Exploring Quality of Life in Adults Living With Late-onset Pompe Disease: A Combined Quantitative and Qualitative Analysis of Patient Perceptions from Australia, France, Italy, and... by Holly Lumgair, Lisa Bashorum, Alasdair MacCulloch, Elizabeth Minas, George Timmins, Drago Bratkovic, Richard Perry, Medi Stone, Vasileios Blazos, Elisabetta Conti, Raymond Saich

“…**Discussion:** These results demonstrate the humanistic burden of LOPD; through declining physical functioning SF-36 scores over increasing time and increased use of aids, and also through factors related to self-reported LOPD status (where declining status was associated with lower scores) and symptomology variances. …”
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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…These disorders, ranging from neurodegenerative diseases to psychiatric conditions, not only impact individuals but also place a substantial burden on healthcare systems and society. A major obstacle in treating these conditions is the blood-brain barrier (BBB), which restricts the passage of therapeutic agents to the brain. …”
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Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma by Hengchang Liu, Jialiang Liu, Xu Guan, Zhixun Zhao, Pu Cheng, Haipeng Chen, Zheng Jiang, Xishan Wang

“…TTN mutations also inhibit ANKRD1 expression via JUN disruption and enhance CD4/CD8 T‐cell infiltration, improving anti‐tumour immunity and outcomes. …”
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Retinopathy among Adult Diabetics and Its Predictors in Northwest Ethiopia by Mulualem Birhan Takele, Dube Jara Boneya, Hailemariam Abiy Alemu, Tesfa Birlew Tsegaye, Molla Yigzaw Birhanu, Simegn Alemu, Tsige Gebre Anto

“…Diabetic retinopathy is the leading cause of blindness among working-aged adults worldwide, including developing countries such as Ethiopia, and the burden of diabetes-related blindness is undeniably posing a massive challenge to the health care system. …”
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Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials by Na-Yeon Ha, Chang-Yul Keum, Jinsung Kim

“…Background: Functional dyspepsia (FD) is the most prevalent pediatric gastrointestinal disorder, imposing a significant burden on healthcare services and often persisting into adulthood. …”
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Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

“…However, patients with a high tumor burden do not benefit from additional LRRT, which inevitably results in toxicity. …”
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Determinants of school-going adolescent girls’ health and nutritional status in district Malir, Karachi: a baseline cross-sectional study by Saira Zafar, Babar Tasneem Shaikh, Zoha Imtiaz Malik, Abdul Momin Rizwan Ahmad

“…Adequate nutrition is essential during this developmental stage, leading to significant physical performance, improved cognitive ability, and productivity. …”
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The association between serum fructosamine and random spot urine fructose levels with the severity of non-alcoholic fatty liver disease – an analytical cross-sectional study by H Kamuzinzi, M Kgomo, P Rheeder, N Dada, P Bester

“…Our local population is burdened with increased metabolic risk factors for NAFLD. …”
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Determinants of Adverse Perinatal Outcomes in Ibadan, Nigeria: The influence of maternal lifestyle. by Ikeola A Adeoye, Chioma O Unogu, Kofoworola Adediran, Babatunde M Gbadebo

“…Understanding these risk factors can help policymakers and healthcare professionals create cost-effective interventions to curtail the burden of APO in Nigeria.…”
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Benefits, limits, and risks of ChatGPT in medicine by Jonathan A. Tangsrivimol, Jonathan A. Tangsrivimol, Erfan Darzidehkalani, Hafeez Ul Hassan Virk, Zhen Wang, Zhen Wang, Jan Egger, Michelle Wang, Sean Hacking, Benjamin S. Glicksberg, Markus Strauss, Markus Strauss, Chayakrit Krittanawong, Chayakrit Krittanawong

“…It streamlines clinical workflows by supporting triage processes, generating discharge summaries, and alleviating administrative burdens, allowing healthcare professionals to focus more on patient care. …”
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Delayed Postoperative Ambulation Results in a Significant Increase in 90-Day Mortality in Surgically Treated Hip Fractures by Robert S. Wood DO, Maddie Vergun BS, Elizabeth Herrera MPH, Jacqueline Krumrey MD

“…Introduction Hip fractures in individuals aged 65 and older present a significant burden to patients, families, and health care systems. …”
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Current regenerative approaches to the treatment of generalized periodontitis in young people (literature review) by O.V Kopchak, I.V. Kovach, Y.V. Litvinova, K.A. Yanishevsky, N.S. Marchenko

“…Periodontal diseases are a component of the global burden of chronic morbidity worldwide. The prevalence of periodontitis increases with age, reaching a high at the age of 40, which has increased medical and social importance. …”
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Central Obesity and Associated Factors among Adult Patients on Antiretroviral Therapy (ART) in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia by Adnan Kemal, Mohammed Ahmed, Melese Sinaga Teshome, Kalkidan Hassen Abate

