Intravenous Lidocaine: Old-School Drug, New Purpose—Reduction of Intractable Pain in Patients with Chemotherapy Induced Peripheral Neuropathy by Sandra A. S. van den Heuvel, Selina E. I. van der Wal, Lotte A. Smedes, Sandra A. Radema, Nens van Alfen, Kris C. P. Vissers, Monique A. H. Steegers

“…Pain reduction persisted in 5 patients for an average of 23 days. Lidocaine did not influence mean PPT, but there was a tendency that the extent of sensory abnormalities decreased after lidocaine. …”
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Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia by Zeng Zhang, Quan Guo, Zhihan Yang, Yukai Sun, Shuaiming Jiang, Yangli He, Jiahe Li, Jiachao Zhang

“…Mechanistically, nicotinic acid restores nicotinamide adenine dinucleotide (NAD+) levels in muscle, inhibits the FoxO3/Atrogin-1/Murf-1 axis, and promotes satellite cell proliferation, reducing muscle atrophy. Additionally, NAD+ activation enhances the silent-information-regulator 1 (SIRT1)/peroxisome-proliferator-activated-receptor-γ-coactivator 1-alpha (PGC-1α) axis, stimulating mitochondrial biogenesis and promoting oxidative metabolism in slow-twitch fibers, ultimately improving muscle function. …”
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The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer by Austin R. Dosch, Mary P. Martos, Samara Singh, Karishma Kodia, Nipun B. Merchant, Nagaraj S. Nagathihalli

“…We further summarize the role of additional myeloid subpopulations such as monocytes and macrophages, dendritic cells, platelets, and eosinophils on promoting disease metastases in GI cancers. …”
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Diagnostic and therapeutic recommendations for chronic pancreatitis. Recommendations of the Working Group of the Polish Society of Gastroenterology and the Polish Pancreas Club by Roland Kadaj-Lipka, Michał Lipiński, Krystian Adrych, Marek Durlik, Anita Gąsiorowska, Mirosław Jarosz, Grażyna Jurkowska, Ewa Małecka-Panas, Grzegorz Oracz, Mariusz Rosołowski, Barbara Skrzydło-Radomańska, Renata Talar-Wojnarowska, Grażyna Rydzewska

“…The results of the voting, together with a brief commentary, have been included with each recommendation put to the vote. In addition, the expert group assessed the value of clinical studies on which the statements are based, on a scale where A means high (based on meta‑analyses and randomised clinical trials), B means medium (based on clinical trials and observational studies), and C means low (based mainly on expert opinion).…”
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A Rare Case of Glioblastoma Multiforme with Osseous Metastases by Rubens Barros Costa, Ricardo Costa, Jason Kaplan, Marcelo Rocha Cruz, Hiral Shah, Maria Matsangou, Benedito Carneiro

“…Physicians caring for patients with GBM and new nonneurologic symptoms may contemplate body imaging.…”
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A Full-Length Reference Floral Transcriptome of Boehmeria tricuspis Provides Insights into Apomeiosis and Polyploidy by Qing Tang, Ying Xu, Canhui Deng, Chaohua Cheng, Zhigang Dai, Zemao Yang, Chan Liu, Jianguang Su

“…Furthermore, our results suggested that different expressions of stress response genes might be important in the preparation for apomeiosis transition. In addition, our observations indicated that the expression of apomeiosis may not depend on polyploidy but rather on deregulation of the sexual pathway in B. tricuspis.…”
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Optimizing rheological behavior of glass-based sealant inks for robocasting deposition: A design of experiment approach by A. Baggio, D. Dalmazzo, F. D’Isanto, E. Santagata, D. Basso, D. Gaia, M. Salvo, F. Smeacetto

“…The information obtained and the resulting models were useful in designing a new formulation that closely mimics the rheology of a state-of-the-art ink formulation.This analytical approach not only facilitated the development of a new sealant ink but also enabled its seamless integration into an existing industrial robocasting deposition process without requiring additional adjustments. The study contributes to a better understanding of the influence of each ink component on the rheological behavior and to the design of a new formulation with rheological characteristics very close to those of a reference paste.…”
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Making Things Right: Nurses' Experiences with Workplace Bullying—A Grounded Theory by Donna A. Gaffney, Rosanna F. DeMarco, Anne Hofmeyer, Judith A. Vessey, Wendy C. Budin

“…While many nurses do engage in a number of effective yet untested strategies, two additional concerns remain: inadequate support among nursing colleagues and silence and inaction by nurse administrators. …”
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Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces by W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens, M. H. M. Heemskerk

“…These findings not only provide additional insights into the mechanism of action of AECs but also broaden the possibilities for genetically fused AECs as an avenue for the redirection of multiple virus-specific T cells toward tumors.…”
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A Case of Abdominal Aortic Retroperitoneal and Mesenteric Amyloid Light Chain Amyloidoma by Kazuhiro Yokota, Dai Kishida, Hidekazu Kayano, Masahide Yazaki, Yuki Shimada, Yuji Akiyama, Toshihide Mimura

“…The patient was clinically diagnosed with retroperitoneal fibrosis, and prednisolone was administered at a dose of 40 mg/day. However, the lesions did not change in size and her symptoms continued. …”
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Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies by Touhidul Islam Tanim, Ayman M. Al-Qaaneh, Raihan Chowdhury, Md. Shimul Bhuia, Tabassum Islam, Md Showkoth Akbor, Md. Tahajul Islam, Md. Mohasin Miah, Ali Raza Ishaq, Mostafa A. Abdel-Maksoud, Mohamed A. El-Tayeb, Mohamed El-Shazly, Muhammad Torequl Islam, Heba A.S. El-Nashar

