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  1. 6401

    Mapping the landscape of Hospital at home (HaH) care: a validated taxonomy for HaH care model classification by Kerstin Denecke

    Published 2025-01-01
    “…The third cluster (20.6%, 7/34) includes complex interventions involving informal caregivers and advanced medical devices, requiring caregiver training, supportive policies, and user-friendly technology to reduce caregiver burden and improve safety. Conclusions The clusters identified highlight practical considerations for adapting HaH care approaches to patient and contextual needs. …”
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  2. 6402

    Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

    Published 2025-01-01
    “…Furthermore, we examined immune infiltration and tumor mutation burden of the genes within our model and scrutinized divergences in the immune microenvironment between high- and low-risk groups. …”
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  3. 6403

    Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

    Published 2025-02-01
    “…Abstract Background Gastric cancer (GC) presents a significant global health burden, necessitating a deeper understanding of its molecular underpinnings for improved diagnostics and therapeutics. …”
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  4. 6404

    Automatic MRI Lymph Node Annotation From CT Labels by Souraja Kundu, Yuji Iwahori, M. K. Bhuyan, Manish Bhatt, Boonserm Kijsirikul, Aili Wang, Akira Ouchi, Yasuhiro Shimizu

    Published 2025-01-01
    “…Our algorithm reduces the burden of manual annotation and the reliance on large labeled datasets and eliminates the need for any MRI ground truth. …”
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  5. 6405

    Design of an RCT on cost-effectiveness of group schema therapy versus individual schema therapy for patients with Cluster-C personality disorder: the QUEST-CLC study protocol by Iuno Z. Groot, Anne-Sophie S. M. Venhuizen, Nathan Bachrach, Simone Walhout, Bregje de Moor, Kasper Nikkels, Susanne Dalmeijer, Myrte Maarschalkerweerd, Joël R. van Aalderen, Hinde de Lange, Renske Wichers, Agatha Ph. Hollander, Silvia M. A. A. Evers, Raoul P. P. P. Grasman, Arnoud Arntz

    Published 2022-10-01
    “…Abstract Background Given the high prevalence of Cluster-C Personality Disorders (PDs) in clinical populations, disease burden, high societal costs and poor prognosis of comorbid disorders, a major gain in health care can be achieved if Cluster-C PDs are adequately treated. …”
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  6. 6406

    The epidemiology and unmet need of migraine in five european countries: results from the national health and wellness survey by Gianluca Coppola, Joshua D. Brown, Amanda R. Mercadante, Sheila Drakeley, Nikoletta Sternbach, Aaron Jenkins, Karin Hygge Blakeman, Astrid Gendolla

    Published 2025-01-01
    “…Abstract Background Despite the high global prevalence, burden, and direct and indicated costs, migraines are often under-diagnosed and undertreated. …”
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  7. 6407

    Pilot study of a ketogenic diet in bipolar disorder: a process evaluation by Benjamin P. Rigby, Nicole Needham, Helen Grossi, Ivana Kamenska, Iain H. Campbell, Ben Meadowcroft, Frances Creasy, Cheryl Fisher, Pankaj Bahuguna, John Norrie, Gerard Thompson, Melissa C. Gibbs, Maja Mitchell-Grigorjeva, Ailsa McLellan, Tessa Moses, Karl Burgess, Rachel Brown, Michael J. Thrippleton, Harry Campbell, Daniel J. Smith, Sharon A. Simpson

    Published 2025-01-01
    “…Results Five themes were identified in the qualitative data: (1) ‘Encouraging entry and supporting exit’ (e.g. recognising and managing participants’ varied motives and expectations, including around weight loss and symptom alleviation); (2) ‘Challenging but potentially transformational,’ which reflects that while it can be difficult to initiate and maintain a ketogenic diet day-to-day, many participants perceived physical and psychological benefits (e.g. significant weight loss, mood stability and enhanced ability to focus); (3) ‘Intervention facilitators,’ including a range of behavioural (e.g. goal setting), social (e.g. family and dietitians) and technological (e.g. apps for monitoring) support mechanisms; (4) ‘Intervention barriers’ (e.g. dietary preferences, concerns about the diet and its impact, the testing burden and capacity of the delivery team); and (5) ‘The wider context’ (e.g. the cost of living and sociocultural expectations) was a crucial factor explaining differential experiences. …”
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  8. 6408

    Antibiotic Use and Resistance Pattern in Ethiopia: Systematic Review and Meta-Analysis by Oumer Abdu Muhie

    Published 2019-01-01
    “…In the last decades, medicines have had an unprecedented positive effect on health, leading to reduced mortality and disease burden and consequently to an improved quality of life. …”
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  9. 6409

    Evaluation of pathology resources for cervical cancer detection between 2018 and 2022: a retrospective study at Moi Teaching and Referral Hospital, Western Kenya by Nelson Anangwe, Jon Steimgrimson, Susan Cu-Uvin

    Published 2025-02-01
    “…Results The number of histopathology laboratory personnel at MTRH increased from 2018 to 2022, during which the facility included two pathologists, one records person, and one office administrator. …”
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  10. 6410

    Magnitude, risk factors and economic impacts of diabetic emergencies in developing countries: A systematic review. by Halefom Kahsay Haile, Teferi Gedif Fenta