“…There are little data on the burden of abdominal obesity using the waist-to-hip ratio measurement in HIV-infected patients in resource-limited settings, including Ethiopia. …”
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Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors by Qiang Wang, Qing Yi, Wei Xiong, Rui Duan, Jianfei Qian, Liuling Xiao, Miao Xian, Pan Su, Chuanchao Zhang, Yabo Li, Ling Zhong, Chengyun Zheng

“…Total mouse IgG or Ig2b ELISA or QuickGel split beta SPE kits and in vivo bioluminescent imaging were used to monitor MM tumor burden. Cytometry by time of flight (CyTOF) was used to quantify MM TME components. …”
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A robust multimodal brain MRI-based diagnostic model for migraine: validation across different migraine phases and longitudinal follow-up data by Jong Young Namgung, Eunchan Noh, Yurim Jang, Mi Ji Lee, Bo-yong Park

“…When validated using follow-up data, which was not included during model training, the model achieved 91%, 94%, 89% accuracies and 0.96, 0.94, 0.98 AUC for the total, interictal, and ictal/peri-ictal phases, respectively, confirming its robustness. …”
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Residence-based disparities of composite index of anthropometric failures in East African under five children; multivariate decomposition analysis by Aznamariam Ayres, Yawkal Tsega, Abel Endawkie, Shimels Derso Kebede, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare, Amare Muche, Fekade Demeke Bayou, Mastewal Arefaynie, Asnakew Molla Mekonen, Abiyu Abadi Tareke, Awoke Keleb, Kaleab Mesfin Abera, Natnael Kebede, Endalkachew Mesfin Gebeyehu

“…Results The current study revealed that the burden of composite index of anthropometric failure (CIAF) in under-5 children were 40.69%, 22.04%, 34.06%, 31.99%, and 33.27% in Ethiopia, Kenya, Rwanda, Uganda, and Tanzania respectively. …”
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Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution. by Nicolas Tessandier, Baptiste Elie, Vanina Boué, Christian Selinger, Massilva Rahmoun, Claire Bernat, Sophie Grasset, Soraya Groc, Anne-Sophie Bedin, Thomas Beneteau, Marine Bonneau, Christelle Graf, Nathalie Jacobs, Tsukushi Kamiya, Marion Kerioui, Julie Lajoie, Imène Melki, Jean-Luc Prétet, Bastien Reyné, Géraldine Schlecht-Louf, Mircea T Sofonea, Olivier Supplisson, Chris Wymant, Vincent Foulongne, Jérémie Guedj, Christophe Hirtz, Marie-Christine Picot, Jacques Reynes, Vincent Tribout, Édouard Tuaillon, Tim Waterboer, Michel Segondy, Ignacio G Bravo, Nathalie Boulle, Carmen Lía Murall, Samuel Alizon

“…Human papillomavirus (HPV) infections drive one in 20 new cancer cases, exerting a particularly high burden on women. Most anogenital HPV infections are cleared in less than two years, but the underlying mechanisms that favour persistence in around 10% of women remain largely unknown. …”
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Dataset on electricity usage measurement for lower-to-middle-income primary and secondary schools in Western Cape, South AfricaMendeley Data by Jason Avron Samuels, Terhemba Michael-Ahile, M. J. (Thinus) Booysen

“…Given this substantial financial burden, a comprehensive dataset to support the sustainability and financial viability of these schools is essential, ensuring that more resources can be directed toward their core educational missions. …”
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Respiratory pathogen spectrum and epidemiological trends in Hainan Province: a retrospective analysis from 2017 to 2023 by Lvying Wu, Jianan Zhang, Zhiming Wu, Hua Pei, You Zhang

“…Abstract Background Respiratory tract infections (RTIs) pose a significant global health burden, caused by various pathogens. The COVID-19 pandemic and non-pharmaceutical interventions (NPIs) have created unprecedented challenges for public health systems, inadvertently altering the dynamics of other respiratory pathogens. …”
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Correlation between nursing dependence and discharge readiness in middle-aged and elderly patients undergoing coronary artery bypass grafting (中老年冠状动脉旁路移植术后患者护理依赖与出院准备度的相关性研究)... by JI Yanxia (纪延霞), ZHENG Donglian (金亚楠), MA Xiaoying (郑栋莲), MA Fuzhen (马晓莹), JIN Yanan (马富珍), GUO Shuping (郭淑萍)

“…Medical staff should focus on the elderly patients and the patients with heavy family medical burden payment ratio. To develop targeted discharge planning services to reduce patients' nursing dependence. …”
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