Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study by Henriette Louise Möllmann, Eman Alhammadi, Soufian Boulghoudan, Julian Kuhlmann, Anica Mevissen, Philipp Olbrich, Louisa Rahm, Helmut Frohnhofen

“…A geriatric assessment with the content of basal and instrumental activities of daily living (basal activities of daily living [Katz index], instrumental activities of daily living [Lawton and Brody score], cognition [6-item screener and clock drawing test], mobility [de Morton Mobility Index and Sit-to-Stand test], sleep [Pittsburgh Sleep Quality Index and Insomnia Severity Index/STOP-BANG], drug therapy [polypharmacy and quality of medication, Fit For The Aged classification, and anticholinergic burden score], and pain assessment and delirium risk (Delirium Risk Assessment Tool) will be performed. …”
Get full text

Using Community Engagement to Create a Telecoaching Intervention to Improve Self-Management in Adolescents and Young Adults With Cystic Fibrosis: Qualitative Study by Christina L Duncan, Emily F Muther, Jennifer J Lindwall, Kristine Durkin, Elizabeth Ruvalcaba, Eliza Williamson, Corrine Ahrabi-Nejad, Evelyn Bord, Angela Green, Megan L Harrison, Deepika Polineni

“… BackgroundAdolescents and young adults (AYA) with cystic fibrosis (CF) are at risk for deviating from their daily treatment regimen due to significant time burden, complicated daily therapies, and life stressors. …”
Get full text

Efficacy and safety of nivolumab plus ipilimumab in gastrointestinal cancers: a systematic review and meta-analysis by Bowen Dai, Jiaping Jiang, Xiaoyu Yu, Haihua Zhan, Zhengchuan Hu

“…IntroductionGastrointestinal (GI) cancers represent a significant global health burden, and the need for more effective treatment options is exceptionally pressing. …”
Get full text

The key role of the NUDT3 gene in lung adenocarcinoma progression and its association with the manganese ion metabolism family by Deyong Ge, Xinyu Xu, Liyi Fang, Huihui Tao

“…Results NUDT3 was found to be significantly upregulated in lung adenocarcinoma and highly correlated with tumor mutation burden (TMB) and mutation enrichment (MEs). Single-cell transcriptomic analyses demonstrated elevated NUDT3 expression in lung adenocarcinoma epithelial cells, with expression levels increasing in cells associated with advanced tumor stages. …”
Get full text

Syphilis reactivity among blood donors in Brazil: associated factors and implications for public health monitoring by Natalia A. Braga, Sheila de Oliveira Garcia Mateos, Renata Buccheri, Vivian I. Avelino-Silva, Donald E. Warden, Cesar de Almeida-Neto, Maisa Ribeiro, Luiz Amorim, Paula Loureiro, Nelson Fraiji, Marcio K. Oikawa, Eduard Grebe, Mars Stone, Ester C. Sabino, Brian Custer, for the NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)

“…Blood donation screening is an opportunity to monitor the burden of asymptomatic infections, providing information on contemporary factors associated with infection and public health insights into transmission. …”
Get full text

Spatial co-distribution of tuberculosis prevalence and low BCG vaccination coverage in Ethiopia by Haileab Fekadu Wolde, Archie C. A. Clements, Beth Gilmour, Kefyalew Addis Alene

“…Substantial spatial co-distribution between high TB prevalence and low BCG coverage was observed in some parts of the country, indicating that there are areas where the TB burden is not being adequately managed through the provision of vaccines in Ethiopia. …”
Get full text

Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study by Yuan Zhan, Ruonan Yang, Jie Feng, Genlong Bai, Xiangyun Shi, Jiaheng Zhang, Jingbo Zhang

“…Abstract Background Chronic respiratory diseases (CRD) represents a series of lung disorders and is posing a global health burden. Systemic inflammation and phenotypic ageing have been respectively reported to associate with certain CRD. …”
Get full text

Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France by Issifou Yaya, Issifou Yaya, Yvenie Amboise, Yvenie Amboise, Guillaume Roucoux, Guillaume Roucoux, Lisa Yombo-Kokule, Lisa Yombo-Kokule, Fabienne Marcellin, Claudine Duvivier, Claudine Duvivier, Karine Lacombe, Karine Lacombe, James W. Griffith, James W. Griffith, Marie Préau, Antoine Cheret, Antoine Cheret, Martin Duracinsky, Martin Duracinsky, Martin Duracinsky

“…The findings underscore the urgent need for targeted support and interventions tailored to address the mental health needs of PLWHA facing the dual burden of HIV/AIDS and COVID-19.…”
Get full text

Association between gestational weight gain and adverse pregnancy outcomes: cohort analysis from South Asia and Sub-Saharan Africa by Anisur Rahman, Fyezah Jehan, Gary M Shaw, Sunil Sazawal, Salahuddin Ahmed, Abdullah H Baqui, David K Stevenson, Monjur Rahman, Jesmin Pervin, Shaki Aktar, Rasheda Khanam, Sayedur Rahman, Nitya Wadhwa, Ge Zhang, Huan Xu, Usma Mehmood, Shinjini Bhatnagar, Jeffrey S A Stringer, Bellington Vwalika, Waqasuddin Khan, Nabidul Haque Chowdhury, Imran Nisar, Javairia Khalid, Nima Aghaeepour, U Tin Nu, Yuri V Sebastião, Ramachandran Thiruvengadam, Ayushi, Bapu Koundinya Desiraju, Fatma Kabole, Muhammad Farrukh Qazi, Margaret Kasaro, Bihila Abdalla Bakari

