang, Lixue Dong, Feng Huang, Juan Tian

“…In the OFO group, the mRNA expression levels of lipolysis genes including lipoprotein lipase (lpl) and hormone-sensitive lipase (hsl) in the muscle were upregulated compared with the FFO group, while, the mRNA expression level of acetyl CoA carboxylase was downregulated. Additionally, under the positive ion mode, the levels of DHA deposition in phosphatidylcholine and phosphatidyl ethanolamine were reduced in the muscle of the OFO group compared to the FFO group. …”
Get full text

High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells by Xiaofei Cheng, Bin Ni, Feng Zhang, Ying Hu, Jie Zhao

“…High glucose resulted in increased ROS generation and p38 MAPK activation. In addition, it negatively regulated the expression of type II collagen, aggrecan, Sox-9, and TIMP-1 and positively regulated MMP-3 expression. …”
Get full text

Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway by A. Rimmon, A. Vexler, L. Berkovich, G. Earon, I. Ron, S. Lev-Ari

“…Escin combined with gemcitabine showed only additive effect, while its combination with cisplatin resulted in a significant synergistic cytotoxic effect in Panc-1 cells. …”
Get full text

Fractional Factorial Design and Desirability Function-Based Approach in Spice Paprika Processing Technology to Improve Extractable Colour Stability by Arnold Koncsek, Lajos Szokol, Vivien Krizsa, Hussein G. Daood, Lajos Helyes, Antal Véha, Balázs Szabó P.

“…Post-harvest ripening, drying, sorting (seed content), milling and additives (paprika seed oil, tocopherol extract) were identified as important for the degradation rate of extractable colour. …”
Get full text

Recurrent nocturnal hypoglycemic hemiplegia: a case report and review of the literature by Hanako Toyama, Kazuyuki Takahashi, Tatsunori Shimizu, Izumi Otaka, Sakiko Abe, Shunsuke Kato, Sayaka Ando, Takehiro Sato, Tsukasa Morii, Hiroki Fujita, Hironori Waki

“…In our patient, depleted endogenous insulin secretion and lipodystrophy at the injection site, may have acted as additional factors, leading to severe hypoglycemia despite the absence of apparent autonomic neuropathy. …”
Get full text

Explainability of Subfield Level Crop Yield Prediction Using Remote Sensing by Hiba Najjar, Miro Miranda, Marlon Nuske, Ribana Roscher, Andreas Dengel

“…Our goal is to develop and explain predictive models for these crops, using a large dataset of satellite images, additional data modalities, and crop yield maps. We employ a long short-term memory network and investigate the impact of using different temporal samplings of the satellite data and the benefit of adding more relevant modalities. …”
Get full text

Hereditary transthyretin amyloidosis incidentally diagnosed by video-associated lung surgery for lung cancer: A case report by Katsuhiro Itogawa, Shintaro Sato, Hideaki Yamakawa, Keiichi Akasaka, Masako Amano, Akiko Adachi, Hidekazu Matsushima

“…Lung cancer was suspected and the following thoracoscopic segmentectomy revealed a diagnosis of adenocarcinoma in situ. In addition, further pathological investigation of the background lung tissue revealed deposition of amyloid transthyretin (TTR), although no radiological findings suggestive of pulmonary amyloidosis were present. …”
Get full text

More Efficient and Reliable: Identifying RRab Stars with Blazhko Effect by Deep Convolutional Neural Network by Nan Jiang, Tianrui Sun, Siyuan Pan, Lingzhi Wang, Xue Li, Bin Sheng, Xiaofeng Wang

“…We then applied our CNN method to some additional RRabs located in the Magellanic Cloud (MC) and the Galactic Bulge (GB), leading to the discovery of 113 and 2496 BL candidates, respectively. …”
Get full text