“…SEL (25 and 50 mg/kg) showed dose-dependent elevation in latency (133.20 ± 2.19 and 293.00 ± 5.27 s) and diminishment in the retching number (16.40 ± 1.15 and 9.40 ± 1.04 times), compared to control. Additionally, SEL can antagonize the activity of ondansetron (OND; 5 mg/kg) and domperidone (DOM; 7 mg/kg), resulting in a decrease in latency (256.00 ± 9.59 and 253.00 ± 2.79 s) and enhancing the number of retches (11.80 ± 0.82 and 12.60 ± 1.04) in combination rather than OND and DOM alone. …”
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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

“…The nanocomplexes were precisely co-assembled in water to stably co-deliver Mn2+ and PPa, enabling tumor-specific release and fluorescence recovery.ResultsFollowing laser irradiation, the activated PPa significantly enhanced the killing effects on primary cancer cells. Additionally, Mn2+ ions activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, promoting maturation of dendritic cells (DCs) and augmenting CD8+-mediated antitumor immune responses.DiscussionThis study advances the on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability by exploiting Mn2+–PPa nanocomplexes with high activatability and effectiveness for targeted PDT and immunotherapy.…”
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Perspectives for Titanium-Derived Fillers Usage on Denture Base Composite Construction: A Review Article by Nidal W. Elshereksi, Mariyam J. Ghazali, Andanastuti Muchtar, Che H. Azhari

“…The clinical problem of using silanes in adhesion promotion is bond degradation over time in oral environment. In addition, silanes do not bond effectively to nonsilica-based dental restorative materials. …”
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One-step introduction of the hexafluoroisobutyl group, synthesis of (S)-5,5,5,5',5',5'-hexafluoroleucine, and its incorporation into peptides and proteins by Delamare, Aline, Naulet, Guillaume, Mummadi, Sandeep, Guichard, Gilles, Compain, Guillaume

“…This methodology was successfully applied to the synthesis of (S)-5,5,5,5',5',5'-hexafluoroleucine (Hfl). Additionally, we summarize the research conducted on incorporating this valuable amino acid into peptides and proteins. …”
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Copper leaching with aqueous foams for the processing of electronic waste by Régnier, Emilie, Hubau, Agathe, Touzé, Solène, Guignot, Sylvain, Meyer, Daniel, Diat, Olivier, Bourgeois, Damien

“…Kinetics of the copper leaching were greatly enhanced through addition of substoechiometric quantity of cupric ions at the beginning of the process, so that extensive grinding of the waste is not necessary.…”
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Polystyrene Nanoplastics Elicit Multiple Responses in Immune Cells of the <i>Eisenia fetida</i> (<i>Savigny</i>, 1826) by Huijian Shi, Yaoyue Wang, Xiangxiang Li, Xiaoyang Wang, Yuntao Qi, Shaoyang Hu, Rutao Liu

“…., superoxide dismutase, catalase, and glutathione), and inducing lipid peroxidation and DNA oxidation. Additionally, assays on neutral red retention time, lysozyme activity, and Ca²⁺ levels demonstrated that NPs resulted in a loss of lysosomal membrane stability and a reduction in immune resistance. …”
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Bilingual Education Programs in Primary Education: What Do Parents Think? by Martina Soledad Ramírez-Orduña, Daniel Rodríguez-Rodríguez, Francisco Javier Batista-Espinosa, Laura Barboyon Combey

“…However, the majority of parents expressed concerns about teaching techniques, teacher training, students' emotions and excessive workload, and their own perceived difficulty in participating in their children's education. Additionally, positive opinions were mostly associated with the macrosystem of the social environment, while negative opinions were linked to the mesosystem of the teaching staff. …”
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Assessing the Role of Vaccination in the Control of Hand, Foot, and Mouth Disease Transmission by Zuhur Alqahtani, Mahmoud H. DarAssi, Yousef AbuHour, Areej Almuneef

“…This work computes the basic reproduction number (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>R</mi><mn>0</mn></msub></semantics></math></inline-formula>) to represent the endemic and epidemic scenarios. Additionally, sensitivity analysis was performed to identify the most critical parameters responsible for the disease dissemination. …”
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Application of UAV-SfM Photogrammetry to Monitor Deformations of Coastal Defense Structures by Santiago García-López, Mercedes Vélez-Nicolás, Verónica Ruiz-Ortiz, Pedro Zarandona-Palacio, Antonio Contreras-de-Villar, Francisco Contreras-de-Villar, Juan José Muñoz-Pérez

“…The photogrammetric outputs, an orthomosaic and a Digital Surface Model (DSM), were validated with in situ RTK-GPS measurements, displaying excellent planimetric accuracy (RMSE 0.043 m and 0.023 m in X and Y, respectively) and adequate altimetric accuracy (0.100 m in Z). In addition, the average enveloping surface inferred from the DSM allowed quantification of the deformation of the breakwater and defining of the deformation mechanisms. …”
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Human values in Bachelor's degree in Nursing’s students by Héctor Cabrera Rodríguez, Zenia Tamara Sánchez García, Ivette Mullens Ramos, Liumys Zayas Alzamora, Ernesto Julio Bernal Valladares, Isys Leyva Betancourt

“…A survey was applied to the students and an observation guide; In addition, an interview was carried out with the professors who teach in said academic year, the Kappa value was used as a statistical procedure.…”
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