Mental health and psychosocial support strategies in highly contagious emerging disease outbreaks of substantial public concern: A systematic scoping review. by Angela M Kunzler, Jutta Stoffers-Winterling, Marlene Stoll, Alexander L Mancini, Sophie Lehmann, Manpreet Blessin, Donya Gilan, Isabella Helmreich, Frank Hufert, Klaus Lieb

“…<h4>Background</h4>Acute disease outbreaks such as the COVID-19 pandemic cause a high burden of psychological distress in people worldwide. …”
Get full text

Economic impact of medication non-adherence by disease groups: a systematic review by Victoria Garcia-Cardenas, Rachelle Louise Cutler, Fernando Fernandez-Llimos, Michael Frommer, Charlie Benrimoj

“…Drummond quality assessment yielded 10 studies of high quality with all studies performing partial economic evaluations to varying extents.Conclusion Medication non-adherence places a significant cost burden on healthcare systems. Current research assessing the economic impact of medication non-adherence is limited and of varying quality, failing to provide adaptable data to influence health policy. …”
Get full text

Use of rituximab in mature, high-grade and advanced-stage pediatric B-lineage non-Hodgkin lymphomas: a systematic review, meta-analysis and the Brazilian reality by Alejandra Adriana Cardoso de Castro, Alejandra Adriana Cardoso de Castro, Alejandra Adriana Cardoso de Castro, Liana Alves de Oliveira, Liana Alves de Oliveira, Diancarlos Pereira de Andrade, Edna Kakitani Carbone, Edna Kakitani Carbone, Roberto Rosati, Roberto Rosati, Roberto Rosati

“…However, access to rituximab in Brazilian hospitals is currently dependent on centers supporting its economic burden.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42021292912).…”
Get full text

Intensity of Nematode Infection in Children Aged 3 to 5 Years Living in Mukuru Kwa Njenga Slum Settlement, Nairobi, Kenya by Lynda Allan, Fiona N. Mbai, Dorcas S. Yole, Moses Owino

“…Background. The burden of nematode infections is high mostly in children below 5 years old, with clinical manifestations ranging from mild to painful symptoms due to severe infections that end up suppressing the immune system of the infected children. …”
Get full text

Young, Empowered & strong (YES): a study protocol paper for a randomized controlled trial of an mHealth symptom monitoring and self-management intervention for adolescent and young... by Kate E Dibble, Shoshana M Rosenberg, Craig Snow, Gregory J Kirkner, Nabihah Tayob, Magnolia Contreras, Noel D Roma, Cecilia R DeGraffinreid, Timiya S Nolan, Dawn L Hershman, Michelle Naughton, Ann H Partridge

“…Abstract Background Compared to older adults with breast cancer (BC), adolescents and young adults (AYAs) develop more aggressive disease necessitating more intensive therapy with curative intent, which is disruptive to planned life trajectories. The burden of unmet needs among AYA BC survivors exists in two domains: (1) symptoms (e.g., sexual problems, anxiety, fatigue, stress, hot flashes) and (2) AYA concerns (e.g., fertility, genetics, relationships, economic attainment). …”
Get full text

Medical Resource Use and Costs of Treating Sickle Cell-related Vaso-occlusive Crisis Episodes: A Retrospective Claims Study by Nirmish Shah, Menaka Bhor, Lin Xie, Jincy Paulose, Huseyin Yuce

“…**Background:** The study investigated the economic burden of vaso-occlusive crisis (VOC) among sickle cell disease (SCD) patients, through assessment of overall utilization and costs and costs per VOC episode (regarding the number of VOC episodes and health care setting, respectively). …”
Get full text

Economic evaluation of Maternal Depression Treatment in HIV (M-DEPTH) for perinatal depression among women living with HIV in Uganda: a cost-effectiveness analysis by Ryan McBain, Adeyemi Okunogbe, Rhoda K Wanyenze, Violet Gwokyalya, Glenn Wagner

“…Change in the prevalence of depressive disorder—from enrolment to 18 months postpartum—was quantified using the Patient Health Questionnaire, with depressive disorder assigned a disability weight according to the Global Burden of Disease project. Incremental cost-effectiveness ratios (ICERs) were expressed as cost per disability-adjusted life years (DALY) averted.Results The estimated economic cost of M-DEPTH was US$128.82 per participant, compared with $1.53 per participant for CAU. …”
Get full text

ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation by Jiaxing Zhang, Jiaxing Zhang, Gang Wang, Jie Liu, Futian Tang, Song Wang, Yumin Li, Yumin Li

“…ITGA4 positively correlated with immune cell infiltration, immune regulatory genes, chemokines, and might reduce microsatellite instability (MSI) and tumor mutation burden (TMB) by promoting MMR gene expression. It could also predict immunotherapy efficacy and chemotherapy sensitivity. …”
Get full text

Multiple Parameters Determination Method of Hardening Soil Model Based on Particle Swarm Optimization by Jingfeng Xiao, Qunwei Wang, Qianhui Zhang, Yunpeng Hei, Youliang Zhang

“…This outcome has the potential to greatly alleviate the burden of conducting indoor tests and holds considerable practical value in engineering applications. …”
Get full text

CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension by Lea Strohm, Henning Ubbens, Dominika Mihalikova, Alexander Czarnowski, Paul Stamm, Michael Molitor, Stefanie Finger, Matthias Oelze, Dorothee Atzler, Philip Wenzel, Philipp Lurz, Thomas Münzel, Christian Weber, Esther Lutgens, Andreas Daiber, Steffen Daub