    Published 2025-01-01
    “…The significant economic burden of these emergencies exacerbates the strain on already limited healthcare resources. …”
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  11. 6411

    Association between oxidative balance scores and peripheral artery disease in US adults: a cross-sectional study by Min Zhou, Min Zhou, Peng-Fei He, Peng-Fei He, Keren Zhang, Li-Juan Deng, Ning Wang, Gang Wang, Guang-Yao Yang, Shang Ju

    Published 2025-01-01
    “…BackgroundThe Oxidative Balance Score (OBS) quantifies the overall oxidative stress burden, with higher scores indicating greater antioxidant (relative to prooxidant) activity. …”
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  12. 6412

    Multiple time points for detecting circulating tumor DNA to monitor the response to neoadjuvant therapy in breast cancer: a meta-analysis by Shuyi Niu, Tie Sun, Mozhi Wang, Litong Yao, Tianyi He, Yusong Wang, Hengjun Zhang, Xiang Li, Yingying Xu

    Published 2025-01-01
    “…We performed a meta-analysis to explore the predictive value of response by monitoring ctDNA at four time points of NAT using pathologic complete response (pCR) and residual cancer burden (RCB). Methods By searching Embase, PubMed, the Cochrane Library, and the Web of Science until December 24, 2023, we selected studies concerning the relationship between ctDNA and response or prognosis. …”
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  13. 6413

    Awareness, knowledge, and attitudes of the Belgian general population towards paternal perinatal depression: a descriptive cross-sectional study by Ayse Akalin, Ayse Akalin, Florence D’haenens, Sandra Tricas-Sauras, Sandra Tricas-Sauras, Joeri Vermeulen, Joeri Vermeulen, Joeri Vermeulen, Dennis Demedts, Dennis Demedts, Ronald Buyl, Maaike Fobelets, Maaike Fobelets

    Published 2025-01-01
    “…BackgroundPaternal perinatal depression affects 10% of fathers, implying a significant burden on families and public health. A better insight into the population’s health literacy could guide professionals and policymakers in addressing these men and making better use of existing healthcare options. …”
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  14. 6414

    Rekomendasi Pemberian Layanan Terapi Trombolisis (rt-PA) Untuk Pasien Stroke Iskemik Akut: Pendekatan Pengambilan Keputusan Multi Kriteria by Jidin Abdullah, Dikky Indrawan, Popong Nurhayati

    Published 2024-09-01
    “…Data from the Global Burden of Diseases Study (2019) and Riskesdas (2018) indicate that 65% of stroke sufferers have a risk of impairment and 15% have a chance of death. …”
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  15. 6415

    Identification of Survival Risk and Immune-Related Characteristics of Kidney Renal Clear Cell Carcinoma by Xiaobin Wu, Yonghui Liang, Xian Chen, Xiangyang Long, Wujun Xu, Li Liu, Binhui Wang, Xiong Zou

    Published 2022-01-01
    “…A series of information such as RNA sequence, clinical data, and tumor mutation burden (TMB) of KIRC patients were downloaded through The Cancer Genome Atlas (TCGA). …”
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  16. 6416

    Effectiveness of mental health interventions for older adults in South Asia: A scoping review. by Hoimonty Mazumder, Farah Faizah, Easter Protiva Gain, Irfath Sharmin Eva, Kaniz Ferdouse Mou, Nobonita Saha, Farzana Rahman, Jyoti Das, A M Khairul Islam, Fazilatun Nesa, M Mahbub Hossain

    Published 2023-01-01
    “…Therefore, future researchers are encouraged to conduct empirical studies to understand disease burden, including associated factors of geriatric mental health, which may help to construct contextually appropriate mental health interventions in this region.…”
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  17. 6417

    Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts by Lewis Steell, Stefanie J. Krauth, Sayem Ahmed, Grace O. Dibben, Emma McIntosh, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair, Bhautesh D. Jani, the PERFORM research team

    Published 2025-01-01
    “…Abstract Background Identifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development of effective and cost-effective targeted healthcare strategies. …”
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  18. 6418

    Preventable hospitalizations through ED: does the number of hospital beds matter under the global budget in a single-payer system in Taiwan? by Hsueh-Fen Chen, Hsueh-Fen Chen, Hsueh-Fen Chen, Hui-Min Hsieh, Hui-Min Hsieh, Hui-Min Hsieh, Wei-Shan Chang

    Published 2025-01-01
    “…The recent increase in the number of hospital beds and the call to enhance the floating-point value to one NTD raise concerns about the potential for increased financial burden without adding value to patient care if hospitals expand their bed capacity for volume-based competition. …”
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  19. 6419

    The effects of PM2.5 components on the cardiovascular disease admissions in Shanghai City, China: a multi- region study by Wanying Su, Heping Liu, Tiantian Han, Yunyun Wang, Yi An, Yan Lin

    Published 2024-12-01
    “…Abstract Background The burden of cardiovascular disease (CVD) is severe worldwide. …”
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  20. 6420

    Prevalence and Associated Factors of Overweight and Obesity among Primary School Children Aged 7–17 Years in Urban Mbarara, Uganda by Benedict Twinomugisha, Abdon Marius Birungi

    Published 2024-01-01
    “…In Uganda, there is a significant burden of overweight and obesity. This study was conducted to determine the prevalence and associated factors that influence overweight and obesity among primary school children in Southwestern Uganda. …”
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