Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China by Liqing Wei, Jun Chen, Zhen Deng, Zefang Zhang, Zhengbin Zhang, Qionghong Duan

“…BackgroundInvestigating the molecular epidemiological characteristics of multidrug-resistant tuberculosis (MDR-TB) in China’s moderate-burden regions, such as Wuhan, is crucial for understanding and controlling disease transmission.Materials and methodsThis study analyzed MDR-TB isolates from pulmonary tuberculosis cases registered at Wuhan Pulmonary Hospital in 2017. …”
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Estimating the impact of school closures on the COVID-19 dynamics in 74 countries: A modelling analysis. by Romain Ragonnet, Angus E Hughes, David S Shipman, Michael T Meehan, Alec S Henderson, Guillaume Briffoteaux, Nouredine Melab, Daniel Tuyttens, Emma S McBryde, James M Trauer

“…We estimated that school closures achieved moderate to significant burden reductions in most settings over the period 2020 to 2022. …”
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Spinal pain prevalence and associated determinants: A population‐based study using the National Survey for Wales by David C. Byfield, Benjamin S. Stacey, Hywel T. Evans, Ian W. Farr, Leon Yandle, Lora Roberts, Teresa Filipponi, Damian M. Bailey

“…This still represents a significant societal burden and these findings may help inform public health initiatives to encourage prevention and evidence‐based interventional strategies and ultimately, improve the quality of life for those suffering with SP in Wales.…”
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Assessment of Knowledge, Attitude, and Practices toward Knee Pain and Its Various Treatment Modalities among Patients by Akhil Bhalla, Sidharth Verma, Sanjog Ramrao Mekewar, Sasmit Dipak Lotliker, Aanchal Sharma, Oshin Agrawal, Maitri Shah, Hritik Madan, Dhriti Sood

“…Addressing these gaps can lead to better pain management strategies and reduced disease burden, especially in resource-constrained settings like India.…”
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Histological chorioamnionitis and its predictors among mothers with premature rupture of membranes delivering at tertiary hospitals in Uganda: a multicenter cross-sectional study by Ibrahim Abdi Abdinasir, Marie Pascaline Sabine Ishimwe, Maxwell Okello, Paul Byaruhanga, Ralph Samson Enyamitoit, Theoneste Hakizimana

“…However, data on its burden and predictors remain scarce in Africa, including Uganda. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…In in vivo assays using xenograft models, 16s3 CFR T cells significantly prolonged the survival of mice xenografted with Raji-wt cells in the presence of RTX (P < 0.001), and effectively reduced tumor burden in mice xenografted with SK-OV-3 cells in the presence of herceptin (P < 0.05). …”
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Prevalence, predisposing factors, and turnover intention related to low back pain among health workers in Accra, Ghana. by Philip Apraku Tawiah, Emmanuel Appiah-Brempong, Paul Okyere, Geoffrey Adu-Fosu, Mary Eyram Ashinyo

“…These findings underscore the importance of targeted interventions aimed at reducing the burden of LBP within these specific areas.…”
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Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections by Mohd Saleem, Soha Abdallah Moursi, Tahani Nasser Almofeed Altamimi, Mohammed Salem Alharbi, Alwaleed Mohammad Alaskar, Sahar Adly Hassan Hammam, Ehab Rakha, Ozair Ilyas Syed Muhammad, Hamoud Abdulmohsin Almalaq, Metab Nasser Alshammari, Azharuddin Sajid Syed Khaja

“…<b>Conclusions:</b> The findings of this study highlight the significant burden of MDR infections, particularly carbapenemase-producing organisms, in DFUs. …”
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Emergency Medicine as a Medical Speciality in Nigeria: Challenges and Prospects by Wahab Yinusa

“…The result of the latter is a casualty department with an overwhelming burden of patients and a high mortality rate. The World Health Assembly (WHA) resolution 60.22 of 2007 mandated every member state government to establish and monitor integrated EM care systems; it is therefore expected that the emergency medical services (EMS) in the country would wear a new look. …”
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Symptoms of anxiety, depression, and post-traumatic stress disorder 6 weeks and 6 months after ICU: Six out of 10 survivors affected by E van der Merwe, L Stroud, G Sharp, N van Vuuren, M Mosola, T Fodo, F Paruk

“…Associations for significant psychological symptoms comprised female sex, younger age, a diagnosis of trauma and frightening memories of the ICU admission. Conclusion. The burden of mental health disease in ICU survivors is substantial, affecting their HRQOL. …”
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Newborn birth weight and its associated risk factors in Somalia using Somalia health and demographic survey by Denekew Bitew Belay, Nigussie Adam Birhan, Mahad Ibrahim Ali, Ding-Geng Chen