“…Cardiovascular disease is the leading cause of disease burden and death worldwide and is fueled by vascular inflammation. …”
Get full text

Scoping review and interpretation of myofascial pain/fibromyalgia syndrome: An attempt to assemble a medical puzzle. by Shiloh Plaut

“…<h4>Background</h4>Myofascial Pain Syndrome (MPS) is a common, overlooked, and underdiagnosed condition and has significant burden. MPS is often dismissed by clinicians while patients remain in pain for years. …”
Get full text

Detection of Elder Abuse Through Emergency Care Technicians Screening Tool Revision for Home-Based Primary Care (DETECT-RPC): a cluster randomised controlled trial study protocol by Melvin D Livingston, Brad Cannell, Jason Burnett, Nicholas Sevey, Kristin Lees Haggerty, Carolyn Pickering

“…Associated with a decrease in quality of life and increase in risk of mortality, EM represents a significant public health burden. Home-based primary care (HBPC) providers are uniquely positioned to address the critical need for robust EM screening and reporting, especially among individuals with AD/ADRD. …”
Get full text

Trauma centers: an underfunded but essential asset to the community by Nasim Ahmed, Joseph L Fracasso

“…Most trauma centers have begun incorporating activation costs to recoup losses from their low reimbursement rate, but these have continued to inflate, and pose a growing burden on vulnerable patients.Lack of funding from external sources such as state or federal appropriations poses a tangible threat to trauma centers for closure, and with multiple trauma centers acting as critical pillars of healthcare infrastructure for disadvantaged communities as well as the impact of this lack of funding being so broad and systemic, multiple ‘trauma deserts’ may emerge, leaving communities—especially disadvantaged communities which rely on the safety-net function of many high designation trauma centers—deprived of an essential treatment resource and increasing annual mortalities that could have otherwise been averted.…”
Get full text

Additive interaction of conjoint tobacco smoking and heavy drinking on hypertension prevalence in rural Uganda: a community-based cross-sectional study by Paineto Masengere, Nynke Halbesma, Rawlance Ndejjo, Bonny Enock Balugaba, Rhoda K. Wanyenze, Fred Nuwaha, Hilde Bastiaens, Geofrey Musinguzi

“…Abstract Background The prevalence of hypertension is high in Uganda, which places a significant burden on an already strained healthcare system. The behavioural risk factors, such as unhealthy diet, tobacco use, physical inactivity, and heavy drinking, contribute to hypertension development and complications. …”
Get full text

Patterns and factors associated with healthcare utilisation in Cambodia: a cross-sectional study based on the World Health Survey Plus 2023 by Kerstin Klipstein-Grobusch, Por Ir, Paul Kowal, Nawi Ng, Srean Chhim, Chhorvann Chhea, Chamnab Ngor, Sereyraksmey Long, Poppy Walton, Khin Thiri Maung, Grace Marie Ku, Heng Sopheab

“…Background The Cambodian government aims to boost healthcare utilisation in public facilities and reduce the spending burden for disadvantaged households. This study aims to describe patterns of public and private outpatient and inpatient healthcare use and investigate the factors associated with public healthcare usage in Cambodia.Method A cross-sectional study was conducted in all provinces in Cambodia, including the capital, Phnom Penh. …”
Get full text

Cost-Effectiveness of the Prenatal Detection of Congenital Heart Diseases: A Systematic Literature Review by Darío Londoño Trujillo, Paula A. Castro García, Kristian K. Rojas López, Karen J. Moreno-Medina, María T. Dominguez Torres, Rodolfo J. Dennis Verano, Nestor F. Sandoval Reyes

“…This significant health and economic burden on healthcare systems and families highlights the relevance of evaluating the cost-effectiveness of methods for early detection of this condition. …”
Get full text

Diagnostic performances of Schistosoma haematobium and Schistosoma mansoni recombinant proteins, peptides and chimeric proteins antibody based tests. Systematic scoping review. by Arthur Vengesai, Victor Muleya, Herald Midzi, Tryphine Vimbai Tinago, Isaac Chipako, Marble Manuwa, Thajasvarie Naicker, Takafira Mduluza

“…Together with the advantages associated with urine sampling technique, we recommend development of multi-peptide chimeric proteins urine based point of care tools.…”
Get full text

The experience of living with human immunodeficiency virus among adolescents at Felege Hiwot Comprehensive Specialized Hospital Bahir-Dar, Northwest Ethiopia, A phenomenological st... by Bazezew Asfaw Guadie, Minyichil Birhanu Belete, Meseret Mekuriaw Beyene, Ayalew Kassie Melese, Tarik Yenew Tessema, Yinager Workineh

“…<h4>Result</h4>Eleven subthemes, including main theme of "lived with burdens of immunodeficiency virus," "disclosure," "ART adherence," and "future aspiration," were used to describe the findings. …”
Get full text

Trends in age‐specific incidence, mortality, and DALYs of female breast cancer from 1990 to 2021 by Subhadra Priyadarshini, Kunja Bihari Panda

“…These findings underscore the need for targeted public health interventions, enhanced screening practices, and ongoing advancements in breast cancer treatment to address the evolving burden of this disease across different age groups.…”
Get full text

Mechanical and Durability Performance of High-Strength Concrete with Waste Tyre Steel Fibres by Daudi Salezi Augustino, Richard Ocharo Onchiri, Charles Kabubo, Christopher Kanali

“…Waste tyres increase the environmental burden due to their resistance to decomposition in landfills. …”
Get full text