“…Introduction Studies of gestational weight gain (GWG) and adverse pregnancy outcomes seldom focus on low-to-middle-income countries (LMICs), despite their high burden of morbidity and mortality. We examined GWG patterns and adverse pregnancy outcomes in a consortium of pregnancy cohorts from LMICs.Methods We analysed data from five observational pregnancy cohorts in Bangladesh (two cohorts), India, Pakistan and Zambia. …”
Get full text

Identification of CD8+ T Cell-Related Genes: Correlations with Immune Phenotypes and Outcomes of Liver Cancer by Qi Pan, Ying Cheng, Donghua Cheng

“…We obtained single nucleotide polymorphism (SNP) data to evaluate the tumor mutation burden. The “estimate” package and the CIBERSORT algorithm were used to evaluate tumor purity and the proportion of CD8+ T lymphocytes in the liver cancer cohort. …”
Get full text

Predominant polarity in bipolar affective disorder and its impact on cognition and quality of life by Shashank Bhardwaj, Deoraj Sinha, Ami Pawar, Astik Mane

“…The outcome of female bipolar patients may be improved if the clinician is mindful of the burden of depression, risk of misdiagnosis, and variable therapy response. …”
Get full text

Research Status of Home-Based Rehabilitation in Chronic Diseases and Construction of Intelligent Rehabilitation Treatment Platform by WANG Jinghua, YU Shaohong, LI Li

“…Chronic diseases seriously affect the health of residents in China and increase the burden on families and society. In China, the mortality rate caused by chronic diseases accounts for about 86% of the mortality rate of all related diseases, so as that the prevention and treatment situation is in a difficult situation. …”
Get full text

Upper Quarter Injury Rates and Risk in United States High School Athletes Prior To and During the Prolonged Sport Stoppage by Garrett Bullock, Charles Thigpen, Albert Prats-Uribe, R. Gill Gilliand, Ellen Shanley

“…The COVID-19 pandemic has created an opportunity to evaluate the potential added burden abrupt and prolonged sport stoppage had on upper quarter injury risk…”
Get full text

Retrospective cohort study based on the MIMIC-IV database: analysis of factors influencing all-cause mortality at 30 days, 90 days, 1 year, and 3 years in patients with different t... by Xuehui Fan, Jing Xu, Ruixue Ye, Qiu Zhang, Yulong Wang

“…Stroke poses a significant global health burden, and understanding its prognostic factors is crucial for clinical management.MethodsThis is a retrospective cohort study based on data from the MIMIC-IV database, including stroke patients from 2010 to 2020. …”
Get full text

Prevalence of soil-transmitted helminths infection and associated risk factors among residents of Jigjiga town, Somali region, Eastern Ethiopia. by Abdlmenur Alewi Sedo, Ahmed Zeynudin, Tariku Belay, Mekdes Mekonen Belay, Ahmed Mohammed Ibrahim, Mohamed Omar Osman, Ramadan Budul Yusuf, Abdifatah Abdulahi

“…Health education on handwashing, regular deworming, improved access to clean water and sanitation facilities to reduce the burden of STH effectively.…”
Get full text

The relationship between kidney function and cardiometabolic risk factors, anthropometric indices, and dietary inflammatory index in the Iranian general population: a cross-section... by Samaneh Madani, Seyed Jalil Masoumi, Afsane Ahmadi, Morteza Zare, Najmeh Hejazi, Sahar Foshati

Subjects: Get full text

Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…Targeted preventive measures should be taken during cold and dry spring days in Rattus-dominant regions, and during warm and moderately humid winter days in Apodemus-dominant regions. …”
Get full text

Immunological mechanisms of tuberculosis susceptibility in TB-infected individuals with type 2 diabetes mellitus: insights from mycobacterial growth inhibition assay and cytokine a... by Bindu Dasan, Anuradha Rajamanickam, Arul Nancy Pandiarajan, Sivakumar Shanmugam, Sujatha Nott, Subash Babu

“…ABSTRACT Several studies have highlighted the increased risk of active tuberculosis (TB) in individuals with diabetes mellitus (DM), especially in TB-endemic regions. This dual burden poses significant challenges for TB control efforts. …”
Get full text

Assessment of hand hygiene practices among nurses at a regional hospital in Kandahar, Afghanistan: A cross-sectional study based on the World Health Organization (WHO) ‘Your 5 Mome... by Abdul Qadeer Baseer, Asmatullah Usmani, Shafiqullah Mushfiq, Mohammad Hassan Hassand, Bilal Ahmad Rahimi, Abdul Wahid Monib, Mohammad Salim Daqiq, Parwiz Niazi

“…Conclusion: While overall compliance was relatively high, significant gaps persist, particularly among younger, less educated, and male nurses, as well as those in high-burden wards. Enhanced training programs, tailored strategies, and regular audits are essential for improving hand hygiene practices and strengthening infection prevention and control efforts, ultimately enhancing patient safety in resource-limited settings. …”
Get full text

Estimating the Health-Related Quality of Life Benefit of Prophylactic Treatment for COVID-19 in Immunocompromised People: A Multimethod Valuation Study by Katy Gallop, Rebekah Hall, Michael Watt, Daniel Squirrell, Neil Branscombe, Sofie Arnetop, Andrew Lloyd

“…**Conclusion:** This study quantified the expected health state utility benefit of reduced psychosocial burden and behavioral restriction. PrEP would potentially result in a utility gain between 0.082 and 0.326, dependent on valuation approach and expected change in behavioral restrictions, leading to improvements in daily activities and emotional well-being.…”
Get full text