“…Low birth weight is a strong indicator of multifaceted public health problems, including unfavorable socio-demographic conditions, chronic illness, and poor health care during pregnancy. The aim of this study was to assess the prevalence and risk factors of newborn birth weight in Somalia. …”
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Risk assessment and photo-disinfection of antibiotic residues and antibiotic-resistant bacteria in water sources from Ede, Nigeria by Gloria O. Taylor, Aemere Ogunlaja, Olumide D. Olukanni, Oluwatosin M. Awopetu, Frances Okodua, Daniel O. Godson, Afolarin Otusile, Daniella Ekpe, Esther Deguenon, Kevin M. Sintondji, Victorien Dougnon, Olumuyiwa O. Ogunlaja, Chidinma G. Olorunnisola, Martins O. Omorogie, Moses O. Alfred, Emmanuel I. Unuabonah

“…Usage, discharge and sales of antibiotics should be guided by policies while routine monitoring of drinking water sources should be encouraged to reduce the AMR burden in the region. The photocatalytic material used in this study for water disinfection offers a promising, cost-effective solution for mitigating AMR risks from drinking water.…”
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The Link between Overweight/Obesity and Noncommunicable Diseases in Ethiopia: Evidences from Nationwide WHO STEPS Survey 2015 by Bedilu Alamirie Ejigu, Fentanesh Nibret Tiruneh

“…Although the literature indicates that the burden of NCDs is increasing in Ethiopia, no research has been conducted to demonstrate a link between overweight/obesity and NCDs. …”
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Laminoplasty vs laminectomy in the surgical management of spinal intradural extramedullary tumors by Deepak Kumar Singh, Prevesh Kumar Sharma, Vipin Kumar Chand, Kaif Mohammad, Kuldeep Yadav, Neha Singh

“…Additionally, it alleviates the need for additional instrumentation, thereby avoiding an extra financial burden while enhancing the quality of life for the patient. …”
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Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects by Feng Cheng, Tao Shen, Fucheng Zhang, Chenghao Lei, Ye Zhu, GuoJun Luo, Dawei Xiao

“…It urgently needs good generic drugs to help ease patients’ burden and improve their quality of life.ObjectiveThe primary objective of this study was to evaluate the bioequivalence of fluticasone propionate nebuliser suspensions between test formulation (generic product) and reference formulation (original product, Flixotide Nebules®) with the pharmacokinetic parameters as the endpoint indicators and the secondary objective was to evaluate the safety of two inhalated fluticasone propionate nebuliser suspensions under the condition of fasting in healthy Chinese subjects.MethodsThe bioequivalence study was conducted with a single-center, randomized, open-label, single-dose, two sequences, two-period crossover design. 24 healthy subjects were randomly assigned into T-R and R-T sequence groups with 12 patients in each group. …”
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Years of Life Lost due to Premature Mortality in Russia, 1990-2021 by Anastasiya I. Pyankova, Timur A. Fattakhov, Mikhail B. Denisenko

“…According to the Global Burden of Disease, in Russia in 2019, the standardised rate of years of life lost from premature mortality reached its lowest value since the early 1990s. …”
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Impact of Arterial Remodeling of Intermediate Coronary Lesions on Long-Term Clinical Outcomes in Patients with Stable Coronary Artery Disease: An Intravascular Ultrasound Study by Liang Geng, Peizhao Du, Yuan Yuan, Liming Gao, Yunkai Wang, Jiming Li, Qi Zhang

“…Negative remodeling lesions had the smallest minimum lumen area (4.16 ± 1.03 mm2 vs. 5.05 ± 1.39 mm2 vs. 4.85 ± 1.76 mm2; P<0.01), smallest plaque burden (63.45 ± 6.13% vs. 66.12 ± 6.82% vs. 71.17 ± 6.45%; P<0.01), and highest area stenosis rate (59.32% ± 10.15% vs. 54.61% ± 9.09% vs. 51.67% ± 12.96%; P<0.01). …”
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Early Markers of Liver Fibrosis in Children with Beta-thalassaemia Major: A Cross-sectional Study by Himani Aggarwal, Monica Verma, Shuchi Bhalla, Dinkar Yadav, Kapil Bhalla, Abhishek Soni

“…Liver biopsy is considered the gold standard; however, it is burdened with a multitude of risks, highlighting the need for ongoing studies to evaluate the risk of fibrosis using less invasive methods. …”
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An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure by Seth Kwadjo Angmorterh, Andrew England, Sonia Aboagye, Eric Kwasi Ofori, Peter Hogg

“…PUs creates a huge financial burden on healthcare authorities and patients, costing billions to treat and manage. …”
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Prevalence of Insomnia and Related Factors Among Cancer Outpatients in China by Zhao K, Yu Z, Wang Y, Feng W

“…Chronic insomnia imposes pronounced physical and psychological burdens on cancer patients, affecting their quality of life and survival rate. …”
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